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Entry version 119 (12 Aug 2020)
Sequence version 1 (01 Oct 2002)
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Protein

Protein FAM133A

Gene

FAM133A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8N9E0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FAM133A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAM133A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000179083.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26748, FAM133A

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N9E0

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
286499

Open Targets

More...
OpenTargetsi
ENSG00000179083

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162386125

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8N9E0, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FAM133A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74751120

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002876191 – 248Protein FAM133AAdd BLAST248

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8N9E0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8N9E0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8N9E0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N9E0

PeptideAtlas

More...
PeptideAtlasi
Q8N9E0

PRoteomics IDEntifications database

More...
PRIDEi
Q8N9E0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
72524

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N9E0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N9E0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000179083, Expressed in buccal mucosa cell and 116 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N9E0, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000179083, Group enriched (brain, pituitary gland, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8N9E0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi45 – 240Lys-richAdd BLAST196
Compositional biasi82 – 198Ser-richAdd BLAST117

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM133 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502RXMT, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111097

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_108741_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N9E0

Identification of Orthologs from Complete Genome Data

More...
OMAi
KTGHRRH

Database of Orthologous Groups

More...
OrthoDBi
1561261at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N9E0

TreeFam database of animal gene trees

More...
TreeFami
TF350193

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026766, Fam133

The PANTHER Classification System

More...
PANTHERi
PTHR31911, PTHR31911, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8N9E0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKRDNRVAY MNPIAMARWR GPTQSVGPTI QDYLNRPRPT WEEVKKQLEN
60 70 80 90 100
KKTGSKALAE FEEKMNENWK KELEKSREKL LSGNESSSKK RERKKKRKKK
110 120 130 140 150
SCRSSSSSSS SDSSSSSSDS EDEEKKQGKR RKKKKNRSYK SSQSSTHESE
160 170 180 190 200
SESKESVKKK KKSKDETEKE KDVRSLSKKR KKSYPDDKPL SSESSSESDY
210 220 230 240
EEDVQAKKKR RCEEREQAKE KVKKKKKKQH KKHSKKKKKK SGSSHKSR
Length:248
Mass (Da):28,941
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDB18B8F3FABFBAF6
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05390767E → K. Corresponds to variant dbSNP:rs34123774Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK094978 mRNA Translation: BAC04467.1
AL009173 Genomic DNA No translation available.
BC113387 mRNA Translation: AAI13388.1
BC113385 mRNA Translation: AAI13386.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14466.1

NCBI Reference Sequences

More...
RefSeqi
NP_001164580.1, NM_001171109.1
NP_001164581.1, NM_001171110.1
NP_001164582.1, NM_001171111.1
NP_775969.1, NM_173698.2
XP_006724704.1, XM_006724641.3
XP_011529227.1, XM_011530925.2
XP_011529228.1, XM_011530926.2
XP_011529229.1, XM_011530927.2
XP_011529230.1, XM_011530928.1
XP_011529231.1, XM_011530929.1
XP_011529233.1, XM_011530931.2
XP_016884943.1, XM_017029454.1
XP_016884944.1, XM_017029455.1
XP_016884945.1, XM_017029456.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000322139; ENSP00000318974; ENSG00000179083
ENST00000332647; ENSP00000362169; ENSG00000179083

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
286499

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:286499

UCSC genome browser

More...
UCSCi
uc004efr.3, human

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094978 mRNA Translation: BAC04467.1
AL009173 Genomic DNA No translation available.
BC113387 mRNA Translation: AAI13388.1
BC113385 mRNA Translation: AAI13386.1
CCDSiCCDS14466.1
RefSeqiNP_001164580.1, NM_001171109.1
NP_001164581.1, NM_001171110.1
NP_001164582.1, NM_001171111.1
NP_775969.1, NM_173698.2
XP_006724704.1, XM_006724641.3
XP_011529227.1, XM_011530925.2
XP_011529228.1, XM_011530926.2
XP_011529229.1, XM_011530927.2
XP_011529230.1, XM_011530928.1
XP_011529231.1, XM_011530929.1
XP_011529233.1, XM_011530931.2
XP_016884943.1, XM_017029454.1
XP_016884944.1, XM_017029455.1
XP_016884945.1, XM_017029456.1

3D structure databases

SMRiQ8N9E0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi130395, 9 interactors
IntActiQ8N9E0, 19 interactors
STRINGi9606.ENSP00000318974

PTM databases

iPTMnetiQ8N9E0
PhosphoSitePlusiQ8N9E0

Polymorphism and mutation databases

BioMutaiFAM133A
DMDMi74751120

Proteomic databases

EPDiQ8N9E0
MassIVEiQ8N9E0
MaxQBiQ8N9E0
PaxDbiQ8N9E0
PeptideAtlasiQ8N9E0
PRIDEiQ8N9E0
ProteomicsDBi72524

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
67595, 62 antibodies

The DNASU plasmid repository

More...
DNASUi
286499

Genome annotation databases

EnsembliENST00000322139; ENSP00000318974; ENSG00000179083
ENST00000332647; ENSP00000362169; ENSG00000179083
GeneIDi286499
KEGGihsa:286499
UCSCiuc004efr.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
286499
DisGeNETi286499
EuPathDBiHostDB:ENSG00000179083.6

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FAM133A
HGNCiHGNC:26748, FAM133A
HPAiENSG00000179083, Group enriched (brain, pituitary gland, testis)
neXtProtiNX_Q8N9E0
OpenTargetsiENSG00000179083
PharmGKBiPA162386125

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502RXMT, Eukaryota
GeneTreeiENSGT00730000111097
HOGENOMiCLU_108741_0_0_1
InParanoidiQ8N9E0
OMAiKTGHRRH
OrthoDBi1561261at2759
PhylomeDBiQ8N9E0
TreeFamiTF350193

Enzyme and pathway databases

PathwayCommonsiQ8N9E0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
286499, 44 hits in 492 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
286499
PharosiQ8N9E0, Tdark

Protein Ontology

More...
PROi
PR:Q8N9E0
RNActiQ8N9E0, protein

Gene expression databases

BgeeiENSG00000179083, Expressed in buccal mucosa cell and 116 other tissues
GenevisibleiQ8N9E0, HS

Family and domain databases

InterProiView protein in InterPro
IPR026766, Fam133
PANTHERiPTHR31911, PTHR31911, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF133A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N9E0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 1, 2002
Last modified: August 12, 2020
This is version 119 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families
  5. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
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