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Entry version 134 (18 Sep 2019)
Sequence version 2 (01 May 2007)
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Protein

Immunoglobulin superfamily member 22

Gene

IGSF22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Immunoglobulin superfamily member 22
Short name:
IgSF22
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IGSF22
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26750 IGSF22

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N9C0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
283284

Open Targets

More...
OpenTargetsi
ENSG00000179057

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671662

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IGSF22

Domain mapping of disease mutations (DMDM)

More...
DMDMi
146324946

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002852551 – 903Immunoglobulin superfamily member 22Add BLAST903

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8N9C0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8N9C0

PeptideAtlas

More...
PeptideAtlasi
Q8N9C0

PRoteomics IDEntifications database

More...
PRIDEi
Q8N9C0

ProteomicsDB human proteome resource

More...
ProteomicsDBi
14735
72522 [Q8N9C0-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N9C0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N9C0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000179057 Expressed in 123 organ(s), highest expression level in skin of leg

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N9C0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB026459

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q8N9C0, 1 interactor

Molecular INTeraction database

More...
MINTi
Q8N9C0

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8N9C0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini67 – 158Ig-like 1Add BLAST92
Domaini232 – 322Ig-like 2Add BLAST91
Domaini418 – 508Ig-like 3Add BLAST91
Domaini606 – 696Ig-like 4Add BLAST91
Domaini703 – 798Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST96
Domaini804 – 898Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST95

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi163 – 228Lys-richAdd BLAST66

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160123

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113015

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N9C0

Identification of Orthologs from Complete Genome Data

More...
OMAi
DRIPIKF

Database of Orthologous Groups

More...
OrthoDBi
103399at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N9C0

TreeFam database of animal gene trees

More...
TreeFami
TF351819

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 8 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR040849 MyBP-C_THB

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041 fn3, 2 hits
PF07679 I-set, 5 hits
PF18362 THB, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 2 hits
SM00409 IG, 6 hits
SM00408 IGc2, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 6 hits
SSF49265 SSF49265, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 2 hits
PS50835 IG_LIKE, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8N9C0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTTIHSRQML QEHVSMEFSS STTHVQTFSQ TTKIVGEEVV RRKSSSIVEF
60 70 80 90 100
FSLVTRSSNI PAGDSVPEFV EKPQPVTAPE GDKAVFRARV QGNAKPHISW
110 120 130 140 150
KRESGIPIKE SAKIFYDSIN KEHVLKLEPL TSDDSDNYKC IASNDHADAI
160 170 180 190 200
YTVSLLVTEG QEKMDFKKML KKRAPPAPKK KQKKVANEKE MLEILSKVPK
210 220 230 240 250
KDFEKVCMEY GFTDFRGLLR KLKEMKKKVE VEAIRILKPL EDKETKVDTT
260 270 280 290 300
VVFDCIMELK DPNVKMIWIK GTEPLRIQYS LGKYDVKQMG TKYMLVISNV
310 320 330 340 350
NMNDAGIYSL SVGDKRMSAE LTVLDEPLKF LGEMKPVKVT ERQTAVFEIR
360 370 380 390 400
LSKKEPNFVW KFNGKELKRD DKYEITVSED GLTHTLKIKD ARLSDSGEFS
410 420 430 440 450
AEAGNLVQKA QLTVDRIPIK FVSNLKNVRV KERSRACLEC ELTSKDVTLR
460 470 480 490 500
WKKDGQLLMH GTKYSMNHEG KRAELIIEDA QLSDGGEYTV VAMQDGDPTE
510 520 530 540 550
YYSTAIVTVE ERLATVKSGM SDVHAATGSP AELCVVLNDE KVEGVWLKDG
560 570 580 590 600
KEITDLPGMQ IVKQGAVHKL IFPSMGPEHE GKYTFRAKGT ESEASVFIAD
610 620 630 640 650
PPTIDPSVLE ALAAHAITVK VGHTAHIKVP FRGKPLPKVT WYKDGMEVTE
660 670 680 690 700
EERVSMERGE DQALLTISNC VREDSGLILL KLKNDHGSAT ATLHLSVLEP
710 720 730 740 750
PGFASQPQVT DVTKEAVTIT WNAPTQDGGA PVLGYIVERR KKGSNLWVPV
760 770 780 790 800
NKDPIQGTKC TVDGLLEDTE YEFRVIAVNK AGPGQPSVPS SSVVAKDPVK
810 820 830 840 850
PPGLVQDLHV SDSSNSSISL AWREPAEGDP PSGYILEMRA EDTKEWSKCT
860 870 880 890 900
KIPISGTCYT VGGLIERQKY FFRIRAVNEA GVGEPVELDK GVRAMPPPGL

TTT
Length:903
Mass (Da):100,400
Last modified:May 1, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0564F44686C144F5
GO
Isoform 2 (identifier: Q8N9C0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     698-698: L → LDRPKPPQGR...TEEVFAGNPI
     899-903: GLTTT → AAPKFDLSAR...SLQKKSKHLM

Note: Gene prediction based on EST data.
Show »
Length:1,326
Mass (Da):147,994
Checksum:iE7F3975084D7B9A4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti69F → L in BAC04488 (PubMed:14702039).Curated1
Sequence conflicti210Y → H in BAC04488 (PubMed:14702039).Curated1
Sequence conflicti839R → W in BAC04488 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0647227R → W Found in a renal cell carcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs117464001Ensembl.1
Natural variantiVAR_03200094A → P. Corresponds to variant dbSNP:rs10832975Ensembl.1
Natural variantiVAR_032001130L → R. Corresponds to variant dbSNP:rs3740710Ensembl.1
Natural variantiVAR_032002414V → I1 PublicationCorresponds to variant dbSNP:rs10766494Ensembl.1
Natural variantiVAR_032003472R → Q1 PublicationCorresponds to variant dbSNP:rs4424652Ensembl.1
Natural variantiVAR_032004503S → I. Corresponds to variant dbSNP:rs3887899Ensembl.1
Natural variantiVAR_032005559M → V1 PublicationCorresponds to variant dbSNP:rs7125943Ensembl.1
Natural variantiVAR_032006677L → F. Corresponds to variant dbSNP:rs11024769Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_047394698L → LDRPKPPQGRVEFLELSGSC VHMKWKAPKDNGGRPVTQFI VERRAVGKKSWIKIGEVDGK VTNFSTNKVEEGKAYQFRIL AVNSEGVSDPLETEEVFAGN PI in isoform 2. Curated1
Alternative sequenceiVSP_047395899 – 903GLTTT → AAPKFDLSARLKSHMVVRAG TALCIHAAFSGSPPPDVIWQ KDGVPTKGRETITKSKNHSQ FLINSTKRSDSGVYRILLQN EFGEARYDIHVRVADFPRPP TNLRLFEEVPNTVTLTWNHS PDVQEDGEAHYIIMKRDAST ATWYTAAERVFSNKYTVTGL LPGRKYYFRVVARNEIGDSE PLDSRDTWLINKDQIQDLSA KLKPYEKKDWRHAPRFVTPL KPHTVLRGQDCTMTCAFLGN PRPTVTLYKGDVNITANSKF WYNSTSGVCTLVIPTCTLKD SGDYSVLVENELGKDRSSCT LTVYDKDDKSVVASITESLQ KKSKHLM in isoform 2. Curated5

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK095113 mRNA Translation: BAC04488.1
AC103974 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41625.2 [Q8N9C0-2]

NCBI Reference Sequences

More...
RefSeqi
NP_775859.3, NM_173588.3 [Q8N9C0-2]
XP_016873097.1, XM_017017608.1 [Q8N9C0-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000319338; ENSP00000322422; ENSG00000179057 [Q8N9C0-1]
ENST00000513874; ENSP00000421191; ENSG00000179057 [Q8N9C0-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
283284

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:283284

UCSC genome browser

More...
UCSCi
uc009yht.3 human [Q8N9C0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095113 mRNA Translation: BAC04488.1
AC103974 Genomic DNA No translation available.
CCDSiCCDS41625.2 [Q8N9C0-2]
RefSeqiNP_775859.3, NM_173588.3 [Q8N9C0-2]
XP_016873097.1, XM_017017608.1 [Q8N9C0-2]

3D structure databases

SMRiQ8N9C0
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ8N9C0, 1 interactor
MINTiQ8N9C0

PTM databases

iPTMnetiQ8N9C0
PhosphoSitePlusiQ8N9C0

Polymorphism and mutation databases

BioMutaiIGSF22
DMDMi146324946

Proteomic databases

jPOSTiQ8N9C0
MassIVEiQ8N9C0
PeptideAtlasiQ8N9C0
PRIDEiQ8N9C0
ProteomicsDBi14735
72522 [Q8N9C0-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319338; ENSP00000322422; ENSG00000179057 [Q8N9C0-1]
ENST00000513874; ENSP00000421191; ENSG00000179057 [Q8N9C0-2]
GeneIDi283284
KEGGihsa:283284
UCSCiuc009yht.3 human [Q8N9C0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
283284
DisGeNETi283284

GeneCards: human genes, protein and diseases

More...
GeneCardsi
IGSF22
HGNCiHGNC:26750 IGSF22
HPAiCAB026459
neXtProtiNX_Q8N9C0
OpenTargetsiENSG00000179057
PharmGKBiPA142671662

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000160123
HOGENOMiHOG000113015
InParanoidiQ8N9C0
OMAiDRIPIKF
OrthoDBi103399at2759
PhylomeDBiQ8N9C0
TreeFamiTF351819

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
283284

Pharos

More...
Pharosi
Q8N9C0

Protein Ontology

More...
PROi
PR:Q8N9C0

Gene expression databases

BgeeiENSG00000179057 Expressed in 123 organ(s), highest expression level in skin of leg
GenevisibleiQ8N9C0 HS

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di2.60.40.10, 8 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR040849 MyBP-C_THB
PfamiView protein in Pfam
PF00041 fn3, 2 hits
PF07679 I-set, 5 hits
PF18362 THB, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 2 hits
SM00409 IG, 6 hits
SM00408 IGc2, 5 hits
SUPFAMiSSF48726 SSF48726, 6 hits
SSF49265 SSF49265, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 2 hits
PS50835 IG_LIKE, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIGS22_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N9C0
Secondary accession number(s): A6NNA0, D6RGV7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: September 18, 2019
This is version 134 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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