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Protein

Immunoglobulin superfamily member 22

Gene

IGSF22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin superfamily member 22
Short name:
IgSF22
Gene namesi
Name:IGSF22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000179057.13
HGNCiHGNC:26750 IGSF22
neXtProtiNX_Q8N9C0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000179057
PharmGKBiPA142671662

Polymorphism and mutation databases

BioMutaiIGSF22
DMDMi146324946

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002852551 – 903Immunoglobulin superfamily member 22Add BLAST903

Proteomic databases

PeptideAtlasiQ8N9C0
PRIDEiQ8N9C0
ProteomicsDBi72522

PTM databases

iPTMnetiQ8N9C0
PhosphoSitePlusiQ8N9C0

Expressioni

Gene expression databases

BgeeiENSG00000179057
CleanExiHS_IGSF22
GenevisibleiQ8N9C0 HS

Organism-specific databases

HPAiCAB026459

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8N9C0, 1 interactor
MINTiQ8N9C0

Structurei

3D structure databases

ProteinModelPortaliQ8N9C0
SMRiQ8N9C0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 158Ig-like 1Add BLAST92
Domaini232 – 322Ig-like 2Add BLAST91
Domaini418 – 508Ig-like 3Add BLAST91
Domaini606 – 696Ig-like 4Add BLAST91
Domaini703 – 798Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST96
Domaini804 – 898Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST95

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi163 – 228Lys-richAdd BLAST66

Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

GeneTreeiENSGT00860000133685
HOGENOMiHOG000113015
InParanoidiQ8N9C0
OMAiDRIPIKF
OrthoDBiEOG091G00JK
PhylomeDBiQ8N9C0
TreeFamiTF351819

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di2.60.40.10, 8 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF00041 fn3, 2 hits
PF07679 I-set, 5 hits
SMARTiView protein in SMART
SM00060 FN3, 2 hits
SM00409 IG, 6 hits
SM00408 IGc2, 5 hits
SUPFAMiSSF48726 SSF48726, 6 hits
SSF49265 SSF49265, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 2 hits
PS50835 IG_LIKE, 4 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N9C0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTTIHSRQML QEHVSMEFSS STTHVQTFSQ TTKIVGEEVV RRKSSSIVEF
60 70 80 90 100
FSLVTRSSNI PAGDSVPEFV EKPQPVTAPE GDKAVFRARV QGNAKPHISW
110 120 130 140 150
KRESGIPIKE SAKIFYDSIN KEHVLKLEPL TSDDSDNYKC IASNDHADAI
160 170 180 190 200
YTVSLLVTEG QEKMDFKKML KKRAPPAPKK KQKKVANEKE MLEILSKVPK
210 220 230 240 250
KDFEKVCMEY GFTDFRGLLR KLKEMKKKVE VEAIRILKPL EDKETKVDTT
260 270 280 290 300
VVFDCIMELK DPNVKMIWIK GTEPLRIQYS LGKYDVKQMG TKYMLVISNV
310 320 330 340 350
NMNDAGIYSL SVGDKRMSAE LTVLDEPLKF LGEMKPVKVT ERQTAVFEIR
360 370 380 390 400
LSKKEPNFVW KFNGKELKRD DKYEITVSED GLTHTLKIKD ARLSDSGEFS
410 420 430 440 450
AEAGNLVQKA QLTVDRIPIK FVSNLKNVRV KERSRACLEC ELTSKDVTLR
460 470 480 490 500
WKKDGQLLMH GTKYSMNHEG KRAELIIEDA QLSDGGEYTV VAMQDGDPTE
510 520 530 540 550
YYSTAIVTVE ERLATVKSGM SDVHAATGSP AELCVVLNDE KVEGVWLKDG
560 570 580 590 600
KEITDLPGMQ IVKQGAVHKL IFPSMGPEHE GKYTFRAKGT ESEASVFIAD
610 620 630 640 650
PPTIDPSVLE ALAAHAITVK VGHTAHIKVP FRGKPLPKVT WYKDGMEVTE
660 670 680 690 700
EERVSMERGE DQALLTISNC VREDSGLILL KLKNDHGSAT ATLHLSVLEP
710 720 730 740 750
PGFASQPQVT DVTKEAVTIT WNAPTQDGGA PVLGYIVERR KKGSNLWVPV
760 770 780 790 800
NKDPIQGTKC TVDGLLEDTE YEFRVIAVNK AGPGQPSVPS SSVVAKDPVK
810 820 830 840 850
PPGLVQDLHV SDSSNSSISL AWREPAEGDP PSGYILEMRA EDTKEWSKCT
860 870 880 890 900
KIPISGTCYT VGGLIERQKY FFRIRAVNEA GVGEPVELDK GVRAMPPPGL

TTT
Length:903
Mass (Da):100,400
Last modified:May 1, 2007 - v2
Checksum:i0564F44686C144F5
GO
Isoform 2 (identifier: Q8N9C0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     698-698: L → LDRPKPPQGR...TEEVFAGNPI
     899-903: GLTTT → AAPKFDLSAR...SLQKKSKHLM

Note: Gene prediction based on EST data.
Show »
Length:1,326
Mass (Da):147,994
Checksum:iE7F3975084D7B9A4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti69F → L in BAC04488 (PubMed:14702039).Curated1
Sequence conflicti210Y → H in BAC04488 (PubMed:14702039).Curated1
Sequence conflicti839R → W in BAC04488 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0647227R → W Found in a renal cell carcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs117464001Ensembl.1
Natural variantiVAR_03200094A → P. Corresponds to variant dbSNP:rs10832975Ensembl.1
Natural variantiVAR_032001130L → R. Corresponds to variant dbSNP:rs3740710Ensembl.1
Natural variantiVAR_032002414V → I1 PublicationCorresponds to variant dbSNP:rs10766494Ensembl.1
Natural variantiVAR_032003472R → Q1 PublicationCorresponds to variant dbSNP:rs4424652Ensembl.1
Natural variantiVAR_032004503S → I. Corresponds to variant dbSNP:rs3887899Ensembl.1
Natural variantiVAR_032005559M → V1 PublicationCorresponds to variant dbSNP:rs7125943Ensembl.1
Natural variantiVAR_032006677L → F. Corresponds to variant dbSNP:rs11024769Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_047394698L → LDRPKPPQGRVEFLELSGSC VHMKWKAPKDNGGRPVTQFI VERRAVGKKSWIKIGEVDGK VTNFSTNKVEEGKAYQFRIL AVNSEGVSDPLETEEVFAGN PI in isoform 2. Curated1
Alternative sequenceiVSP_047395899 – 903GLTTT → AAPKFDLSARLKSHMVVRAG TALCIHAAFSGSPPPDVIWQ KDGVPTKGRETITKSKNHSQ FLINSTKRSDSGVYRILLQN EFGEARYDIHVRVADFPRPP TNLRLFEEVPNTVTLTWNHS PDVQEDGEAHYIIMKRDAST ATWYTAAERVFSNKYTVTGL LPGRKYYFRVVARNEIGDSE PLDSRDTWLINKDQIQDLSA KLKPYEKKDWRHAPRFVTPL KPHTVLRGQDCTMTCAFLGN PRPTVTLYKGDVNITANSKF WYNSTSGVCTLVIPTCTLKD SGDYSVLVENELGKDRSSCT LTVYDKDDKSVVASITESLQ KKSKHLM in isoform 2. Curated5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095113 mRNA Translation: BAC04488.1
AC103974 Genomic DNA No translation available.
CCDSiCCDS41625.2 [Q8N9C0-2]
RefSeqiNP_775859.3, NM_173588.3
XP_016873097.1, XM_017017608.1 [Q8N9C0-2]
UniGeneiHs.434152

Genome annotation databases

EnsembliENST00000319338; ENSP00000322422; ENSG00000179057 [Q8N9C0-1]
ENST00000513874; ENSP00000421191; ENSG00000179057 [Q8N9C0-2]
GeneIDi283284
KEGGihsa:283284
UCSCiuc009yht.3 human [Q8N9C0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiIGS22_HUMAN
AccessioniPrimary (citable) accession number: Q8N9C0
Secondary accession number(s): A6NNA0, D6RGV7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: July 18, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

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