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Protein

Zinc finger protein 557

Gene

ZNF557

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri145 – 167C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri173 – 195C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri201 – 223C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri229 – 251C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri257 – 279C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 557
Gene namesi
Name:ZNF557
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000130544.11
HGNCiHGNC:28632 ZNF557
neXtProtiNX_Q8N988

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000130544
PharmGKBiPA134866521

Polymorphism and mutation databases

BioMutaiZNF557
DMDMi68566211

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476471 – 423Zinc finger protein 557Add BLAST423

Proteomic databases

MaxQBiQ8N988
PaxDbiQ8N988
PeptideAtlasiQ8N988
PRIDEiQ8N988
ProteomicsDBi72505
72506 [Q8N988-2]

PTM databases

iPTMnetiQ8N988
PhosphoSitePlusiQ8N988

Expressioni

Gene expression databases

BgeeiENSG00000130544
CleanExiHS_ZNF557
GenevisibleiQ8N988 HS

Organism-specific databases

HPAiHPA003151
HPA029291

Interactioni

Protein-protein interaction databases

BioGridi122606, 10 interactors
IntActiQ8N988, 5 interactors
MINTiQ8N988
STRINGi9606.ENSP00000252840

Structurei

3D structure databases

ProteinModelPortaliQ8N988
SMRiQ8N988
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 107KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri145 – 167C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri173 – 195C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri201 – 223C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri229 – 251C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri257 – 279C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00840000129830
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ8N988
KOiK09228
OMAiKLHVFRK
OrthoDBiEOG091G02KC
PhylomeDBiQ8N988
TreeFamiTF337055

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N988-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAVVLPPTA ASQREGHTEG GELVNELLKS WLKGLVTFED VAVEFTQEEW
60 70 80 90 100
ALLDPAQRTL YRDVMLENCR NLASLGNQVD KPRLISQLEQ EDKVMTEERG
110 120 130 140 150
ILSGTCPDVE NPFKAKGLTP KLHVFRKEQS RNMKMERNHL GATLNECNQC
160 170 180 190 200
FKVFSTKSSL TRHRKIHTGE RPYGCSECGK SYSSRSYLAV HKRIHNGEKP
210 220 230 240 250
YECNDCGKTF SSRSYLTVHK RIHNGEKPYE CSDCGKTFSN SSYLRPHLRI
260 270 280 290 300
HTGEKPYKCN QCFREFRTQS IFTRHKRVHT GEGHYVCNQC GKAFGTRSSL
310 320 330 340 350
SSHYSIHTGE YPYECHDCGR TFRRRSNLTQ HIRTHTGEKP YTCNECGKSF
360 370 380 390 400
TNSFSLTIHR RIHNGEKSYE CSDCGKSFNV LSSVKKHMRT HTGKKPYECN
410 420
YCGKSFTSNS YLSVHTRMHN RQM
Length:423
Mass (Da):48,627
Last modified:July 5, 2005 - v2
Checksum:iB9B98806E91AFD85
GO
Isoform 2 (identifier: Q8N988-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     11-11: A → ALSSLFPA

Show »
Length:430
Mass (Da):49,343
Checksum:i3875A8152D9FC546
GO

Sequence cautioni

The sequence AAH58040 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAC04567 differs from that shown. Reason: Frameshift at position 23.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01451511A → ALSSLFPA in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095524 mRNA Translation: BAC04567.1 Sequence problems.
BC003020 mRNA Translation: AAH03020.1
BC058040 mRNA Translation: AAH58040.1 Sequence problems.
CCDSiCCDS42485.1 [Q8N988-2]
CCDS45945.1 [Q8N988-1]
RefSeqiNP_001037852.1, NM_001044387.1 [Q8N988-2]
NP_001037853.1, NM_001044388.1 [Q8N988-1]
NP_077317.2, NM_024341.2 [Q8N988-2]
UniGeneiHs.591380

Genome annotation databases

EnsembliENST00000252840; ENSP00000252840; ENSG00000130544 [Q8N988-2]
ENST00000414706; ENSP00000404065; ENSG00000130544 [Q8N988-1]
GeneIDi79230
KEGGihsa:79230
UCSCiuc002mga.4 human [Q8N988-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZN557_HUMAN
AccessioniPrimary (citable) accession number: Q8N988
Secondary accession number(s): Q6PEJ3, Q9BTZ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: June 20, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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