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Protein

39S ribosomal protein L43, mitochondrial

Gene

MRPL43

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L43, mitochondrial
Short name:
L43mt
Short name:
MRP-L43
Alternative name(s):
Mitochondrial large ribosomal subunit protein mL431 Publication
Mitochondrial ribosomal protein bMRP36a
Gene namesi
Name:MRPL43
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000055950.16
HGNCiHGNC:14517 MRPL43
MIMi611848 gene
neXtProtiNX_Q8N983

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000055950
PharmGKBiPA30975

Polymorphism and mutation databases

BioMutaiMRPL43
DMDMi50401603

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000030561? – 21539S ribosomal protein L43, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

EPDiQ8N983
MaxQBiQ8N983
PaxDbiQ8N983
PeptideAtlasiQ8N983
PRIDEiQ8N983
ProteomicsDBi72499
72500 [Q8N983-2]
72501 [Q8N983-3]
72502 [Q8N983-4]
TopDownProteomicsiQ8N983-4 [Q8N983-4]

PTM databases

iPTMnetiQ8N983
PhosphoSitePlusiQ8N983

Expressioni

Tissue specificityi

High relative levels in skeletal muscle and testis. Lower levels of expression in the heart, brain, placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and leukocytes. Expression is coregulated with TWNK.1 Publication

Gene expression databases

BgeeiENSG00000055950 Expressed in 200 organ(s), highest expression level in testis
CleanExiHS_MRPL43
ExpressionAtlasiQ8N983 baseline and differential
GenevisibleiQ8N983 HS

Organism-specific databases

HPAiHPA073022

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:28892042, PubMed:25838379, PubMed:25278503). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
FXR2P511163EBI-1043145,EBI-740459

Protein-protein interaction databases

BioGridi124130, 54 interactors
CORUMiQ8N983
IntActiQ8N983, 19 interactors
MINTiQ8N983
STRINGi9606.ENSP00000339844

Structurei

Secondary structure

1215
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8N983
SMRiQ8N983
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3445 Eukaryota
ENOG4111S17 LUCA
GeneTreeiENSGT00390000015375
HOGENOMiHOG000177285
HOVERGENiHBG056363
InParanoidiQ8N983
KOiK17424
OMAiISKWIDL
OrthoDBiEOG091G0PD3
PhylomeDBiQ8N983
TreeFamiTF314535

Family and domain databases

InterProiView protein in InterPro
IPR039927 MRPL43/MRPL51
IPR007741 Ribosome/NADH_DH
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR21396 PTHR21396, 1 hit
PfamiView protein in Pfam
PF05047 L51_S25_CI-B8, 1 hit
SMARTiView protein in SMART
SM00916 L51_S25_CI-B8, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit

Sequences (6+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N983-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTARGTPSRF LASVLHNGLG RYVQQLQRLS FSVSRDGASS RGAREFVERE
60 70 80 90 100
VIDFARRNPG VVIYVNSRPC CVPRVVAEYL NGAVREESIH CKSVEEISTL
110 120 130 140 150
VQKLADQSGL DVIRIRKPFH TDNPSIQGQW HPFTNKPTTF RGLRPREVQD
160 170 180 190 200
PAPAQDTGLR LSAVAPQILL PGWPDPPDLP TVDPISSSLT SAPAPMLSAV
210
SCLPIVPALT TVCSA
Length:215
Mass (Da):23,431
Last modified:October 1, 2002 - v1
Checksum:i059C6E36FEB0D235
GO
Isoform 2 (identifier: Q8N983-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     177-215: PDLPTVDPISSSLTSAPAPMLSAVSCLPIVPALTTVCSA → ISVQSSDLPWGNTHYRPEPLSSTTWL

Show »
Length:202
Mass (Da):22,580
Checksum:i30A1ACC6D3F30CA8
GO
Isoform 3 (identifier: Q8N983-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     156-164: DTGLRLSAV → CLLLGAVTL
     165-215: Missing.

Show »
Length:164
Mass (Da):18,311
Checksum:i8BBA76364E45CA58
GO
Isoform 4 (identifier: Q8N983-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     156-159: DTGL → VQAQ
     160-215: Missing.

Show »
Length:159
Mass (Da):17,853
Checksum:i3430B94F1152F375
GO
Isoform 5 (identifier: Q8N983-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     157-215: TGLRLSAVAP...VPALTTVCSA → AAEFLGEGAG...SSLGKYPLPS

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:235
Mass (Da):25,862
Checksum:iC47FD0F42CE0F80E
GO
Isoform 6 (identifier: Q8N983-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     157-215: TGLRLSAVAP...VPALTTVCSA → AAEFLGEGAG...DHCVLSVKAA

Note: No experimental confirmation available.
Show »
Length:261
Mass (Da):28,676
Checksum:i4A4FAA0C31C80A5C
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AL05B1AL05_HUMAN
39S ribosomal protein L43, mitochon...
MRPL43
184Annotation score:
H0YBU8H0YBU8_HUMAN
39S ribosomal protein L43, mitochon...
MRPL43
148Annotation score:
H0Y6Y8H0Y6Y8_HUMAN
39S ribosomal protein L43, mitochon...
MRPL43
169Annotation score:
M0R051M0R051_HUMAN
39S ribosomal protein L43, mitochon...
MRPL43
44Annotation score:

Sequence cautioni

The sequence BAB40861 differs from that shown. Reason: Frameshift at position 131.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011027156 – 164DTGLRLSAV → CLLLGAVTL in isoform 3. 1 Publication9
Alternative sequenceiVSP_011029156 – 159DTGL → VQAQ in isoform 4. 2 Publications4
Alternative sequenceiVSP_054092157 – 215TGLRL…TVCSA → AAEFLGEGAGPCWYSIVALP QKHIAIAIHPPQPAGQCHQA IGHWPETVCSCTADPPARLA RPNISSVIRSSLGKYPLPS in isoform 5. CuratedAdd BLAST59
Alternative sequenceiVSP_054093157 – 215TGLRL…TVCSA → AAEFLGEGAGPCWYSIVALP QKHIAIAIHPPQPAGQCHQA IGHWPETVCSCTADPPARLA RPTRPPHSGSYLILIDLCSS PYAVRSFLPPDCPCTDHCVL SVKAA in isoform 6. 1 PublicationAdd BLAST59
Alternative sequenceiVSP_011030160 – 215Missing in isoform 4. 2 PublicationsAdd BLAST56
Alternative sequenceiVSP_011028165 – 215Missing in isoform 3. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_011026177 – 215PDLPT…TVCSA → ISVQSSDLPWGNTHYRPEPL SSTTWL in isoform 2. 1 PublicationAdd BLAST39

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049656 mRNA Translation: BAB40861.1 Frameshift.
AK095556 mRNA Translation: BAC04572.1
AK300237 mRNA Translation: BAG62005.1
AL133215 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49795.1
CH471066 Genomic DNA Translation: EAW49796.1
CH471066 Genomic DNA Translation: EAW49797.1
CH471066 Genomic DNA Translation: EAW49799.1
BC015905 mRNA Translation: AAH15905.1
BC041165 mRNA Translation: AAH41165.1
BC052639 mRNA Translation: AAH52639.1
BC053373 mRNA Translation: AAH53373.1
CCDSiCCDS7502.1 [Q8N983-1]
CCDS7503.1 [Q8N983-2]
CCDS7504.1 [Q8N983-6]
CCDS7505.1 [Q8N983-4]
CCDS76331.1 [Q8N983-3]
RefSeqiNP_001295325.1, NM_001308396.1 [Q8N983-3]
NP_115488.2, NM_032112.2 [Q8N983-4]
NP_789762.1, NM_176792.2 [Q8N983-1]
NP_789763.1, NM_176793.1 [Q8N983-2]
NP_789764.1, NM_176794.1 [Q8N983-6]
XP_005270288.1, XM_005270231.2 [Q8N983-4]
XP_006718098.1, XM_006718035.3 [Q8N983-4]
UniGeneiHs.421848

Genome annotation databases

EnsembliENST00000299179; ENSP00000299179; ENSG00000055950 [Q8N983-2]
ENST00000318325; ENSP00000315364; ENSG00000055950 [Q8N983-1]
ENST00000318364; ENSP00000315948; ENSG00000055950 [Q8N983-4]
ENST00000342071; ENSP00000339844; ENSG00000055950 [Q8N983-6]
ENST00000370234; ENSP00000359254; ENSG00000055950 [Q8N983-3]
ENST00000370236; ENSP00000359256; ENSG00000055950 [Q8N983-4]
ENST00000370242; ENSP00000359262; ENSG00000055950 [Q8N983-7]
GeneIDi84545
KEGGihsa:84545
UCSCiuc001kry.2 human [Q8N983-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049656 mRNA Translation: BAB40861.1 Frameshift.
AK095556 mRNA Translation: BAC04572.1
AK300237 mRNA Translation: BAG62005.1
AL133215 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49795.1
CH471066 Genomic DNA Translation: EAW49796.1
CH471066 Genomic DNA Translation: EAW49797.1
CH471066 Genomic DNA Translation: EAW49799.1
BC015905 mRNA Translation: AAH15905.1
BC041165 mRNA Translation: AAH41165.1
BC052639 mRNA Translation: AAH52639.1
BC053373 mRNA Translation: AAH53373.1
CCDSiCCDS7502.1 [Q8N983-1]
CCDS7503.1 [Q8N983-2]
CCDS7504.1 [Q8N983-6]
CCDS7505.1 [Q8N983-4]
CCDS76331.1 [Q8N983-3]
RefSeqiNP_001295325.1, NM_001308396.1 [Q8N983-3]
NP_115488.2, NM_032112.2 [Q8N983-4]
NP_789762.1, NM_176792.2 [Q8N983-1]
NP_789763.1, NM_176793.1 [Q8N983-2]
NP_789764.1, NM_176794.1 [Q8N983-6]
XP_005270288.1, XM_005270231.2 [Q8N983-4]
XP_006718098.1, XM_006718035.3 [Q8N983-4]
UniGeneiHs.421848

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40b1-155[»]
3J9Melectron microscopy3.50b1-155[»]
5OOLelectron microscopy3.06b1-215[»]
5OOMelectron microscopy3.03b1-215[»]
ProteinModelPortaliQ8N983
SMRiQ8N983
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124130, 54 interactors
CORUMiQ8N983
IntActiQ8N983, 19 interactors
MINTiQ8N983
STRINGi9606.ENSP00000339844

PTM databases

iPTMnetiQ8N983
PhosphoSitePlusiQ8N983

Polymorphism and mutation databases

BioMutaiMRPL43
DMDMi50401603

Proteomic databases

EPDiQ8N983
MaxQBiQ8N983
PaxDbiQ8N983
PeptideAtlasiQ8N983
PRIDEiQ8N983
ProteomicsDBi72499
72500 [Q8N983-2]
72501 [Q8N983-3]
72502 [Q8N983-4]
TopDownProteomicsiQ8N983-4 [Q8N983-4]

Protocols and materials databases

DNASUi84545
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299179; ENSP00000299179; ENSG00000055950 [Q8N983-2]
ENST00000318325; ENSP00000315364; ENSG00000055950 [Q8N983-1]
ENST00000318364; ENSP00000315948; ENSG00000055950 [Q8N983-4]
ENST00000342071; ENSP00000339844; ENSG00000055950 [Q8N983-6]
ENST00000370234; ENSP00000359254; ENSG00000055950 [Q8N983-3]
ENST00000370236; ENSP00000359256; ENSG00000055950 [Q8N983-4]
ENST00000370242; ENSP00000359262; ENSG00000055950 [Q8N983-7]
GeneIDi84545
KEGGihsa:84545
UCSCiuc001kry.2 human [Q8N983-1]

Organism-specific databases

CTDi84545
EuPathDBiHostDB:ENSG00000055950.16
GeneCardsiMRPL43
HGNCiHGNC:14517 MRPL43
HPAiHPA073022
MIMi611848 gene
neXtProtiNX_Q8N983
OpenTargetsiENSG00000055950
PharmGKBiPA30975
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3445 Eukaryota
ENOG4111S17 LUCA
GeneTreeiENSGT00390000015375
HOGENOMiHOG000177285
HOVERGENiHBG056363
InParanoidiQ8N983
KOiK17424
OMAiISKWIDL
OrthoDBiEOG091G0PD3
PhylomeDBiQ8N983
TreeFamiTF314535

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

ChiTaRSiMRPL43 human
GenomeRNAii84545
PROiPR:Q8N983
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000055950 Expressed in 200 organ(s), highest expression level in testis
CleanExiHS_MRPL43
ExpressionAtlasiQ8N983 baseline and differential
GenevisibleiQ8N983 HS

Family and domain databases

InterProiView protein in InterPro
IPR039927 MRPL43/MRPL51
IPR007741 Ribosome/NADH_DH
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR21396 PTHR21396, 1 hit
PfamiView protein in Pfam
PF05047 L51_S25_CI-B8, 1 hit
SMARTiView protein in SMART
SM00916 L51_S25_CI-B8, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRM43_HUMAN
AccessioniPrimary (citable) accession number: Q8N983
Secondary accession number(s): B1AL06
, B1AL07, B1AL09, B1AL10, C9J5Q3, D3DR71, Q5JW06, Q7Z719, Q7Z7H6, Q86XN1, Q9BYC7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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