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UniProtKB - Q8N961 (ABTB2_HUMAN)
Protein
Ankyrin repeat and BTB/POZ domain-containing protein 2
Gene
ABTB2
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in the initiation of hepatocyte growth.
By similarityGO - Molecular functioni
- protein heterodimerization activity Source: InterPro
GO - Biological processi
- cellular response to toxic substance Source: Ensembl
Enzyme and pathway databases
PathwayCommonsi | Q8N961 |
SignaLinki | Q8N961 |
Names & Taxonomyi
Protein namesi | Recommended name: Ankyrin repeat and BTB/POZ domain-containing protein 2 |
Gene namesi | Name:ABTB2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23842, ABTB2 |
neXtProti | NX_Q8N961 |
VEuPathDBi | HostDB:ENSG00000166016 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 25841 |
OpenTargetsi | ENSG00000166016 |
PharmGKBi | PA134937734 |
Miscellaneous databases
Pharosi | Q8N961, Tdark |
Genetic variation databases
BioMutai | ABTB2 |
DMDMi | 485955977 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000066887 | 1 – 1025 | Ankyrin repeat and BTB/POZ domain-containing protein 2Add BLAST | 1025 |
Proteomic databases
EPDi | Q8N961 |
jPOSTi | Q8N961 |
MassIVEi | Q8N961 |
MaxQBi | Q8N961 |
PaxDbi | Q8N961 |
PeptideAtlasi | Q8N961 |
PRIDEi | Q8N961 |
ProteomicsDBi | 23438 72494 [Q8N961-1] |
PTM databases
iPTMneti | Q8N961 |
PhosphoSitePlusi | Q8N961 |
Expressioni
Gene expression databases
Bgeei | ENSG00000166016, Expressed in secondary oocyte and 207 other tissues |
Genevisiblei | Q8N961, HS |
Organism-specific databases
HPAi | ENSG00000166016, Low tissue specificity |
Interactioni
GO - Molecular functioni
- protein heterodimerization activity Source: InterPro
Protein-protein interaction databases
BioGRIDi | 117367, 123 interactors |
IntActi | Q8N961, 5 interactors |
STRINGi | 9606.ENSP00000410157 |
Miscellaneous databases
RNActi | Q8N961, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 521 – 550 | ANK 1Add BLAST | 30 | |
Repeati | 567 – 596 | ANK 2Add BLAST | 30 | |
Repeati | 606 – 635 | ANK 3Add BLAST | 30 | |
Repeati | 649 – 678 | ANK 4Add BLAST | 30 | |
Domaini | 845 – 914 | BTBPROSITE-ProRule annotationAdd BLAST | 70 |
Keywords - Domaini
ANK repeat, RepeatPhylogenomic databases
eggNOGi | ENOG502QSQY, Eukaryota |
GeneTreei | ENSGT00940000157661 |
HOGENOMi | CLU_001918_0_0_1 |
InParanoidi | Q8N961 |
OMAi | LQCNGST |
OrthoDBi | 416322at2759 |
PhylomeDBi | Q8N961 |
TreeFami | TF106437 |
Family and domain databases
Gene3Di | 1.10.20.10, 1 hit 1.25.40.20, 1 hit 3.30.710.10, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR000210, BTB/POZ_dom IPR009072, Histone-fold IPR011333, SKP1/BTB/POZ_sf |
Pfami | View protein in Pfam PF00023, Ank, 1 hit PF12796, Ank_2, 1 hit PF00651, BTB, 1 hit |
SMARTi | View protein in SMART SM00248, ANK, 5 hits SM00225, BTB, 1 hit |
SUPFAMi | SSF47113, SSF47113, 2 hits SSF48403, SSF48403, 1 hit SSF54695, SSF54695, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 3 hits PS50097, BTB, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q8N961-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAGTYSSTLK TLEDLTLDSG YGAGDSCRSL SLSSSKSNSQ ALNSSAQQHR
60 70 80 90 100
GAAWWCYSGS MNSRHNSWDT VNTVLPEDPE VADLFSRCPR LPELEEFPWT
110 120 130 140 150
EGDVARVLRK GAGGRRLPQF SAEAVRRLAG LLRRALIRVA REAQRLSVLH
160 170 180 190 200
AKCTRFEVQS AVRLVHSWAL AESCALAAVK ALSLYSMSAG DGLRRGKSAR
210 220 230 240 250
CGLTFSVGRF FRWMVDTRIS VRIHEYAAIS LTACMENLVE EIRARVMASH
260 270 280 290 300
SPDGGGAGGG EVSAEALEMV INNDAELWGV LQPYEHLICG KNANGVLSLP
310 320 330 340 350
AYFSPYNGGS LGHDERADAY AQLELRTLEQ SLLATCVGSI SELSDLVSRA
360 370 380 390 400
MHHMQGRHPL CPGASPARQA RQPPQPITWS PDALHTLYYF LRCPQMESME
410 420 430 440 450
NPNLDPPRMT LNNERPFMLL PPLMEWMRVA ITYAEHRRSL TVDSGDIRQA
460 470 480 490 500
ARLLLPGLDC EPRQLKPEHC FSSFRRLDAR AATEKFNQDL GFRMLNCGRT
510 520 530 540 550
DLINQAIEAL GPDGVNTMDD QGMTPLMYAC AAGDEAMVQM LIDAGANLDI
560 570 580 590 600
QVPSNSPRHP SIHPDSRHWT SLTFAVLHGH ISVVQLLLDA GAHVEGSAVN
610 620 630 640 650
GGEDSYAETP LQLASAAGNY ELVSLLLSRG ADPLLSMLEA HGMGSSLHED
660 670 680 690 700
MNCFSHSAAH GHRNVLRKLL TQPQQAKADV LSLEEILAEG VEESDASSQG
710 720 730 740 750
SGSEGPVRLS RTRTKALQEA MYYSAEHGYV DITMELRALG VPWKLHIWIE
760 770 780 790 800
SLRTSFSQSR YSVVQSLLRD FSSIREEEYN EELVTEGLQL MFDILKTSKN
810 820 830 840 850
DSVIQQLATI FTHCYGSSPI PSIPEIRKTL PARLDPHFLN NKEMSDVTFL
860 870 880 890 900
VEGKLFYAHK VLLVTASNRF KTLMTNKSEQ DGDSSKTIEI SDMKYHIFQM
910 920 930 940 950
MMQYLYYGGT ESMEIPTTDI LELLSAASLF QLDALQRHCE ILCSQTLSME
960 970 980 990 1000
SAVNTYKYAK IHNAPELALF CEGFFLKHMK ALLEQDAFRQ LIYGRSSKVQ
1010 1020
GLDPLQDLQN TLAERVHSVY ITSRV
Sequence cautioni
The sequence AAH93968 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC03697 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAF84433 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAF84433 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 189 | A → D in BAF84433 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_022087 | 250 | H → Q1 PublicationCorresponds to variant dbSNP:rs1925368Ensembl. | 1 | |
Natural variantiVAR_024171 | 918 | T → A. Corresponds to variant dbSNP:rs2473928Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_046439 | 1 – 186 | Missing in isoform 2. 1 PublicationAdd BLAST | 186 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK091560 mRNA Translation: BAC03697.1 Different initiation. AK095632 mRNA Translation: BAC04595.1 AK291744 mRNA Translation: BAF84433.1 Sequence problems. AC090469 Genomic DNA No translation available. AL035079 Genomic DNA No translation available. AL133294 Genomic DNA No translation available. AL139174 Genomic DNA No translation available. BC093968 mRNA Translation: AAH93968.1 Different initiation. BX640841 mRNA Translation: CAE45913.3 |
CCDSi | CCDS7890.2 [Q8N961-1] |
RefSeqi | NP_665803.2, NM_145804.2 [Q8N961-1] |
Genome annotation databases
Ensembli | ENST00000435224.3; ENSP00000410157.2; ENSG00000166016.6 |
GeneIDi | 25841 |
KEGGi | hsa:25841 |
MANE-Selecti | ENST00000435224.3; ENSP00000410157.2; NM_145804.3; NP_665803.2 |
UCSCi | uc001mvl.3, human [Q8N961-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK091560 mRNA Translation: BAC03697.1 Different initiation. AK095632 mRNA Translation: BAC04595.1 AK291744 mRNA Translation: BAF84433.1 Sequence problems. AC090469 Genomic DNA No translation available. AL035079 Genomic DNA No translation available. AL133294 Genomic DNA No translation available. AL139174 Genomic DNA No translation available. BC093968 mRNA Translation: AAH93968.1 Different initiation. BX640841 mRNA Translation: CAE45913.3 |
CCDSi | CCDS7890.2 [Q8N961-1] |
RefSeqi | NP_665803.2, NM_145804.2 [Q8N961-1] |
3D structure databases
AlphaFoldDBi | Q8N961 |
SMRi | Q8N961 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 117367, 123 interactors |
IntActi | Q8N961, 5 interactors |
STRINGi | 9606.ENSP00000410157 |
PTM databases
iPTMneti | Q8N961 |
PhosphoSitePlusi | Q8N961 |
Genetic variation databases
BioMutai | ABTB2 |
DMDMi | 485955977 |
Proteomic databases
EPDi | Q8N961 |
jPOSTi | Q8N961 |
MassIVEi | Q8N961 |
MaxQBi | Q8N961 |
PaxDbi | Q8N961 |
PeptideAtlasi | Q8N961 |
PRIDEi | Q8N961 |
ProteomicsDBi | 23438 72494 [Q8N961-1] |
Protocols and materials databases
Antibodypediai | 12992, 67 antibodies from 17 providers |
DNASUi | 25841 |
Genome annotation databases
Ensembli | ENST00000435224.3; ENSP00000410157.2; ENSG00000166016.6 |
GeneIDi | 25841 |
KEGGi | hsa:25841 |
MANE-Selecti | ENST00000435224.3; ENSP00000410157.2; NM_145804.3; NP_665803.2 |
UCSCi | uc001mvl.3, human [Q8N961-1] |
Organism-specific databases
CTDi | 25841 |
DisGeNETi | 25841 |
GeneCardsi | ABTB2 |
HGNCi | HGNC:23842, ABTB2 |
HPAi | ENSG00000166016, Low tissue specificity |
neXtProti | NX_Q8N961 |
OpenTargetsi | ENSG00000166016 |
PharmGKBi | PA134937734 |
VEuPathDBi | HostDB:ENSG00000166016 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QSQY, Eukaryota |
GeneTreei | ENSGT00940000157661 |
HOGENOMi | CLU_001918_0_0_1 |
InParanoidi | Q8N961 |
OMAi | LQCNGST |
OrthoDBi | 416322at2759 |
PhylomeDBi | Q8N961 |
TreeFami | TF106437 |
Enzyme and pathway databases
PathwayCommonsi | Q8N961 |
SignaLinki | Q8N961 |
Miscellaneous databases
BioGRID-ORCSi | 25841, 19 hits in 1114 CRISPR screens |
ChiTaRSi | ABTB2, human |
GenomeRNAii | 25841 |
Pharosi | Q8N961, Tdark |
PROi | PR:Q8N961 |
RNActi | Q8N961, protein |
Gene expression databases
Bgeei | ENSG00000166016, Expressed in secondary oocyte and 207 other tissues |
Genevisiblei | Q8N961, HS |
Family and domain databases
Gene3Di | 1.10.20.10, 1 hit 1.25.40.20, 1 hit 3.30.710.10, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR000210, BTB/POZ_dom IPR009072, Histone-fold IPR011333, SKP1/BTB/POZ_sf |
Pfami | View protein in Pfam PF00023, Ank, 1 hit PF12796, Ank_2, 1 hit PF00651, BTB, 1 hit |
SMARTi | View protein in SMART SM00248, ANK, 5 hits SM00225, BTB, 1 hit |
SUPFAMi | SSF47113, SSF47113, 2 hits SSF48403, SSF48403, 1 hit SSF54695, SSF54695, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 3 hits PS50097, BTB, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ABTB2_HUMAN | |
Accessioni | Q8N961Primary (citable) accession number: Q8N961 Secondary accession number(s): A8K6S9 Q8NB44 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 2005 |
Last sequence update: | May 1, 2013 | |
Last modified: | May 25, 2022 | |
This is version 160 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports