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UniProtKB - Q8N961 (ABTB2_HUMAN)

Entry version 149 (26 Feb 2020)
Sequence version 2 (01 May 2013)
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Protein

Ankyrin repeat and BTB/POZ domain-containing protein 2

Gene

ABTB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in the initiation of hepatocyte growth.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ankyrin repeat and BTB/POZ domain-containing protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ABTB2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:23842 ABTB2

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8N961

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000166016

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134937734

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8N961 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ABTB2

Domain mapping of disease mutations (DMDM)

More...DMDMi		485955977

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000668871 – 1025Ankyrin repeat and BTB/POZ domain-containing protein 2Add BLAST1025

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8N961

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8N961

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8N961

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8N961

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8N961

PeptideAtlas

More...PeptideAtlasi		Q8N961

PRoteomics IDEntifications database

More...PRIDEi		Q8N961

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		23438
72494 [Q8N961-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8N961

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8N961

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000166016 Expressed in secondary oocyte and 187 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8N961 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA020065
HPA030699

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		117367, 97 interactors

Protein interaction database and analysis system

More...IntActi		Q8N961, 3 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000410157

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8N961 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8N961

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati521 – 550ANK 1Add BLAST30
Repeati567 – 596ANK 2Add BLAST30
Repeati606 – 635ANK 3Add BLAST30
Repeati649 – 678ANK 4Add BLAST30
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini845 – 914BTBPROSITE-ProRule annotationAdd BLAST70

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IESM Eukaryota
ENOG410XRDX LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157661

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001918_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8N961

KEGG Orthology (KO)

More...KOi		K10521

Identification of Orthologs from Complete Genome Data

More...OMAi		HRGIMPA

Database of Orthologous Groups

More...OrthoDBi		416322at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8N961

TreeFam database of animal gene trees

More...TreeFami		TF106437

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.20.10, 1 hit
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR000210 BTB/POZ_dom
IPR009072 Histone-fold
IPR011333 SKP1/BTB/POZ_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12796 Ank_2, 1 hit
PF00651 BTB, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00248 ANK, 5 hits
SM00225 BTB, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47113 SSF47113, 2 hits
SSF48403 SSF48403, 1 hit
SSF54695 SSF54695, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits
PS50097 BTB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8N961-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGTYSSTLK TLEDLTLDSG YGAGDSCRSL SLSSSKSNSQ ALNSSAQQHR 
        60         70         80         90        100
GAAWWCYSGS MNSRHNSWDT VNTVLPEDPE VADLFSRCPR LPELEEFPWT 
       110        120        130        140        150
EGDVARVLRK GAGGRRLPQF SAEAVRRLAG LLRRALIRVA REAQRLSVLH 
       160        170        180        190        200
AKCTRFEVQS AVRLVHSWAL AESCALAAVK ALSLYSMSAG DGLRRGKSAR 
       210        220        230        240        250
CGLTFSVGRF FRWMVDTRIS VRIHEYAAIS LTACMENLVE EIRARVMASH 
       260        270        280        290        300
SPDGGGAGGG EVSAEALEMV INNDAELWGV LQPYEHLICG KNANGVLSLP 
       310        320        330        340        350
AYFSPYNGGS LGHDERADAY AQLELRTLEQ SLLATCVGSI SELSDLVSRA 
       360        370        380        390        400
MHHMQGRHPL CPGASPARQA RQPPQPITWS PDALHTLYYF LRCPQMESME 
       410        420        430        440        450
NPNLDPPRMT LNNERPFMLL PPLMEWMRVA ITYAEHRRSL TVDSGDIRQA 
       460        470        480        490        500
ARLLLPGLDC EPRQLKPEHC FSSFRRLDAR AATEKFNQDL GFRMLNCGRT 
       510        520        530        540        550
DLINQAIEAL GPDGVNTMDD QGMTPLMYAC AAGDEAMVQM LIDAGANLDI 
       560        570        580        590        600
QVPSNSPRHP SIHPDSRHWT SLTFAVLHGH ISVVQLLLDA GAHVEGSAVN 
       610        620        630        640        650
GGEDSYAETP LQLASAAGNY ELVSLLLSRG ADPLLSMLEA HGMGSSLHED 
       660        670        680        690        700
MNCFSHSAAH GHRNVLRKLL TQPQQAKADV LSLEEILAEG VEESDASSQG 
       710        720        730        740        750
SGSEGPVRLS RTRTKALQEA MYYSAEHGYV DITMELRALG VPWKLHIWIE 
       760        770        780        790        800
SLRTSFSQSR YSVVQSLLRD FSSIREEEYN EELVTEGLQL MFDILKTSKN 
       810        820        830        840        850
DSVIQQLATI FTHCYGSSPI PSIPEIRKTL PARLDPHFLN NKEMSDVTFL 
       860        870        880        890        900
VEGKLFYAHK VLLVTASNRF KTLMTNKSEQ DGDSSKTIEI SDMKYHIFQM 
       910        920        930        940        950
MMQYLYYGGT ESMEIPTTDI LELLSAASLF QLDALQRHCE ILCSQTLSME 
       960        970        980        990       1000
SAVNTYKYAK IHNAPELALF CEGFFLKHMK ALLEQDAFRQ LIYGRSSKVQ 
      1010       1020 
GLDPLQDLQN TLAERVHSVY ITSRV
Length:1,025
Mass (Da):113,656
Last modified:May 1, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE0DBA1B9BC0AFB82
GO
Isoform 2 (identifier: Q8N961-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-186: Missing.

Show »
Length:839
Mass (Da):93,290
Checksum:i0E48EE96F0C85DB2
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH93968 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC03697 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAF84433 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAF84433 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti189A → D in BAF84433 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_022087250H → Q1 PublicationCorresponds to variant dbSNP:rs1925368Ensembl.1
Natural variantiVAR_024171918T → A. Corresponds to variant dbSNP:rs2473928Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0464391 – 186Missing in isoform 2. 1 PublicationAdd BLAST186

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK091560 mRNA Translation: BAC03697.1 Different initiation.
AK095632 mRNA Translation: BAC04595.1
AK291744 mRNA Translation: BAF84433.1 Sequence problems.
AC090469 Genomic DNA No translation available.
AL035079 Genomic DNA No translation available.
AL133294 Genomic DNA No translation available.
AL139174 Genomic DNA No translation available.
BC093968 mRNA Translation: AAH93968.1 Different initiation.
BX640841 mRNA Translation: CAE45913.3

The Consensus CDS (CCDS) project

More...CCDSi		CCDS7890.2 [Q8N961-1]

NCBI Reference Sequences

More...RefSeqi		NP_665803.2, NM_145804.2 [Q8N961-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000435224; ENSP00000410157; ENSG00000166016 [Q8N961-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		25841

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:25841

UCSC genome browser

More...UCSCi		uc001mvl.3 human [Q8N961-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091560 mRNA Translation: BAC03697.1 Different initiation.
AK095632 mRNA Translation: BAC04595.1
AK291744 mRNA Translation: BAF84433.1 Sequence problems.
AC090469 Genomic DNA No translation available.
AL035079 Genomic DNA No translation available.
AL133294 Genomic DNA No translation available.
AL139174 Genomic DNA No translation available.
BC093968 mRNA Translation: AAH93968.1 Different initiation.
BX640841 mRNA Translation: CAE45913.3
CCDSiCCDS7890.2 [Q8N961-1]
RefSeqiNP_665803.2, NM_145804.2 [Q8N961-1]

3D structure databases

SMRiQ8N961
ModBaseiSearch...

Protein-protein interaction databases

BioGridi117367, 97 interactors
IntActiQ8N961, 3 interactors
STRINGi9606.ENSP00000410157

PTM databases

iPTMnetiQ8N961
PhosphoSitePlusiQ8N961

Polymorphism and mutation databases

BioMutaiABTB2
DMDMi485955977

Proteomic databases

EPDiQ8N961
jPOSTiQ8N961
MassIVEiQ8N961
MaxQBiQ8N961
PaxDbiQ8N961
PeptideAtlasiQ8N961
PRIDEiQ8N961
ProteomicsDBi23438
72494 [Q8N961-1]

Genome annotation databases

EnsembliENST00000435224; ENSP00000410157; ENSG00000166016 [Q8N961-1]
GeneIDi25841
KEGGihsa:25841
UCSCiuc001mvl.3 human [Q8N961-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		25841

GeneCards: human genes, protein and diseases

More...GeneCardsi		ABTB2
HGNCiHGNC:23842 ABTB2
HPAiHPA020065
HPA030699
neXtProtiNX_Q8N961
OpenTargetsiENSG00000166016
PharmGKBiPA134937734

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IESM Eukaryota
ENOG410XRDX LUCA
GeneTreeiENSGT00940000157661
HOGENOMiCLU_001918_0_0_1
InParanoidiQ8N961
KOiK10521
OMAiHRGIMPA
OrthoDBi416322at2759
PhylomeDBiQ8N961
TreeFamiTF106437

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ABTB2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		25841
PharosiQ8N961 Tdark

Protein Ontology

More...PROi		PR:Q8N961
RNActiQ8N961 protein

Gene expression databases

BgeeiENSG00000166016 Expressed in secondary oocyte and 187 other tissues
GenevisibleiQ8N961 HS

Family and domain databases

Gene3Di1.10.20.10, 1 hit
1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR000210 BTB/POZ_dom
IPR009072 Histone-fold
IPR011333 SKP1/BTB/POZ_sf
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF00651 BTB, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 5 hits
SM00225 BTB, 1 hit
SUPFAMiSSF47113 SSF47113, 2 hits
SSF48403 SSF48403, 1 hit
SSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits
PS50097 BTB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiABTB2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N961
Secondary accession number(s): A8K6S9
, E9PRW7, Q52LD6, Q6MZW4, Q8NB44
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: May 1, 2013
Last modified: February 26, 2020
This is version 149 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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