UniProtKB - Q8N954 (GPT11_HUMAN)
Protein
G patch domain-containing protein 11
Gene
GPATCH11
Organism
Homo sapiens (Human)
Status
Functioni
Caution
It is uncertain whether Met-1 or Met-27 is the initiator.Curated
GO - Molecular functioni
- nucleic acid binding Source: InterPro
Names & Taxonomyi
Protein namesi | Recommended name: G patch domain-containing protein 11Alternative name(s): Coiled-coil domain-containing protein 75 |
Gene namesi | Name:GPATCH11 Synonyms:CCDC75, CENP-Y1 Publication |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26768 GPATCH11 |
neXtProti | NX_Q8N954 |
Subcellular locationi
Other locations
- kinetochore 1 Publication
Other locations
- condensed chromosome kinetochore Source: UniProtKB-SubCell
- kinetochore Source: UniProtKB
Keywords - Cellular componenti
Centromere, Chromosome, KinetochorePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000152133 |
PharmGKBi | PA143485427 |
Miscellaneous databases
Pharosi | Q8N954 |
Polymorphism and mutation databases
BioMutai | GPATCH11 |
DMDMi | 294862520 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000279751 | 1 – 285 | G patch domain-containing protein 11Add BLAST | 285 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 141 | PhosphoserineCombined sources | 1 | |
Modified residuei | 149 | N6-acetyllysineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q8N954 |
jPOSTi | Q8N954 |
MassIVEi | Q8N954 |
PaxDbi | Q8N954 |
PeptideAtlasi | Q8N954 |
PRIDEi | Q8N954 |
ProteomicsDBi | 72488 [Q8N954-1] 72489 [Q8N954-2] |
PTM databases
iPTMneti | Q8N954 |
PhosphoSitePlusi | Q8N954 |
Expressioni
Gene expression databases
Bgeei | ENSG00000152133 Expressed in 201 organ(s), highest expression level in testis |
Genevisiblei | Q8N954 HS |
Organism-specific databases
HPAi | HPA038231 HPA038232 |
Interactioni
Binary interactionsi
Protein-protein interaction databases
BioGridi | 128977, 21 interactors |
IntActi | Q8N954, 20 interactors |
MINTi | Q8N954 |
STRINGi | 9606.ENSP00000386772 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 95 – 141 | G-patchPROSITE-ProRule annotationAdd BLAST | 47 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 51 – 87 | Sequence analysisAdd BLAST | 37 |
Sequence similaritiesi
Belongs to the GPATCH11 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG1994 Eukaryota ENOG4110RFF LUCA |
GeneTreei | ENSGT00440000039029 |
HOGENOMi | HOG000007475 |
InParanoidi | Q8N954 |
OMAi | YWCGTHY |
OrthoDBi | 1277915at2759 |
PhylomeDBi | Q8N954 |
TreeFami | TF313583 |
Family and domain databases
InterProi | View protein in InterPro IPR025239 DUF4187 IPR000467 G_patch_dom IPR039249 GPATCH11 |
PANTHERi | PTHR21032 PTHR21032, 1 hit |
Pfami | View protein in Pfam PF13821 DUF4187, 1 hit PF01585 G-patch, 1 hit |
SMARTi | View protein in SMART SM01173 DUF4187, 1 hit SM00443 G_patch, 1 hit |
PROSITEi | View protein in PROSITE PS50174 G_PATCH, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q8N954-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRSARSTALN RGEQRAVRYY SHMKLNMAEE EDYMSDSFIN VQEDIRPGLP
60 70 80 90 100
MLRQIREARR KEEKQQEANL KNRQKSLKEE EQERRDIGLK NALGCENKGF
110 120 130 140 150
ALLQKMGYKS GQALGKSGGG IVEPIPLNIK TGKSGIGHEA SLKRKAEEKL
160 170 180 190 200
ESYRKKIHMK NQAEEKAAEQ FRMRLKNKQD EMKLEGDLRR SQRACQQLDV
210 220 230 240 250
QKNIQVPREA WYWLRLEEET EEDEEEKEQD EDEYKSEDLS VLEKLQILTS
260 270 280
YLREEHLYCI WCGTAYEDKE DLSSNCPGPT SADHD
Note: No experimental confirmation available.Curated
Sequence cautioni
The sequence BAH11850 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_023505 | 1 – 129 | Missing in isoform 2. 2 PublicationsAdd BLAST | 129 | |
Alternative sequenceiVSP_023506 | 130 – 132 | KTG → MSR in isoform 2. 2 Publications | 3 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK095667 mRNA Translation: BAC04602.1 AK289504 mRNA Translation: BAF82193.1 AK294697 mRNA Translation: BAH11850.1 Different initiation. AC007899 Genomic DNA Translation: AAY24316.1 CH471053 Genomic DNA Translation: EAX00410.1 BC071798 mRNA No translation available. |
CCDSi | CCDS1785.3 [Q8N954-1] CCDS62891.1 [Q8N954-2] |
RefSeqi | NP_001265434.1, NM_001278505.1 [Q8N954-2] NP_001309178.1, NM_001322249.1 NP_777591.3, NM_174931.3 [Q8N954-1] XP_016859237.1, XM_017003748.1 |
Genome annotation databases
Ensembli | ENST00000281932; ENSP00000281932; ENSG00000152133 [Q8N954-2] ENST00000409774; ENSP00000386772; ENSG00000152133 [Q8N954-1] |
GeneIDi | 253635 |
KEGGi | hsa:253635 |
UCSCi | uc002rpr.6 human [Q8N954-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK095667 mRNA Translation: BAC04602.1 AK289504 mRNA Translation: BAF82193.1 AK294697 mRNA Translation: BAH11850.1 Different initiation. AC007899 Genomic DNA Translation: AAY24316.1 CH471053 Genomic DNA Translation: EAX00410.1 BC071798 mRNA No translation available. |
CCDSi | CCDS1785.3 [Q8N954-1] CCDS62891.1 [Q8N954-2] |
RefSeqi | NP_001265434.1, NM_001278505.1 [Q8N954-2] NP_001309178.1, NM_001322249.1 NP_777591.3, NM_174931.3 [Q8N954-1] XP_016859237.1, XM_017003748.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGridi | 128977, 21 interactors |
IntActi | Q8N954, 20 interactors |
MINTi | Q8N954 |
STRINGi | 9606.ENSP00000386772 |
PTM databases
iPTMneti | Q8N954 |
PhosphoSitePlusi | Q8N954 |
Polymorphism and mutation databases
BioMutai | GPATCH11 |
DMDMi | 294862520 |
Proteomic databases
EPDi | Q8N954 |
jPOSTi | Q8N954 |
MassIVEi | Q8N954 |
PaxDbi | Q8N954 |
PeptideAtlasi | Q8N954 |
PRIDEi | Q8N954 |
ProteomicsDBi | 72488 [Q8N954-1] 72489 [Q8N954-2] |
Protocols and materials databases
DNASUi | 253635 |
Genome annotation databases
Ensembli | ENST00000281932; ENSP00000281932; ENSG00000152133 [Q8N954-2] ENST00000409774; ENSP00000386772; ENSG00000152133 [Q8N954-1] |
GeneIDi | 253635 |
KEGGi | hsa:253635 |
UCSCi | uc002rpr.6 human [Q8N954-1] |
Organism-specific databases
CTDi | 253635 |
GeneCardsi | GPATCH11 |
HGNCi | HGNC:26768 GPATCH11 |
HPAi | HPA038231 HPA038232 |
neXtProti | NX_Q8N954 |
OpenTargetsi | ENSG00000152133 |
PharmGKBi | PA143485427 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1994 Eukaryota ENOG4110RFF LUCA |
GeneTreei | ENSGT00440000039029 |
HOGENOMi | HOG000007475 |
InParanoidi | Q8N954 |
OMAi | YWCGTHY |
OrthoDBi | 1277915at2759 |
PhylomeDBi | Q8N954 |
TreeFami | TF313583 |
Miscellaneous databases
GenomeRNAii | 253635 |
Pharosi | Q8N954 |
PROi | PR:Q8N954 |
Gene expression databases
Bgeei | ENSG00000152133 Expressed in 201 organ(s), highest expression level in testis |
Genevisiblei | Q8N954 HS |
Family and domain databases
InterProi | View protein in InterPro IPR025239 DUF4187 IPR000467 G_patch_dom IPR039249 GPATCH11 |
PANTHERi | PTHR21032 PTHR21032, 1 hit |
Pfami | View protein in Pfam PF13821 DUF4187, 1 hit PF01585 G-patch, 1 hit |
SMARTi | View protein in SMART SM01173 DUF4187, 1 hit SM00443 G_patch, 1 hit |
PROSITEi | View protein in PROSITE PS50174 G_PATCH, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GPT11_HUMAN | |
Accessioni | Q8N954Primary (citable) accession number: Q8N954 Secondary accession number(s): A0A0A0MSF9 B8ZZ44 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 6, 2007 |
Last sequence update: | March 28, 2018 | |
Last modified: | October 16, 2019 | |
This is version 130 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM