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Entry version 116 (17 Jun 2020)
Sequence version 1 (01 Oct 2002)
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Protein

Nutritionally-regulated adipose and cardiac enriched protein homolog

Gene

NRAC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nutritionally-regulated adipose and cardiac enriched protein homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NRAC
Synonyms:C14orf180, C14orf77
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000184601.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:33795 C14orf180

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N912

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei101 – 121HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000184601

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162378139

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8N912 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
C14orf180

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003260521 – 160Nutritionally-regulated adipose and cardiac enriched protein homologAdd BLAST160

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N912

PeptideAtlas

More...
PeptideAtlasi
Q8N912

PRoteomics IDEntifications database

More...
PRIDEi
Q8N912

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
72484

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000184601 Expressed in apex of heart and 104 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8N912 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N912 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000184601 Tissue enhanced (adipose tissue, heart muscle)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q8N912
With#Exp.IntAct
AQP3 [Q92482]3EBI-12051377,EBI-2808854
AQP6 [Q13520]3EBI-12051377,EBI-13059134
ASZ1 [Q8WWH4]3EBI-12051377,EBI-12239061
BIK [Q13323]3EBI-12051377,EBI-700794
CCDC155 [Q8N6L0]3EBI-12051377,EBI-749265
CD74 - isoform 2 [P04233-2]4EBI-12051377,EBI-12222807
CD79A [P11912]3EBI-12051377,EBI-7797864
CISD2 [Q8N5K1]3EBI-12051377,EBI-1045797
CLEC7A - isoform 6 [Q9BXN2-6]3EBI-12051377,EBI-11989440
CPLX4 [Q7Z7G2]3EBI-12051377,EBI-18013275
CYBC1 [Q9BQA9]3EBI-12051377,EBI-2680384
EBAG9 [O00559]3EBI-12051377,EBI-8787095
ERGIC3 [Q9Y282]3EBI-12051377,EBI-781551
FAM174A [Q8TBP5]3EBI-12051377,EBI-18636064
FAM209A [Q5JX71]3EBI-12051377,EBI-18304435
GPR152 [Q8TDT2]3EBI-12051377,EBI-13345167
GPRC5D [Q9NZD1]3EBI-12051377,EBI-13067820
GPX8 [Q8TED1]3EBI-12051377,EBI-11721746
HAS3 - isoform 2 [O00219-2]3EBI-12051377,EBI-17186025
KCNJ6 [P48051]3EBI-12051377,EBI-12017638
LHFPL5 [Q8TAF8]3EBI-12051377,EBI-2820517
LIME1 [Q9H400]3EBI-12051377,EBI-2830566
MFF - isoform 5 [Q9GZY8-5]3EBI-12051377,EBI-11956541
MFSD14B [Q5SR56]3EBI-12051377,EBI-373355
MGST3 [O14880]3EBI-12051377,EBI-724754
MUC1 - isoform Y-LSP [P15941-11]3EBI-12051377,EBI-17263240
NCR3LG1 [Q68D85]3EBI-12051377,EBI-14061804
PDZK1IP1 [Q13113]3EBI-12051377,EBI-716063
PPP1CB [P62140]3EBI-12051377,EBI-352350
PPP1CC [P36873]3EBI-12051377,EBI-356283
REEP4 [Q9H6H4]3EBI-12051377,EBI-7545592
SAR1A [Q9NR31]3EBI-12051377,EBI-3920694
SLC35C2 - isoform 3 [Q9NQQ7-3]3EBI-12051377,EBI-17295964
TEX29 [Q8N6K0]3EBI-12051377,EBI-19027521
TIMMDC1 [Q9NPL8]3EBI-12051377,EBI-6268651
TM4SF19 [Q96DZ7]3EBI-12051377,EBI-6448756
TMEM106C [Q9BVX2]3EBI-12051377,EBI-2821497
TMEM14B [Q9NUH8]3EBI-12051377,EBI-8638294
TMEM167B [Q9NRX6]3EBI-12051377,EBI-17684533
TMEM207 [Q6UWW9]3EBI-12051377,EBI-13301303
TMEM51 [Q9NW97]3EBI-12051377,EBI-726044
TMEM80 [Q96HE8]3EBI-12051377,EBI-11742770
VSIR [Q9H7M9]3EBI-12051377,EBI-744988
ZDHHC15 [Q96MV8]3EBI-12051377,EBI-12837904

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q8N912, 44 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000333041

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8N912 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8N912

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J5MZ Eukaryota
ENOG411168H LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000001214

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_139836_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N912

Database of Orthologous Groups

More...
OrthoDBi
1483884at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N912

TreeFam database of animal gene trees

More...
TreeFami
TF336371

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028114 DUF4658

The PANTHER Classification System

More...
PANTHERi
PTHR36868 PTHR36868, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15555 DUF4658, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8N912-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRTAAGAVSP DSRPETRRQT RKNEEAAWGP RVCRAEREDN RKCPPSILKR
60 70 80 90 100
SRPEHHRPEA KPQRTSRRVW FREPPAVTVH YIADKNATAT VRVPGRPRPH
110 120 130 140 150
GGSLLLQLCV CVLLVLALGL YCGRAKPVAT ALEDLRARLL GLVLHLRHVA
160
LTCWRGLLRL
Length:160
Mass (Da):18,051
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCFDFAF575988E9E1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KNP8J3KNP8_HUMAN
Chromosome 14 open reading frame 18...
C14orf180
177Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK095913 mRNA Translation: BAC04645.1
BX161457 mRNA Translation: CAD61919.1
CH471061 Genomic DNA Translation: EAW81864.1
BC041103 mRNA Translation: AAH41103.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32166.1

NCBI Reference Sequences

More...
RefSeqi
NP_001008404.1, NM_001008404.2
NP_001273328.1, NM_001286399.1
NP_001273329.1, NM_001286400.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000410013; ENSP00000386487; ENSG00000184601
ENST00000557649; ENSP00000452502; ENSG00000184601
ENST00000618752; ENSP00000480567; ENSG00000274126
ENST00000630349; ENSP00000487058; ENSG00000274126

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
400258

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:400258

UCSC genome browser

More...
UCSCi
uc001yow.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095913 mRNA Translation: BAC04645.1
BX161457 mRNA Translation: CAD61919.1
CH471061 Genomic DNA Translation: EAW81864.1
BC041103 mRNA Translation: AAH41103.1
CCDSiCCDS32166.1
RefSeqiNP_001008404.1, NM_001008404.2
NP_001273328.1, NM_001286399.1
NP_001273329.1, NM_001286400.1

3D structure databases

SMRiQ8N912
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ8N912, 44 interactors
STRINGi9606.ENSP00000333041

Polymorphism and mutation databases

BioMutaiC14orf180

Proteomic databases

PaxDbiQ8N912
PeptideAtlasiQ8N912
PRIDEiQ8N912
ProteomicsDBi72484

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
28178 64 antibodies

Genome annotation databases

EnsembliENST00000410013; ENSP00000386487; ENSG00000184601
ENST00000557649; ENSP00000452502; ENSG00000184601
ENST00000618752; ENSP00000480567; ENSG00000274126
ENST00000630349; ENSP00000487058; ENSG00000274126
GeneIDi400258
KEGGihsa:400258
UCSCiuc001yow.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
400258
EuPathDBiHostDB:ENSG00000184601.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
C14orf180
HGNCiHGNC:33795 C14orf180
HPAiENSG00000184601 Tissue enhanced (adipose tissue, heart muscle)
neXtProtiNX_Q8N912
OpenTargetsiENSG00000184601
PharmGKBiPA162378139

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J5MZ Eukaryota
ENOG411168H LUCA
GeneTreeiENSGT00390000001214
HOGENOMiCLU_139836_0_0_1
InParanoidiQ8N912
OrthoDBi1483884at2759
PhylomeDBiQ8N912
TreeFamiTF336371

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
400258 0 hits in 782 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
400258
PharosiQ8N912 Tdark

Protein Ontology

More...
PROi
PR:Q8N912
RNActiQ8N912 protein

Gene expression databases

BgeeiENSG00000184601 Expressed in apex of heart and 104 other tissues
ExpressionAtlasiQ8N912 baseline and differential
GenevisibleiQ8N912 HS

Family and domain databases

InterProiView protein in InterPro
IPR028114 DUF4658
PANTHERiPTHR36868 PTHR36868, 1 hit
PfamiView protein in Pfam
PF15555 DUF4658, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNRAC_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N912
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 1, 2002
Last modified: June 17, 2020
This is version 116 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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