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Protein

Zinc finger protein 41 homolog

Gene

ZFP41

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

A putative DNA-binding regulatory protein associated with meiosis in spermatogenesis.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri87 – 109C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri115 – 137C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri143 – 165C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri171 – 193C2H2-type 4PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Spermatogenesis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 41 homolog
Short name:
Zfp-41
Gene namesi
Name:ZFP41
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:26786 ZFP41
neXtProtiNX_Q8N8Y5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670529

Polymorphism and mutation databases

DMDMi74760014

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002961861 – 198Zinc finger protein 41 homologAdd BLAST198

Proteomic databases

PaxDbiQ8N8Y5
PeptideAtlasiQ8N8Y5
PRIDEiQ8N8Y5
ProteomicsDBi72475

PTM databases

iPTMnetiQ8N8Y5
PhosphoSitePlusiQ8N8Y5

Expressioni

Gene expression databases

CleanExiHS_ZFP41
GenevisibleiQ8N8Y5 HS

Organism-specific databases

HPAiHPA047232
HPA056268

Interactioni

Protein-protein interaction databases

BioGridi130307, 47 interactors
IntActiQ8N8Y5, 7 interactors
STRINGi9606.ENSP00000428966

Structurei

3D structure databases

ProteinModelPortaliQ8N8Y5
SMRiQ8N8Y5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri87 – 109C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri115 – 137C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri143 – 165C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri171 – 193C2H2-type 4PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
HOGENOMiHOG000234617
HOVERGENiHBG098192
InParanoidiQ8N8Y5
OMAiRHPRKKH
PhylomeDBiQ8N8Y5
TreeFamiTF337091

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8N8Y5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKPAGRKKK TPTPREEADV QKSALREEKV SGDRKPPERP TVPRKPRTEP
60 70 80 90 100
CLSPEDEEHV FDAFDASFKD DFEGVPVFIP FQRKKPYECS ECGRIFKHKT
110 120 130 140 150
DHIRHQRVHT GEKPFKCAQC GKAFRHSSDV TKHQRTHTGE KPFKCGECGK
160 170 180 190
AFNCGSNLLK HQKTHTGEKP YECTHCGKAF AYSSCLIRHQ KRHPRKKP
Length:198
Mass (Da):22,806
Last modified:October 1, 2002 - v1
Checksum:iA41841AA44CCBDE1
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JH32A0A0G2JH32_HUMAN
Zinc finger protein 41 homolog
ZFP41
199Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096024 mRNA Translation: BAC04676.1
CH471162 Genomic DNA Translation: EAW82273.1
CH471162 Genomic DNA Translation: EAW82274.1
CH471162 Genomic DNA Translation: EAW82275.1
BC034608 mRNA Translation: AAH34608.1
CCDSiCCDS6397.2
RefSeqiNP_001258085.2, NM_001271156.2
NP_776193.2, NM_173832.5
UniGeneiHs.668016

Genome annotation databases

EnsembliENST00000626353; ENSP00000486248; ENSG00000181638
ENST00000627729; ENSP00000486020; ENSG00000181638
GeneIDi286128
KEGGihsa:286128
UCSCiuc003yxw.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096024 mRNA Translation: BAC04676.1
CH471162 Genomic DNA Translation: EAW82273.1
CH471162 Genomic DNA Translation: EAW82274.1
CH471162 Genomic DNA Translation: EAW82275.1
BC034608 mRNA Translation: AAH34608.1
CCDSiCCDS6397.2
RefSeqiNP_001258085.2, NM_001271156.2
NP_776193.2, NM_173832.5
UniGeneiHs.668016

3D structure databases

ProteinModelPortaliQ8N8Y5
SMRiQ8N8Y5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130307, 47 interactors
IntActiQ8N8Y5, 7 interactors
STRINGi9606.ENSP00000428966

PTM databases

iPTMnetiQ8N8Y5
PhosphoSitePlusiQ8N8Y5

Polymorphism and mutation databases

DMDMi74760014

Proteomic databases

PaxDbiQ8N8Y5
PeptideAtlasiQ8N8Y5
PRIDEiQ8N8Y5
ProteomicsDBi72475

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000626353; ENSP00000486248; ENSG00000181638
ENST00000627729; ENSP00000486020; ENSG00000181638
GeneIDi286128
KEGGihsa:286128
UCSCiuc003yxw.5 human

Organism-specific databases

CTDi286128
GeneCardsiZFP41
HGNCiHGNC:26786 ZFP41
HPAiHPA047232
HPA056268
neXtProtiNX_Q8N8Y5
PharmGKBiPA142670529
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
HOGENOMiHOG000234617
HOVERGENiHBG098192
InParanoidiQ8N8Y5
OMAiRHPRKKH
PhylomeDBiQ8N8Y5
TreeFamiTF337091

Miscellaneous databases

GenomeRNAii286128
PROiPR:Q8N8Y5

Gene expression databases

CleanExiHS_ZFP41
GenevisibleiQ8N8Y5 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZFP41_HUMAN
AccessioniPrimary (citable) accession number: Q8N8Y5
Secondary accession number(s): D3DWJ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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