UniProtKB - Q8N8Y5 (ZFP41_HUMAN)
Protein
Zinc finger protein 41 homolog
Gene
ZFP41
Organism
Homo sapiens (Human)
Status
Functioni
A putative DNA-binding regulatory protein associated with meiosis in spermatogenesis.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 87 – 109 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 115 – 137 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 143 – 165 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 171 – 193 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- cell differentiation Source: UniProtKB-KW
- multicellular organism development Source: UniProtKB-KW
- regulation of transcription by RNA polymerase II Source: GO_Central
- spermatogenesis Source: UniProtKB-KW
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Differentiation, Spermatogenesis, Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q8N8Y5 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 41 homologShort name: Zfp-41 |
Gene namesi | Name:ZFP41 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26786, ZFP41 |
neXtProti | NX_Q8N8Y5 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- nuclear chromatin Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 286128 |
OpenTargetsi | ENSG00000181638 |
PharmGKBi | PA142670529 |
Miscellaneous databases
Pharosi | Q8N8Y5, Tdark |
Polymorphism and mutation databases
BioMutai | ZFP41 |
DMDMi | 74760014 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000296186 | 1 – 198 | Zinc finger protein 41 homologAdd BLAST | 198 |
Proteomic databases
MassIVEi | Q8N8Y5 |
PaxDbi | Q8N8Y5 |
PeptideAtlasi | Q8N8Y5 |
PRIDEi | Q8N8Y5 |
ProteomicsDBi | 72475 |
PTM databases
iPTMneti | Q8N8Y5 |
PhosphoSitePlusi | Q8N8Y5 |
Expressioni
Gene expression databases
ExpressionAtlasi | Q8N8Y5, baseline and differential |
Genevisiblei | Q8N8Y5, HS |
Interactioni
Binary interactionsi
Hide detailsQ8N8Y5
Protein-protein interaction databases
BioGRIDi | 130307, 56 interactors |
IntActi | Q8N8Y5, 42 interactors |
STRINGi | 9606.ENSP00000428966 |
Miscellaneous databases
RNActi | Q8N8Y5, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 87 – 109 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 115 – 137 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 143 – 165 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 171 – 193 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT01010000222430 |
HOGENOMi | CLU_002678_2_6_1 |
InParanoidi | Q8N8Y5 |
OMAi | RHPRKKH |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8N8Y5 |
TreeFami | TF337091 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 4 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
i Sequence
Sequence statusi: Complete.
Q8N8Y5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEKPAGRKKK TPTPREEADV QKSALREEKV SGDRKPPERP TVPRKPRTEP
60 70 80 90 100
CLSPEDEEHV FDAFDASFKD DFEGVPVFIP FQRKKPYECS ECGRIFKHKT
110 120 130 140 150
DHIRHQRVHT GEKPFKCAQC GKAFRHSSDV TKHQRTHTGE KPFKCGECGK
160 170 180 190
AFNCGSNLLK HQKTHTGEKP YECTHCGKAF AYSSCLIRHQ KRHPRKKP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK096024 mRNA Translation: BAC04676.1 CH471162 Genomic DNA Translation: EAW82273.1 CH471162 Genomic DNA Translation: EAW82274.1 CH471162 Genomic DNA Translation: EAW82275.1 BC034608 mRNA Translation: AAH34608.1 |
CCDSi | CCDS6397.2 |
RefSeqi | NP_001258085.2, NM_001271156.2 NP_776193.2, NM_173832.5 |
Genome annotation databases
Ensembli | ENST00000330701; ENSP00000327427; ENSG00000181638 ENST00000520584; ENSP00000430465; ENSG00000181638 |
GeneIDi | 286128 |
KEGGi | hsa:286128 |
UCSCi | uc003yxw.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK096024 mRNA Translation: BAC04676.1 CH471162 Genomic DNA Translation: EAW82273.1 CH471162 Genomic DNA Translation: EAW82274.1 CH471162 Genomic DNA Translation: EAW82275.1 BC034608 mRNA Translation: AAH34608.1 |
CCDSi | CCDS6397.2 |
RefSeqi | NP_001258085.2, NM_001271156.2 NP_776193.2, NM_173832.5 |
3D structure databases
SMRi | Q8N8Y5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 130307, 56 interactors |
IntActi | Q8N8Y5, 42 interactors |
STRINGi | 9606.ENSP00000428966 |
PTM databases
iPTMneti | Q8N8Y5 |
PhosphoSitePlusi | Q8N8Y5 |
Polymorphism and mutation databases
BioMutai | ZFP41 |
DMDMi | 74760014 |
Proteomic databases
MassIVEi | Q8N8Y5 |
PaxDbi | Q8N8Y5 |
PeptideAtlasi | Q8N8Y5 |
PRIDEi | Q8N8Y5 |
ProteomicsDBi | 72475 |
Protocols and materials databases
Antibodypediai | 27860, 11 antibodies |
Genome annotation databases
Ensembli | ENST00000330701; ENSP00000327427; ENSG00000181638 ENST00000520584; ENSP00000430465; ENSG00000181638 |
GeneIDi | 286128 |
KEGGi | hsa:286128 |
UCSCi | uc003yxw.5, human |
Organism-specific databases
CTDi | 286128 |
DisGeNETi | 286128 |
GeneCardsi | ZFP41 |
HGNCi | HGNC:26786, ZFP41 |
neXtProti | NX_Q8N8Y5 |
OpenTargetsi | ENSG00000181638 |
PharmGKBi | PA142670529 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT01010000222430 |
HOGENOMi | CLU_002678_2_6_1 |
InParanoidi | Q8N8Y5 |
OMAi | RHPRKKH |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8N8Y5 |
TreeFami | TF337091 |
Enzyme and pathway databases
PathwayCommonsi | Q8N8Y5 |
Miscellaneous databases
BioGRID-ORCSi | 286128, 9 hits in 862 CRISPR screens |
ChiTaRSi | ZFP41, human |
GenomeRNAii | 286128 |
Pharosi | Q8N8Y5, Tdark |
PROi | PR:Q8N8Y5 |
RNActi | Q8N8Y5, protein |
Gene expression databases
ExpressionAtlasi | Q8N8Y5, baseline and differential |
Genevisiblei | Q8N8Y5, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 4 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZFP41_HUMAN | |
Accessioni | Q8N8Y5Primary (citable) accession number: Q8N8Y5 Secondary accession number(s): D3DWJ5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 24, 2007 |
Last sequence update: | October 1, 2002 | |
Last modified: | December 2, 2020 | |
This is version 156 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM