ZFP41

Functionⁱ

A putative DNA-binding regulatory protein associated with meiosis in spermatogenesis.By similarity

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	87 – 109	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	115 – 137	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	143 – 165	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	171 – 193	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell differentiation Source: UniProtKB-KW
multicellular organism development Source: UniProtKB-KW
spermatogenesis Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, DNA-binding
Biological process	Differentiation, Spermatogenesis, Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein 41 homolog Short name: Zfp-41
Gene namesⁱ	Name:ZFP41
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Unplaced

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:26786 ZFP41
neXtProtⁱ	NX_Q8N8Y5

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA142670529

PharmGKBⁱ

PA142670529

Polymorphism and mutation databases

DMDMⁱ	74760014

DMDMⁱ

74760014

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000296186	1 – 198	Zinc finger protein 41 homologAdd BLAST		198

Proteomic databases

PaxDbⁱ	Q8N8Y5
PeptideAtlas More...PeptideAtlasⁱ	Q8N8Y5
PRIDEⁱ	Q8N8Y5
ProteomicsDBⁱ	72475

PTM databases

iPTMnetⁱ	Q8N8Y5
PhosphoSitePlusⁱ	Q8N8Y5

Expressionⁱ

Gene expression databases

CleanExⁱ	HS_ZFP41
Genevisibleⁱ	Q8N8Y5 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA047232 HPA056268

HPAⁱ

HPA047232
HPA056268

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	130307, 47 interactors
IntActⁱ	Q8N8Y5, 7 interactors
STRINGⁱ	9606.ENSP00000428966

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8N8Y5
SMRⁱ	Q8N8Y5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	87 – 109	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	115 – 137	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	143 – 165	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	171 – 193	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
HOGENOMⁱ	HOG000234617
HOVERGENⁱ	HBG098192
InParanoidⁱ	Q8N8Y5
OMAⁱ	RHPRKKH
PhylomeDBⁱ	Q8N8Y5
TreeFamⁱ	TF337091

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 4 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 4 hits
SUPFAMⁱ	SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 4 hits PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q8N8Y5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEKPAGRKKK TPTPREEADV QKSALREEKV SGDRKPPERP TVPRKPRTEP 
        60         70         80         90        100
CLSPEDEEHV FDAFDASFKD DFEGVPVFIP FQRKKPYECS ECGRIFKHKT 
       110        120        130        140        150
DHIRHQRVHT GEKPFKCAQC GKAFRHSSDV TKHQRTHTGE KPFKCGECGK 
       160        170        180        190 
AFNCGSNLLK HQKTHTGEKP YECTHCGKAF AYSSCLIRHQ KRHPRKKP

Length:198

Mass (Da):22,806

Last modified:October 1, 2002 - v1

Checksum:ⁱA41841AA44CCBDE1

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A0G2JH32	A0A0G2JH32_HUMAN		Zinc finger protein 41 homolog Zinc finger protein 41 homolog	ZFP41	199	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK096024 mRNA Translation: BAC04676.1 CH471162 Genomic DNA Translation: EAW82273.1 CH471162 Genomic DNA Translation: EAW82274.1 CH471162 Genomic DNA Translation: EAW82275.1 BC034608 mRNA Translation: AAH34608.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6397.2
NCBI Reference Sequences More...RefSeqⁱ	NP_001258085.2, NM_001271156.2 NP_776193.2, NM_173832.5
UniGeneⁱ	Hs.668016

Genome annotation databases

Ensemblⁱ	ENST00000626353; ENSP00000486248; ENSG00000181638 ENST00000627729; ENSP00000486020; ENSG00000181638
GeneIDⁱ	286128
KEGGⁱ	hsa:286128
UCSC genome browser More...UCSCⁱ	uc003yxw.5 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8N8Y5	Uncharacterized protein DKFZp761O1618 (Fragment)		HUMAN		540	UniRef100_Q8N8Y5

Protein	Similar proteins		Species	Score	Length	Source
Q8N8Y5	Uncharacterized protein DKFZp761O1618 (Fragment)		HUMAN		540	UniRef90_Q8N8Y5

Protein	Similar proteins		Species	Score	Length	Source
Q8N8Y5	Uncharacterized protein DKFZp761O1618 (Fragment)		HUMAN		540	UniRef50_Q8N8Y5
Uncharacterized protein		OTOGA		546
UPI00064408D0		OTOGA		198

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK096024 mRNA Translation: BAC04676.1 CH471162 Genomic DNA Translation: EAW82273.1 CH471162 Genomic DNA Translation: EAW82274.1 CH471162 Genomic DNA Translation: EAW82275.1 BC034608 mRNA Translation: AAH34608.1
CCDSⁱ	CCDS6397.2
RefSeqⁱ	NP_001258085.2, NM_001271156.2 NP_776193.2, NM_173832.5
UniGeneⁱ	Hs.668016

3D structure databases

ProteinModelPortalⁱ	Q8N8Y5
SMRⁱ	Q8N8Y5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	130307, 47 interactors
IntActⁱ	Q8N8Y5, 7 interactors
STRINGⁱ	9606.ENSP00000428966

PTM databases

iPTMnetⁱ	Q8N8Y5
PhosphoSitePlusⁱ	Q8N8Y5

Polymorphism and mutation databases

DMDMⁱ	74760014

DMDMⁱ

74760014

Proteomic databases

PaxDbⁱ	Q8N8Y5
PeptideAtlasⁱ	Q8N8Y5
PRIDEⁱ	Q8N8Y5
ProteomicsDBⁱ	72475

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000626353; ENSP00000486248; ENSG00000181638 ENST00000627729; ENSP00000486020; ENSG00000181638
GeneIDⁱ	286128
KEGGⁱ	hsa:286128
UCSCⁱ	uc003yxw.5 human

Organism-specific databases

CTDⁱ	286128
GeneCardsⁱ	ZFP41
HGNCⁱ	HGNC:26786 ZFP41
HPAⁱ	HPA047232 HPA056268
neXtProtⁱ	NX_Q8N8Y5
PharmGKBⁱ	PA142670529
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
HOGENOMⁱ	HOG000234617
HOVERGENⁱ	HBG098192
InParanoidⁱ	Q8N8Y5
OMAⁱ	RHPRKKH
PhylomeDBⁱ	Q8N8Y5
TreeFamⁱ	TF337091

Miscellaneous databases

GenomeRNAiⁱ	286128
Protein Ontology More...PROⁱ	PR:Q8N8Y5

Gene expression databases

CleanExⁱ	HS_ZFP41
Genevisibleⁱ	Q8N8Y5 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 4 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 4 hits
SUPFAMⁱ	SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 4 hits PS50157 ZINC_FINGER_C2H2_2, 4 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZFP41_HUMAN
Accessionⁱ	Q8N8Y5Primary (citable) accession number: Q8N8Y5 Secondary accession number(s): D3DWJ5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 24, 2007
	Last sequence update:	October 1, 2002
	Last modified:	November 7, 2018
	This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8N8Y5 (ZFP41_HUMAN)

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Zinc finger protein 41 homolog

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ