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Protein

Protein mab-21-like 3

Gene

MAB21L3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein mab-21-like 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MAB21L3
Synonyms:C1orf161
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000173212.4

Human Gene Nomenclature Database

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HGNCi
HGNC:26787 MAB21L3

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N8X9

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000173212

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142672412

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MAB21L3

Domain mapping of disease mutations (DMDM)

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DMDMi
147742988

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002865841 – 362Protein mab-21-like 3Add BLAST362

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8N8X9

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8N8X9

PeptideAtlas

More...
PeptideAtlasi
Q8N8X9

PRoteomics IDEntifications database

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PRIDEi
Q8N8X9

ProteomicsDB human proteome resource

More...
ProteomicsDBi
72471

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000173212 Expressed in 55 organ(s), highest expression level in ectocervix

CleanEx database of gene expression profiles

More...
CleanExi
HS_C1orf161

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N8X9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA039551
HPA046187

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
126023, 9 interactors

Protein interaction database and analysis system

More...
IntActi
Q8N8X9, 29 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q8N8X9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8N8X9

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the mab-21 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3963 Eukaryota
ENOG410XNRJ LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000154062

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG107559

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8N8X9

Identification of Orthologs from Complete Genome Data

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OMAi
PEGLQQW

Database of Orthologous Groups

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OrthoDBi
653783at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N8X9

TreeFam database of animal gene trees

More...
TreeFami
TF315012

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR034324 Mab-21-like_3
IPR024810 Mab-21_dom

The PANTHER Classification System

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PANTHERi
PTHR10656:SF30 PTHR10656:SF30, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF03281 Mab-21, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01265 Mab-21, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8N8X9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKYLTVGDLE DCLLNKVDLR RQQISQAVEE VQKVVHHLTT NISNQDIRFQ
60 70 80 90 100
AVPYSDTYNE NIKVLAPSQF LVTVPIKGLA GYREAREQHW RYYTLQGTRL
110 120 130 140 150
PCPLRDPEGL QQWLEVEQFM KSLWQWHETD VNIDGDIVPA KVLLVFRKLV
160 170 180 190 200
ENAVRTCHLS GKVSLLGNRS AVWVAVETSA YQVELELVPA VEIPTTWSKK
210 220 230 240 250
ARWPRCLQRW PSQERVECIK SFGFNLLACS NYHWQLSFLR AEQVLLEQLD
260 270 280 290 300
EDGGCRRKCF QVMRHLKEDI WCPGNRPVIT SHHLQTVLFW TCEKYPHFKD
310 320 330 340 350
WQVFSKAFLR LVRKLHKCVS QHFLKHYFVR NSNLFQCTNP TELDTVAQKL
360
ATFLKNPQIG PP
Length:362
Mass (Da):42,357
Last modified:May 15, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFE18C96B4E90CE42
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti338T → A in BAC04682 (PubMed:14702039).Curated1
Sequence conflicti338T → A in AAI28150 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK096035 mRNA Translation: BAC04682.1
AL121982 Genomic DNA No translation available.
BC128148 mRNA Translation: AAI28149.1
BC128149 mRNA Translation: AAI28150.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS886.1

NCBI Reference Sequences

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RefSeqi
NP_689580.2, NM_152367.2
XP_011538925.1, XM_011540623.2
XP_011538927.1, XM_011540625.2
XP_011538928.1, XM_011540626.2
XP_016855749.1, XM_017000260.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.376194

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000369500; ENSP00000358512; ENSG00000173212

Database of genes from NCBI RefSeq genomes

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GeneIDi
126868

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:126868

UCSC genome browser

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UCSCi
uc001egc.1 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096035 mRNA Translation: BAC04682.1
AL121982 Genomic DNA No translation available.
BC128148 mRNA Translation: AAI28149.1
BC128149 mRNA Translation: AAI28150.1
CCDSiCCDS886.1
RefSeqiNP_689580.2, NM_152367.2
XP_011538925.1, XM_011540623.2
XP_011538927.1, XM_011540625.2
XP_011538928.1, XM_011540626.2
XP_016855749.1, XM_017000260.1
UniGeneiHs.376194

3D structure databases

ProteinModelPortaliQ8N8X9
SMRiQ8N8X9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126023, 9 interactors
IntActiQ8N8X9, 29 interactors

Polymorphism and mutation databases

BioMutaiMAB21L3
DMDMi147742988

Proteomic databases

jPOSTiQ8N8X9
PaxDbiQ8N8X9
PeptideAtlasiQ8N8X9
PRIDEiQ8N8X9
ProteomicsDBi72471

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369500; ENSP00000358512; ENSG00000173212
GeneIDi126868
KEGGihsa:126868
UCSCiuc001egc.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
126868
EuPathDBiHostDB:ENSG00000173212.4

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MAB21L3
HGNCiHGNC:26787 MAB21L3
HPAiHPA039551
HPA046187
neXtProtiNX_Q8N8X9
OpenTargetsiENSG00000173212
PharmGKBiPA142672412

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3963 Eukaryota
ENOG410XNRJ LUCA
GeneTreeiENSGT00940000154062
HOVERGENiHBG107559
InParanoidiQ8N8X9
OMAiPEGLQQW
OrthoDBi653783at2759
PhylomeDBiQ8N8X9
TreeFamiTF315012

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MAB21L3 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
126868

Protein Ontology

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PROi
PR:Q8N8X9

Gene expression databases

BgeeiENSG00000173212 Expressed in 55 organ(s), highest expression level in ectocervix
CleanExiHS_C1orf161
GenevisibleiQ8N8X9 HS

Family and domain databases

InterProiView protein in InterPro
IPR034324 Mab-21-like_3
IPR024810 Mab-21_dom
PANTHERiPTHR10656:SF30 PTHR10656:SF30, 1 hit
PfamiView protein in Pfam
PF03281 Mab-21, 1 hit
SMARTiView protein in SMART
SM01265 Mab-21, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMB213_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N8X9
Secondary accession number(s): Q5TDL7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: January 16, 2019
This is version 102 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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