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Entry version 110 (13 Feb 2019)
Sequence version 1 (01 Oct 2002)
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Protein

Retrotransposon Gag-like protein 3

Gene

RTL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May function as a transcriptional regulator. Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal.By similarity

Miscellaneous

RTL3 is one of at least 11 genes called Mar or Mart related to long terminal repeat retrotransposons. They do not correspond to functional retrotransposons, but rather to neofunctionalized retrotransposons genes.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri443 – 462CCHC-typePROSITE-ProRule annotationAdd BLAST20

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Retrotransposon Gag-like protein 3Imported
Alternative name(s):
Zinc finger CCHC domain-containing protein 5Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RTL3Imported
Synonyms:MAR31 Publication, MART31 Publication, ZCCHC5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000179300.3

Human Gene Nomenclature Database

More...
HGNCi
HGNC:22997 RTL3

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N8U3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
203430

Open Targets

More...
OpenTargetsi
ENSG00000179300

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134958360

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RTL3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
34223121

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001509561 – 475Retrotransposon Gag-like protein 3Add BLAST475

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N8U3

PRoteomics IDEntifications database

More...
PRIDEi
Q8N8U3

ProteomicsDB human proteome resource

More...
ProteomicsDBi
72460

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N8U3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000179300 Expressed in 47 organ(s), highest expression level in thoracic aorta

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N8U3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA051991
HPA053174
HPA075136

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000316794

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8N8U3

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi61 – 194Pro-richAdd BLAST134

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri443 – 462CCHC-typePROSITE-ProRule annotationAdd BLAST20

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410JFQX Eukaryota
ENOG4111E4H LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163808

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000143388

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG056204

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N8U3

Identification of Orthologs from Complete Genome Data

More...
OMAi
RREGHLC

Database of Orthologous Groups

More...
OrthoDBi
583605at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N8U3

TreeFam database of animal gene trees

More...
TreeFami
TF335133

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032549 DUF4939
IPR032567 LDOC1-rel
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf

The PANTHER Classification System

More...
PANTHERi
PTHR15503 PTHR15503, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16297 DUF4939, 1 hit
PF00098 zf-CCHC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00343 ZnF_C2HC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57756 SSF57756, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50158 ZF_CCHC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8N8U3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVEDLAASYI VLKLENEIRQ AQVQWLMEEN AALQAQIPEL QKSQAAKEYD
60 70 80 90 100
LLRKSSEAKE PQKLPEHMNP PAAWEAQKTP EFKEPQKPPE PQDLLPWEPP
110 120 130 140 150
AAWELQEAPA APESLAPPAT RESQKPPMAH EIPTVLEGQG PANTQDATIA
160 170 180 190 200
QEPKNSEPQD PPNIEKPQEA PEYQETAAQL EFLELPPPQE PLEPSNAQEF
210 220 230 240 250
LELSAAQESL EGLIVVETSA ASEFPQAPIG LEATDFPLQY TLTFSGDSQK
260 270 280 290 300
LPEFLVQLYS YMRVRGHLYP TEAALVSFVG NCFSGRAGWW FQLLLDIQSP
310 320 330 340 350
LLEQCESFIP VLQDTFDNPE NMKDANQCIH QLCQGEGHVA THFHLIAQEL
360 370 380 390 400
NWDESTLWIQ FQEGLASSIQ DELSHTSPAT NLSDLITQCI SLEEKPDPNP
410 420 430 440 450
LGKSSSAEGD GPESPPAENQ PMQAAINCPH ISEAEWVRWH KGRLCLYCGY
460 470
PGHFARDCPV KPHQALQAGN IQACQ
Length:475
Mass (Da):52,817
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0A56ABB62220F56D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053752117P → S1 PublicationCorresponds to variant dbSNP:rs4077512Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK096184 mRNA Translation: BAC04719.1
AL662885 Genomic DNA No translation available.
BC136548 mRNA Translation: AAI36549.1
BC136549 mRNA Translation: AAI36550.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14440.1

NCBI Reference Sequences

More...
RefSeqi
NP_689907.1, NM_152694.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.134873

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000321110; ENSP00000316794; ENSG00000179300

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
203430

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:203430

UCSC genome browser

More...
UCSCi
uc004edc.1 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096184 mRNA Translation: BAC04719.1
AL662885 Genomic DNA No translation available.
BC136548 mRNA Translation: AAI36549.1
BC136549 mRNA Translation: AAI36550.1
CCDSiCCDS14440.1
RefSeqiNP_689907.1, NM_152694.2
UniGeneiHs.134873

3D structure databases

ProteinModelPortaliQ8N8U3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000316794

PTM databases

PhosphoSitePlusiQ8N8U3

Polymorphism and mutation databases

BioMutaiRTL3
DMDMi34223121

Proteomic databases

PaxDbiQ8N8U3
PRIDEiQ8N8U3
ProteomicsDBi72460

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321110; ENSP00000316794; ENSG00000179300
GeneIDi203430
KEGGihsa:203430
UCSCiuc004edc.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
203430
DisGeNETi203430
EuPathDBiHostDB:ENSG00000179300.3

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RTL3
HGNCiHGNC:22997 RTL3
HPAiHPA051991
HPA053174
HPA075136
neXtProtiNX_Q8N8U3
OpenTargetsiENSG00000179300
PharmGKBiPA134958360

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410JFQX Eukaryota
ENOG4111E4H LUCA
GeneTreeiENSGT00940000163808
HOGENOMiHOG000143388
HOVERGENiHBG056204
InParanoidiQ8N8U3
OMAiRREGHLC
OrthoDBi583605at2759
PhylomeDBiQ8N8U3
TreeFamiTF335133

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
203430

Protein Ontology

More...
PROi
PR:Q8N8U3

Gene expression databases

BgeeiENSG00000179300 Expressed in 47 organ(s), highest expression level in thoracic aorta
GenevisibleiQ8N8U3 HS

Family and domain databases

InterProiView protein in InterPro
IPR032549 DUF4939
IPR032567 LDOC1-rel
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf
PANTHERiPTHR15503 PTHR15503, 1 hit
PfamiView protein in Pfam
PF16297 DUF4939, 1 hit
PF00098 zf-CCHC, 1 hit
SMARTiView protein in SMART
SM00343 ZnF_C2HC, 1 hit
SUPFAMiSSF57756 SSF57756, 1 hit
PROSITEiView protein in PROSITE
PS50158 ZF_CCHC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRTL3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N8U3
Secondary accession number(s): B2RMZ0, Q5JQE9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: October 1, 2002
Last modified: February 13, 2019
This is version 110 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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