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Protein

Chromodomain Y-like protein 2

Gene

CDYL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • catalytic activity Source: InterPro
  • methylated histone binding Source: Ensembl
  • transcription corepressor activity Source: GO_Central

Names & Taxonomyi

Protein namesi
Recommended name:
Chromodomain Y-like protein 2
Short name:
CDY-like 2
Gene namesi
Name:CDYL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000166446.14
HGNCiHGNC:23030 CDYL2
neXtProtiNX_Q8N8U2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi124359
OpenTargetsiENSG00000166446
PharmGKBiPA134903387

Chemistry databases

ChEMBLiCHEMBL3879857

Polymorphism and mutation databases

BioMutaiCDYL2
DMDMi229462825

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000802231 – 506Chromodomain Y-like protein 2Add BLAST506

Proteomic databases

EPDiQ8N8U2
MaxQBiQ8N8U2
PaxDbiQ8N8U2
PeptideAtlasiQ8N8U2
PRIDEiQ8N8U2
ProteomicsDBi72459

PTM databases

iPTMnetiQ8N8U2
PhosphoSitePlusiQ8N8U2

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSG00000166446 Expressed in 185 organ(s), highest expression level in placenta
CleanExiHS_CDYL2
ExpressionAtlasiQ8N8U2 baseline and differential
GenevisibleiQ8N8U2 HS

Organism-specific databases

HPAiHPA041016

Interactioni

Subunit structurei

Interacts (via chromo domain) with histone H3K9me3.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
PRMT5O147442EBI-8467076,EBI-351098

GO - Molecular functioni

Protein-protein interaction databases

BioGridi125860, 12 interactors
IntActiQ8N8U2, 14 interactors
MINTiQ8N8U2
STRINGi9606.ENSP00000299564

Structurei

Secondary structure

1506
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8N8U2
SMRiQ8N8U2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 67ChromoPROSITE-ProRule annotationAdd BLAST61

Phylogenomic databases

eggNOGiKOG0016 Eukaryota
KOG1911 Eukaryota
COG1024 LUCA
GeneTreeiENSGT00890000139344
HOGENOMiHOG000111507
HOVERGENiHBG006723
InParanoidiQ8N8U2
KOiK00653
PhylomeDBiQ8N8U2
TreeFamiTF313375

Family and domain databases

CDDicd00024 CHROMO, 1 hit
Gene3Di1.10.12.10, 1 hit
InterProiView protein in InterPro
IPR016197 Chromo-like_dom_sf
IPR000953 Chromo/chromo_shadow_dom
IPR023780 Chromo_domain
IPR023779 Chromodomain_CS
IPR029045 ClpP/crotonase-like_dom_sf
IPR001753 Enoyl-CoA_hydra/iso
IPR014748 Enoyl-CoA_hydra_C
PfamiView protein in Pfam
PF00385 Chromo, 1 hit
PF00378 ECH_1, 1 hit
SMARTiView protein in SMART
SM00298 CHROMO, 1 hit
SUPFAMiSSF52096 SSF52096, 1 hit
SSF54160 SSF54160, 1 hit
PROSITEiView protein in PROSITE
PS00598 CHROMO_1, 1 hit
PS50013 CHROMO_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8N8U2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASGDLYEVE RIVDKRKNKK GKWEYLIRWK GYGSTEDTWE PEHHLLHCEE
60 70 80 90 100
FIDEFNGLHM SKDKRIKSGK QSSTSKLLRD SRGPSVEKLS HRPSDPGKSK
110 120 130 140 150
GTSHKRKRIN PPLAKPKKGY SGKPSSGGDR ATKTVSYRTT PSGLQIMPLK
160 170 180 190 200
KSQNGMENGD AGSEKDERHF GNGSHQPGLD LNDHVGEQDM GECDVNHATL
210 220 230 240 250
AENGLGSALT NGGLNLHSPV KRKLEAEKDY VFDKRLRYSV RQNESNCRFR
260 270 280 290 300
DIVVRKEEGF THILLSSQTS DNNALTPEIM KEVRRALCNA ATDDSKLLLL
310 320 330 340 350
SAVGSVFCSG LDYSYLIGRL SSDRRKESTR IAEAIRDFVK AFIQFKKPIV
360 370 380 390 400
VAINGPALGL GASILPLCDI VWASEKAWFQ TPYATIRLTP AGCSSYTFPQ
410 420 430 440 450
ILGVALANEM LFCGRKLTAQ EACSRGLVSQ VFWPTTFSQE VMLRVKEMAS
460 470 480 490 500
CSAVVLEESK CLVRSFLKSV LEDVNEKECL MLKQLWSSSK GLDSLFSYLQ

DKIYEV
Length:506
Mass (Da):56,500
Last modified:May 5, 2009 - v2
Checksum:iC5093B57FDF6AEBE
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4J291A0A0B4J291_HUMAN
Chromodomain Y-like protein 2
CDYL2
507Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti196N → D in BAC04720 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY273798 mRNA Translation: AAP83842.1
AK096185 mRNA Translation: BAC04720.1
AC092332 Genomic DNA No translation available.
BC069440 mRNA Translation: AAH69440.1
BC100803 mRNA Translation: AAI00804.1
BC100804 mRNA Translation: AAI00805.1
BC100805 mRNA Translation: AAI00806.1
BC100806 mRNA Translation: AAI00807.1
CCDSiCCDS32493.1
RefSeqiNP_689555.2, NM_152342.3
UniGeneiHs.373908
Hs.60257

Genome annotation databases

EnsembliENST00000570137; ENSP00000476295; ENSG00000166446
GeneIDi124359
KEGGihsa:124359
UCSCiuc002ffs.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY273798 mRNA Translation: AAP83842.1
AK096185 mRNA Translation: BAC04720.1
AC092332 Genomic DNA No translation available.
BC069440 mRNA Translation: AAH69440.1
BC100803 mRNA Translation: AAI00804.1
BC100804 mRNA Translation: AAI00805.1
BC100805 mRNA Translation: AAI00806.1
BC100806 mRNA Translation: AAI00807.1
CCDSiCCDS32493.1
RefSeqiNP_689555.2, NM_152342.3
UniGeneiHs.373908
Hs.60257

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MJ8NMR-A2-64[»]
4HAEX-ray2.00A2-64[»]
5JJZX-ray2.00A2-66[»]
ProteinModelPortaliQ8N8U2
SMRiQ8N8U2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125860, 12 interactors
IntActiQ8N8U2, 14 interactors
MINTiQ8N8U2
STRINGi9606.ENSP00000299564

Chemistry databases

ChEMBLiCHEMBL3879857

PTM databases

iPTMnetiQ8N8U2
PhosphoSitePlusiQ8N8U2

Polymorphism and mutation databases

BioMutaiCDYL2
DMDMi229462825

Proteomic databases

EPDiQ8N8U2
MaxQBiQ8N8U2
PaxDbiQ8N8U2
PeptideAtlasiQ8N8U2
PRIDEiQ8N8U2
ProteomicsDBi72459

Protocols and materials databases

DNASUi124359
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000570137; ENSP00000476295; ENSG00000166446
GeneIDi124359
KEGGihsa:124359
UCSCiuc002ffs.4 human

Organism-specific databases

CTDi124359
DisGeNETi124359
EuPathDBiHostDB:ENSG00000166446.14
GeneCardsiCDYL2
H-InvDBiHIX0013264
HGNCiHGNC:23030 CDYL2
HPAiHPA041016
neXtProtiNX_Q8N8U2
OpenTargetsiENSG00000166446
PharmGKBiPA134903387
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0016 Eukaryota
KOG1911 Eukaryota
COG1024 LUCA
GeneTreeiENSGT00890000139344
HOGENOMiHOG000111507
HOVERGENiHBG006723
InParanoidiQ8N8U2
KOiK00653
PhylomeDBiQ8N8U2
TreeFamiTF313375

Miscellaneous databases

ChiTaRSiCDYL2 human
GenomeRNAii124359
PROiPR:Q8N8U2

Gene expression databases

BgeeiENSG00000166446 Expressed in 185 organ(s), highest expression level in placenta
CleanExiHS_CDYL2
ExpressionAtlasiQ8N8U2 baseline and differential
GenevisibleiQ8N8U2 HS

Family and domain databases

CDDicd00024 CHROMO, 1 hit
Gene3Di1.10.12.10, 1 hit
InterProiView protein in InterPro
IPR016197 Chromo-like_dom_sf
IPR000953 Chromo/chromo_shadow_dom
IPR023780 Chromo_domain
IPR023779 Chromodomain_CS
IPR029045 ClpP/crotonase-like_dom_sf
IPR001753 Enoyl-CoA_hydra/iso
IPR014748 Enoyl-CoA_hydra_C
PfamiView protein in Pfam
PF00385 Chromo, 1 hit
PF00378 ECH_1, 1 hit
SMARTiView protein in SMART
SM00298 CHROMO, 1 hit
SUPFAMiSSF52096 SSF52096, 1 hit
SSF54160 SSF54160, 1 hit
PROSITEiView protein in PROSITE
PS00598 CHROMO_1, 1 hit
PS50013 CHROMO_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCDYL2_HUMAN
AccessioniPrimary (citable) accession number: Q8N8U2
Secondary accession number(s): Q7Z5I8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: May 5, 2009
Last modified: November 7, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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