Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein enabled homolog

Gene

ENAH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation (By similarity).By similarity2 Publications

Miscellaneous

Required to transform actin polymerization into active movement for the propulsive force of Listeria monocytogenes.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin binding Source: UniProtKB-KW
  • SH3 domain binding Source: UniProtKB-KW
  • WW domain binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-202433 Generation of second messenger molecules
R-HSA-376176 Signaling by ROBO receptors

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein enabled homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ENAH
Synonyms:MENA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000154380.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18271 ENAH

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609061 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N8S7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Cytoskeleton, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55740

Open Targets

More...
OpenTargetsi
ENSG00000154380

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38517

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ENAH

Domain mapping of disease mutations (DMDM)

More...
DMDMi
48428086

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000869711 – 591Protein enabled homologAdd BLAST591

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei125PhosphoserineCombined sources1
Modified residuei265Phosphoserine; by PKABy similarity1
Modified residuei506PhosphoserineCombined sources1
Modified residuei508PhosphoserineCombined sources1
Isoform 3 (identifier: Q8N8S7-3)
Modified residuei465PhosphothreonineCombined sources1
Modified residuei471PhosphoserineCombined sources1
Modified residuei475PhosphoserineCombined sources1
Isoform 2 (identifier: Q8N8S7-2)
Modified residuei502PhosphothreonineCombined sources1
Modified residuei508PhosphoserineCombined sources1
Modified residuei512PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

NTN1-induced PKA phosphorylation on Ser-265 directly parallels the formation of filopodial protrusions.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8N8S7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8N8S7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8N8S7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N8S7

PeptideAtlas

More...
PeptideAtlasi
Q8N8S7

PRoteomics IDEntifications database

More...
PRIDEi
Q8N8S7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
72457
72458 [Q8N8S7-2]

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q8N8S7

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N8S7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N8S7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in myoepithelia of parotid, breast, bronchial glands and sweat glands. Expressed in colon-rectum muscolaris mucosae epithelium, pancreas acinar ductal epithelium, endometrium epithelium, prostate fibromuscolar stroma and placenta vascular media. Overexpressed in a majority of breast cancer cell lines and primary breast tumor lesions.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000154380 Expressed in 231 organ(s), highest expression level in saphenous vein

CleanEx database of gene expression profiles

More...
CleanExi
HS_ENAH

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8N8S7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N8S7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA028448
HPA028696

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer (By similarity). Interacts with APBB1IP, APBB1, PFN1 and ROBO4. Isoforms, containing the polyproline-rich regions with PPLP motifs, bind the WW domain of APBB1IP. Isoforms, containing the PPSY motif, bind, in vitro, to the WW2 and WW3 domains of NEDD4 and to the WW1 domain of YAP1. Binds the SH3 domain of BAIAP2-alpha but only after the autoinhibitory region of BAIAP2-alpha has been blocked by interaction with CDC42. Interacts, via the EVH1/WH1 domain, with the Pro-rich domains from VCL, ZYX and Listeria monocytogenes actA and with TES (via LIM domains). The TES LIM domain and the Pro-rich domains from VCL or ZYX compete for the same binding site. Interaction with ZYX is important for targeting ENAH to focal adhesions and enhances production of actin-rich structures at the apical surface of cells. Interacts, through the Pro-rich region, with the C-terminal SH3 domain of DNMPB. Binds GPHN (By similarity). Interacts with FAT1 (via EVH1 domains) (By similarity). Heterotrimer with TES and ACTL7A.By similarity8 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120858, 51 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q8N8S7

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q8N8S7

Protein interaction database and analysis system

More...
IntActi
Q8N8S7, 23 interactors

Molecular INTeraction database

More...
MINTi
Q8N8S7

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000355809

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1591
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HO2X-ray1.33B347-356[»]
2IYBX-ray2.35A/B/C/D1-113[»]
2XQNX-ray2.62M1-116[»]
4MY6X-ray1.70A/B1-111[»]
5N91X-ray1.49A/B1-111[»]
5N9CX-ray1.16A/B1-111[»]
5N9PX-ray1.80A/B1-111[»]
5NAJX-ray1.46A/B/C/D1-111[»]
5NBFX-ray1.15A1-111[»]
5NBXX-ray1.65A/B1-111[»]
5NC2X-ray1.58A/B1-111[»]
5NC7X-ray2.70A/B/C/D1-111[»]
5NCFX-ray1.40A/B1-111[»]
5NCGX-ray1.02A/B1-111[»]
5NCPX-ray1.65A1-111[»]
5ND0X-ray1.45A/B1-111[»]
5NDUX-ray1.42A/B1-111[»]
5NEGX-ray1.29A/B1-111[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8N8S7

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8N8S7

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8N8S7

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 111WH1PROSITE-ProRule annotationAdd BLAST111
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati156 – 16015
Repeati161 – 16525
Repeati166 – 17035
Repeati171 – 17545
Repeati176 – 18055
Repeati181 – 18565
Repeati186 – 19075
Repeati191 – 19585
Repeati196 – 20095

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni156 – 2009 X 5 AA tandem repeats of [LMQ]-E-[QR]-E-[QR]Add BLAST45
Regioni391 – 588EVH2Add BLAST198
Regioni391 – 411EVH2 block AAdd BLAST21
Regioni442 – 459EVH2 block BAdd BLAST18
Regioni554 – 588EVH2 block CAdd BLAST35

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili135 – 265Sequence analysisAdd BLAST131
Coiled coili557 – 587Sequence analysisAdd BLAST31

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi400 – 403KLKR4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi310 – 373Pro-richAdd BLAST64

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The EVH2 domain is comprised of 3 regions. Block A is a thymosin-like domain required for G-actin binding. The KLKR motif within this block is essential for the G-actin binding and for actin polymerization. Block B is required for F-actin binding and subcellular location, and Block C for tetramerization.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Ena/VASP family.Curated

Keywords - Domaini

Coiled coil, Repeat, SH3-binding

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4590 Eukaryota
ENOG41101TS LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157376

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG006655

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N8S7

KEGG Orthology (KO)

More...
KOi
K05746

Database of Orthologous Groups

More...
OrthoDBi
972128at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N8S7

TreeFam database of animal gene trees

More...
TreeFami
TF321411

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011993 PH-like_dom_sf
IPR038023 VASP_sf
IPR014885 VASP_tetra
IPR000697 WH1/EVH1_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08776 VASP_tetra, 1 hit
PF00568 WH1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00461 WH1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF118370 SSF118370, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50229 WH1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N8S7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSEQSICQAR AAVMVYDDAN KKWVPAGGST GFSRVHIYHH TGNNTFRVVG
60 70 80 90 100
RKIQDHQVVI NCAIPKGLKY NQATQTFHQW RDARQVYGLN FGSKEDANVF
110 120 130 140 150
ASAMMHALEV LNSQETGPTL PRQNSQLPAQ VQNGPSQEEL EIQRRQLQEQ
160 170 180 190 200
QRQKELERER LERERMERER LERERLERER LERERLEQEQ LERERQERER
210 220 230 240 250
QERLERQERL ERQERLERQE RLDRERQERQ ERERLERLER ERQERERQEQ
260 270 280 290 300
LEREQLEWER ERRISSAAAP ASVETPLNSV LGDSSASEPG LQAASQPAET
310 320 330 340 350
PSQQGIVLGP LAPPPPPPLP PGPAQASVAL PPPPGPPPPP PLPSTGPPPP
360 370 380 390 400
PPPPPLPNQV PPPPPPPPAP PLPASGFFLA SMSEDNRPLT GLAAAIAGAK
410 420 430 440 450
LRKVSRMEDT SFPSGGNAIG VNSASSKTDT GRGNGPLPLG GSGLMEEMSA
460 470 480 490 500
LLARRRRIAE KGSTIETEQK EDKGEDSEPV TSKASSTSTP EPTRKPWERT
510 520 530 540 550
NTMNGSKSPV ISRRDSPRKN QIVFDNRSYD SLHRPKSTPL SQPSANGVQT
560 570 580 590
EGLDYDRLKQ DILDEMRKEL TKLKEELIDA IRQELSKSNT A
Length:591
Mass (Da):66,510
Last modified:June 7, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBF3252F6FCD1988B
GO
Isoform 2 (identifier: Q8N8S7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     514-534: Missing.

Show »
Length:570
Mass (Da):63,924
Checksum:i7BC390588F822497
GO
Isoform 3 (identifier: Q8N8S7-3) [UniParc]FASTAAdd to basket
Also known as: Deltav6

The sequence of this isoform differs from the canonical sequence as follows:
     268-304: Missing.
     513-533: Missing.

Note: Expression restricted to invasive cancer cells.Combined sources
Show »
Length:533
Mass (Da):60,349
Checksum:iF84762C64B6181C5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0U1RRM6A0A0U1RRM6_HUMAN
Protein enabled homolog
ENAH
802Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A075B6E5A0A075B6E5_HUMAN
Protein enabled homolog
ENAH
213Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RQP7A0A0U1RQP7_HUMAN
Protein enabled homolog
ENAH
242Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91799 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC04736 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti493T → I in AAH95481 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_053772268 – 304Missing in isoform 3. 1 PublicationAdd BLAST37
Alternative sequenceiVSP_053773513 – 533Missing in isoform 3. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_010564514 – 534Missing in isoform 2. 4 PublicationsAdd BLAST21

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY345143 mRNA Translation: AAR04685.1
AF519769 mRNA Translation: AAQ08487.1
EU255274 mRNA Translation: ABY78022.1
AC092811 Genomic DNA No translation available.
AL356216 Genomic DNA No translation available.
AL591380 Genomic DNA No translation available.
BC065238 mRNA Translation: AAH65238.1
BC095481 mRNA Translation: AAH95481.1
AK001635 mRNA Translation: BAA91799.1 Different initiation.
AK096246 mRNA Translation: BAC04736.1 Different initiation.
AL133059 mRNA Translation: CAB61384.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31040.1 [Q8N8S7-2]
CCDS31041.1 [Q8N8S7-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
T42661

NCBI Reference Sequences

More...
RefSeqi
NP_001008493.1, NM_001008493.2 [Q8N8S7-1]
NP_060682.2, NM_018212.5 [Q8N8S7-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.497893

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000366843; ENSP00000355808; ENSG00000154380 [Q8N8S7-2]
ENST00000366844; ENSP00000355809; ENSG00000154380 [Q8N8S7-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55740

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55740

UCSC genome browser

More...
UCSCi
uc001hpc.2 human [Q8N8S7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY345143 mRNA Translation: AAR04685.1
AF519769 mRNA Translation: AAQ08487.1
EU255274 mRNA Translation: ABY78022.1
AC092811 Genomic DNA No translation available.
AL356216 Genomic DNA No translation available.
AL591380 Genomic DNA No translation available.
BC065238 mRNA Translation: AAH65238.1
BC095481 mRNA Translation: AAH95481.1
AK001635 mRNA Translation: BAA91799.1 Different initiation.
AK096246 mRNA Translation: BAC04736.1 Different initiation.
AL133059 mRNA Translation: CAB61384.1
CCDSiCCDS31040.1 [Q8N8S7-2]
CCDS31041.1 [Q8N8S7-1]
PIRiT42661
RefSeqiNP_001008493.1, NM_001008493.2 [Q8N8S7-1]
NP_060682.2, NM_018212.5 [Q8N8S7-2]
UniGeneiHs.497893

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HO2X-ray1.33B347-356[»]
2IYBX-ray2.35A/B/C/D1-113[»]
2XQNX-ray2.62M1-116[»]
4MY6X-ray1.70A/B1-111[»]
5N91X-ray1.49A/B1-111[»]
5N9CX-ray1.16A/B1-111[»]
5N9PX-ray1.80A/B1-111[»]
5NAJX-ray1.46A/B/C/D1-111[»]
5NBFX-ray1.15A1-111[»]
5NBXX-ray1.65A/B1-111[»]
5NC2X-ray1.58A/B1-111[»]
5NC7X-ray2.70A/B/C/D1-111[»]
5NCFX-ray1.40A/B1-111[»]
5NCGX-ray1.02A/B1-111[»]
5NCPX-ray1.65A1-111[»]
5ND0X-ray1.45A/B1-111[»]
5NDUX-ray1.42A/B1-111[»]
5NEGX-ray1.29A/B1-111[»]
ProteinModelPortaliQ8N8S7
SMRiQ8N8S7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120858, 51 interactors
CORUMiQ8N8S7
ELMiQ8N8S7
IntActiQ8N8S7, 23 interactors
MINTiQ8N8S7
STRINGi9606.ENSP00000355809

PTM databases

CarbonylDBiQ8N8S7
iPTMnetiQ8N8S7
PhosphoSitePlusiQ8N8S7

Polymorphism and mutation databases

BioMutaiENAH
DMDMi48428086

Proteomic databases

EPDiQ8N8S7
jPOSTiQ8N8S7
MaxQBiQ8N8S7
PaxDbiQ8N8S7
PeptideAtlasiQ8N8S7
PRIDEiQ8N8S7
ProteomicsDBi72457
72458 [Q8N8S7-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366843; ENSP00000355808; ENSG00000154380 [Q8N8S7-2]
ENST00000366844; ENSP00000355809; ENSG00000154380 [Q8N8S7-1]
GeneIDi55740
KEGGihsa:55740
UCSCiuc001hpc.2 human [Q8N8S7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55740
DisGeNETi55740
EuPathDBiHostDB:ENSG00000154380.17

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ENAH
HGNCiHGNC:18271 ENAH
HPAiHPA028448
HPA028696
MIMi609061 gene
neXtProtiNX_Q8N8S7
OpenTargetsiENSG00000154380
PharmGKBiPA38517

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4590 Eukaryota
ENOG41101TS LUCA
GeneTreeiENSGT00940000157376
HOVERGENiHBG006655
InParanoidiQ8N8S7
KOiK05746
OrthoDBi972128at2759
PhylomeDBiQ8N8S7
TreeFamiTF321411

Enzyme and pathway databases

ReactomeiR-HSA-202433 Generation of second messenger molecules
R-HSA-376176 Signaling by ROBO receptors

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ENAH human
EvolutionaryTraceiQ8N8S7

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ENAH_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55740

Protein Ontology

More...
PROi
PR:Q8N8S7

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000154380 Expressed in 231 organ(s), highest expression level in saphenous vein
CleanExiHS_ENAH
ExpressionAtlasiQ8N8S7 baseline and differential
GenevisibleiQ8N8S7 HS

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR038023 VASP_sf
IPR014885 VASP_tetra
IPR000697 WH1/EVH1_dom
PfamiView protein in Pfam
PF08776 VASP_tetra, 1 hit
PF00568 WH1, 1 hit
SMARTiView protein in SMART
SM00461 WH1, 1 hit
SUPFAMiSSF118370 SSF118370, 1 hit
PROSITEiView protein in PROSITE
PS50229 WH1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiENAH_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N8S7
Secondary accession number(s): D0PQI2
, Q502W5, Q5T5M7, Q5VTQ9, Q5VTR0, Q9NVF3, Q9UFB8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: January 16, 2019
This is version 162 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again