UniProtKB - Q8N8R7 (AL14E_HUMAN)
Protein
ARL14 effector protein
Gene
ARL14EP
Organism
Homo sapiens (Human)
Status
Functioni
Through its interaction with ARL14 and MYO1E, may connect MHC class II-containing cytoplasmic vesicles to the actin network and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells.1 Publication
Enzyme and pathway databases
PathwayCommonsi | Q8N8R7 |
Names & Taxonomyi
Protein namesi | Recommended name: ARL14 effector proteinAlternative name(s): ARF7 effector protein |
Gene namesi | Name:ARL14EP Synonyms:ARF7EP, C11orf46 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26798, ARL14EP |
MIMi | 612295, gene |
neXtProti | NX_Q8N8R7 |
VEuPathDBi | HostDB:ENSG00000152219.4 |
Subcellular locationi
Other locations
- Cytoplasm 1 Publication
Cytosol
- cytosol Source: HPA
Nucleus
- nucleolus Source: HPA
- nucleoplasm Source: HPA
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- focal adhesion Source: HPA
- intracellular membrane-bounded organelle Source: HPA
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 120534 |
OpenTargetsi | ENSG00000152219 |
PharmGKBi | PA142672291 |
Miscellaneous databases
Pharosi | Q8N8R7, Tdark |
Genetic variation databases
BioMutai | ARL14EP |
DMDMi | 74729511 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000251892 | 1 – 260 | ARL14 effector proteinAdd BLAST | 260 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Cross-linki | 177 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 183 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q8N8R7 |
jPOSTi | Q8N8R7 |
MassIVEi | Q8N8R7 |
MaxQBi | Q8N8R7 |
PaxDbi | Q8N8R7 |
PeptideAtlasi | Q8N8R7 |
PRIDEi | Q8N8R7 |
ProteomicsDBi | 72456 |
PTM databases
iPTMneti | Q8N8R7 |
PhosphoSitePlusi | Q8N8R7 |
Expressioni
Tissue specificityi
Expressed in the immune system.1 Publication
Gene expression databases
Bgeei | ENSG00000152219, Expressed in secondary oocyte and 208 other tissues |
ExpressionAtlasi | Q8N8R7, baseline and differential |
Genevisiblei | Q8N8R7, HS |
Organism-specific databases
HPAi | ENSG00000152219, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with ARL14 and MYO1E.
1 PublicationBinary interactionsi
Hide detailsQ8N8R7
Protein-protein interaction databases
BioGRIDi | 125690, 10 interactors |
IntActi | Q8N8R7, 12 interactors |
STRINGi | 9606.ENSP00000282032 |
Miscellaneous databases
RNActi | Q8N8R7, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 209 – 237 | Cys-richAdd BLAST | 29 |
Phylogenomic databases
eggNOGi | KOG4850, Eukaryota |
GeneTreei | ENSGT00940000156586 |
HOGENOMi | CLU_093502_0_0_1 |
InParanoidi | Q8N8R7 |
OMAi | QFANPGR |
OrthoDBi | 1056242at2759 |
PhylomeDBi | Q8N8R7 |
TreeFami | TF333216 |
Family and domain databases
InterProi | View protein in InterPro IPR029264, ARF7EP_C IPR026515, ARL14EP |
PANTHERi | PTHR46536, PTHR46536, 1 hit |
Pfami | View protein in Pfam PF14949, ARF7EP_C, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q8N8R7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMDPCSVGVQ LRTTNECHKT YYTRHTGFKT LQELSSNDML LLQLRTGMTL
60 70 80 90 100
SGNNTICFHH VKIYIDRFED LQKSCCDPFN IHKKLAKKNL HVIDLDDATF
110 120 130 140 150
LSAKFGRQLV PGWKLCPKCT QIINGSVDVD TEDRQKRKPE SDGRTAKALR
160 170 180 190 200
SLQFTNPGRQ TEFAPETGKR EKRRLTKNAT AGSDRQVIPA KSKVYDSQGL
210 220 230 240 250
LIFSGMDLCD CLDEDCLGCF YACPACGSTK CGAECRCDRK WLYEQIEIEG
260
GEIIHNKHAG
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE9PRK7 | E9PRK7_HUMAN | ARL14 effector protein | ARL14EP | 168 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 88 | K → KK in CAI46092 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 245 | Q → QK in CAI46092 (PubMed:17974005).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_033740 | 180 | T → P. Corresponds to variant dbSNP:rs7940297EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK096287 mRNA Translation: BAC04747.1 BX647617 mRNA Translation: CAI46092.1 BC047775 mRNA Translation: AAH47775.1 |
CCDSi | CCDS7869.1 |
RefSeqi | NP_689529.1, NM_152316.2 |
Genome annotation databases
Ensembli | ENST00000282032; ENSP00000282032; ENSG00000152219 |
GeneIDi | 120534 |
KEGGi | hsa:120534 |
UCSCi | uc001mso.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK096287 mRNA Translation: BAC04747.1 BX647617 mRNA Translation: CAI46092.1 BC047775 mRNA Translation: AAH47775.1 |
CCDSi | CCDS7869.1 |
RefSeqi | NP_689529.1, NM_152316.2 |
3D structure databases
SMRi | Q8N8R7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 125690, 10 interactors |
IntActi | Q8N8R7, 12 interactors |
STRINGi | 9606.ENSP00000282032 |
PTM databases
iPTMneti | Q8N8R7 |
PhosphoSitePlusi | Q8N8R7 |
Genetic variation databases
BioMutai | ARL14EP |
DMDMi | 74729511 |
Proteomic databases
EPDi | Q8N8R7 |
jPOSTi | Q8N8R7 |
MassIVEi | Q8N8R7 |
MaxQBi | Q8N8R7 |
PaxDbi | Q8N8R7 |
PeptideAtlasi | Q8N8R7 |
PRIDEi | Q8N8R7 |
ProteomicsDBi | 72456 |
Protocols and materials databases
Antibodypediai | 53638, 117 antibodies |
DNASUi | 120534 |
Genome annotation databases
Ensembli | ENST00000282032; ENSP00000282032; ENSG00000152219 |
GeneIDi | 120534 |
KEGGi | hsa:120534 |
UCSCi | uc001mso.2, human |
Organism-specific databases
CTDi | 120534 |
DisGeNETi | 120534 |
GeneCardsi | ARL14EP |
HGNCi | HGNC:26798, ARL14EP |
HPAi | ENSG00000152219, Low tissue specificity |
MIMi | 612295, gene |
neXtProti | NX_Q8N8R7 |
OpenTargetsi | ENSG00000152219 |
PharmGKBi | PA142672291 |
VEuPathDBi | HostDB:ENSG00000152219.4 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4850, Eukaryota |
GeneTreei | ENSGT00940000156586 |
HOGENOMi | CLU_093502_0_0_1 |
InParanoidi | Q8N8R7 |
OMAi | QFANPGR |
OrthoDBi | 1056242at2759 |
PhylomeDBi | Q8N8R7 |
TreeFami | TF333216 |
Enzyme and pathway databases
PathwayCommonsi | Q8N8R7 |
Miscellaneous databases
BioGRID-ORCSi | 120534, 13 hits in 874 CRISPR screens |
ChiTaRSi | ARL14EP, human |
GenomeRNAii | 120534 |
Pharosi | Q8N8R7, Tdark |
PROi | PR:Q8N8R7 |
RNActi | Q8N8R7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000152219, Expressed in secondary oocyte and 208 other tissues |
ExpressionAtlasi | Q8N8R7, baseline and differential |
Genevisiblei | Q8N8R7, HS |
Family and domain databases
InterProi | View protein in InterPro IPR029264, ARF7EP_C IPR026515, ARL14EP |
PANTHERi | PTHR46536, PTHR46536, 1 hit |
Pfami | View protein in Pfam PF14949, ARF7EP_C, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AL14E_HUMAN | |
Accessioni | Q8N8R7Primary (citable) accession number: Q8N8R7 Secondary accession number(s): Q5HYH9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 3, 2006 |
Last sequence update: | October 1, 2002 | |
Last modified: | February 10, 2021 | |
This is version 128 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot