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UniProtKB - Q8N8Q9 (NIPA2_HUMAN)

Entry version 134 (10 Feb 2021)
Sequence version 1 (01 Oct 2002)
Previous versions | rss
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Protein

Magnesium transporter NIPA2

Gene

NIPA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a selective Mg2+ transporter.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

  • magnesium ion transport Source: GO_Central
Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Transport
LigandMagnesium

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8N8Q9

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-5223345, Miscellaneous transport and binding events

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.7.25.2, the drug/metabolite transporter (dmt) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Magnesium transporter NIPA2
Alternative name(s):
Non-imprinted in Prader-Willi/Angelman syndrome region protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NIPA2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:17044, NIPA2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		608146, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8N8Q9

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000140157.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 9ExtracellularSequence analysis9
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Topological domaini31 – 56CytoplasmicSequence analysisAdd BLAST26
Transmembranei57 – 77HelicalSequence analysisAdd BLAST21
Topological domaini78ExtracellularSequence analysis1
Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
Topological domaini100 – 107CytoplasmicSequence analysis8
Transmembranei108 – 128HelicalSequence analysisAdd BLAST21
Topological domaini129 – 149ExtracellularSequence analysisAdd BLAST21
Transmembranei150 – 170HelicalSequence analysisAdd BLAST21
Topological domaini171 – 175CytoplasmicSequence analysis5
Transmembranei176 – 196HelicalSequence analysisAdd BLAST21
Topological domaini197 – 215ExtracellularSequence analysisAdd BLAST19
Transmembranei216 – 236HelicalSequence analysisAdd BLAST21
Topological domaini237 – 246CytoplasmicSequence analysis10
Transmembranei247 – 267HelicalSequence analysisAdd BLAST21
Topological domaini268 – 278ExtracellularSequence analysisAdd BLAST11
Transmembranei279 – 299HelicalSequence analysisAdd BLAST21
Topological domaini300 – 360CytoplasmicSequence analysisAdd BLAST61

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		81614

Open Targets

More...OpenTargetsi		ENSG00000140157

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134911294

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8N8Q9, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NIPA2

Domain mapping of disease mutations (DMDM)

More...DMDMi		73921217

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001917431 – 360Magnesium transporter NIPA2Add BLAST360

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8N8Q9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8N8Q9

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8N8Q9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8N8Q9

PeptideAtlas

More...PeptideAtlasi		Q8N8Q9

PRoteomics IDEntifications database

More...PRIDEi		Q8N8Q9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		30041
72453 [Q8N8Q9-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8N8Q9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8N8Q9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000140157, Expressed in colonic mucosa and 236 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8N8Q9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8N8Q9, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000140157, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		123549, 2 interactors

Protein interaction database and analysis system

More...IntActi		Q8N8Q9, 3 interactors

Molecular INTeraction database

More...MINTi		Q8N8Q9

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000337618

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8N8Q9, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NIPA family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2922, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155651

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_012349_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8N8Q9

Identification of Orthologs from Complete Genome Data

More...OMAi		KNPLAWI

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8N8Q9

TreeFam database of animal gene trees

More...TreeFami		TF313214

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR008521, Mg_trans_NIPA

The PANTHER Classification System

More...PANTHERi		PTHR12570, PTHR12570, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05653, Mg_trans_NIPA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N8Q9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSQGRGKYDF YIGLGLAMSS SIFIGGSFIL KKKGLLRLAR KGSMRAGQGG 
        60         70         80         90        100
HAYLKEWLWW AGLLSMGAGE VANFAAYAFA PATLVTPLGA LSVLVSAILS 
       110        120        130        140        150
SYFLNERLNL HGKIGCLLSI LGSTVMVIHA PKEEEIETLN EMSHKLGDPG 
       160        170        180        190        200
FVVFATLVVI VALILIFVVG PRHGQTNILV YITICSVIGA FSVSCVKGLG 
       210        220        230        240        250
IAIKELFAGK PVLRHPLAWI LLLSLIVCVS TQINYLNRAL DIFNTSIVTP 
       260        270        280        290        300
IYYVFFTTSV LTCSAILFKE WQDMPVDDVI GTLSGFFTII VGIFLLHAFK 
       310        320        330        340        350
DVSFSLASLP VSFRKDEKAM NGNLSNMYEV LNNNEESLTC GIEQHTGENV 
       360
SRRNGNLTAF
Length:360
Mass (Da):39,185
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA8ED640DA7AF7F4B
GO
Isoform 2 (identifier: Q8N8Q9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     47-66: GQGGHAYLKEWLWWAGLLSM → V

Show »
Length:341
Mass (Da):36,999
Checksum:i893B0E54C8CEA4E3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YMQ7H0YMQ7_HUMAN
Magnesium transporter NIPA2
NIPA2
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6I8PUB5A0A6I8PUB5_HUMAN
Magnesium transporter NIPA2
NIPA2
32Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti303S → G in AAU34000 (Ref. 2) Curated1
Sequence conflicti303S → G in AAH11775 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04458747 – 66GQGGH…GLLSM → V in isoform 2. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BK001120 mRNA Translation: DAA01509.1
AY732242 mRNA Translation: AAU34000.1
AK096305 mRNA Translation: BAC04757.1
AK300843 mRNA Translation: BAG62494.1
CR606982 mRNA No translation available.
AC011767 Genomic DNA No translation available.
BC000957 mRNA Translation: AAH00957.3
BC011775 mRNA Translation: AAH11775.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS73693.1 [Q8N8Q9-1]
CCDS73694.1 [Q8N8Q9-2]

NCBI Reference Sequences

More...RefSeqi		NP_001008860.1, NM_001008860.2 [Q8N8Q9-1]
NP_001008892.1, NM_001008892.2 [Q8N8Q9-1]
NP_001008894.1, NM_001008894.2 [Q8N8Q9-2]
NP_001171817.1, NM_001184888.1 [Q8N8Q9-2]
NP_001171818.1, NM_001184889.1 [Q8N8Q9-1]
NP_112184.4, NM_030922.6 [Q8N8Q9-1]
XP_005272603.1, XM_005272546.3 [Q8N8Q9-1]
XP_005272604.1, XM_005272547.4 [Q8N8Q9-1]
XP_005272605.1, XM_005272548.3 [Q8N8Q9-1]
XP_005272607.1, XM_005272550.3 [Q8N8Q9-1]
XP_005272609.1, XM_005272552.3 [Q8N8Q9-1]
XP_005272610.1, XM_005272553.4 [Q8N8Q9-1]
XP_006720427.1, XM_006720364.2 [Q8N8Q9-1]
XP_006720428.1, XM_006720365.2 [Q8N8Q9-1]
XP_006720429.1, XM_006720366.3 [Q8N8Q9-1]
XP_006720430.1, XM_006720367.1 [Q8N8Q9-2]
XP_011542179.1, XM_011543877.2 [Q8N8Q9-1]
XP_011542180.1, XM_011543878.2 [Q8N8Q9-1]
XP_011542181.1, XM_011543879.2 [Q8N8Q9-1]
XP_011542182.1, XM_011543880.2 [Q8N8Q9-1]
XP_016878134.1, XM_017022645.1 [Q8N8Q9-1]
XP_016878135.1, XM_017022646.1 [Q8N8Q9-1]
XP_016878136.1, XM_017022647.1 [Q8N8Q9-1]
XP_016878137.1, XM_017022648.1 [Q8N8Q9-1]
XP_016878138.1, XM_017022649.1 [Q8N8Q9-1]
XP_016878139.1, XM_017022650.1 [Q8N8Q9-1]
XP_016878140.1, XM_017022651.1 [Q8N8Q9-1]
XP_016878141.1, XM_017022652.1 [Q8N8Q9-1]
XP_016878142.1, XM_017022653.1 [Q8N8Q9-1]
XP_016878143.1, XM_017022654.1 [Q8N8Q9-1]
XP_016878144.1, XM_017022655.1 [Q8N8Q9-2]
XP_016878145.1, XM_017022656.1 [Q8N8Q9-2]
XP_016878146.1, XM_017022657.1 [Q8N8Q9-2]
XP_016878147.1, XM_017022658.1 [Q8N8Q9-2]
XP_016878148.1, XM_017022659.1 [Q8N8Q9-2]
XP_016878149.1, XM_017022660.1 [Q8N8Q9-2]
XP_016878150.1, XM_017022661.1 [Q8N8Q9-2]
XP_016878151.1, XM_017022662.1 [Q8N8Q9-2]
XP_016878152.1, XM_017022663.1 [Q8N8Q9-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000337451; ENSP00000337618; ENSG00000140157 [Q8N8Q9-1]
ENST00000359727; ENSP00000352762; ENSG00000140157 [Q8N8Q9-2]
ENST00000398013; ENSP00000381095; ENSG00000140157 [Q8N8Q9-1]
ENST00000398014; ENSP00000381096; ENSG00000140157 [Q8N8Q9-2]
ENST00000539711; ENSP00000437746; ENSG00000140157 [Q8N8Q9-2]
ENST00000674173; ENSP00000501408; ENSG00000140157 [Q8N8Q9-1]
ENST00000674289; ENSP00000501412; ENSG00000140157 [Q8N8Q9-1]
ENST00000674330; ENSP00000501373; ENSG00000140157 [Q8N8Q9-1]
ENST00000674477; ENSP00000501489; ENSG00000140157 [Q8N8Q9-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		81614

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:81614

UCSC genome browser

More...UCSCi		uc001yux.4, human [Q8N8Q9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BK001120 mRNA Translation: DAA01509.1
AY732242 mRNA Translation: AAU34000.1
AK096305 mRNA Translation: BAC04757.1
AK300843 mRNA Translation: BAG62494.1
CR606982 mRNA No translation available.
AC011767 Genomic DNA No translation available.
BC000957 mRNA Translation: AAH00957.3
BC011775 mRNA Translation: AAH11775.1
CCDSiCCDS73693.1 [Q8N8Q9-1]
CCDS73694.1 [Q8N8Q9-2]
RefSeqiNP_001008860.1, NM_001008860.2 [Q8N8Q9-1]
NP_001008892.1, NM_001008892.2 [Q8N8Q9-1]
NP_001008894.1, NM_001008894.2 [Q8N8Q9-2]
NP_001171817.1, NM_001184888.1 [Q8N8Q9-2]
NP_001171818.1, NM_001184889.1 [Q8N8Q9-1]
NP_112184.4, NM_030922.6 [Q8N8Q9-1]
XP_005272603.1, XM_005272546.3 [Q8N8Q9-1]
XP_005272604.1, XM_005272547.4 [Q8N8Q9-1]
XP_005272605.1, XM_005272548.3 [Q8N8Q9-1]
XP_005272607.1, XM_005272550.3 [Q8N8Q9-1]
XP_005272609.1, XM_005272552.3 [Q8N8Q9-1]
XP_005272610.1, XM_005272553.4 [Q8N8Q9-1]
XP_006720427.1, XM_006720364.2 [Q8N8Q9-1]
XP_006720428.1, XM_006720365.2 [Q8N8Q9-1]
XP_006720429.1, XM_006720366.3 [Q8N8Q9-1]
XP_006720430.1, XM_006720367.1 [Q8N8Q9-2]
XP_011542179.1, XM_011543877.2 [Q8N8Q9-1]
XP_011542180.1, XM_011543878.2 [Q8N8Q9-1]
XP_011542181.1, XM_011543879.2 [Q8N8Q9-1]
XP_011542182.1, XM_011543880.2 [Q8N8Q9-1]
XP_016878134.1, XM_017022645.1 [Q8N8Q9-1]
XP_016878135.1, XM_017022646.1 [Q8N8Q9-1]
XP_016878136.1, XM_017022647.1 [Q8N8Q9-1]
XP_016878137.1, XM_017022648.1 [Q8N8Q9-1]
XP_016878138.1, XM_017022649.1 [Q8N8Q9-1]
XP_016878139.1, XM_017022650.1 [Q8N8Q9-1]
XP_016878140.1, XM_017022651.1 [Q8N8Q9-1]
XP_016878141.1, XM_017022652.1 [Q8N8Q9-1]
XP_016878142.1, XM_017022653.1 [Q8N8Q9-1]
XP_016878143.1, XM_017022654.1 [Q8N8Q9-1]
XP_016878144.1, XM_017022655.1 [Q8N8Q9-2]
XP_016878145.1, XM_017022656.1 [Q8N8Q9-2]
XP_016878146.1, XM_017022657.1 [Q8N8Q9-2]
XP_016878147.1, XM_017022658.1 [Q8N8Q9-2]
XP_016878148.1, XM_017022659.1 [Q8N8Q9-2]
XP_016878149.1, XM_017022660.1 [Q8N8Q9-2]
XP_016878150.1, XM_017022661.1 [Q8N8Q9-2]
XP_016878151.1, XM_017022662.1 [Q8N8Q9-2]
XP_016878152.1, XM_017022663.1 [Q8N8Q9-2]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi123549, 2 interactors
IntActiQ8N8Q9, 3 interactors
MINTiQ8N8Q9
STRINGi9606.ENSP00000337618

Protein family/group databases

TCDBi2.A.7.25.2, the drug/metabolite transporter (dmt) superfamily

PTM databases

iPTMnetiQ8N8Q9
PhosphoSitePlusiQ8N8Q9

Genetic variation databases

BioMutaiNIPA2
DMDMi73921217

Proteomic databases

jPOSTiQ8N8Q9
MassIVEiQ8N8Q9
MaxQBiQ8N8Q9
PaxDbiQ8N8Q9
PeptideAtlasiQ8N8Q9
PRIDEiQ8N8Q9
ProteomicsDBi30041
72453 [Q8N8Q9-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		22214, 39 antibodies

Genome annotation databases

EnsembliENST00000337451; ENSP00000337618; ENSG00000140157 [Q8N8Q9-1]
ENST00000359727; ENSP00000352762; ENSG00000140157 [Q8N8Q9-2]
ENST00000398013; ENSP00000381095; ENSG00000140157 [Q8N8Q9-1]
ENST00000398014; ENSP00000381096; ENSG00000140157 [Q8N8Q9-2]
ENST00000539711; ENSP00000437746; ENSG00000140157 [Q8N8Q9-2]
ENST00000674173; ENSP00000501408; ENSG00000140157 [Q8N8Q9-1]
ENST00000674289; ENSP00000501412; ENSG00000140157 [Q8N8Q9-1]
ENST00000674330; ENSP00000501373; ENSG00000140157 [Q8N8Q9-1]
ENST00000674477; ENSP00000501489; ENSG00000140157 [Q8N8Q9-1]
GeneIDi81614
KEGGihsa:81614
UCSCiuc001yux.4, human [Q8N8Q9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		81614
DisGeNETi81614

GeneCards: human genes, protein and diseases

More...GeneCardsi		NIPA2
HGNCiHGNC:17044, NIPA2
HPAiENSG00000140157, Low tissue specificity
MIMi608146, gene
neXtProtiNX_Q8N8Q9
OpenTargetsiENSG00000140157
PharmGKBiPA134911294
VEuPathDBiHostDB:ENSG00000140157.14

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2922, Eukaryota
GeneTreeiENSGT00940000155651
HOGENOMiCLU_012349_1_1_1
InParanoidiQ8N8Q9
OMAiKNPLAWI
PhylomeDBiQ8N8Q9
TreeFamiTF313214

Enzyme and pathway databases

PathwayCommonsiQ8N8Q9
ReactomeiR-HSA-5223345, Miscellaneous transport and binding events

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		81614, 8 hits in 872 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NIPA2, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		NIPA2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		81614
PharosiQ8N8Q9, Tbio

Protein Ontology

More...PROi		PR:Q8N8Q9
RNActiQ8N8Q9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000140157, Expressed in colonic mucosa and 236 other tissues
ExpressionAtlasiQ8N8Q9, baseline and differential
GenevisibleiQ8N8Q9, HS

Family and domain databases

InterProiView protein in InterPro
IPR008521, Mg_trans_NIPA
PANTHERiPTHR12570, PTHR12570, 1 hit
PfamiView protein in Pfam
PF05653, Mg_trans_NIPA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNIPA2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N8Q9
Secondary accession number(s): F8W7Y8, Q96F03, Q9BVS2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: October 1, 2002
Last modified: February 10, 2021
This is version 134 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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