NIPA2

Functionⁱ

Acts as a selective Mg²⁺ transporter.By similarity

GO - Molecular functionⁱ

magnesium ion transmembrane transporter activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

magnesium ion transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Ion transport, Transport
Ligand	Magnesium

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5223345 Miscellaneous transport and binding events

Reactomeⁱ

R-HSA-5223345 Miscellaneous transport and binding events

Protein family/group databases

TCDBⁱ	2.A.7.25.2 the drug/metabolite transporter (dmt) superfamily

TCDBⁱ

2.A.7.25.2 the drug/metabolite transporter (dmt) superfamily

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Magnesium transporter NIPA2 Alternative name(s): Non-imprinted in Prader-Willi/Angelman syndrome region protein 2
Gene namesⁱ	Name:NIPA2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 15

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000140157.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17044 NIPA2
MIMⁱ	608146 gene
neXtProtⁱ	NX_Q8N8Q9

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 9	ExtracellularSequence analysis	9
Transmembraneⁱ	10 – 30	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	31 – 56	CytoplasmicSequence analysisAdd BLAST	26
Transmembraneⁱ	57 – 77	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	78	ExtracellularSequence analysis	1
Transmembraneⁱ	79 – 99	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	100 – 107	CytoplasmicSequence analysis	8
Transmembraneⁱ	108 – 128	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	129 – 149	ExtracellularSequence analysisAdd BLAST	21
Transmembraneⁱ	150 – 170	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	171 – 175	CytoplasmicSequence analysis	5
Transmembraneⁱ	176 – 196	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	197 – 215	ExtracellularSequence analysisAdd BLAST	19
Transmembraneⁱ	216 – 236	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	237 – 246	CytoplasmicSequence analysis	10
Transmembraneⁱ	247 – 267	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	268 – 278	ExtracellularSequence analysisAdd BLAST	11
Transmembraneⁱ	279 – 299	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	300 – 360	CytoplasmicSequence analysisAdd BLAST	61

Keywords - Cellular componentⁱ

Cell membrane, Endosome, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	81614
Open Targets More...OpenTargetsⁱ	ENSG00000140157
PharmGKBⁱ	PA134911294

Polymorphism and mutation databases

BioMutaⁱ	NIPA2
DMDMⁱ	73921217

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000191743	1 – 360	Magnesium transporter NIPA2Add BLAST		360

Proteomic databases

EPDⁱ	Q8N8Q9
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8N8Q9
PaxDbⁱ	Q8N8Q9
PeptideAtlas More...PeptideAtlasⁱ	Q8N8Q9
PRIDEⁱ	Q8N8Q9
ProteomicsDBⁱ	72453

PTM databases

iPTMnetⁱ	Q8N8Q9
PhosphoSitePlusⁱ	Q8N8Q9

Expressionⁱ

Tissue specificityⁱ

Widely expressed.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000140157 Expressed in 225 organ(s), highest expression level in colonic mucosa
CleanExⁱ	HS_NIPA2
ExpressionAtlasⁱ	Q8N8Q9 baseline and differential
Genevisibleⁱ	Q8N8Q9 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA067160 HPA071342

HPAⁱ

HPA067160
HPA071342

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	123549, 2 interactors
STRINGⁱ	9606.ENSP00000337618

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8N8Q9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the NIPA family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG2922 Eukaryota ENOG410XNR8 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074395
HOGENOMⁱ	HOG000203962
HOVERGENⁱ	HBG055032
InParanoidⁱ	Q8N8Q9
KEGG Orthology (KO) More...KOⁱ	K22733
OMAⁱ	KEWQHMA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0M8A
PhylomeDBⁱ	Q8N8Q9
TreeFamⁱ	TF313214

Family and domain databases

InterProⁱ	View protein in InterPro IPR008521 Mg_trans_NIPA
PANTHERⁱ	PTHR12570 PTHR12570, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05653 Mg_trans_NIPA, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q8N8Q9-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSQGRGKYDF YIGLGLAMSS SIFIGGSFIL KKKGLLRLAR KGSMRAGQGG 
        60         70         80         90        100
HAYLKEWLWW AGLLSMGAGE VANFAAYAFA PATLVTPLGA LSVLVSAILS 
       110        120        130        140        150
SYFLNERLNL HGKIGCLLSI LGSTVMVIHA PKEEEIETLN EMSHKLGDPG 
       160        170        180        190        200
FVVFATLVVI VALILIFVVG PRHGQTNILV YITICSVIGA FSVSCVKGLG 
       210        220        230        240        250
IAIKELFAGK PVLRHPLAWI LLLSLIVCVS TQINYLNRAL DIFNTSIVTP 
       260        270        280        290        300
IYYVFFTTSV LTCSAILFKE WQDMPVDDVI GTLSGFFTII VGIFLLHAFK 
       310        320        330        340        350
DVSFSLASLP VSFRKDEKAM NGNLSNMYEV LNNNEESLTC GIEQHTGENV 
       360
SRRNGNLTAF

Length:360

Mass (Da):39,185

Last modified:October 1, 2002 - v1

Checksum:ⁱA8ED640DA7AF7F4B

GO

Isoform 2 (identifier: Q8N8Q9-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
47-66: GQGGHAYLKEWLWWAGLLSM → V

« Hide

        10         20         30         40         50
MSQGRGKYDF YIGLGLAMSS SIFIGGSFIL KKKGLLRLAR KGSMRAVGAG 
        60         70         80         90        100
EVANFAAYAF APATLVTPLG ALSVLVSAIL SSYFLNERLN LHGKIGCLLS 
       110        120        130        140        150
ILGSTVMVIH APKEEEIETL NEMSHKLGDP GFVVFATLVV IVALILIFVV 
       160        170        180        190        200
GPRHGQTNIL VYITICSVIG AFSVSCVKGL GIAIKELFAG KPVLRHPLAW 
       210        220        230        240        250
ILLLSLIVCV STQINYLNRA LDIFNTSIVT PIYYVFFTTS VLTCSAILFK 
       260        270        280        290        300
EWQDMPVDDV IGTLSGFFTI IVGIFLLHAF KDVSFSLASL PVSFRKDEKA 
       310        320        330        340 
MNGNLSNMYE VLNNNEESLT CGIEQHTGEN VSRRNGNLTA F

Note: Not experimental evidence available.

Show »

Length:341

Mass (Da):36,999

Checksum:ⁱ893B0E54C8CEA4E3

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	H0YMQ7	H0YMQ7_HUMAN		Magnesium transporter NIPA2 Magnesium transporter NIPA2	NIPA2	59	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	303	S → G in AAU34000 (Ref. 2) Curated		1
Sequence conflictⁱ	303	S → G in AAH11775 (PubMed:15489334).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_044587	47 – 66	GQGGH…GLLSM → V in isoform 2. 1 PublicationAdd BLAST		20

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BK001120 mRNA Translation: DAA01509.1 AY732242 mRNA Translation: AAU34000.1 AK096305 mRNA Translation: BAC04757.1 AK300843 mRNA Translation: BAG62494.1 CR606982 mRNA No translation available. AC011767 Genomic DNA No translation available. BC000957 mRNA Translation: AAH00957.3 BC011775 mRNA Translation: AAH11775.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS73693.1 [Q8N8Q9-1] CCDS73694.1 [Q8N8Q9-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001008860.1, NM_001008860.2 [Q8N8Q9-1] NP_001008892.1, NM_001008892.2 [Q8N8Q9-1] NP_001008894.1, NM_001008894.2 [Q8N8Q9-2] NP_001171817.1, NM_001184888.1 [Q8N8Q9-2] NP_001171818.1, NM_001184889.1 [Q8N8Q9-1] NP_112184.4, NM_030922.6 [Q8N8Q9-1] XP_005272603.1, XM_005272546.3 [Q8N8Q9-1] XP_005272604.1, XM_005272547.4 [Q8N8Q9-1] XP_005272605.1, XM_005272548.3 [Q8N8Q9-1] XP_005272607.1, XM_005272550.3 [Q8N8Q9-1] XP_005272609.1, XM_005272552.3 [Q8N8Q9-1] XP_005272610.1, XM_005272553.4 [Q8N8Q9-1] XP_006720427.1, XM_006720364.2 [Q8N8Q9-1] XP_006720428.1, XM_006720365.2 [Q8N8Q9-1] XP_006720429.1, XM_006720366.3 [Q8N8Q9-1] XP_006720430.1, XM_006720367.1 [Q8N8Q9-2] XP_011542179.1, XM_011543877.2 [Q8N8Q9-1] XP_011542180.1, XM_011543878.2 [Q8N8Q9-1] XP_011542181.1, XM_011543879.2 [Q8N8Q9-1] XP_011542182.1, XM_011543880.2 [Q8N8Q9-1] XP_016878134.1, XM_017022645.1 [Q8N8Q9-1] XP_016878135.1, XM_017022646.1 [Q8N8Q9-1] XP_016878136.1, XM_017022647.1 [Q8N8Q9-1] XP_016878137.1, XM_017022648.1 [Q8N8Q9-1] XP_016878138.1, XM_017022649.1 [Q8N8Q9-1] XP_016878139.1, XM_017022650.1 [Q8N8Q9-1] XP_016878140.1, XM_017022651.1 [Q8N8Q9-1] XP_016878141.1, XM_017022652.1 [Q8N8Q9-1] XP_016878142.1, XM_017022653.1 [Q8N8Q9-1] XP_016878143.1, XM_017022654.1 [Q8N8Q9-1] XP_016878144.1, XM_017022655.1 [Q8N8Q9-2] XP_016878145.1, XM_017022656.1 [Q8N8Q9-2] XP_016878146.1, XM_017022657.1 [Q8N8Q9-2] XP_016878147.1, XM_017022658.1 [Q8N8Q9-2] XP_016878148.1, XM_017022659.1 [Q8N8Q9-2] XP_016878149.1, XM_017022660.1 [Q8N8Q9-2] XP_016878150.1, XM_017022661.1 [Q8N8Q9-2] XP_016878151.1, XM_017022662.1 [Q8N8Q9-2] XP_016878152.1, XM_017022663.1 [Q8N8Q9-2]
UniGeneⁱ	Hs.591003

Genome annotation databases

Ensemblⁱ	ENST00000337451; ENSP00000337618; ENSG00000140157 [Q8N8Q9-1] ENST00000359727; ENSP00000352762; ENSG00000140157 [Q8N8Q9-2] ENST00000398013; ENSP00000381095; ENSG00000140157 [Q8N8Q9-1] ENST00000398014; ENSP00000381096; ENSG00000140157 [Q8N8Q9-1] ENST00000539711; ENSP00000437746; ENSG00000140157 [Q8N8Q9-2]
GeneIDⁱ	81614
KEGGⁱ	hsa:81614
UCSC genome browser More...UCSCⁱ	uc001yux.4 human [Q8N8Q9-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8N8Q9	Magnesium transporter NIPA2		PONAB		360	UniRef100_Q8N8Q9
Non imprinted in Prader-Willi/Angelman syndrome 2, isoform CRA_a		HUMAN		360
NIPA2 isoform 1		PONAB		360
Q8N8Q9-2	NIPA2 isoform 4		PONAB		341	UniRef100_A0A2J8R7N1

Protein	Similar proteins		Species	Score	Length	Source
Q8N8Q9	Magnesium transporter NIPA2		MOUSE		359	UniRef90_Q9JJC8
Magnesium transporter NIPA2		BOVIN		360
Magnesium transporter NIPA2		PONAB		360
Magnesium transporter NIPA2		MYODS		440
Uncharacterized protein		MYOLU		363
+109
Q8N8Q9-2	NIPA magnesium transporter 2		SARHA		372	UniRef90_G3VYH6
magnesium transporter NIPA2 isoform X2		LEPWE		341
Magnesium transporter NIPA2 (Fragment)		NEOVI		341
Uncharacterized protein		Cebus capucinus imitator		341
NIPA magnesium transporter 2		GORGO		341
+17

Protein	Similar proteins		Species	Score	Length	Source
Q8N8Q9	Magnesium transporter NIPA2		MOUSE		359	UniRef50_Q9JJC8
Magnesium transporter NIPA2		PONAB		360
Magnesium transporter NIPA2		BOVIN		360
Magnesium transporter NIPA3		HUMAN		410
Magnesium transporter NIPA2		MYODS		440
+385
Q8N8Q9-2	NIPA magnesium transporter 2		SARHA		372	UniRef50_G3VYH6
Uncharacterized protein		RHIBE		341
magnesium transporter NIPA2 isoform X2		LIPVE		341
Uncharacterized protein		MACFA		341
Uncharacterized protein		CERAT		341
+126

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BK001120 mRNA Translation: DAA01509.1 AY732242 mRNA Translation: AAU34000.1 AK096305 mRNA Translation: BAC04757.1 AK300843 mRNA Translation: BAG62494.1 CR606982 mRNA No translation available. AC011767 Genomic DNA No translation available. BC000957 mRNA Translation: AAH00957.3 BC011775 mRNA Translation: AAH11775.1
CCDSⁱ	CCDS73693.1 [Q8N8Q9-1] CCDS73694.1 [Q8N8Q9-2]
RefSeqⁱ	NP_001008860.1, NM_001008860.2 [Q8N8Q9-1] NP_001008892.1, NM_001008892.2 [Q8N8Q9-1] NP_001008894.1, NM_001008894.2 [Q8N8Q9-2] NP_001171817.1, NM_001184888.1 [Q8N8Q9-2] NP_001171818.1, NM_001184889.1 [Q8N8Q9-1] NP_112184.4, NM_030922.6 [Q8N8Q9-1] XP_005272603.1, XM_005272546.3 [Q8N8Q9-1] XP_005272604.1, XM_005272547.4 [Q8N8Q9-1] XP_005272605.1, XM_005272548.3 [Q8N8Q9-1] XP_005272607.1, XM_005272550.3 [Q8N8Q9-1] XP_005272609.1, XM_005272552.3 [Q8N8Q9-1] XP_005272610.1, XM_005272553.4 [Q8N8Q9-1] XP_006720427.1, XM_006720364.2 [Q8N8Q9-1] XP_006720428.1, XM_006720365.2 [Q8N8Q9-1] XP_006720429.1, XM_006720366.3 [Q8N8Q9-1] XP_006720430.1, XM_006720367.1 [Q8N8Q9-2] XP_011542179.1, XM_011543877.2 [Q8N8Q9-1] XP_011542180.1, XM_011543878.2 [Q8N8Q9-1] XP_011542181.1, XM_011543879.2 [Q8N8Q9-1] XP_011542182.1, XM_011543880.2 [Q8N8Q9-1] XP_016878134.1, XM_017022645.1 [Q8N8Q9-1] XP_016878135.1, XM_017022646.1 [Q8N8Q9-1] XP_016878136.1, XM_017022647.1 [Q8N8Q9-1] XP_016878137.1, XM_017022648.1 [Q8N8Q9-1] XP_016878138.1, XM_017022649.1 [Q8N8Q9-1] XP_016878139.1, XM_017022650.1 [Q8N8Q9-1] XP_016878140.1, XM_017022651.1 [Q8N8Q9-1] XP_016878141.1, XM_017022652.1 [Q8N8Q9-1] XP_016878142.1, XM_017022653.1 [Q8N8Q9-1] XP_016878143.1, XM_017022654.1 [Q8N8Q9-1] XP_016878144.1, XM_017022655.1 [Q8N8Q9-2] XP_016878145.1, XM_017022656.1 [Q8N8Q9-2] XP_016878146.1, XM_017022657.1 [Q8N8Q9-2] XP_016878147.1, XM_017022658.1 [Q8N8Q9-2] XP_016878148.1, XM_017022659.1 [Q8N8Q9-2] XP_016878149.1, XM_017022660.1 [Q8N8Q9-2] XP_016878150.1, XM_017022661.1 [Q8N8Q9-2] XP_016878151.1, XM_017022662.1 [Q8N8Q9-2] XP_016878152.1, XM_017022663.1 [Q8N8Q9-2]
UniGeneⁱ	Hs.591003

3D structure databases

ProteinModelPortalⁱ	Q8N8Q9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	123549, 2 interactors
STRINGⁱ	9606.ENSP00000337618

Protein family/group databases

TCDBⁱ	2.A.7.25.2 the drug/metabolite transporter (dmt) superfamily

TCDBⁱ

2.A.7.25.2 the drug/metabolite transporter (dmt) superfamily

PTM databases

iPTMnetⁱ	Q8N8Q9
PhosphoSitePlusⁱ	Q8N8Q9

Polymorphism and mutation databases

BioMutaⁱ	NIPA2
DMDMⁱ	73921217

Proteomic databases

EPDⁱ	Q8N8Q9
MaxQBⁱ	Q8N8Q9
PaxDbⁱ	Q8N8Q9
PeptideAtlasⁱ	Q8N8Q9
PRIDEⁱ	Q8N8Q9
ProteomicsDBⁱ	72453

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000337451; ENSP00000337618; ENSG00000140157 [Q8N8Q9-1] ENST00000359727; ENSP00000352762; ENSG00000140157 [Q8N8Q9-2] ENST00000398013; ENSP00000381095; ENSG00000140157 [Q8N8Q9-1] ENST00000398014; ENSP00000381096; ENSG00000140157 [Q8N8Q9-1] ENST00000539711; ENSP00000437746; ENSG00000140157 [Q8N8Q9-2]
GeneIDⁱ	81614
KEGGⁱ	hsa:81614
UCSCⁱ	uc001yux.4 human [Q8N8Q9-1]

Organism-specific databases

CTDⁱ	81614
DisGeNETⁱ	81614
EuPathDBⁱ	HostDB:ENSG00000140157.14
GeneCardsⁱ	NIPA2
HGNCⁱ	HGNC:17044 NIPA2
HPAⁱ	HPA067160 HPA071342
MIMⁱ	608146 gene
neXtProtⁱ	NX_Q8N8Q9
OpenTargetsⁱ	ENSG00000140157
PharmGKBⁱ	PA134911294
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2922 Eukaryota ENOG410XNR8 LUCA
GeneTreeⁱ	ENSGT00550000074395
HOGENOMⁱ	HOG000203962
HOVERGENⁱ	HBG055032
InParanoidⁱ	Q8N8Q9
KOⁱ	K22733
OMAⁱ	KEWQHMA
OrthoDBⁱ	EOG091G0M8A
PhylomeDBⁱ	Q8N8Q9
TreeFamⁱ	TF313214

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5223345 Miscellaneous transport and binding events

Reactomeⁱ

R-HSA-5223345 Miscellaneous transport and binding events

Miscellaneous databases

GeneWikiⁱ	NIPA2
GenomeRNAiⁱ	81614
Protein Ontology More...PROⁱ	PR:Q8N8Q9
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000140157 Expressed in 225 organ(s), highest expression level in colonic mucosa
CleanExⁱ	HS_NIPA2
ExpressionAtlasⁱ	Q8N8Q9 baseline and differential
Genevisibleⁱ	Q8N8Q9 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR008521 Mg_trans_NIPA
PANTHERⁱ	PTHR12570 PTHR12570, 1 hit
Pfamⁱ	View protein in Pfam PF05653 Mg_trans_NIPA, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NIPA2_HUMAN
Accessionⁱ	Q8N8Q9Primary (citable) accession number: Q8N8Q9 Secondary accession number(s): F8W7Y8, Q96F03, Q9BVS2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
	Last sequence update:	October 1, 2002
	Last modified:	November 7, 2018
	This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8N8Q9 (NIPA2_HUMAN)

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Magnesium transporter NIPA2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Endosome

Endosome

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ