UniProtKB - Q8N8Q9 (NIPA2_HUMAN)
Protein
Magnesium transporter NIPA2
Gene
NIPA2
Organism
Homo sapiens (Human)
Status
Functioni
Acts as a selective Mg2+ transporter.By similarity
GO - Molecular functioni
- magnesium ion transmembrane transporter activity Source: InterPro
GO - Biological processi
- magnesium ion transport Source: GO_Central
Keywordsi
Biological process | Ion transport, Transport |
Ligand | Magnesium |
Enzyme and pathway databases
PathwayCommonsi | Q8N8Q9 |
Reactomei | R-HSA-5223345, Miscellaneous transport and binding events |
Protein family/group databases
TCDBi | 2.A.7.25.2, the drug/metabolite transporter (dmt) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Magnesium transporter NIPA2Alternative name(s): Non-imprinted in Prader-Willi/Angelman syndrome region protein 2 |
Gene namesi | Name:NIPA2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17044, NIPA2 |
MIMi | 608146, gene |
neXtProti | NX_Q8N8Q9 |
VEuPathDBi | HostDB:ENSG00000140157.14 |
Subcellular locationi
Endosome
- Early endosome By similarity
Plasma membrane
- Cell membrane Curated; Multi-pass membrane protein Curated
Note: Recruited to the cell membrane in response to low extracellular magnesium.By similarity
Endosome
- early endosome Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 9 | ExtracellularSequence analysis | 9 | |
Transmembranei | 10 – 30 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 31 – 56 | CytoplasmicSequence analysisAdd BLAST | 26 | |
Transmembranei | 57 – 77 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 78 | ExtracellularSequence analysis | 1 | |
Transmembranei | 79 – 99 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 100 – 107 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 108 – 128 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 129 – 149 | ExtracellularSequence analysisAdd BLAST | 21 | |
Transmembranei | 150 – 170 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 171 – 175 | CytoplasmicSequence analysis | 5 | |
Transmembranei | 176 – 196 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 197 – 215 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 216 – 236 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 237 – 246 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 247 – 267 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 268 – 278 | ExtracellularSequence analysisAdd BLAST | 11 | |
Transmembranei | 279 – 299 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 300 – 360 | CytoplasmicSequence analysisAdd BLAST | 61 |
Keywords - Cellular componenti
Cell membrane, Endosome, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 81614 |
OpenTargetsi | ENSG00000140157 |
PharmGKBi | PA134911294 |
Miscellaneous databases
Pharosi | Q8N8Q9, Tbio |
Genetic variation databases
BioMutai | NIPA2 |
DMDMi | 73921217 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000191743 | 1 – 360 | Magnesium transporter NIPA2Add BLAST | 360 |
Proteomic databases
jPOSTi | Q8N8Q9 |
MassIVEi | Q8N8Q9 |
MaxQBi | Q8N8Q9 |
PaxDbi | Q8N8Q9 |
PeptideAtlasi | Q8N8Q9 |
PRIDEi | Q8N8Q9 |
ProteomicsDBi | 30041 72453 [Q8N8Q9-1] |
PTM databases
iPTMneti | Q8N8Q9 |
PhosphoSitePlusi | Q8N8Q9 |
Expressioni
Tissue specificityi
Widely expressed.1 Publication
Gene expression databases
Bgeei | ENSG00000140157, Expressed in colonic mucosa and 236 other tissues |
ExpressionAtlasi | Q8N8Q9, baseline and differential |
Genevisiblei | Q8N8Q9, HS |
Organism-specific databases
HPAi | ENSG00000140157, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 123549, 2 interactors |
IntActi | Q8N8Q9, 3 interactors |
MINTi | Q8N8Q9 |
STRINGi | 9606.ENSP00000337618 |
Miscellaneous databases
RNActi | Q8N8Q9, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the NIPA family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2922, Eukaryota |
GeneTreei | ENSGT00940000155651 |
HOGENOMi | CLU_012349_1_1_1 |
InParanoidi | Q8N8Q9 |
OMAi | KNPLAWI |
PhylomeDBi | Q8N8Q9 |
TreeFami | TF313214 |
Family and domain databases
InterProi | View protein in InterPro IPR008521, Mg_trans_NIPA |
PANTHERi | PTHR12570, PTHR12570, 1 hit |
Pfami | View protein in Pfam PF05653, Mg_trans_NIPA, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8N8Q9-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSQGRGKYDF YIGLGLAMSS SIFIGGSFIL KKKGLLRLAR KGSMRAGQGG
60 70 80 90 100
HAYLKEWLWW AGLLSMGAGE VANFAAYAFA PATLVTPLGA LSVLVSAILS
110 120 130 140 150
SYFLNERLNL HGKIGCLLSI LGSTVMVIHA PKEEEIETLN EMSHKLGDPG
160 170 180 190 200
FVVFATLVVI VALILIFVVG PRHGQTNILV YITICSVIGA FSVSCVKGLG
210 220 230 240 250
IAIKELFAGK PVLRHPLAWI LLLSLIVCVS TQINYLNRAL DIFNTSIVTP
260 270 280 290 300
IYYVFFTTSV LTCSAILFKE WQDMPVDDVI GTLSGFFTII VGIFLLHAFK
310 320 330 340 350
DVSFSLASLP VSFRKDEKAM NGNLSNMYEV LNNNEESLTC GIEQHTGENV
360
SRRNGNLTAF
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YMQ7 | H0YMQ7_HUMAN | Magnesium transporter NIPA2 | NIPA2 | 59 | Annotation score: | ||
A0A6I8PUB5 | A0A6I8PUB5_HUMAN | Magnesium transporter NIPA2 | NIPA2 | 32 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 303 | S → G in AAU34000 (Ref. 2) Curated | 1 | |
Sequence conflicti | 303 | S → G in AAH11775 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_044587 | 47 – 66 | GQGGH…GLLSM → V in isoform 2. 1 PublicationAdd BLAST | 20 |
Sequence databases
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 123549, 2 interactors |
IntActi | Q8N8Q9, 3 interactors |
MINTi | Q8N8Q9 |
STRINGi | 9606.ENSP00000337618 |
Protein family/group databases
TCDBi | 2.A.7.25.2, the drug/metabolite transporter (dmt) superfamily |
PTM databases
iPTMneti | Q8N8Q9 |
PhosphoSitePlusi | Q8N8Q9 |
Genetic variation databases
BioMutai | NIPA2 |
DMDMi | 73921217 |
Proteomic databases
jPOSTi | Q8N8Q9 |
MassIVEi | Q8N8Q9 |
MaxQBi | Q8N8Q9 |
PaxDbi | Q8N8Q9 |
PeptideAtlasi | Q8N8Q9 |
PRIDEi | Q8N8Q9 |
ProteomicsDBi | 30041 72453 [Q8N8Q9-1] |
Protocols and materials databases
Antibodypediai | 22214, 39 antibodies |
Genome annotation databases
Organism-specific databases
CTDi | 81614 |
DisGeNETi | 81614 |
GeneCardsi | NIPA2 |
HGNCi | HGNC:17044, NIPA2 |
HPAi | ENSG00000140157, Low tissue specificity |
MIMi | 608146, gene |
neXtProti | NX_Q8N8Q9 |
OpenTargetsi | ENSG00000140157 |
PharmGKBi | PA134911294 |
VEuPathDBi | HostDB:ENSG00000140157.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2922, Eukaryota |
GeneTreei | ENSGT00940000155651 |
HOGENOMi | CLU_012349_1_1_1 |
InParanoidi | Q8N8Q9 |
OMAi | KNPLAWI |
PhylomeDBi | Q8N8Q9 |
TreeFami | TF313214 |
Enzyme and pathway databases
PathwayCommonsi | Q8N8Q9 |
Reactomei | R-HSA-5223345, Miscellaneous transport and binding events |
Miscellaneous databases
BioGRID-ORCSi | 81614, 8 hits in 872 CRISPR screens |
ChiTaRSi | NIPA2, human |
GeneWikii | NIPA2 |
GenomeRNAii | 81614 |
Pharosi | Q8N8Q9, Tbio |
PROi | PR:Q8N8Q9 |
RNActi | Q8N8Q9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000140157, Expressed in colonic mucosa and 236 other tissues |
ExpressionAtlasi | Q8N8Q9, baseline and differential |
Genevisiblei | Q8N8Q9, HS |
Family and domain databases
InterProi | View protein in InterPro IPR008521, Mg_trans_NIPA |
PANTHERi | PTHR12570, PTHR12570, 1 hit |
Pfami | View protein in Pfam PF05653, Mg_trans_NIPA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NIPA2_HUMAN | |
Accessioni | Q8N8Q9Primary (citable) accession number: Q8N8Q9 Secondary accession number(s): F8W7Y8, Q96F03, Q9BVS2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 30, 2005 |
Last sequence update: | October 1, 2002 | |
Last modified: | February 10, 2021 | |
This is version 134 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM