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Protein

Endonuclease V

Gene

ENDOV

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine. Has strong preference for single-stranded RNAs (ssRNAs) toward double-stranded RNAs (dsRNAs). Cleaves mRNAs and tRNAs containing inosine. Also able to cleave structure-specific dsRNA substrates containing the specific sites 5'-IIUI-3' and 5'-UIUU-3'. Inosine is present in a number of RNAs following editing; the function of inosine-specific endoribonuclease is still unclear: it could either play a regulatory role in edited RNAs, or be involved in antiviral response by removing the hyperedited long viral dsRNA genome that has undergone A-to-I editing. Binds branched DNA structures.3 Publications

Miscellaneous

Was initially characterized as an endodeoxyribonuclease involved in DNA repair (PubMed:22664237). While it shows some weak endodeoxyribonuclease activity in vitro, such activity probably does not exist in vivo.1 Publication

Cofactori

Mg2+1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi52MagnesiumCurated1
Metal bindingi126MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Endonuclease, Hydrolase, Nuclease, RNA-binding
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Endonuclease V (EC:3.1.26.-)
Short name:
hEndoV
Alternative name(s):
Inosine-specific endoribonuclease
Gene namesi
Name:ENDOV
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000173818.16
HGNCiHGNC:26640 ENDOV
neXtProtiNX_Q8N8Q3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi52D → A: Abolishes ribonuclease activity. 2 Publications1
Mutagenesisi90 – 93PYVS → GGGG: Abolishes ability to bind branched DNA and RNA. 1 Publication4
Mutagenesisi91Y → A: Abolishes ribonuclease activity without affecting ability to bind branched DNA. 2 Publications1
Mutagenesisi100E → A: Abolishes ribonuclease activity. 1 Publication1
Mutagenesisi248 – 249RK → AA: Abolishes ability to bind branched DNA and RNA. 1 Publication2

Organism-specific databases

DisGeNETi284131
OpenTargetsiENSG00000173818

Polymorphism and mutation databases

BioMutaiENDOV
DMDMi74729504

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003492231 – 282Endonuclease VAdd BLAST282

Proteomic databases

MaxQBiQ8N8Q3
PaxDbiQ8N8Q3
PeptideAtlasiQ8N8Q3
PRIDEiQ8N8Q3
ProteomicsDBi72445
72446 [Q8N8Q3-2]
72447 [Q8N8Q3-3]
72448 [Q8N8Q3-4]

PTM databases

iPTMnetiQ8N8Q3
PhosphoSitePlusiQ8N8Q3

Expressioni

Gene expression databases

BgeeiENSG00000173818 Expressed in 177 organ(s), highest expression level in quadriceps femoris
ExpressionAtlasiQ8N8Q3 baseline and differential
GenevisibleiQ8N8Q3 HS

Interactioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei91Interaction with target RNACurated1

Protein-protein interaction databases

BioGridi129772, 11 interactors
IntActiQ8N8Q3, 2 interactors
STRINGi9606.ENSP00000429190

Structurei

Secondary structure

1282
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8N8Q3
SMRiQ8N8Q3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi225 – 228Poly-Cys4

Sequence similaritiesi

Belongs to the endonuclease V family.Curated

Phylogenomic databases

eggNOGiKOG4417 Eukaryota
COG1515 LUCA
GeneTreeiENSGT00390000011880
HOVERGENiHBG062398
InParanoidiQ8N8Q3
KOiK21813
OMAiCKYRVPE
OrthoDBiEOG091G0LHO
PhylomeDBiQ8N8Q3
TreeFamiTF300065

Family and domain databases

CDDicd06559 Endonuclease_V, 1 hit
HAMAPiMF_00801 Endonuclease_5, 1 hit
InterProiView protein in InterPro
IPR007581 Endonuclease-V
PANTHERiPTHR28511 PTHR28511, 1 hit
PfamiView protein in Pfam
PF04493 Endonuclease_5, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 14 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N8Q3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALEAAGGPP EETLSLWKRE QARLKAHVVD RDTEAWQRDP AFSGLQRVGG
60 70 80 90 100
VDVSFVKGDS VRACASLVVL SFPELEVVYE ESRMVSLTAP YVSGFLAFRE
110 120 130 140 150
VPFLLELVQQ LREKEPGLMP QVLLVDGNGV LHHRGFGVAC HLGVLTDLPC
160 170 180 190 200
VGVAKKLLQV DGLENNALHK EKIRLLQTRG DSFPLLGDSG TVLGMALRSH
210 220 230 240 250
DRSTRPLYIS VGHRMSLEAA VRLTCCCCRF RIPEPVRQAD ICSREHIRKS
260 270 280
LGLPGPPTPR SPKAQRPVAC PKGDSGESSA LC
Length:282
Mass (Da):30,792
Last modified:October 1, 2002 - v1
Checksum:iEDB10210FB508A51
GO
Isoform 2 (identifier: Q8N8Q3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     77-121: Missing.

Show »
Length:237
Mass (Da):25,612
Checksum:iA89BC40B3E5E0D22
GO
Isoform 3 (identifier: Q8N8Q3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     77-121: Missing.
     280-282: ALC → GEGQPPQDHSPGPRTAPRPGSQEQAGKDWQ

Show »
Length:264
Mass (Da):28,503
Checksum:iEA8145ACC6AB8CF9
GO
Isoform 4 (identifier: Q8N8Q3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-194: Missing.
     239-282: ADICSREHIRKSLGLPGPPTPRSPKAQRPVACPKGDSGESSALC → HFVERGGESTRPRLIPDRTRW

Show »
Length:65
Mass (Da):7,665
Checksum:iE75AB2F40226FC4E
GO
Isoform 5 (identifier: Q8N8Q3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-194: Missing.

Show »
Length:88
Mass (Da):9,670
Checksum:i77BE0951D5518E2F
GO

Computationally mapped potential isoform sequencesi

There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YAY5H0YAY5_HUMAN
Endonuclease V
ENDOV
236Annotation score:
I3L4V7I3L4V7_HUMAN
Endonuclease V
ENDOV
155Annotation score:
I3L485I3L485_HUMAN
Endonuclease V
ENDOV
105Annotation score:
I3L0L4I3L0L4_HUMAN
Endonuclease V
ENDOV
115Annotation score:
I3L1V3I3L1V3_HUMAN
Endonuclease V
ENDOV
97Annotation score:
H0YBZ5H0YBZ5_HUMAN
Endonuclease V
ENDOV
170Annotation score:
E5RHX4E5RHX4_HUMAN
Endonuclease V
ENDOV
50Annotation score:
E5RJ92E5RJ92_HUMAN
Endonuclease V
ENDOV
97Annotation score:
H0YBX8H0YBX8_HUMAN
Endonuclease V
ENDOV
131Annotation score:
E5RFW0E5RFW0_HUMAN
Endonuclease V
ENDOV
105Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19R → W in BAC03912 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04628529V → I1 PublicationCorresponds to variant dbSNP:rs35549084Ensembl.1
Natural variantiVAR_046286112R → Q1 PublicationCorresponds to variant dbSNP:rs34933300Ensembl.1
Natural variantiVAR_046287114K → R1 PublicationCorresponds to variant dbSNP:rs41298706Ensembl.1
Natural variantiVAR_046288141H → Y1 PublicationCorresponds to variant dbSNP:rs41299812Ensembl.1
Natural variantiVAR_046289201D → N1 PublicationCorresponds to variant dbSNP:rs35929621Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0352281 – 194Missing in isoform 4 and isoform 5. 2 PublicationsAdd BLAST194
Alternative sequenceiVSP_03522977 – 121Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST45
Alternative sequenceiVSP_035230239 – 282ADICS…SSALC → HFVERGGESTRPRLIPDRTR W in isoform 4. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_035231280 – 282ALC → GEGQPPQDHSPGPRTAPRPG SQEQAGKDWQ in isoform 3. 1 Publication3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092539 mRNA Translation: BAC03912.1
AK096344 mRNA Translation: BAC04765.1
AK096802 mRNA No translation available.
DQ500957 Genomic DNA Translation: ABF47100.1
AC120024 Genomic DNA No translation available.
CH471099 Genomic DNA Translation: EAW89607.1
CH471099 Genomic DNA Translation: EAW89605.1
CH471099 Genomic DNA Translation: EAW89615.1
BC037889 mRNA Translation: AAH37889.1
BC045824 mRNA Translation: AAH45824.1
BC064545 mRNA Translation: AAH64545.1
CCDSiCCDS54172.1 [Q8N8Q3-1]
CCDS54173.1 [Q8N8Q3-2]
CCDS54174.1 [Q8N8Q3-3]
RefSeqiNP_001158109.1, NM_001164637.2 [Q8N8Q3-2]
NP_001158110.1, NM_001164638.1 [Q8N8Q3-3]
NP_775898.2, NM_173627.4 [Q8N8Q3-1]
UniGeneiHs.389678
Hs.728933

Genome annotation databases

EnsembliENST00000323854; ENSP00000317810; ENSG00000173818 [Q8N8Q3-3]
ENST00000517795; ENSP00000461577; ENSG00000173818 [Q8N8Q3-5]
ENST00000518137; ENSP00000429190; ENSG00000173818 [Q8N8Q3-1]
ENST00000518901; ENSP00000460685; ENSG00000173818 [Q8N8Q3-5]
ENST00000518907; ENSP00000458361; ENSG00000173818 [Q8N8Q3-4]
ENST00000520284; ENSP00000458391; ENSG00000173818 [Q8N8Q3-4]
ENST00000520367; ENSP00000431036; ENSG00000173818 [Q8N8Q3-2]
GeneIDi284131
KEGGihsa:284131
UCSCiuc002jyk.4 human [Q8N8Q3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092539 mRNA Translation: BAC03912.1
AK096344 mRNA Translation: BAC04765.1
AK096802 mRNA No translation available.
DQ500957 Genomic DNA Translation: ABF47100.1
AC120024 Genomic DNA No translation available.
CH471099 Genomic DNA Translation: EAW89607.1
CH471099 Genomic DNA Translation: EAW89605.1
CH471099 Genomic DNA Translation: EAW89615.1
BC037889 mRNA Translation: AAH37889.1
BC045824 mRNA Translation: AAH45824.1
BC064545 mRNA Translation: AAH64545.1
CCDSiCCDS54172.1 [Q8N8Q3-1]
CCDS54173.1 [Q8N8Q3-2]
CCDS54174.1 [Q8N8Q3-3]
RefSeqiNP_001158109.1, NM_001164637.2 [Q8N8Q3-2]
NP_001158110.1, NM_001164638.1 [Q8N8Q3-3]
NP_775898.2, NM_173627.4 [Q8N8Q3-1]
UniGeneiHs.389678
Hs.728933

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4NSPX-ray2.30A13-250[»]
ProteinModelPortaliQ8N8Q3
SMRiQ8N8Q3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129772, 11 interactors
IntActiQ8N8Q3, 2 interactors
STRINGi9606.ENSP00000429190

PTM databases

iPTMnetiQ8N8Q3
PhosphoSitePlusiQ8N8Q3

Polymorphism and mutation databases

BioMutaiENDOV
DMDMi74729504

Proteomic databases

MaxQBiQ8N8Q3
PaxDbiQ8N8Q3
PeptideAtlasiQ8N8Q3
PRIDEiQ8N8Q3
ProteomicsDBi72445
72446 [Q8N8Q3-2]
72447 [Q8N8Q3-3]
72448 [Q8N8Q3-4]

Protocols and materials databases

DNASUi284131
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000323854; ENSP00000317810; ENSG00000173818 [Q8N8Q3-3]
ENST00000517795; ENSP00000461577; ENSG00000173818 [Q8N8Q3-5]
ENST00000518137; ENSP00000429190; ENSG00000173818 [Q8N8Q3-1]
ENST00000518901; ENSP00000460685; ENSG00000173818 [Q8N8Q3-5]
ENST00000518907; ENSP00000458361; ENSG00000173818 [Q8N8Q3-4]
ENST00000520284; ENSP00000458391; ENSG00000173818 [Q8N8Q3-4]
ENST00000520367; ENSP00000431036; ENSG00000173818 [Q8N8Q3-2]
GeneIDi284131
KEGGihsa:284131
UCSCiuc002jyk.4 human [Q8N8Q3-1]

Organism-specific databases

CTDi284131
DisGeNETi284131
EuPathDBiHostDB:ENSG00000173818.16
GeneCardsiENDOV
HGNCiHGNC:26640 ENDOV
neXtProtiNX_Q8N8Q3
OpenTargetsiENSG00000173818
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4417 Eukaryota
COG1515 LUCA
GeneTreeiENSGT00390000011880
HOVERGENiHBG062398
InParanoidiQ8N8Q3
KOiK21813
OMAiCKYRVPE
OrthoDBiEOG091G0LHO
PhylomeDBiQ8N8Q3
TreeFamiTF300065

Miscellaneous databases

GenomeRNAii284131
PROiPR:Q8N8Q3

Gene expression databases

BgeeiENSG00000173818 Expressed in 177 organ(s), highest expression level in quadriceps femoris
ExpressionAtlasiQ8N8Q3 baseline and differential
GenevisibleiQ8N8Q3 HS

Family and domain databases

CDDicd06559 Endonuclease_V, 1 hit
HAMAPiMF_00801 Endonuclease_5, 1 hit
InterProiView protein in InterPro
IPR007581 Endonuclease-V
PANTHERiPTHR28511 PTHR28511, 1 hit
PfamiView protein in Pfam
PF04493 Endonuclease_5, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiENDOV_HUMAN
AccessioniPrimary (citable) accession number: Q8N8Q3
Secondary accession number(s): I3L3S4
, Q6P2G2, Q86X99, Q8NAK0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: October 1, 2002
Last modified: September 12, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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