ENDOV

Functionⁱ

Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine. Has strong preference for single-stranded RNAs (ssRNAs) toward double-stranded RNAs (dsRNAs). Cleaves mRNAs and tRNAs containing inosine. Also able to cleave structure-specific dsRNA substrates containing the specific sites 5'-IIUI-3' and 5'-UIUU-3'. Inosine is present in a number of RNAs following editing; the function of inosine-specific endoribonuclease is still unclear: it could either play a regulatory role in edited RNAs, or be involved in antiviral response by removing the hyperedited long viral dsRNA genome that has undergone A-to-I editing. Binds branched DNA structures.3 Publications

Miscellaneous

Was initially characterized as an endodeoxyribonuclease involved in DNA repair (PubMed:22664237). While it shows some weak endodeoxyribonuclease activity in vitro, such activity probably does not exist in vivo.1 Publication

Cofactorⁱ

Mg²⁺1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Metal bindingⁱ	52	MagnesiumCurated		1
Metal bindingⁱ	126	MagnesiumBy similarity		1

GO - Molecular functionⁱ

DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 23139746
endodeoxyribonuclease activity, producing 5'-phosphomonoesters Source: UniProtKB
endoribonuclease activity, producing 5'-phosphomonoesters
Source: UniProtKB
Inferred from direct assayⁱ
- 23912683
- 23912718
magnesium ion binding Source: UniProtKB
single-stranded RNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 23912683
- 23912718

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

DNA repair Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, Endonuclease, Hydrolase, Nuclease, RNA-binding
Ligand	Magnesium, Metal-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Endonuclease V (EC:3.1.26.-) Short name: hEndoV Alternative name(s): Inosine-specific endoribonuclease
Gene namesⁱ	Name:ENDOV
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000173818.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:26640 ENDOV
neXtProtⁱ	NX_Q8N8Q3

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	52	D → A: Abolishes ribonuclease activity. 2 Publications	1
Mutagenesisⁱ	90 – 93	PYVS → GGGG: Abolishes ability to bind branched DNA and RNA. 1 Publication	4
Mutagenesisⁱ	91	Y → A: Abolishes ribonuclease activity without affecting ability to bind branched DNA. 2 Publications	1
Mutagenesisⁱ	100	E → A: Abolishes ribonuclease activity. 1 Publication	1
Mutagenesisⁱ	248 – 249	RK → AA: Abolishes ability to bind branched DNA and RNA. 1 Publication	2

Organism-specific databases

DisGeNET More...DisGeNETⁱ	284131
Open Targets More...OpenTargetsⁱ	ENSG00000173818

Polymorphism and mutation databases

BioMutaⁱ	ENDOV
DMDMⁱ	74729504

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000349223	1 – 282	Endonuclease VAdd BLAST		282

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8N8Q3
PaxDbⁱ	Q8N8Q3
PeptideAtlas More...PeptideAtlasⁱ	Q8N8Q3
PRIDEⁱ	Q8N8Q3
ProteomicsDBⁱ	72445 72446 [Q8N8Q3-2] 72447 [Q8N8Q3-3] 72448 [Q8N8Q3-4]

PTM databases

iPTMnetⁱ	Q8N8Q3
PhosphoSitePlusⁱ	Q8N8Q3

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000173818 Expressed in 177 organ(s), highest expression level in quadriceps femoris
ExpressionAtlasⁱ	Q8N8Q3 baseline and differential
Genevisibleⁱ	Q8N8Q3 HS

Interactionⁱ

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	91	Interaction with target RNACurated		1

Protein-protein interaction databases

BioGridⁱ	129772, 11 interactors
IntActⁱ	Q8N8Q3, 2 interactors
STRINGⁱ	9606.ENSP00000429190

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	15 – 25	Combined sources	11
Helixⁱ	35 – 38	Combined sources	4
Beta strandⁱ	47 – 55	Combined sources	9
Beta strandⁱ	61 – 71	Combined sources	11
Turnⁱ	72 – 74	Combined sources	3
Beta strandⁱ	77 – 86	Combined sources	10
Helixⁱ	97 – 114	Combined sources	18
Helixⁱ	116 – 118	Combined sources	3
Beta strandⁱ	121 – 127	Combined sources	7
Beta strandⁱ	129 – 132	Combined sources	4
Helixⁱ	138 – 146	Combined sources	9
Beta strandⁱ	150 – 156	Combined sources	7
Helixⁱ	167 – 175	Combined sources	9
Beta strandⁱ	182 – 186	Combined sources	5
Beta strandⁱ	192 – 197	Combined sources	6
Beta strandⁱ	207 – 215	Combined sources	9
Helixⁱ	217 – 226	Combined sources	10
Beta strandⁱ	229 – 232	Combined sources	4
Helixⁱ	234 – 250	Combined sources	17

Show more details

3D structure databases

ProteinModelPortalⁱ	Q8N8Q3
SMRⁱ	Q8N8Q3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	225 – 228	Poly-Cys		4

Sequence similaritiesⁱ

Belongs to the endonuclease V family.Curated

Phylogenomic databases

eggNOGⁱ	KOG4417 Eukaryota COG1515 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000011880
HOVERGENⁱ	HBG062398
InParanoidⁱ	Q8N8Q3
KEGG Orthology (KO) More...KOⁱ	K21813
OMAⁱ	CKYRVPE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0LHO
PhylomeDBⁱ	Q8N8Q3
TreeFamⁱ	TF300065

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06559 Endonuclease_V, 1 hit
HAMAPⁱ	MF_00801 Endonuclease_5, 1 hit
InterProⁱ	View protein in InterPro IPR007581 Endonuclease-V
PANTHERⁱ	PTHR28511 PTHR28511, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04493 Endonuclease_5, 1 hit

Sequences (5+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 5 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 5 described isoforms and 14 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q8N8Q3-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALEAAGGPP EETLSLWKRE QARLKAHVVD RDTEAWQRDP AFSGLQRVGG 
        60         70         80         90        100
VDVSFVKGDS VRACASLVVL SFPELEVVYE ESRMVSLTAP YVSGFLAFRE 
       110        120        130        140        150
VPFLLELVQQ LREKEPGLMP QVLLVDGNGV LHHRGFGVAC HLGVLTDLPC 
       160        170        180        190        200
VGVAKKLLQV DGLENNALHK EKIRLLQTRG DSFPLLGDSG TVLGMALRSH 
       210        220        230        240        250
DRSTRPLYIS VGHRMSLEAA VRLTCCCCRF RIPEPVRQAD ICSREHIRKS 
       260        270        280 
LGLPGPPTPR SPKAQRPVAC PKGDSGESSA LC

Length:282

Mass (Da):30,792

Last modified:October 1, 2002 - v1

Checksum:ⁱEDB10210FB508A51

GO

Isoform 2 (identifier: Q8N8Q3-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
77-121: Missing.

« Hide

        10         20         30         40         50
MALEAAGGPP EETLSLWKRE QARLKAHVVD RDTEAWQRDP AFSGLQRVGG 
        60         70         80         90        100
VDVSFVKGDS VRACASLVVL SFPELEVLLV DGNGVLHHRG FGVACHLGVL 
       110        120        130        140        150
TDLPCVGVAK KLLQVDGLEN NALHKEKIRL LQTRGDSFPL LGDSGTVLGM 
       160        170        180        190        200
ALRSHDRSTR PLYISVGHRM SLEAAVRLTC CCCRFRIPEP VRQADICSRE 
       210        220        230 
HIRKSLGLPG PPTPRSPKAQ RPVACPKGDS GESSALC

Show »

Length:237

Mass (Da):25,612

Checksum:ⁱA89BC40B3E5E0D22

GO

Isoform 3 (identifier: Q8N8Q3-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
77-121: Missing.
280-282: ALC → GEGQPPQDHSPGPRTAPRPGSQEQAGKDWQ

« Hide

        10         20         30         40         50
MALEAAGGPP EETLSLWKRE QARLKAHVVD RDTEAWQRDP AFSGLQRVGG 
        60         70         80         90        100
VDVSFVKGDS VRACASLVVL SFPELEVLLV DGNGVLHHRG FGVACHLGVL 
       110        120        130        140        150
TDLPCVGVAK KLLQVDGLEN NALHKEKIRL LQTRGDSFPL LGDSGTVLGM 
       160        170        180        190        200
ALRSHDRSTR PLYISVGHRM SLEAAVRLTC CCCRFRIPEP VRQADICSRE 
       210        220        230        240        250
HIRKSLGLPG PPTPRSPKAQ RPVACPKGDS GESSGEGQPP QDHSPGPRTA 
       260 
PRPGSQEQAG KDWQ

Show »

Length:264

Mass (Da):28,503

Checksum:ⁱEA8145ACC6AB8CF9

GO

Isoform 4 (identifier: Q8N8Q3-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-194: Missing.
239-282: ADICSREHIRKSLGLPGPPTPRSPKAQRPVACPKGDSGESSALC → HFVERGGESTRPRLIPDRTRW

« Hide

        10         20         30         40         50
MALRSHDRST RPLYISVGHR MSLEAAVRLT CCCCRFRIPE PVRQHFVERG 
        60 
GESTRPRLIP DRTRW

Show »

Length:65

Mass (Da):7,665

Checksum:ⁱE75AB2F40226FC4E

GO

Isoform 5 (identifier: Q8N8Q3-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-194: Missing.

« Hide

        10         20         30         40         50
MALRSHDRST RPLYISVGHR MSLEAAVRLT CCCCRFRIPE PVRQADICSR 
        60         70         80 
EHIRKSLGLP GPPTPRSPKA QRPVACPKGD SGESSALC

Show »

Length:88

Mass (Da):9,670

Checksum:ⁱ77BE0951D5518E2F

GO

Computationally mapped potential isoform sequencesⁱ

There are 14 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	H0YAY5	H0YAY5_HUMAN	Endonuclease V Endonuclease V	ENDOV	236	Annotation score:
	I3L4V7	I3L4V7_HUMAN	Endonuclease V Endonuclease V	ENDOV	155	Annotation score:
	I3L485	I3L485_HUMAN	Endonuclease V Endonuclease V	ENDOV	105	Annotation score:
	I3L0L4	I3L0L4_HUMAN	Endonuclease V Endonuclease V	ENDOV	115	Annotation score:
	I3L1V3	I3L1V3_HUMAN	Endonuclease V Endonuclease V	ENDOV	97	Annotation score:
	H0YBZ5	H0YBZ5_HUMAN	Endonuclease V Endonuclease V	ENDOV	170	Annotation score:
	E5RHX4	E5RHX4_HUMAN	Endonuclease V Endonuclease V	ENDOV	50	Annotation score:
	E5RJ92	E5RJ92_HUMAN	Endonuclease V Endonuclease V	ENDOV	97	Annotation score:
	H0YBX8	H0YBX8_HUMAN	Endonuclease V Endonuclease V	ENDOV	131	Annotation score:
	E5RFW0	E5RFW0_HUMAN	Endonuclease V Endonuclease V	ENDOV	105	Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	19	R → W in BAC03912 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_046285	29	V → I1 PublicationCorresponds to variant dbSNP:rs35549084Ensembl.	1
Natural variantⁱVAR_046286	112	R → Q1 PublicationCorresponds to variant dbSNP:rs34933300Ensembl.	1
Natural variantⁱVAR_046287	114	K → R1 PublicationCorresponds to variant dbSNP:rs41298706Ensembl.	1
Natural variantⁱVAR_046288	141	H → Y1 PublicationCorresponds to variant dbSNP:rs41299812Ensembl.	1
Natural variantⁱVAR_046289	201	D → N1 PublicationCorresponds to variant dbSNP:rs35929621Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_035228	1 – 194	Missing in isoform 4 and isoform 5. 2 PublicationsAdd BLAST	194
Alternative sequenceⁱVSP_035229	77 – 121	Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST	45
Alternative sequenceⁱVSP_035230	239 – 282	ADICS…SSALC → HFVERGGESTRPRLIPDRTR W in isoform 4. 1 PublicationAdd BLAST	44
Alternative sequenceⁱVSP_035231	280 – 282	ALC → GEGQPPQDHSPGPRTAPRPG SQEQAGKDWQ in isoform 3. 1 Publication	3

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK092539 mRNA Translation: BAC03912.1 AK096344 mRNA Translation: BAC04765.1 AK096802 mRNA No translation available. DQ500957 Genomic DNA Translation: ABF47100.1 AC120024 Genomic DNA No translation available. CH471099 Genomic DNA Translation: EAW89607.1 CH471099 Genomic DNA Translation: EAW89605.1 CH471099 Genomic DNA Translation: EAW89615.1 BC037889 mRNA Translation: AAH37889.1 BC045824 mRNA Translation: AAH45824.1 BC064545 mRNA Translation: AAH64545.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS54172.1 [Q8N8Q3-1] CCDS54173.1 [Q8N8Q3-2] CCDS54174.1 [Q8N8Q3-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001158109.1, NM_001164637.2 [Q8N8Q3-2] NP_001158110.1, NM_001164638.1 [Q8N8Q3-3] NP_775898.2, NM_173627.4 [Q8N8Q3-1]
UniGeneⁱ	Hs.389678 Hs.728933

Genome annotation databases

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8N8Q3	Uncharacterized protein		HUMAN		88	UniRef100_Q8N8Q3
Isoform 5 of Endonuclease V		HUMAN		88
UPI0007DC695D		HUMAN		199

Protein	Similar proteins		Species	Score	Length	Source
Q8N8Q3	Uncharacterized protein		HUMAN		88	UniRef90_Q8N8Q3
Uncharacterized protein		NOMLE		309
Uncharacterized protein		PANPA		309
Uncharacterized protein		PANTR		309
Uncharacterized protein		PONAB		309
+46
Q8N8Q3-2	Uncharacterized protein		COLAP		285	UniRef90_Q8N8Q3-2
ENDOV isoform 4		PANTR		237
ENDOV isoform 4		PONAB		237
Q8N8Q3-3	Uncharacterized protein		PANPA		264	UniRef90_Q8N8Q3-3
Endonuclease V		GORGO		264
Uncharacterized protein		PANTR		264
Uncharacterized protein		NOMLE		264
ENDOV isoform 9		PONAB		264
+15
Q8N8Q3-4	Uncharacterized protein		MACFA		260	UniRef90_Q8N8Q3-4
Uncharacterized protein		MACMU		260
Endonuclease V		HUMAN		236
Endonuclease V		GORGO		65
UPI0007DBDFA4		PANTR		317
+12

Protein	Similar proteins		Species	Score	Length	Source
Q8N8Q3	Endonuclease V	)	MOUSE		338	UniRef50_Q8N8Q3
Uncharacterized protein		HUMAN		88
Uncharacterized protein		PONAB		309
Endonuclease V		GORGO		309
Uncharacterized protein		PANPA		309
+137
Q8N8Q3-2	Uncharacterized protein		COLAP		285	UniRef50_Q8N8Q3-2
ENDOV isoform 4		PANTR		237
ENDOV isoform 4		PONAB		237
endonuclease V isoform X9		PHYCD		261
endonuclease V isoform X5		DELLE		325
+14
Q8N8Q3-3	ENDOV isoform 9		PONAB		264	UniRef50_Q8N8Q3-3
ENDOV isoform 8		PANTR		264
Uncharacterized protein		NOMLE		264
Uncharacterized protein		PANPA		264
Endonuclease V		GORGO		264
+28
Q8N8Q3-4	Uncharacterized protein		MACFA		260	UniRef50_Q8N8Q3-4
Uncharacterized protein		MACMU		260
Endonuclease V		HUMAN		236
Endonuclease V		GORGO		65
ENDOV isoform 1		PONAB		384
+17

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK092539 mRNA Translation: BAC03912.1 AK096344 mRNA Translation: BAC04765.1 AK096802 mRNA No translation available. DQ500957 Genomic DNA Translation: ABF47100.1 AC120024 Genomic DNA No translation available. CH471099 Genomic DNA Translation: EAW89607.1 CH471099 Genomic DNA Translation: EAW89605.1 CH471099 Genomic DNA Translation: EAW89615.1 BC037889 mRNA Translation: AAH37889.1 BC045824 mRNA Translation: AAH45824.1 BC064545 mRNA Translation: AAH64545.1
CCDSⁱ	CCDS54172.1 [Q8N8Q3-1] CCDS54173.1 [Q8N8Q3-2] CCDS54174.1 [Q8N8Q3-3]
RefSeqⁱ	NP_001158109.1, NM_001164637.2 [Q8N8Q3-2] NP_001158110.1, NM_001164638.1 [Q8N8Q3-3] NP_775898.2, NM_173627.4 [Q8N8Q3-1]
UniGeneⁱ	Hs.389678 Hs.728933

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4NSP	X-ray	2.30	A	13-250	[»]
ProteinModelPortalⁱ	Q8N8Q3
SMRⁱ	Q8N8Q3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	129772, 11 interactors
IntActⁱ	Q8N8Q3, 2 interactors
STRINGⁱ	9606.ENSP00000429190

PTM databases

iPTMnetⁱ	Q8N8Q3
PhosphoSitePlusⁱ	Q8N8Q3

Polymorphism and mutation databases

BioMutaⁱ	ENDOV
DMDMⁱ	74729504

Proteomic databases

MaxQBⁱ	Q8N8Q3
PaxDbⁱ	Q8N8Q3
PeptideAtlasⁱ	Q8N8Q3
PRIDEⁱ	Q8N8Q3
ProteomicsDBⁱ	72445 72446 [Q8N8Q3-2] 72447 [Q8N8Q3-3] 72448 [Q8N8Q3-4]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	284131
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000323854; ENSP00000317810; ENSG00000173818 [Q8N8Q3-3] ENST00000517795; ENSP00000461577; ENSG00000173818 [Q8N8Q3-5] ENST00000518137; ENSP00000429190; ENSG00000173818 [Q8N8Q3-1] ENST00000518901; ENSP00000460685; ENSG00000173818 [Q8N8Q3-5] ENST00000518907; ENSP00000458361; ENSG00000173818 [Q8N8Q3-4] ENST00000520284; ENSP00000458391; ENSG00000173818 [Q8N8Q3-4] ENST00000520367; ENSP00000431036; ENSG00000173818 [Q8N8Q3-2]
GeneIDⁱ	284131
KEGGⁱ	hsa:284131
UCSCⁱ	uc002jyk.4 human [Q8N8Q3-1]

Organism-specific databases

CTDⁱ	284131
DisGeNETⁱ	284131
EuPathDBⁱ	HostDB:ENSG00000173818.16
GeneCardsⁱ	ENDOV
HGNCⁱ	HGNC:26640 ENDOV
neXtProtⁱ	NX_Q8N8Q3
OpenTargetsⁱ	ENSG00000173818
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4417 Eukaryota COG1515 LUCA
GeneTreeⁱ	ENSGT00390000011880
HOVERGENⁱ	HBG062398
InParanoidⁱ	Q8N8Q3
KOⁱ	K21813
OMAⁱ	CKYRVPE
OrthoDBⁱ	EOG091G0LHO
PhylomeDBⁱ	Q8N8Q3
TreeFamⁱ	TF300065

Miscellaneous databases

GenomeRNAiⁱ	284131
Protein Ontology More...PROⁱ	PR:Q8N8Q3

Gene expression databases

Bgeeⁱ	ENSG00000173818 Expressed in 177 organ(s), highest expression level in quadriceps femoris
ExpressionAtlasⁱ	Q8N8Q3 baseline and differential
Genevisibleⁱ	Q8N8Q3 HS

Family and domain databases

CDDⁱ	cd06559 Endonuclease_V, 1 hit
HAMAPⁱ	MF_00801 Endonuclease_5, 1 hit
InterProⁱ	View protein in InterPro IPR007581 Endonuclease-V
PANTHERⁱ	PTHR28511 PTHR28511, 1 hit
Pfamⁱ	View protein in Pfam PF04493 Endonuclease_5, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ENDOV_HUMAN
Accessionⁱ	Q8N8Q3Primary (citable) accession number: Q8N8Q3 Secondary accession number(s): I3L3S4 , Q6P2G2, Q86X99, Q8NAK0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
	Last sequence update:	October 1, 2002
	Last modified:	September 12, 2018
	This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM

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UniProtKB - Q8N8Q3 (ENDOV_HUMAN)

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Endonuclease V

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Sites

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ