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UniProtKB - Q8N8Q3 (ENDOV_HUMAN)

Entry version 127 (02 Dec 2020)
Sequence version 1 (01 Oct 2002)
Previous versions | rss
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Protein

Endonuclease V

Gene

ENDOV

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine (PubMed:23912683, PubMed:23912718, PubMed:27573237, PubMed:31703097, PubMed:25195743). Active against both single-stranded and double-stranded RNAs (PubMed:31703097, PubMed:25195743). Has strong preference for single-stranded RNAs (ssRNAs) toward double-stranded RNAs (dsRNAs) (PubMed:23912718). Cleaves mRNAs and tRNAs containing inosine (PubMed:23912683, PubMed:31703097). Also able to cleave structure-specific dsRNA substrates containing the specific sites 5'-IIUI-3' and 5'-UIUU-3' (PubMed:23912718, PubMed:27573237). Inosine is present in a number of RNAs following editing; the function of inosine-specific endoribonuclease is still unclear: it could either play a regulatory role in edited RNAs, or be involved in antiviral response by removing the hyperedited long viral dsRNA genome that has undergone A-to-I editing (Probable). Binds branched DNA structures (PubMed:23139746).Curated6 Publications
Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine (PubMed:31703097). Active against both single-stranded and double-stranded RNAs (PubMed:31703097). Cleaves tRNAs containing inosine (PubMed:31703097).1 Publication
Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine (PubMed:31703097). Active against both single-stranded and double-stranded RNAs (PubMed:31703097). Cleaves tRNAs containing inosine (PubMed:31703097).1 Publication

Caution

Was initially characterized as an endodeoxyribonuclease involved in DNA repair (PubMed:22664237). While it shows some weak endodeoxyribonuclease activity in vitro, such activity probably does not exist in vivo.1 Publication

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by normal intracellular concentrations of ATP.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi52MagnesiumCurated1
Metal bindingi126MagnesiumBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Endonuclease, Hydrolase, Nuclease, RNA-binding
LigandMagnesium, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8N8Q3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Endonuclease V (EC:3.1.26.-5 Publications)
Short name:
hEndoV
Alternative name(s):
Inosine-specific endoribonuclease
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ENDOV
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000173818.16

Human Gene Nomenclature Database

More...HGNCi		HGNC:26640, ENDOV

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8N8Q3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi35 – 40Missing : Does not gain activity against single- or double-stranded DNA. 1 Publication6
Mutagenesisi52D → A: Abolishes ribonuclease activity. 3 Publications1
Mutagenesisi57 – 60KGDS → QGGE: Does not gain activity against single- or double-stranded DNA. 1 Publication4
Mutagenesisi90 – 93PYVS → GGGG: Abolishes ability to bind branched DNA and RNA. 1 Publication4
Mutagenesisi91Y → A: Abolishes ribonuclease activity without affecting ability to bind branched DNA. 2 Publications1
Mutagenesisi100E → A: Abolishes ribonuclease activity. 1 Publication1
Mutagenesisi115 – 119Missing : Does not gain activity against single- or double-stranded DNA. 1 Publication5
Mutagenesisi161 – 166Missing : Does not gain activity against single- or double-stranded DNA. 1 Publication6
Mutagenesisi171E → A: No effect on subcellular location or activity; when associated with A-174. 1 Publication1
Mutagenesisi174R → A: No effect on subcellular location or activity; when associated with A-171. 1 Publication1
Mutagenesisi225C → S: No significant effect on activity. 1 Publication1
Mutagenesisi226C → S: No significant effect on activity. 1 Publication1
Mutagenesisi227C → S: 68% decrease in activity. 1 Publication1
Mutagenesisi228C → S: 46% decrease in activity. 1 Publication1
Mutagenesisi248 – 249RK → AA: Abolishes ability to bind branched DNA and RNA. 1 Publication2

Organism-specific databases

DisGeNET

More...DisGeNETi		284131

Open Targets

More...OpenTargetsi		ENSG00000173818

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8N8Q3, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ENDOV

Domain mapping of disease mutations (DMDM)

More...DMDMi		74729504

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003492231 – 282Endonuclease VAdd BLAST282

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8N8Q3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8N8Q3

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8N8Q3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8N8Q3

PeptideAtlas

More...PeptideAtlasi		Q8N8Q3

PRoteomics IDEntifications database

More...PRIDEi		Q8N8Q3

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		47312
72445 [Q8N8Q3-1]
72446 [Q8N8Q3-2]
72447 [Q8N8Q3-3]
72448 [Q8N8Q3-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8N8Q3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8N8Q3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000173818, Expressed in quadriceps femoris and 192 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8N8Q3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8N8Q3, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000173818, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer (PubMed:25195743).

Interacts with PABPC1; the interaction is RNA-dependent and stimulates ENDOV activity (PubMed:27573237).

2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei91Interaction with target RNACurated1

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		129772, 12 interactors

Protein interaction database and analysis system

More...IntActi		Q8N8Q3, 9 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000429190

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8N8Q3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1282
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8N8Q3

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi225 – 228Poly-Cys4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the endonuclease V family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4417, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000011880

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_047631_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8N8Q3

Identification of Orthologs from Complete Genome Data

More...OMAi		GIATHIG

Database of Orthologous Groups

More...OrthoDBi		1416056at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8N8Q3

TreeFam database of animal gene trees

More...TreeFami		TF300065

Family and domain databases

Conserved Domains Database

More...CDDi		cd06559, Endonuclease_V, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_00801, Endonuclease_5, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007581, Endonuclease-V

The PANTHER Classification System

More...PANTHERi		PTHR28511, PTHR28511, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04493, Endonuclease_5, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 14 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N8Q3-1) [UniParc]FASTAAdd to basket
Also known as: hENDOV 2821 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALEAAGGPP EETLSLWKRE QARLKAHVVD RDTEAWQRDP AFSGLQRVGG 
        60         70         80         90        100
VDVSFVKGDS VRACASLVVL SFPELEVVYE ESRMVSLTAP YVSGFLAFRE 
       110        120        130        140        150
VPFLLELVQQ LREKEPGLMP QVLLVDGNGV LHHRGFGVAC HLGVLTDLPC 
       160        170        180        190        200
VGVAKKLLQV DGLENNALHK EKIRLLQTRG DSFPLLGDSG TVLGMALRSH 
       210        220        230        240        250
DRSTRPLYIS VGHRMSLEAA VRLTCCCCRF RIPEPVRQAD ICSREHIRKS 
       260        270        280 
LGLPGPPTPR SPKAQRPVAC PKGDSGESSA LC
Length:282
Mass (Da):30,792
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEDB10210FB508A51
GO
Isoform 2 (identifier: Q8N8Q3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     77-121: Missing.

Show »
Length:237
Mass (Da):25,612
Checksum:iA89BC40B3E5E0D22
GO
Isoform 3 (identifier: Q8N8Q3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     77-121: Missing.
     280-282: ALC → GEGQPPQDHSPGPRTAPRPGSQEQAGKDWQ

Show »
Length:264
Mass (Da):28,503
Checksum:iEA8145ACC6AB8CF9
GO
Isoform 4 (identifier: Q8N8Q3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-194: Missing.
     239-282: ADICSREHIRKSLGLPGPPTPRSPKAQRPVACPKGDSGESSALC → HFVERGGESTRPRLIPDRTRW

Show »
Length:65
Mass (Da):7,665
Checksum:iE75AB2F40226FC4E
GO
Isoform 5 (identifier: Q8N8Q3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-194: Missing.

Show »
Length:88
Mass (Da):9,670
Checksum:i77BE0951D5518E2F
GO
Isoform 6 (identifier: Q8N8Q3-6) [UniParc]FASTAAdd to basket
Also known as: hENDOV 3081 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     280-282: ALC → GGAPSPQRQADRTTPGGRRSTAQHQVGQR

Show »
Length:308
Mass (Da):33,545
Checksum:i2566DF0EABB56FD6
GO
Isoform 7 (identifier: Q8N8Q3-7) [UniParc]FASTAAdd to basket
Also known as: hENDOV 3091 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     280-282: ALC → GEGQPPQDHSPGPRTAPRPGSQEQAGKDWQ

Show »
Length:309
Mass (Da):33,683
Checksum:i537BA71CD9874245
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YAY5H0YAY5_HUMAN
Endonuclease V
ENDOV
236Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBX8H0YBX8_HUMAN
Endonuclease V
ENDOV
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBZ5H0YBZ5_HUMAN
Endonuclease V
ENDOV
170Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L0L4I3L0L4_HUMAN
Endonuclease V
ENDOV
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L4V7I3L4V7_HUMAN
Endonuclease V
ENDOV
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RFW0E5RFW0_HUMAN
Endonuclease V
ENDOV
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L485I3L485_HUMAN
Endonuclease V
ENDOV
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RII5E5RII5_HUMAN
Endonuclease V
ENDOV
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RJ92E5RJ92_HUMAN
Endonuclease V
ENDOV
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RHX4E5RHX4_HUMAN
Endonuclease V
ENDOV
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti19R → W in BAC03912 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04628529V → I1 PublicationCorresponds to variant dbSNP:rs35549084Ensembl.1
Natural variantiVAR_046286112R → Q1 PublicationCorresponds to variant dbSNP:rs34933300Ensembl.1
Natural variantiVAR_046287114K → R1 PublicationCorresponds to variant dbSNP:rs41298706Ensembl.1
Natural variantiVAR_046288141H → Y1 PublicationCorresponds to variant dbSNP:rs41299812EnsemblClinVar.1
Natural variantiVAR_046289201D → N1 PublicationCorresponds to variant dbSNP:rs35929621Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0352281 – 194Missing in isoform 4 and isoform 5. 2 PublicationsAdd BLAST194
Alternative sequenceiVSP_03522977 – 121Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST45
Alternative sequenceiVSP_035230239 – 282ADICS…SSALC → HFVERGGESTRPRLIPDRTR W in isoform 4. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_035231280 – 282ALC → GEGQPPQDHSPGPRTAPRPG SQEQAGKDWQ in isoform 3 and isoform 7. 1 Publication3
Alternative sequenceiVSP_060583280 – 282ALC → GGAPSPQRQADRTTPGGRRS TAQHQVGQR in isoform 6. 3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK092539 mRNA Translation: BAC03912.1
AK096344 mRNA Translation: BAC04765.1
AK096802 mRNA No translation available.
DQ500957 Genomic DNA Translation: ABF47100.1
AC120024 Genomic DNA No translation available.
CH471099 Genomic DNA Translation: EAW89607.1
CH471099 Genomic DNA Translation: EAW89605.1
CH471099 Genomic DNA Translation: EAW89615.1
BC037889 mRNA Translation: AAH37889.1
BC045824 mRNA Translation: AAH45824.1
BC064545 mRNA Translation: AAH64545.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS54172.1 [Q8N8Q3-1]
CCDS54173.1 [Q8N8Q3-2]
CCDS54174.1 [Q8N8Q3-3]

NCBI Reference Sequences

More...RefSeqi		NP_001158109.1, NM_001164637.2 [Q8N8Q3-2]
NP_001158110.1, NM_001164638.1 [Q8N8Q3-3]
NP_775898.2, NM_173627.4 [Q8N8Q3-1]
XP_005257301.1, XM_005257244.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000323854; ENSP00000317810; ENSG00000173818 [Q8N8Q3-3]
ENST00000517795; ENSP00000461577; ENSG00000173818 [Q8N8Q3-5]
ENST00000518137; ENSP00000429190; ENSG00000173818 [Q8N8Q3-1]
ENST00000518901; ENSP00000460685; ENSG00000173818 [Q8N8Q3-5]
ENST00000518907; ENSP00000458361; ENSG00000173818 [Q8N8Q3-4]
ENST00000520284; ENSP00000458391; ENSG00000173818 [Q8N8Q3-4]
ENST00000520367; ENSP00000431036; ENSG00000173818 [Q8N8Q3-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		284131

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:284131

UCSC genome browser

More...UCSCi		uc002jyk.4, human [Q8N8Q3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092539 mRNA Translation: BAC03912.1
AK096344 mRNA Translation: BAC04765.1
AK096802 mRNA No translation available.
DQ500957 Genomic DNA Translation: ABF47100.1
AC120024 Genomic DNA No translation available.
CH471099 Genomic DNA Translation: EAW89607.1
CH471099 Genomic DNA Translation: EAW89605.1
CH471099 Genomic DNA Translation: EAW89615.1
BC037889 mRNA Translation: AAH37889.1
BC045824 mRNA Translation: AAH45824.1
BC064545 mRNA Translation: AAH64545.1
CCDSiCCDS54172.1 [Q8N8Q3-1]
CCDS54173.1 [Q8N8Q3-2]
CCDS54174.1 [Q8N8Q3-3]
RefSeqiNP_001158109.1, NM_001164637.2 [Q8N8Q3-2]
NP_001158110.1, NM_001164638.1 [Q8N8Q3-3]
NP_775898.2, NM_173627.4 [Q8N8Q3-1]
XP_005257301.1, XM_005257244.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4NSPX-ray2.30A13-250[»]
6OZEX-ray1.50A9-254[»]
SMRiQ8N8Q3
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi129772, 12 interactors
IntActiQ8N8Q3, 9 interactors
STRINGi9606.ENSP00000429190

PTM databases

iPTMnetiQ8N8Q3
PhosphoSitePlusiQ8N8Q3

Polymorphism and mutation databases

BioMutaiENDOV
DMDMi74729504

Proteomic databases

jPOSTiQ8N8Q3
MassIVEiQ8N8Q3
MaxQBiQ8N8Q3
PaxDbiQ8N8Q3
PeptideAtlasiQ8N8Q3
PRIDEiQ8N8Q3
ProteomicsDBi47312
72445 [Q8N8Q3-1]
72446 [Q8N8Q3-2]
72447 [Q8N8Q3-3]
72448 [Q8N8Q3-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		32763, 28 antibodies

The DNASU plasmid repository

More...DNASUi		284131

Genome annotation databases

EnsembliENST00000323854; ENSP00000317810; ENSG00000173818 [Q8N8Q3-3]
ENST00000517795; ENSP00000461577; ENSG00000173818 [Q8N8Q3-5]
ENST00000518137; ENSP00000429190; ENSG00000173818 [Q8N8Q3-1]
ENST00000518901; ENSP00000460685; ENSG00000173818 [Q8N8Q3-5]
ENST00000518907; ENSP00000458361; ENSG00000173818 [Q8N8Q3-4]
ENST00000520284; ENSP00000458391; ENSG00000173818 [Q8N8Q3-4]
ENST00000520367; ENSP00000431036; ENSG00000173818 [Q8N8Q3-2]
GeneIDi284131
KEGGihsa:284131
UCSCiuc002jyk.4, human [Q8N8Q3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		284131
DisGeNETi284131
EuPathDBiHostDB:ENSG00000173818.16

GeneCards: human genes, protein and diseases

More...GeneCardsi		ENDOV
HGNCiHGNC:26640, ENDOV
HPAiENSG00000173818, Low tissue specificity
neXtProtiNX_Q8N8Q3
OpenTargetsiENSG00000173818

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4417, Eukaryota
GeneTreeiENSGT00390000011880
HOGENOMiCLU_047631_0_1_1
InParanoidiQ8N8Q3
OMAiGIATHIG
OrthoDBi1416056at2759
PhylomeDBiQ8N8Q3
TreeFamiTF300065

Enzyme and pathway databases

PathwayCommonsiQ8N8Q3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		284131, 3 hits in 842 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		284131
PharosiQ8N8Q3, Tbio

Protein Ontology

More...PROi		PR:Q8N8Q3
RNActiQ8N8Q3, protein

Gene expression databases

BgeeiENSG00000173818, Expressed in quadriceps femoris and 192 other tissues
ExpressionAtlasiQ8N8Q3, baseline and differential
GenevisibleiQ8N8Q3, HS

Family and domain databases

CDDicd06559, Endonuclease_V, 1 hit
HAMAPiMF_00801, Endonuclease_5, 1 hit
InterProiView protein in InterPro
IPR007581, Endonuclease-V
PANTHERiPTHR28511, PTHR28511, 1 hit
PfamiView protein in Pfam
PF04493, Endonuclease_5, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiENDOV_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N8Q3
Secondary accession number(s): I3L3S4
, Q6P2G2, Q86X99, Q8NAK0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: October 1, 2002
Last modified: December 2, 2020
This is version 127 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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