UniProtKB - Q8N8Q1 (C56D1_HUMAN)
Protein
Cytochrome b561 domain-containing protein 1
Gene
CYB561D1
Organism
Homo sapiens (Human)
Status
Functioni
Cofactori
hemeBy similarityNote: Binds 2 heme groups non-covalently.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 55 | Iron (heme axial ligand)PROSITE-ProRule annotation | 1 | |
Metal bindingi | 93 | Iron (heme axial ligand)PROSITE-ProRule annotation | 1 | |
Metal bindingi | 127 | Iron (heme axial ligand)PROSITE-ProRule annotation | 1 | |
Metal bindingi | 166 | Iron (heme axial ligand)PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- heme binding Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- oxidoreductase activity Source: GO_Central
Keywordsi
Biological process | Electron transport, Transport |
Ligand | Heme, Iron, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | Q8N8Q1 |
Names & Taxonomyi
Protein namesi | Recommended name: Cytochrome b561 domain-containing protein 1 |
Gene namesi | Name:CYB561D1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26804, CYB561D1 |
neXtProti | NX_Q8N8Q1 |
VEuPathDBi | HostDB:ENSG00000174151.14 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 24 | CytoplasmicSequence analysisAdd BLAST | 24 | |
Transmembranei | 25 – 45 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 54 – 74 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 92 – 112 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 129 – 149 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 170 – 190 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 194 – 214 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 215 – 229 | CytoplasmicSequence analysisAdd BLAST | 15 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 284613 |
OpenTargetsi | ENSG00000174151 |
PharmGKBi | PA134872038 |
Miscellaneous databases
Pharosi | Q8N8Q1, Tdark |
Genetic variation databases
BioMutai | CYB561D1 |
DMDMi | 67462193 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000151034 | 1 – 229 | Cytochrome b561 domain-containing protein 1Add BLAST | 229 |
Proteomic databases
jPOSTi | Q8N8Q1 |
MassIVEi | Q8N8Q1 |
MaxQBi | Q8N8Q1 |
PeptideAtlasi | Q8N8Q1 |
PRIDEi | Q8N8Q1 |
ProteomicsDBi | 19474 64575 72442 [Q8N8Q1-1] 72443 [Q8N8Q1-2] 72444 [Q8N8Q1-3] |
TopDownProteomicsi | Q8N8Q1-1 [Q8N8Q1-1] |
PTM databases
iPTMneti | Q8N8Q1 |
PhosphoSitePlusi | Q8N8Q1 |
Expressioni
Gene expression databases
Bgeei | ENSG00000174151, Expressed in upper arm skin and 167 other tissues |
ExpressionAtlasi | Q8N8Q1, baseline and differential |
Genevisiblei | Q8N8Q1, HS |
Organism-specific databases
HPAi | ENSG00000174151, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ8N8Q1
With | #Exp. | IntAct |
---|---|---|
AQP6 [Q13520] | 3 | EBI-12873482,EBI-13059134 |
GAD2 [Q05329] | 3 | EBI-12873482,EBI-9304251 |
TMED8 [Q6PL24] | 3 | EBI-12873482,EBI-11603430 |
Protein-protein interaction databases
BioGRIDi | 129916, 3 interactors |
IntActi | Q8N8Q1, 3 interactors |
Miscellaneous databases
RNActi | Q8N8Q1, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 22 – 224 | Cytochrome b561PROSITE-ProRule annotationAdd BLAST | 203 |
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
GeneTreei | ENSGT00440000038072 |
HOGENOMi | CLU_072399_3_1_1 |
InParanoidi | Q8N8Q1 |
OMAi | LYHATCG |
PhylomeDBi | Q8N8Q1 |
TreeFami | TF323584 |
Family and domain databases
InterProi | View protein in InterPro IPR006593, Cyt_b561/ferric_Rdtase_TM |
Pfami | View protein in Pfam PF03188, Cytochrom_B561, 1 hit |
SMARTi | View protein in SMART SM00665, B561, 1 hit |
PROSITEi | View protein in PROSITE PS50939, CYTOCHROME_B561, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8N8Q1-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MQPLEVGLVP APAGEPRLTR WLRRGSGILA HLVALGFTIF LTALSRPGTS
60 70 80 90 100
LFSWHPVFMA LAFCLCMAEA ILLFSPEHSL FFFCSRKARI RLHWAGQTLA
110 120 130 140 150
ILCAALGLGF IISSRTRSEL PHLVSWHSWV GALTLLATAV QALCGLCLLC
160 170 180 190 200
PRAARVSRVA RLKLYHLTCG LVVYLMATVT VLLGMYSVWF QAQIKGAAWY
210 220
LCLALPVYPA LVIMHQISRS YLPRKKMEM
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PIJ2 | E9PIJ2_HUMAN | Cytochrome b561 domain-containing p... | CYB561D1 | 64 | Annotation score: | ||
E9PQU0 | E9PQU0_HUMAN | Cytochrome b561 domain-containing p... | CYB561D1 | 231 | Annotation score: | ||
E9PM70 | E9PM70_HUMAN | Cytochrome b561 domain-containing p... | CYB561D1 | 55 | Annotation score: | ||
E9PIK3 | E9PIK3_HUMAN | Cytochrome b561 domain-containing p... | CYB561D1 | 54 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_046985 | 6 – 62 | Missing in isoform 5. CuratedAdd BLAST | 57 | |
Alternative sequenceiVSP_046986 | 50 – 229 | SLFSW…KKMEM → KTGPLMEDRSEGGRARWVMP EIPALWEADAGGSLEVFSPG TLYSWPWRMYESTSFFSGLQ ARHEAYWLSPMFTVLPLHG in isoform 4. CuratedAdd BLAST | 180 | |
Alternative sequenceiVSP_038649 | 50 – 133 | SLFSW…WVGAL → KTGPLMEDRSEGGRARWVMP EIPALWEADAGGSLEVFSPG TLYSWPWRSASAWLKPSYSS HLNTPCSSSAPEKHGSGSTG QGRP in isoform 2. 1 PublicationAdd BLAST | 84 | |
Alternative sequenceiVSP_041162 | 50 – 62 | SLFSW…FMALA → KTGPLMEDRSEGGRARWVMP EIPALWEADAGGSLE in isoform 3. 1 PublicationAdd BLAST | 13 | |
Alternative sequenceiVSP_038650 | 134 – 229 | Missing in isoform 2. 1 PublicationAdd BLAST | 96 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK096354 mRNA Translation: BAC04767.1 AK294992 mRNA Translation: BAG58058.1 DA092655 mRNA No translation available. AL355145 Genomic DNA No translation available. BC093683 mRNA Translation: AAH93683.1 BC111999 mRNA Translation: AAI12000.1 |
CCDSi | CCDS44188.1 [Q8N8Q1-3] CCDS44189.1 [Q8N8Q1-5] CCDS44190.1 [Q8N8Q1-2] CCDS44191.1 [Q8N8Q1-4] CCDS800.1 [Q8N8Q1-1] |
RefSeqi | NP_001127872.1, NM_001134400.1 [Q8N8Q1-3] NP_001127874.1, NM_001134402.1 [Q8N8Q1-5] NP_872386.1, NM_182580.2 [Q8N8Q1-1] |
Genome annotation databases
Ensembli | ENST00000310611; ENSP00000309324; ENSG00000174151 [Q8N8Q1-2] ENST00000369868; ENSP00000358884; ENSG00000174151 [Q8N8Q1-3] ENST00000393709; ENSP00000377312; ENSG00000174151 [Q8N8Q1-5] ENST00000420578; ENSP00000413530; ENSG00000174151 [Q8N8Q1-1] ENST00000430195; ENSP00000416898; ENSG00000174151 [Q8N8Q1-4] |
GeneIDi | 284613 |
KEGGi | hsa:284613 |
UCSCi | uc001dxu.4, human [Q8N8Q1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK096354 mRNA Translation: BAC04767.1 AK294992 mRNA Translation: BAG58058.1 DA092655 mRNA No translation available. AL355145 Genomic DNA No translation available. BC093683 mRNA Translation: AAH93683.1 BC111999 mRNA Translation: AAI12000.1 |
CCDSi | CCDS44188.1 [Q8N8Q1-3] CCDS44189.1 [Q8N8Q1-5] CCDS44190.1 [Q8N8Q1-2] CCDS44191.1 [Q8N8Q1-4] CCDS800.1 [Q8N8Q1-1] |
RefSeqi | NP_001127872.1, NM_001134400.1 [Q8N8Q1-3] NP_001127874.1, NM_001134402.1 [Q8N8Q1-5] NP_872386.1, NM_182580.2 [Q8N8Q1-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 129916, 3 interactors |
IntActi | Q8N8Q1, 3 interactors |
PTM databases
iPTMneti | Q8N8Q1 |
PhosphoSitePlusi | Q8N8Q1 |
Genetic variation databases
BioMutai | CYB561D1 |
DMDMi | 67462193 |
Proteomic databases
jPOSTi | Q8N8Q1 |
MassIVEi | Q8N8Q1 |
MaxQBi | Q8N8Q1 |
PeptideAtlasi | Q8N8Q1 |
PRIDEi | Q8N8Q1 |
ProteomicsDBi | 19474 64575 72442 [Q8N8Q1-1] 72443 [Q8N8Q1-2] 72444 [Q8N8Q1-3] |
TopDownProteomicsi | Q8N8Q1-1 [Q8N8Q1-1] |
Protocols and materials databases
Antibodypediai | 20066, 112 antibodies |
Genome annotation databases
Ensembli | ENST00000310611; ENSP00000309324; ENSG00000174151 [Q8N8Q1-2] ENST00000369868; ENSP00000358884; ENSG00000174151 [Q8N8Q1-3] ENST00000393709; ENSP00000377312; ENSG00000174151 [Q8N8Q1-5] ENST00000420578; ENSP00000413530; ENSG00000174151 [Q8N8Q1-1] ENST00000430195; ENSP00000416898; ENSG00000174151 [Q8N8Q1-4] |
GeneIDi | 284613 |
KEGGi | hsa:284613 |
UCSCi | uc001dxu.4, human [Q8N8Q1-1] |
Organism-specific databases
CTDi | 284613 |
DisGeNETi | 284613 |
GeneCardsi | CYB561D1 |
HGNCi | HGNC:26804, CYB561D1 |
HPAi | ENSG00000174151, Low tissue specificity |
neXtProti | NX_Q8N8Q1 |
OpenTargetsi | ENSG00000174151 |
PharmGKBi | PA134872038 |
VEuPathDBi | HostDB:ENSG00000174151.14 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00440000038072 |
HOGENOMi | CLU_072399_3_1_1 |
InParanoidi | Q8N8Q1 |
OMAi | LYHATCG |
PhylomeDBi | Q8N8Q1 |
TreeFami | TF323584 |
Enzyme and pathway databases
PathwayCommonsi | Q8N8Q1 |
Miscellaneous databases
BioGRID-ORCSi | 284613, 11 hits in 993 CRISPR screens |
ChiTaRSi | CYB561D1, human |
GenomeRNAii | 284613 |
Pharosi | Q8N8Q1, Tdark |
PROi | PR:Q8N8Q1 |
RNActi | Q8N8Q1, protein |
Gene expression databases
Bgeei | ENSG00000174151, Expressed in upper arm skin and 167 other tissues |
ExpressionAtlasi | Q8N8Q1, baseline and differential |
Genevisiblei | Q8N8Q1, HS |
Family and domain databases
InterProi | View protein in InterPro IPR006593, Cyt_b561/ferric_Rdtase_TM |
Pfami | View protein in Pfam PF03188, Cytochrom_B561, 1 hit |
SMARTi | View protein in SMART SM00665, B561, 1 hit |
PROSITEi | View protein in PROSITE PS50939, CYTOCHROME_B561, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | C56D1_HUMAN | |
Accessioni | Q8N8Q1Primary (citable) accession number: Q8N8Q1 Secondary accession number(s): B4DH97 Q5T6C3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2005 |
Last sequence update: | October 1, 2002 | |
Last modified: | April 7, 2021 | |
This is version 135 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM