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Entry version 147 (13 Feb 2019)
Sequence version 1 (01 Oct 2002)
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Protein

Prostaglandin reductase 2

Gene

PTGR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation (By similarity).By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=11.21 µM for 15-keto-PGE21 Publication
  2. KM=15.87 µM for NADPH1 Publication
  1. Vmax=159 nmol/min/mg enzyme for 15-keto-PGE21 Publication
  2. Vmax=67 nmol/min/mg enzyme for NADPH1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei192NADP1
Binding sitei208NADP1
Binding sitei231NADP1
Binding sitei337NADP1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi165 – 168NADP4
Nucleotide bindingi253 – 259NADP7
Nucleotide bindingi287 – 289NADP3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • 13-prostaglandin reductase activity Source: UniProtKB-EC
  • 15-oxoprostaglandin 13-oxidase activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
LigandNADP

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001640 [Q8N8N7-1]

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Prostaglandin reductase 2 (EC:1.3.1.48)
Short name:
PRG-2
Alternative name(s):
15-oxoprostaglandin 13-reductase
Zinc-binding alcohol dehydrogenase domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PTGR2
Synonyms:ZADH1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000140043.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20149 PTGR2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608642 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N8N7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi64Y → F: Increases affinity for 15-keto-PGE2. Reduces affinity for NADP and Vmax. 1 Publication1
Mutagenesisi259Y → F: Increases affinity for 15-keto-PGE2. Reduces affinity for NADP and Vmax. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
145482

Open Targets

More...
OpenTargetsi
ENSG00000140043

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162400323

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00328 Indomethacin

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PTGR2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
62901454

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002180701 – 351Prostaglandin reductase 2Add BLAST351

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8N8N7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8N8N7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N8N7

PeptideAtlas

More...
PeptideAtlasi
Q8N8N7

PRoteomics IDEntifications database

More...
PRIDEi
Q8N8N7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
72438
72439 [Q8N8N7-2]

2D gel databases

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00167515

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N8N7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N8N7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000140043 Expressed in 178 organ(s), highest expression level in muscle of leg

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8N8N7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N8N7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA001125

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
126915, 15 interactors

Protein interaction database and analysis system

More...
IntActi
Q8N8N7, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000267568

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1351
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VNAX-ray2.17A1-349[»]
2W4QX-ray2.00A1-349[»]
2W98X-ray1.85A/B1-349[»]
2ZB4X-ray1.63A1-351[»]
2ZB7X-ray1.80A1-351[»]
2ZB8X-ray2.00A1-351[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8N8N7

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8N8N7

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8N8N7

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni99 – 100Substrate binding2
Regioni288 – 290Substrate binding3

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1196 Eukaryota
COG2130 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156793

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000294663

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG055024

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N8N7

KEGG Orthology (KO)

More...
KOi
K13949

Identification of Orthologs from Complete Genome Data

More...
OMAi
SFNWPWQ

Database of Orthologous Groups

More...
OrthoDBi
884151at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N8N7

TreeFam database of animal gene trees

More...
TreeFami
TF324201

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08293 PTGR2, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013149 ADH_C
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR037399 PTGR2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00107 ADH_zinc_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N8N7-1) [UniParc]FASTAAdd to basket
Also known as: ZADH1b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIVQRVVLNS RPGKNGNPVA ENFRMEEVYL PDNINEGQVQ VRTLYLSVDP
60 70 80 90 100
YMRCRMNEDT GTDYITPWQL SQVVDGGGIG IIEESKHTNL TKGDFVTSFY
110 120 130 140 150
WPWQTKVILD GNSLEKVDPQ LVDGHLSYFL GAIGMPGLTS LIGIQEKGHI
160 170 180 190 200
TAGSNKTMVV SGAAGACGSV AGQIGHFLGC SRVVGICGTH EKCILLTSEL
210 220 230 240 250
GFDAAINYKK DNVAEQLRES CPAGVDVYFD NVGGNISDTV ISQMNENSHI
260 270 280 290 300
ILCGQISQYN KDVPYPPPLS PAIEAIQKER NITRERFLVL NYKDKFEPGI
310 320 330 340 350
LQLSQWFKEG KLKIKETVIN GLENMGAAFQ SMMTGGNIGK QIVCISEEIS

L
Length:351
Mass (Da):38,499
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i118ED6D2FB984F3A
GO
Isoform 2 (identifier: Q8N8N7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     174-180: IGHFLGC → VNFLRII
     181-351: Missing.

Note: No experimental confirmation available.
Show »
Length:180
Mass (Da):19,675
Checksum:iB2E6EB6A71991004
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V2R9G3V2R9_HUMAN
Prostaglandin reductase 2
PTGR2
217Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_013526174 – 180IGHFLGC → VNFLRII in isoform 2. 1 Publication7
Alternative sequenceiVSP_013527181 – 351Missing in isoform 2. 1 PublicationAdd BLAST171

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY346133 mRNA Translation: AAR05101.1
AY424308 mRNA Translation: AAR82927.1
AK096410 mRNA Translation: BAC04781.1
BX641118 mRNA Translation: CAE46055.1
CH471061 Genomic DNA Translation: EAW81132.1
BC059364 mRNA Translation: AAH59364.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9820.1 [Q8N8N7-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001139626.1, NM_001146154.1 [Q8N8N7-1]
NP_001139627.1, NM_001146155.1 [Q8N8N7-1]
NP_689657.1, NM_152444.2 [Q8N8N7-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.632344

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000267568; ENSP00000267568; ENSG00000140043 [Q8N8N7-1]
ENST00000555228; ENSP00000450975; ENSG00000140043 [Q8N8N7-1]
ENST00000555661; ENSP00000452280; ENSG00000140043 [Q8N8N7-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
145482

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:145482

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY346133 mRNA Translation: AAR05101.1
AY424308 mRNA Translation: AAR82927.1
AK096410 mRNA Translation: BAC04781.1
BX641118 mRNA Translation: CAE46055.1
CH471061 Genomic DNA Translation: EAW81132.1
BC059364 mRNA Translation: AAH59364.1
CCDSiCCDS9820.1 [Q8N8N7-1]
RefSeqiNP_001139626.1, NM_001146154.1 [Q8N8N7-1]
NP_001139627.1, NM_001146155.1 [Q8N8N7-1]
NP_689657.1, NM_152444.2 [Q8N8N7-1]
UniGeneiHs.632344

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VNAX-ray2.17A1-349[»]
2W4QX-ray2.00A1-349[»]
2W98X-ray1.85A/B1-349[»]
2ZB4X-ray1.63A1-351[»]
2ZB7X-ray1.80A1-351[»]
2ZB8X-ray2.00A1-351[»]
ProteinModelPortaliQ8N8N7
SMRiQ8N8N7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126915, 15 interactors
IntActiQ8N8N7, 1 interactor
STRINGi9606.ENSP00000267568

Chemistry databases

DrugBankiDB00328 Indomethacin
SwissLipidsiSLP:000001640 [Q8N8N7-1]

PTM databases

iPTMnetiQ8N8N7
PhosphoSitePlusiQ8N8N7

Polymorphism and mutation databases

BioMutaiPTGR2
DMDMi62901454

2D gel databases

REPRODUCTION-2DPAGEiIPI00167515

Proteomic databases

EPDiQ8N8N7
jPOSTiQ8N8N7
PaxDbiQ8N8N7
PeptideAtlasiQ8N8N7
PRIDEiQ8N8N7
ProteomicsDBi72438
72439 [Q8N8N7-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
145482
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267568; ENSP00000267568; ENSG00000140043 [Q8N8N7-1]
ENST00000555228; ENSP00000450975; ENSG00000140043 [Q8N8N7-1]
ENST00000555661; ENSP00000452280; ENSG00000140043 [Q8N8N7-1]
GeneIDi145482
KEGGihsa:145482

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
145482
DisGeNETi145482
EuPathDBiHostDB:ENSG00000140043.11

GeneCards: human genes, protein and diseases

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GeneCardsi
PTGR2
HGNCiHGNC:20149 PTGR2
HPAiHPA001125
MIMi608642 gene
neXtProtiNX_Q8N8N7
OpenTargetsiENSG00000140043
PharmGKBiPA162400323

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1196 Eukaryota
COG2130 LUCA
GeneTreeiENSGT00940000156793
HOGENOMiHOG000294663
HOVERGENiHBG055024
InParanoidiQ8N8N7
KOiK13949
OMAiSFNWPWQ
OrthoDBi884151at2759
PhylomeDBiQ8N8N7
TreeFamiTF324201

Enzyme and pathway databases

ReactomeiR-HSA-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PTGR2 human
EvolutionaryTraceiQ8N8N7

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
145482

Protein Ontology

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PROi
PR:Q8N8N7

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000140043 Expressed in 178 organ(s), highest expression level in muscle of leg
ExpressionAtlasiQ8N8N7 baseline and differential
GenevisibleiQ8N8N7 HS

Family and domain databases

CDDicd08293 PTGR2, 1 hit
InterProiView protein in InterPro
IPR013149 ADH_C
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR037399 PTGR2
PfamiView protein in Pfam
PF00107 ADH_zinc_N, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPTGR2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N8N7
Secondary accession number(s): Q3L8A4, Q6MZH8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: October 1, 2002
Last modified: February 13, 2019
This is version 147 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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