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Protein

E3 ubiquitin-protein ligase RNF152

Gene

RNF152

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability (PubMed:25936802). Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed (PubMed:21203937).2 Publications

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.1 Publication
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri12 – 55RING-typePROSITE-ProRule annotationAdd BLAST44

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • small GTPase binding Source: UniProtKB
  • ubiquitin protein ligase activity Source: UniProtKB
  • ubiquitin-protein transferase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processApoptosis, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins
UniPathwayi
UPA00143

Protein family/group databases

MoonDBiQ8N8N0 Predicted

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase RNF152Curated (EC:2.3.2.271 Publication)
Alternative name(s):
RING finger protein 152Imported
RING-type E3 ubiquitin transferase RNF152Curated
Gene namesi
Name:RNF152Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000176641.10
HGNCiHGNC:26811 RNF152
MIMi616512 gene
neXtProtiNX_Q8N8N0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000176641
PharmGKBiPA134984811

Polymorphism and mutation databases

BioMutaiRNF152
DMDMi41017760

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000561111 – 203E3 ubiquitin-protein ligase RNF152Add BLAST203

Post-translational modificationi

Ubiquitinated. Autoubiquitinated in vitro, leading to its degradation by the proteasome (Probable).1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ8N8N0
PeptideAtlasiQ8N8N0
PRIDEiQ8N8N0
ProteomicsDBi72437

PTM databases

iPTMnetiQ8N8N0
PhosphoSitePlusiQ8N8N0

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000176641 Expressed in 101 organ(s), highest expression level in cerebellar vermis
CleanExiHS_RNF152
ExpressionAtlasiQ8N8N0 baseline and differential
GenevisibleiQ8N8N0 HS

Interactioni

Subunit structurei

Interacts with RRAGA (inactive GDP-bound form); stimulated by amino acid starvation (PubMed:25936802). Interacts with SEC16A (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi128647, 5 interactors
IntActiQ8N8N0, 8 interactors
STRINGi9606.ENSP00000316628

Structurei

3D structure databases

ProteinModelPortaliQ8N8N0
SMRiQ8N8N0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni106 – 165Necessary for interaction with RRAGA1 PublicationAdd BLAST60

Sequence similaritiesi

Belongs to the RNF152 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri12 – 55RING-typePROSITE-ProRule annotationAdd BLAST44

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiENOG410ITF4 Eukaryota
ENOG4111BNB LUCA
GeneTreeiENSGT00730000111317
HOGENOMiHOG000120123
HOVERGENiHBG054053
InParanoidiQ8N8N0
KOiK15705
OMAiSQKDLRC
OrthoDBiEOG091G0KUF
PhylomeDBiQ8N8N0
TreeFamiTF331690

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR033609 RNF152
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR25464 PTHR25464, 3 hits
PfamiView protein in Pfam
PF14634 zf-RING_5, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS50089 ZF_RING_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8N8N0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METLSQDSLL ECQICFNYYS PRRRPKLLDC KHTCCSVCLQ QMRTSQKDVR
60 70 80 90 100
CPWCRGVTKL PPGFSVSQLP DDPEVLAVIA IPHTSEHTPV FIKLPSNGCY
110 120 130 140 150
MLPLPISKER ALLPGDMGCR LLPGSQQKSV TVVTIPAEQQ PLQGGAPQEA
160 170 180 190 200
VEEEQDRRGV VKSSTWSGVC TVILVACVLV FLLGIVLHNM SCISKRFTVI

SCG
Length:203
Mass (Da):22,357
Last modified:October 1, 2002 - v1
Checksum:i0DFA570D00744BFA
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EMG3K7EMG3_HUMAN
E3 ubiquitin-protein ligase RNF152
RNF152
114Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12C → S in BAG53711 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096495 mRNA Translation: BAC04805.1
AK122758 mRNA Translation: BAG53711.1
AC105094 Genomic DNA No translation available.
BC094004 mRNA Translation: AAH94004.1
BC111956 mRNA Translation: AAI11957.1
CCDSiCCDS11978.1
RefSeqiNP_775828.1, NM_173557.2
XP_005266707.1, XM_005266650.3
XP_005266709.1, XM_005266652.3
XP_011524180.1, XM_011525878.2
XP_011524181.1, XM_011525879.2
XP_016881101.1, XM_017025612.1
XP_016881102.1, XM_017025613.1
UniGeneiHs.165062
Hs.667457

Genome annotation databases

EnsembliENST00000312828; ENSP00000316628; ENSG00000176641
GeneIDi220441
KEGGihsa:220441
UCSCiuc002lih.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096495 mRNA Translation: BAC04805.1
AK122758 mRNA Translation: BAG53711.1
AC105094 Genomic DNA No translation available.
BC094004 mRNA Translation: AAH94004.1
BC111956 mRNA Translation: AAI11957.1
CCDSiCCDS11978.1
RefSeqiNP_775828.1, NM_173557.2
XP_005266707.1, XM_005266650.3
XP_005266709.1, XM_005266652.3
XP_011524180.1, XM_011525878.2
XP_011524181.1, XM_011525879.2
XP_016881101.1, XM_017025612.1
XP_016881102.1, XM_017025613.1
UniGeneiHs.165062
Hs.667457

3D structure databases

ProteinModelPortaliQ8N8N0
SMRiQ8N8N0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128647, 5 interactors
IntActiQ8N8N0, 8 interactors
STRINGi9606.ENSP00000316628

Protein family/group databases

MoonDBiQ8N8N0 Predicted

PTM databases

iPTMnetiQ8N8N0
PhosphoSitePlusiQ8N8N0

Polymorphism and mutation databases

BioMutaiRNF152
DMDMi41017760

Proteomic databases

PaxDbiQ8N8N0
PeptideAtlasiQ8N8N0
PRIDEiQ8N8N0
ProteomicsDBi72437

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312828; ENSP00000316628; ENSG00000176641
GeneIDi220441
KEGGihsa:220441
UCSCiuc002lih.2 human

Organism-specific databases

CTDi220441
EuPathDBiHostDB:ENSG00000176641.10
GeneCardsiRNF152
HGNCiHGNC:26811 RNF152
MIMi616512 gene
neXtProtiNX_Q8N8N0
OpenTargetsiENSG00000176641
PharmGKBiPA134984811
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITF4 Eukaryota
ENOG4111BNB LUCA
GeneTreeiENSGT00730000111317
HOGENOMiHOG000120123
HOVERGENiHBG054053
InParanoidiQ8N8N0
KOiK15705
OMAiSQKDLRC
OrthoDBiEOG091G0KUF
PhylomeDBiQ8N8N0
TreeFamiTF331690

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins

Miscellaneous databases

ChiTaRSiRNF152 human
GenomeRNAii220441
PROiPR:Q8N8N0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000176641 Expressed in 101 organ(s), highest expression level in cerebellar vermis
CleanExiHS_RNF152
ExpressionAtlasiQ8N8N0 baseline and differential
GenevisibleiQ8N8N0 HS

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR033609 RNF152
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR25464 PTHR25464, 3 hits
PfamiView protein in Pfam
PF14634 zf-RING_5, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS50089 ZF_RING_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRN152_HUMAN
AccessioniPrimary (citable) accession number: Q8N8N0
Secondary accession number(s): B3KV99, Q52LA4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
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