UniProtKB - Q8N8L2 (ZN491_HUMAN)
Protein
Zinc finger protein 491
Gene
ZNF491
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 35 – 59 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 103 – 125 | C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 131 – 153 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 159 – 181 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 187 – 209 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 215 – 237 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 243 – 265 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 271 – 293 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 299 – 321 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 327 – 349 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 355 – 377 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 383 – 405 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 411 – 433 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- negative regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q8N8L2 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 491 |
Gene namesi | Name:ZNF491 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23706, ZNF491 |
neXtProti | NX_Q8N8L2 |
VEuPathDBi | HostDB:ENSG00000177599.12 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nuclear chromatin Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 126069 |
OpenTargetsi | ENSG00000177599 |
PharmGKBi | PA134982286 |
Miscellaneous databases
Pharosi | Q8N8L2, Tdark |
Genetic variation databases
BioMutai | ZNF491 |
DMDMi | 51316965 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047614 | 1 – 437 | Zinc finger protein 491Add BLAST | 437 |
Proteomic databases
jPOSTi | Q8N8L2 |
MassIVEi | Q8N8L2 |
MaxQBi | Q8N8L2 |
PaxDbi | Q8N8L2 |
PeptideAtlasi | Q8N8L2 |
PRIDEi | Q8N8L2 |
ProteomicsDBi | 72434 |
PTM databases
iPTMneti | Q8N8L2 |
PhosphoSitePlusi | Q8N8L2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000177599, Expressed in muscle tissue and 114 other tissues |
ExpressionAtlasi | Q8N8L2, baseline and differential |
Genevisiblei | Q8N8L2, HS |
Organism-specific databases
HPAi | ENSG00000177599, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ8N8L2
Protein-protein interaction databases
BioGRIDi | 125952, 20 interactors |
IntActi | Q8N8L2, 19 interactors |
STRINGi | 9606.ENSP00000313443 |
Miscellaneous databases
RNActi | Q8N8L2, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 35 – 59 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 103 – 125 | C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 131 – 153 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 159 – 181 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 187 – 209 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 215 – 237 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 243 – 265 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 271 – 293 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 299 – 321 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 327 – 349 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 355 – 377 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 383 – 405 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 411 – 433 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163273 |
HOGENOMi | CLU_002678_44_0_1 |
InParanoidi | Q8N8L2 |
OMAi | CFRTHER |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8N8L2 |
TreeFami | TF338854 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 4 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 12 hits |
SUPFAMi | SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 10 hits PS50157, ZINC_FINGER_C2H2_2, 13 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q8N8L2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGERLFESAE GSQCGETFTQ VPEDMLNKKT LPGVKSCESG TCGEIFMGYS
60 70 80 90 100
SFNRNIRTDT GHQPHKCQKF LEKPYKHKQR RKALSHSHCF RTHERPHTRE
110 120 130 140 150
KPFDCKECEK SFISPASIRR YMVTHSGDGP YKCKFCGKAL DCLSLYLTHE
160 170 180 190 200
RTHTGEKRYE CKQCGKAFSW HSSVRIHERT HTGEKPYECK ECGKSFNFSS
210 220 230 240 250
SFRRHERTHT GEKPYKCKEC GKAFNCPSSF HRHERTHTGE KPYECKLYGK
260 270 280 290 300
ALSRLISFRR HMRMHTGERP HKCKICGKAF YSPSSFQRHE RSHTGEKPYK
310 320 330 340 350
CKQCGKAFTC STSFQYHERT HTGEKPDGCK QCGKAFRSAK YIRIHGRTHT
360 370 380 390 400
GEKPYECKQC GKAFHCVSSF HRHERTHAGE KPYECKHCGK AFTCSIYIRI
410 420 430
HERIHTGEKP YQCKECGKAF IRSSYCRKHE RTHTINI
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketC9IYV0 | C9IYV0_HUMAN | Zinc finger protein 491 | ZNF491 | 139 | Annotation score: |
Sequence cautioni
The sequence BAC03809 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK092110 mRNA Translation: BAC03809.1 Sequence problems. AK096593 mRNA Translation: BAC04824.1 BC101590 mRNA Translation: AAI01591.1 BC101592 mRNA Translation: AAI01593.1 |
CCDSi | CCDS12267.1 |
RefSeqi | NP_689569.2, NM_152356.3 XP_005259787.1, XM_005259730.3 |
Genome annotation databases
Ensembli | ENST00000323169; ENSP00000313443; ENSG00000177599 |
GeneIDi | 126069 |
KEGGi | hsa:126069 |
UCSCi | uc002mso.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK092110 mRNA Translation: BAC03809.1 Sequence problems. AK096593 mRNA Translation: BAC04824.1 BC101590 mRNA Translation: AAI01591.1 BC101592 mRNA Translation: AAI01593.1 |
CCDSi | CCDS12267.1 |
RefSeqi | NP_689569.2, NM_152356.3 XP_005259787.1, XM_005259730.3 |
3D structure databases
SMRi | Q8N8L2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 125952, 20 interactors |
IntActi | Q8N8L2, 19 interactors |
STRINGi | 9606.ENSP00000313443 |
PTM databases
iPTMneti | Q8N8L2 |
PhosphoSitePlusi | Q8N8L2 |
Genetic variation databases
BioMutai | ZNF491 |
DMDMi | 51316965 |
Proteomic databases
jPOSTi | Q8N8L2 |
MassIVEi | Q8N8L2 |
MaxQBi | Q8N8L2 |
PaxDbi | Q8N8L2 |
PeptideAtlasi | Q8N8L2 |
PRIDEi | Q8N8L2 |
ProteomicsDBi | 72434 |
Protocols and materials databases
Antibodypediai | 13218, 41 antibodies |
Genome annotation databases
Ensembli | ENST00000323169; ENSP00000313443; ENSG00000177599 |
GeneIDi | 126069 |
KEGGi | hsa:126069 |
UCSCi | uc002mso.2, human |
Organism-specific databases
CTDi | 126069 |
DisGeNETi | 126069 |
GeneCardsi | ZNF491 |
HGNCi | HGNC:23706, ZNF491 |
HPAi | ENSG00000177599, Low tissue specificity |
neXtProti | NX_Q8N8L2 |
OpenTargetsi | ENSG00000177599 |
PharmGKBi | PA134982286 |
VEuPathDBi | HostDB:ENSG00000177599.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163273 |
HOGENOMi | CLU_002678_44_0_1 |
InParanoidi | Q8N8L2 |
OMAi | CFRTHER |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8N8L2 |
TreeFami | TF338854 |
Enzyme and pathway databases
PathwayCommonsi | Q8N8L2 |
Miscellaneous databases
BioGRID-ORCSi | 126069, 5 hits in 878 CRISPR screens |
GenomeRNAii | 126069 |
Pharosi | Q8N8L2, Tdark |
PROi | PR:Q8N8L2 |
RNActi | Q8N8L2, protein |
Gene expression databases
Bgeei | ENSG00000177599, Expressed in muscle tissue and 114 other tissues |
ExpressionAtlasi | Q8N8L2, baseline and differential |
Genevisiblei | Q8N8L2, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 4 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 12 hits |
SUPFAMi | SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 10 hits PS50157, ZINC_FINGER_C2H2_2, 13 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN491_HUMAN | |
Accessioni | Q8N8L2Primary (citable) accession number: Q8N8L2 Secondary accession number(s): Q3MJ35, Q8NAT8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 16, 2004 |
Last sequence update: | October 1, 2002 | |
Last modified: | February 10, 2021 | |
This is version 145 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM