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UniProtKB - Q8N8L2 (ZN491_HUMAN)

Entry version 141 (17 Jun 2020)
Sequence version 1 (01 Oct 2002)
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Protein

Zinc finger protein 491

Gene

ZNF491

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri35 – 59C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri103 – 125C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri131 – 153C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri159 – 181C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri187 – 209C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri215 – 237C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri243 – 265C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri271 – 293C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri299 – 321C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri327 – 349C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri355 – 377C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri383 – 405C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri411 – 433C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 491
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF491
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000177599.12

Human Gene Nomenclature Database

More...HGNCi		HGNC:23706 ZNF491

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8N8L2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000177599

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134982286

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8N8L2 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZNF491

Domain mapping of disease mutations (DMDM)

More...DMDMi		51316965

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000476141 – 437Zinc finger protein 491Add BLAST437

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8N8L2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8N8L2

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8N8L2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8N8L2

PeptideAtlas

More...PeptideAtlasi		Q8N8L2

PRoteomics IDEntifications database

More...PRIDEi		Q8N8L2

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		72434

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8N8L2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8N8L2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000177599 Expressed in lung and 87 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8N8L2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8N8L2 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000177599 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		125952, 11 interactors

Protein interaction database and analysis system

More...IntActi		Q8N8L2, 19 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000313443

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8N8L2 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8N8L2

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri35 – 59C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri103 – 125C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri131 – 153C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri159 – 181C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri187 – 209C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri215 – 237C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri243 – 265C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri271 – 293C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri299 – 321C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri327 – 349C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri355 – 377C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri383 – 405C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri411 – 433C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000163273

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002678_44_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8N8L2

Identification of Orthologs from Complete Genome Data

More...OMAi		CFRTHER

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8N8L2

TreeFam database of animal gene trees

More...TreeFami		TF338854

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00096 zf-C2H2, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00355 ZnF_C2H2, 12 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57667 SSF57667, 7 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8N8L2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGERLFESAE GSQCGETFTQ VPEDMLNKKT LPGVKSCESG TCGEIFMGYS 
        60         70         80         90        100
SFNRNIRTDT GHQPHKCQKF LEKPYKHKQR RKALSHSHCF RTHERPHTRE 
       110        120        130        140        150
KPFDCKECEK SFISPASIRR YMVTHSGDGP YKCKFCGKAL DCLSLYLTHE 
       160        170        180        190        200
RTHTGEKRYE CKQCGKAFSW HSSVRIHERT HTGEKPYECK ECGKSFNFSS 
       210        220        230        240        250
SFRRHERTHT GEKPYKCKEC GKAFNCPSSF HRHERTHTGE KPYECKLYGK 
       260        270        280        290        300
ALSRLISFRR HMRMHTGERP HKCKICGKAF YSPSSFQRHE RSHTGEKPYK 
       310        320        330        340        350
CKQCGKAFTC STSFQYHERT HTGEKPDGCK QCGKAFRSAK YIRIHGRTHT 
       360        370        380        390        400
GEKPYECKQC GKAFHCVSSF HRHERTHAGE KPYECKHCGK AFTCSIYIRI 
       410        420        430 
HERIHTGEKP YQCKECGKAF IRSSYCRKHE RTHTINI
Length:437
Mass (Da):50,950
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1F4BC6E07A031634
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9IYV0C9IYV0_HUMAN
Zinc finger protein 491
ZNF491
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC03809 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK092110 mRNA Translation: BAC03809.1 Sequence problems.
AK096593 mRNA Translation: BAC04824.1
BC101590 mRNA Translation: AAI01591.1
BC101592 mRNA Translation: AAI01593.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12267.1

NCBI Reference Sequences

More...RefSeqi		NP_689569.2, NM_152356.3
XP_005259787.1, XM_005259730.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000323169; ENSP00000313443; ENSG00000177599

Database of genes from NCBI RefSeq genomes

More...GeneIDi		126069

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:126069

UCSC genome browser

More...UCSCi		uc002mso.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092110 mRNA Translation: BAC03809.1 Sequence problems.
AK096593 mRNA Translation: BAC04824.1
BC101590 mRNA Translation: AAI01591.1
BC101592 mRNA Translation: AAI01593.1
CCDSiCCDS12267.1
RefSeqiNP_689569.2, NM_152356.3
XP_005259787.1, XM_005259730.3

3D structure databases

SMRiQ8N8L2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi125952, 11 interactors
IntActiQ8N8L2, 19 interactors
STRINGi9606.ENSP00000313443

PTM databases

iPTMnetiQ8N8L2
PhosphoSitePlusiQ8N8L2

Polymorphism and mutation databases

BioMutaiZNF491
DMDMi51316965

Proteomic databases

jPOSTiQ8N8L2
MassIVEiQ8N8L2
MaxQBiQ8N8L2
PaxDbiQ8N8L2
PeptideAtlasiQ8N8L2
PRIDEiQ8N8L2
ProteomicsDBi72434

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		13218 41 antibodies

Genome annotation databases

EnsembliENST00000323169; ENSP00000313443; ENSG00000177599
GeneIDi126069
KEGGihsa:126069
UCSCiuc002mso.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		126069
EuPathDBiHostDB:ENSG00000177599.12

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZNF491
HGNCiHGNC:23706 ZNF491
HPAiENSG00000177599 Low tissue specificity
neXtProtiNX_Q8N8L2
OpenTargetsiENSG00000177599
PharmGKBiPA134982286

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000163273
HOGENOMiCLU_002678_44_0_1
InParanoidiQ8N8L2
OMAiCFRTHER
OrthoDBi1318335at2759
PhylomeDBiQ8N8L2
TreeFamiTF338854

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		126069 2 hits in 803 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		126069
PharosiQ8N8L2 Tdark

Protein Ontology

More...PROi		PR:Q8N8L2
RNActiQ8N8L2 protein

Gene expression databases

BgeeiENSG00000177599 Expressed in lung and 87 other tissues
ExpressionAtlasiQ8N8L2 baseline and differential
GenevisibleiQ8N8L2 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 12 hits
SUPFAMiSSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN491_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N8L2
Secondary accession number(s): Q3MJ35, Q8NAT8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 1, 2002
Last modified: June 17, 2020
This is version 141 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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