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Protein

Zinc finger protein 615

Gene

ZNF615

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Caution

It is uncertain whether Met-1 or Met-2 is the initiator.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri204 – 226C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri232 – 254C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 310C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri456 – 478C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri484 – 506C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri512 – 534C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri540 – 562C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri568 – 590C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri596 – 618C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri624 – 646C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri652 – 674C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri680 – 702C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri708 – 730C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 615
Gene namesi
Name:ZNF615
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000197619.13
HGNCiHGNC:24740 ZNF615
neXtProtiNX_Q8N8J6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197619
PharmGKBiPA134872929

Polymorphism and mutation databases

BioMutaiZNF615
DMDMi161784348

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476901 – 731Zinc finger protein 615Add BLAST731

Proteomic databases

MaxQBiQ8N8J6
PaxDbiQ8N8J6
PeptideAtlasiQ8N8J6
PRIDEiQ8N8J6
ProteomicsDBi72428
72429 [Q8N8J6-2]
72430 [Q8N8J6-3]

PTM databases

iPTMnetiQ8N8J6
PhosphoSitePlusiQ8N8J6

Expressioni

Gene expression databases

BgeeiENSG00000197619 Expressed in 189 organ(s), highest expression level in corpus callosum
CleanExiHS_ZNF615
ExpressionAtlasiQ8N8J6 baseline and differential
GenevisibleiQ8N8J6 HS

Organism-specific databases

HPAiHPA052422

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000365906

Structurei

3D structure databases

ProteinModelPortaliQ8N8J6
SMRiQ8N8J6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 79KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri204 – 226C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri232 – 254C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 310C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri456 – 478C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri484 – 506C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri512 – 534C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri540 – 562C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri568 – 590C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri596 – 618C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri624 – 646C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri652 – 674C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri680 – 702C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri708 – 730C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00900000140826
HOVERGENiHBG018163
InParanoidiQ8N8J6
KOiK09228
OMAiTSFACTE
OrthoDBiEOG091G02KC
PhylomeDBiQ8N8J6
TreeFamiTF350804

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 19 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 10 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 18 hits
PS50157 ZINC_FINGER_C2H2_2, 19 hits

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q8N8J6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMQAQESLTL EDVAVDFTWE EWQFLSPAQK DLYRDVMLEN YSNLVAVGYQ
60 70 80 90 100
ASKPDALSKL ERGEETCTTE DEIYSRICSE IRKIDDPLQH HLQNQSIQKS
110 120 130 140 150
VKQCHEQNMF GNIVNQNKGH FLLKQDCDTF DLHEKPLKSN LSFENQKRSS
160 170 180 190 200
GLKNSAEFNR DGKSLFHANH KQFYTEMKFP AIAKPINKSQ FIKQQRTHNI
210 220 230 240 250
ENAHVCSECG KAFLKLSQFI DHQRVHTGEK PHVCSMCGKA FSRKSRLMDH
260 270 280 290 300
QRTHTELKHY ECTECDKTFL KKSQLNIHQK THMGGKPYTC SQCGKAFIKK
310 320 330 340 350
CRLIYHQRTH TGEKPHGCSV CGKAFSTKFS LTTHQKTHTG EKPYICSECG
360 370 380 390 400
KGFIEKRRLT AHHRTHTGEK PFICNKCGKG FTLKNSLITH QQTHTGEKLY
410 420 430 440 450
TCSECGKGFS MKHCLMVHQR THTGEKPYKC NECGKGFALK SPLIRHQRTH
460 470 480 490 500
TGEKPYVCTE CRKGFTMKSD LIVHQRTHTA EKPYICNDCG KGFTVKSRLI
510 520 530 540 550
VHQRTHTGEK PYVCGECGKG FPAKIRLMGH QRTHTGEKPY ICNECGKGFT
560 570 580 590 600
EKSHLNVHRR THTGEKPYVC SECGKGLTGK SMLIAHQRTH TGEKPYICNE
610 620 630 640 650
CGKGFTMKST LSIHQQTHTG EKPYKCNECD KTFRKKTCLI QHQRFHTGKT
660 670 680 690 700
SFACTECGKF SLRKNDLITH QRIHTGEKPY KCSDCGKAFT TKSGLNVHQR
710 720 730
KHTGERPYGC SDCGKAFAHL SILVKHRRIH R
Length:731
Mass (Da):83,739
Last modified:December 4, 2007 - v2
Checksum:i4FE44AC660649A85
GO
Isoform 2 (identifier: Q8N8J6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     79-79: S → SDSGGASGGAYA

Show »
Length:742
Mass (Da):84,633
Checksum:i276ED355E6EA73B0
GO
Isoform 3 (identifier: Q8N8J6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-5: MMQAQ → M
     79-79: S → SDSGGASGGAYA

Show »
Length:738
Mass (Da):84,174
Checksum:i522FD931D0B35131
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H9KV89H9KV89_HUMAN
Zinc finger protein 615
ZNF615
736Annotation score:
A0A087X254A0A087X254_HUMAN
Zinc finger protein 615
ZNF615
740Annotation score:
M0QZZ4M0QZZ4_HUMAN
Zinc finger protein 615
ZNF615
103Annotation score:
M0R0F8M0R0F8_HUMAN
Zinc finger protein 615
ZNF615
160Annotation score:
M0QZR2M0QZR2_HUMAN
Zinc finger protein 615
ZNF615
98Annotation score:
M0R130M0R130_HUMAN
Zinc finger protein 615
ZNF615
96Annotation score:
A0A0G2JLJ6A0A0G2JLJ6_HUMAN
Zinc finger protein 615
ZNF615
8Annotation score:

Sequence cautioni

The sequence BAC87399 differs from that shown. aberrant splicing.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti576G → D in BAD18638 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037285129T → M2 PublicationsCorresponds to variant dbSNP:rs10500311Ensembl.1
Natural variantiVAR_037286360T → I2 PublicationsCorresponds to variant dbSNP:rs1978717Ensembl.1
Natural variantiVAR_037287727R → K2 PublicationsCorresponds to variant dbSNP:rs16983353Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0397171 – 5MMQAQ → M in isoform 3. 1 Publication5
Alternative sequenceiVSP_02958279S → SDSGGASGGAYA in isoform 2 and isoform 3. 3 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128361 mRNA Translation: BAC87399.1 Sequence problems.
AK131494 mRNA Translation: BAD18638.1
CR936612 mRNA Translation: CAI56755.1
AC011460 Genomic DNA No translation available.
AC011468 Genomic DNA No translation available.
BC105100 mRNA Translation: AAI05101.1
BC105102 mRNA Translation: AAI05103.1
BC143429 mRNA Translation: AAI43430.1
CCDSiCCDS12846.1 [Q8N8J6-1]
CCDS59418.1 [Q8N8J6-2]
RefSeqiNP_001186253.1, NM_001199324.1 [Q8N8J6-2]
NP_001308247.1, NM_001321318.1 [Q8N8J6-3]
NP_001308248.1, NM_001321319.1 [Q8N8J6-2]
NP_001308249.1, NM_001321320.1 [Q8N8J6-1]
NP_001308250.1, NM_001321321.1 [Q8N8J6-2]
NP_940882.3, NM_198480.3 [Q8N8J6-1]
XP_011525126.1, XM_011526824.1 [Q8N8J6-2]
XP_011525127.1, XM_011526825.1 [Q8N8J6-2]
XP_011525128.1, XM_011526826.1 [Q8N8J6-2]
XP_016882137.1, XM_017026648.1 [Q8N8J6-1]
XP_016882138.1, XM_017026649.1 [Q8N8J6-1]
UniGeneiHs.368355

Genome annotation databases

EnsembliENST00000376716; ENSP00000365906; ENSG00000197619 [Q8N8J6-1]
ENST00000594083; ENSP00000471549; ENSG00000197619 [Q8N8J6-2]
ENST00000598071; ENSP00000471041; ENSG00000197619 [Q8N8J6-2]
ENST00000602063; ENSP00000473089; ENSG00000197619 [Q8N8J6-1]
ENST00000618487; ENSP00000483676; ENSG00000197619 [Q8N8J6-2]
GeneIDi284370
KEGGihsa:284370
UCSCiuc002pye.3 human [Q8N8J6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN615_HUMAN
AccessioniPrimary (citable) accession number: Q8N8J6
Secondary accession number(s): B7ZKW9
, Q2M2Y6, Q5CZB0, Q6ZMT7, Q6ZRB3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: December 4, 2007
Last modified: September 12, 2018
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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