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Protein

Transcription cofactor vestigial-like protein 2

Gene

VGLL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a specific coactivator for the mammalian TEFs. May play a role in the development of skeletal muscles.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription cofactor vestigial-like protein 2
Short name:
Vgl-2
Alternative name(s):
Protein VITO1
Gene namesi
Name:VGLL2
Synonyms:VITO1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000170162.13
HGNCiHGNC:20232 VGLL2
MIMi609979 gene
neXtProtiNX_Q8N8G2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi245806
OpenTargetsiENSG00000170162
PharmGKBiPA134881890

Polymorphism and mutation databases

BioMutaiVGLL2
DMDMi50401602

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001913491 – 317Transcription cofactor vestigial-like protein 2Add BLAST317

Proteomic databases

PaxDbiQ8N8G2
PeptideAtlasiQ8N8G2
PRIDEiQ8N8G2
ProteomicsDBi72420
72421 [Q8N8G2-2]

PTM databases

iPTMnetiQ8N8G2
PhosphoSitePlusiQ8N8G2

Expressioni

Tissue specificityi

Skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000170162
CleanExiHS_VGLL2
GenevisibleiQ8N8G2 HS

Interactioni

Subunit structurei

Interacts with TEFs. Binds to TEAD1/TEF1.

Binary interactionsi

WithEntry#Exp.IntActNotes
TEAD3Q995943EBI-10267981,EBI-746720

GO - Molecular functioni

Protein-protein interaction databases

BioGridi128830, 1 interactor
IntActiQ8N8G2, 1 interactor
STRINGi9606.ENSP00000320957

Structurei

3D structure databases

ProteinModelPortaliQ8N8G2
SMRiQ8N8G2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the vestigial family.Curated

Phylogenomic databases

eggNOGiENOG410IJDA Eukaryota
ENOG410Y23M LUCA
GeneTreeiENSGT00530000063353
HOGENOMiHOG000143402
HOVERGENiHBG057778
InParanoidiQ8N8G2
OMAiTEPWHHA
OrthoDBiEOG091G0GKN
PhylomeDBiQ8N8G2
TreeFamiTF326340

Family and domain databases

InterProiView protein in InterPro
IPR011520 Vg_fam
PANTHERiPTHR15950 PTHR15950, 1 hit
PfamiView protein in Pfam
PF07545 Vg_Tdu, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N8G2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSCLDVMYQV YGPPQPYFAA AYTPYHQKLA YYSKMQEAQE CNASPSSSGS
60 70 80 90 100
GSSSFSSQTP ASIKEEEGSP EKERPPEAEY INSRCVLFTY FQGDISSVVD
110 120 130 140 150
EHFSRALSQP SSYSPSCTSS KAPRSSGPWR DCSFPMSQRS FPASFWNSAY
160 170 180 190 200
QAPVPPPLGS PLATAHSELP FAAADPYSPA ALHGHLHQGA TEPWHHAHPH
210 220 230 240 250
HAHPHHPYAL GGALGAQAAP YPRPAAVHEV YAPHFDPRYG PLLMPAASGR
260 270 280 290 300
PARLATAPAP APGSPPCELS GKGEPAGAAW AGPGGPFASP SGDVAQGLGL
310
SVDSARRYSL CGASLLS
Length:317
Mass (Da):33,426
Last modified:October 1, 2002 - v1
Checksum:i2C08E5D1070FF10D
GO
Isoform 2 (identifier: Q8N8G2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     131-304: Missing.

Show »
Length:143
Mass (Da):15,701
Checksum:i8DF01823AE66F5F3
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_032166131 – 304Missing in isoform 2. 2 PublicationsAdd BLAST174

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ578053 mRNA Translation: CAE17331.1
AY056583 mRNA Translation: AAL17720.1
AK096878 mRNA Translation: BAC04881.1
Z98880 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48211.1
BC069316 mRNA Translation: AAH69316.1
BC100798 mRNA Translation: AAI00799.1
BC100799 mRNA Translation: AAI00800.1
BC118545 mRNA Translation: AAI18546.1
BC118622 mRNA Translation: AAI18623.1
CCDSiCCDS5114.1 [Q8N8G2-2]
CCDS5115.1 [Q8N8G2-1]
RefSeqiNP_703154.1, NM_153453.1 [Q8N8G2-2]
NP_872586.1, NM_182645.3 [Q8N8G2-1]
UniGeneiHs.99324

Genome annotation databases

EnsembliENST00000326274; ENSP00000320957; ENSG00000170162 [Q8N8G2-1]
ENST00000352536; ENSP00000305405; ENSG00000170162 [Q8N8G2-2]
GeneIDi245806
KEGGihsa:245806
UCSCiuc003pxn.4 human [Q8N8G2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiVGLL2_HUMAN
AccessioniPrimary (citable) accession number: Q8N8G2
Secondary accession number(s): Q8WWX1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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