UniProtKB - Q8N8D1 (PDCD7_HUMAN)
Protein
Programmed cell death protein 7
Gene
PDCD7
Organism
Homo sapiens (Human)
Status
Functioni
Promotes apoptosis when overexpressed.By similarity
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- mRNA splicing, via spliceosome Source: Reactome
- response to glucocorticoid Source: HGNC-UCL
- RNA splicing Source: HGNC-UCL
Keywordsi
Biological process | Apoptosis |
Enzyme and pathway databases
PathwayCommonsi | Q8N8D1 |
Reactomei | R-HSA-72165, mRNA Splicing - Minor Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Programmed cell death protein 7Alternative name(s): ES18 Short name: hES18 |
Gene namesi | Name:PDCD7 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000090470.14 |
HGNCi | HGNC:8767, PDCD7 |
MIMi | 608138, gene |
neXtProti | NX_Q8N8D1 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleoplasm Source: Reactome
- U12-type spliceosomal complex Source: HGNC-UCL
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 10081 |
OpenTargetsi | ENSG00000090470 |
PharmGKBi | PA33117 |
Miscellaneous databases
Pharosi | Q8N8D1, Tbio |
Polymorphism and mutation databases
BioMutai | PDCD7 |
DMDMi | 38258174 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000058269 | 1 – 485 | Programmed cell death protein 7Add BLAST | 485 |
Proteomic databases
EPDi | Q8N8D1 |
jPOSTi | Q8N8D1 |
MassIVEi | Q8N8D1 |
MaxQBi | Q8N8D1 |
PaxDbi | Q8N8D1 |
PeptideAtlasi | Q8N8D1 |
PRIDEi | Q8N8D1 |
ProteomicsDBi | 72402 |
PTM databases
iPTMneti | Q8N8D1 |
MetOSitei | Q8N8D1 |
PhosphoSitePlusi | Q8N8D1 |
Expressioni
Gene expression databases
Bgeei | ENSG00000090470, Expressed in secondary oocyte and 232 other tissues |
ExpressionAtlasi | Q8N8D1, baseline and differential |
Genevisiblei | Q8N8D1, HS |
Organism-specific databases
HPAi | ENSG00000090470, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with RBM40.
Component of the U11/U12 snRNPs that are part of the U12-type spliceosome.
2 PublicationsProtein-protein interaction databases
BioGRIDi | 115390, 41 interactors |
CORUMi | Q8N8D1 |
IntActi | Q8N8D1, 21 interactors |
MINTi | Q8N8D1 |
STRINGi | 9606.ENSP00000204549 |
Miscellaneous databases
RNActi | Q8N8D1, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 232 – 335 | Sequence analysisAdd BLAST | 104 | |
Coiled coili | 362 – 411 | Sequence analysisAdd BLAST | 50 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 4 – 129 | Pro-richAdd BLAST | 126 | |
Compositional biasi | 236 – 278 | Arg/Glu-richAdd BLAST | 43 |
Keywords - Domaini
Coiled coil, RepeatPhylogenomic databases
eggNOGi | ENOG502QQNP, Eukaryota |
GeneTreei | ENSGT00390000017392 |
HOGENOMi | CLU_027959_0_0_1 |
InParanoidi | Q8N8D1 |
OMAi | AFENQVE |
OrthoDBi | 1097362at2759 |
PhylomeDBi | Q8N8D1 |
TreeFami | TF332996 |
Family and domain databases
InterProi | View protein in InterPro IPR031974, PDCD7 |
Pfami | View protein in Pfam PF16021, PDCD7, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q8N8D1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALPPFFGQG RPGPPPPQPP PPAPFGCPPP PLPSPAFPPP LPQRPGPFPG
60 70 80 90 100
ASAPFLQPPL ALQPRASAEA SRGGGGAGAF YPVPPPPLPP PPPQCRPFPG
110 120 130 140 150
TDAGERPRPP PPGPGPPWSP RWPEAPPPPA DVLGDAALQR LRDRQWLEAV
160 170 180 190 200
FGTPRRAGCP VPQRTHAGPS LGEVRARLLR ALRLVRRLRG LSQALREAEA
210 220 230 240 250
DGAAWVLLYS QTAPLRAELA ERLQPLTQAA YVGEARRRLE RVRRRRLRLR
260 270 280 290 300
ERAREREAER EAEAARAVER EQEIDRWRVK CVQEVEEKKR EQELKAAADG
310 320 330 340 350
VLSEVRKKQA DTKRMVDILR ALEKLRKLRK EAAARKGVCP PASADETFTH
360 370 380 390 400
HLQRLRKLIK KRSELYEAEE RALRVMLEGE QEEERKRELE KKQRKEKEKI
410 420 430 440 450
LLQKREIESK LFGDPDEFPL AHLLEPFRQY YLQAEHSLPA LIQIRHDWDQ
460 470 480
YLVPSDHPKG NFVPQGWVLP PLPSNDIWAT AVKLH
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH3BT73 | H3BT73_HUMAN | Programmed cell death protein 7 | PDCD7 | 103 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 292 | Q → GE in AAD20241 (PubMed:10037816).Curated | 1 | |
Sequence conflicti | 303 | S → A in AAD20241 (PubMed:10037816).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK096970 mRNA Translation: BAC04915.1 AF083930 mRNA Translation: AAD20241.1 BC016992 mRNA Translation: AAH16992.2 BT007395 mRNA Translation: AAP36059.1 |
CCDSi | CCDS10201.1 |
RefSeqi | NP_005698.1, NM_005707.1 |
Genome annotation databases
Ensembli | ENST00000204549; ENSP00000204549; ENSG00000090470 |
GeneIDi | 10081 |
KEGGi | hsa:10081 |
UCSCi | uc002aol.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK096970 mRNA Translation: BAC04915.1 AF083930 mRNA Translation: AAD20241.1 BC016992 mRNA Translation: AAH16992.2 BT007395 mRNA Translation: AAP36059.1 |
CCDSi | CCDS10201.1 |
RefSeqi | NP_005698.1, NM_005707.1 |
3D structure databases
SMRi | Q8N8D1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 115390, 41 interactors |
CORUMi | Q8N8D1 |
IntActi | Q8N8D1, 21 interactors |
MINTi | Q8N8D1 |
STRINGi | 9606.ENSP00000204549 |
PTM databases
iPTMneti | Q8N8D1 |
MetOSitei | Q8N8D1 |
PhosphoSitePlusi | Q8N8D1 |
Polymorphism and mutation databases
BioMutai | PDCD7 |
DMDMi | 38258174 |
Proteomic databases
EPDi | Q8N8D1 |
jPOSTi | Q8N8D1 |
MassIVEi | Q8N8D1 |
MaxQBi | Q8N8D1 |
PaxDbi | Q8N8D1 |
PeptideAtlasi | Q8N8D1 |
PRIDEi | Q8N8D1 |
ProteomicsDBi | 72402 |
Protocols and materials databases
Antibodypediai | 25914, 234 antibodies |
DNASUi | 10081 |
Genome annotation databases
Ensembli | ENST00000204549; ENSP00000204549; ENSG00000090470 |
GeneIDi | 10081 |
KEGGi | hsa:10081 |
UCSCi | uc002aol.3, human |
Organism-specific databases
CTDi | 10081 |
DisGeNETi | 10081 |
EuPathDBi | HostDB:ENSG00000090470.14 |
GeneCardsi | PDCD7 |
HGNCi | HGNC:8767, PDCD7 |
HPAi | ENSG00000090470, Low tissue specificity |
MIMi | 608138, gene |
neXtProti | NX_Q8N8D1 |
OpenTargetsi | ENSG00000090470 |
PharmGKBi | PA33117 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QQNP, Eukaryota |
GeneTreei | ENSGT00390000017392 |
HOGENOMi | CLU_027959_0_0_1 |
InParanoidi | Q8N8D1 |
OMAi | AFENQVE |
OrthoDBi | 1097362at2759 |
PhylomeDBi | Q8N8D1 |
TreeFami | TF332996 |
Enzyme and pathway databases
PathwayCommonsi | Q8N8D1 |
Reactomei | R-HSA-72165, mRNA Splicing - Minor Pathway |
Miscellaneous databases
BioGRID-ORCSi | 10081, 563 hits in 851 CRISPR screens |
ChiTaRSi | PDCD7, human |
GeneWikii | PDCD7 |
GenomeRNAii | 10081 |
Pharosi | Q8N8D1, Tbio |
PROi | PR:Q8N8D1 |
RNActi | Q8N8D1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000090470, Expressed in secondary oocyte and 232 other tissues |
ExpressionAtlasi | Q8N8D1, baseline and differential |
Genevisiblei | Q8N8D1, HS |
Family and domain databases
InterProi | View protein in InterPro IPR031974, PDCD7 |
Pfami | View protein in Pfam PF16021, PDCD7, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PDCD7_HUMAN | |
Accessioni | Q8N8D1Primary (citable) accession number: Q8N8D1 Secondary accession number(s): Q96AK8, Q9Y6D7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 31, 2003 |
Last sequence update: | October 1, 2002 | |
Last modified: | December 2, 2020 | |
This is version 138 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM