PDCD7

Functionⁱ

Promotes apoptosis when overexpressed.By similarity

GO - Biological processⁱ

apoptotic process Source: UniProtKB-KW
mRNA splicing, via spliceosome Source: Reactome
response to glucocorticoid
Source: HGNC
Inferred from sequence or structural similarityⁱ
- 10037816
RNA splicing
Source: HGNC
Inferred by curatorⁱ
- 15146077

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Apoptosis

Biological process

Apoptosis

Enzyme and pathway databases

Reactomeⁱ	R-HSA-72165 mRNA Splicing - Minor Pathway

Reactomeⁱ

R-HSA-72165 mRNA Splicing - Minor Pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Programmed cell death protein 7 Alternative name(s): ES18 Short name: hES18
Gene namesⁱ	Name:PDCD7
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 15

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000090470.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8767 PDCD7
MIMⁱ	608138 gene
neXtProtⁱ	NX_Q8N8D1

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10081
Open Targets More...OpenTargetsⁱ	ENSG00000090470
PharmGKBⁱ	PA33117

Polymorphism and mutation databases

BioMutaⁱ	PDCD7
DMDMⁱ	38258174

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000058269	1 – 485	Programmed cell death protein 7Add BLAST		485

Proteomic databases

EPDⁱ	Q8N8D1
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8N8D1
PaxDbⁱ	Q8N8D1
PeptideAtlas More...PeptideAtlasⁱ	Q8N8D1
PRIDEⁱ	Q8N8D1
ProteomicsDBⁱ	72402

PTM databases

iPTMnetⁱ	Q8N8D1
PhosphoSitePlusⁱ	Q8N8D1

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000090470 Expressed in 218 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_PDCD7
ExpressionAtlasⁱ	Q8N8D1 baseline and differential
Genevisibleⁱ	Q8N8D1 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA049388

HPAⁱ

HPA049388

Interactionⁱ

Subunit structureⁱ

Interacts with RBM40. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome.2 Publications

Protein-protein interaction databases

BioGridⁱ	115390, 38 interactors
CORUMⁱ	Q8N8D1
IntActⁱ	Q8N8D1, 9 interactors
Molecular INTeraction database More...MINTⁱ	Q8N8D1
STRINGⁱ	9606.ENSP00000204549

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8N8D1
SMRⁱ	Q8N8D1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	232 – 335	Sequence analysisAdd BLAST		104
Coiled coilⁱ	362 – 411	Sequence analysisAdd BLAST		50

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	4 – 129	Pro-richAdd BLAST		126
Compositional biasⁱ	236 – 278	Arg/Glu-richAdd BLAST		43

Keywords - Domainⁱ

Coiled coil, Repeat

Phylogenomic databases

eggNOGⁱ	ENOG410IVC0 Eukaryota ENOG41124DX LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000017392
HOGENOMⁱ	HOG000115476
HOVERGENⁱ	HBG053537
InParanoidⁱ	Q8N8D1
OMAⁱ	TSFWQRD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0R7S
PhylomeDBⁱ	Q8N8D1
TreeFamⁱ	TF332996

Family and domain databases

InterProⁱ	View protein in InterPro IPR031974 PDCD7
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF16021 PDCD7, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q8N8D1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MALPPFFGQG RPGPPPPQPP PPAPFGCPPP PLPSPAFPPP LPQRPGPFPG 
        60         70         80         90        100
ASAPFLQPPL ALQPRASAEA SRGGGGAGAF YPVPPPPLPP PPPQCRPFPG 
       110        120        130        140        150
TDAGERPRPP PPGPGPPWSP RWPEAPPPPA DVLGDAALQR LRDRQWLEAV 
       160        170        180        190        200
FGTPRRAGCP VPQRTHAGPS LGEVRARLLR ALRLVRRLRG LSQALREAEA 
       210        220        230        240        250
DGAAWVLLYS QTAPLRAELA ERLQPLTQAA YVGEARRRLE RVRRRRLRLR 
       260        270        280        290        300
ERAREREAER EAEAARAVER EQEIDRWRVK CVQEVEEKKR EQELKAAADG 
       310        320        330        340        350
VLSEVRKKQA DTKRMVDILR ALEKLRKLRK EAAARKGVCP PASADETFTH 
       360        370        380        390        400
HLQRLRKLIK KRSELYEAEE RALRVMLEGE QEEERKRELE KKQRKEKEKI 
       410        420        430        440        450
LLQKREIESK LFGDPDEFPL AHLLEPFRQY YLQAEHSLPA LIQIRHDWDQ 
       460        470        480 
YLVPSDHPKG NFVPQGWVLP PLPSNDIWAT AVKLH

Length:485

Mass (Da):54,700

Last modified:October 1, 2002 - v1

Checksum:ⁱFF907D6D2187832A

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	H3BT73	H3BT73_HUMAN		Programmed cell death protein 7 Programmed cell death protein 7	PDCD7	103	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	292	Q → GE in AAD20241 (PubMed:10037816).Curated		1
Sequence conflictⁱ	303	S → A in AAD20241 (PubMed:10037816).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK096970 mRNA Translation: BAC04915.1 AF083930 mRNA Translation: AAD20241.1 BC016992 mRNA Translation: AAH16992.2 BT007395 mRNA Translation: AAP36059.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10201.1
NCBI Reference Sequences More...RefSeqⁱ	NP_005698.1, NM_005707.1
UniGeneⁱ	Hs.458596

Genome annotation databases

Ensemblⁱ	ENST00000204549; ENSP00000204549; ENSG00000090470
GeneIDⁱ	10081
KEGGⁱ	hsa:10081
UCSC genome browser More...UCSCⁱ	uc002aol.3 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8N8D1	Programmed cell death 7, isoform CRA_a		HUMAN		485	UniRef100_Q8N8D1
PDCD7 isoform 1		PANTR		485

Protein	Similar proteins		Species	Score	Length	Source
Q8N8D1	Programmed cell death 7, isoform CRA_a		HUMAN		485	UniRef90_Q8N8D1
PDCD7 isoform 1		PANTR		485
Uncharacterized protein		Cebus capucinus imitator		489
Uncharacterized protein		CERAT		489
Programmed cell death protein 7 (Fragment)		MACMU		272
+52

Protein	Similar proteins		Species	Score	Length	Source
Q8N8D1	Programmed cell death protein 7		MOUSE		482	UniRef50_Q9WTY1
Uncharacterized protein		RABIT		401
Programmed cell death 7		CANLF		364
programmed cell death protein 7		MESAU		485
programmed cell death protein 7 isoform X2		NEOSC		467
+83

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK096970 mRNA Translation: BAC04915.1 AF083930 mRNA Translation: AAD20241.1 BC016992 mRNA Translation: AAH16992.2 BT007395 mRNA Translation: AAP36059.1
CCDSⁱ	CCDS10201.1
RefSeqⁱ	NP_005698.1, NM_005707.1
UniGeneⁱ	Hs.458596

3D structure databases

ProteinModelPortalⁱ	Q8N8D1
SMRⁱ	Q8N8D1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115390, 38 interactors
CORUMⁱ	Q8N8D1
IntActⁱ	Q8N8D1, 9 interactors
MINTⁱ	Q8N8D1
STRINGⁱ	9606.ENSP00000204549

PTM databases

iPTMnetⁱ	Q8N8D1
PhosphoSitePlusⁱ	Q8N8D1

Polymorphism and mutation databases

BioMutaⁱ	PDCD7
DMDMⁱ	38258174

Proteomic databases

EPDⁱ	Q8N8D1
MaxQBⁱ	Q8N8D1
PaxDbⁱ	Q8N8D1
PeptideAtlasⁱ	Q8N8D1
PRIDEⁱ	Q8N8D1
ProteomicsDBⁱ	72402

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	10081
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000204549; ENSP00000204549; ENSG00000090470
GeneIDⁱ	10081
KEGGⁱ	hsa:10081
UCSCⁱ	uc002aol.3 human

Organism-specific databases

CTDⁱ	10081
DisGeNETⁱ	10081
EuPathDBⁱ	HostDB:ENSG00000090470.14
GeneCardsⁱ	PDCD7
HGNCⁱ	HGNC:8767 PDCD7
HPAⁱ	HPA049388
MIMⁱ	608138 gene
neXtProtⁱ	NX_Q8N8D1
OpenTargetsⁱ	ENSG00000090470
PharmGKBⁱ	PA33117
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IVC0 Eukaryota ENOG41124DX LUCA
GeneTreeⁱ	ENSGT00390000017392
HOGENOMⁱ	HOG000115476
HOVERGENⁱ	HBG053537
InParanoidⁱ	Q8N8D1
OMAⁱ	TSFWQRD
OrthoDBⁱ	EOG091G0R7S
PhylomeDBⁱ	Q8N8D1
TreeFamⁱ	TF332996

Enzyme and pathway databases

Reactomeⁱ	R-HSA-72165 mRNA Splicing - Minor Pathway

Reactomeⁱ

R-HSA-72165 mRNA Splicing - Minor Pathway

Miscellaneous databases

ChiTaRSⁱ	PDCD7 human
GeneWikiⁱ	PDCD7
GenomeRNAiⁱ	10081
Protein Ontology More...PROⁱ	PR:Q8N8D1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000090470 Expressed in 218 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_PDCD7
ExpressionAtlasⁱ	Q8N8D1 baseline and differential
Genevisibleⁱ	Q8N8D1 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR031974 PDCD7
Pfamⁱ	View protein in Pfam PF16021 PDCD7, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PDCD7_HUMAN
Accessionⁱ	Q8N8D1Primary (citable) accession number: Q8N8D1 Secondary accession number(s): Q96AK8, Q9Y6D7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 31, 2003
	Last sequence update:	October 1, 2002
	Last modified:	November 7, 2018
	This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8N8D1 (PDCD7_HUMAN)

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Programmed cell death protein 7

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ