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Entry version 144 (13 Feb 2019)
Sequence version 3 (16 Dec 2008)
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Protein

Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B

Gene

ANKRD44

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates.

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B
Short name:
PP6-ARS-B
Short name:
Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B
Alternative name(s):
Ankyrin repeat domain-containing protein 44
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANKRD44
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000065413.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25259 ANKRD44

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N8A2

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
91526

Open Targets

More...
OpenTargetsi
ENSG00000065413

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142672611

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ANKRD44

Domain mapping of disease mutations (DMDM)

More...
DMDMi
218512105

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002445721 – 993Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit BAdd BLAST993

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8N8A2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8N8A2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8N8A2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N8A2

PeptideAtlas

More...
PeptideAtlasi
Q8N8A2

PRoteomics IDEntifications database

More...
PRIDEi
Q8N8A2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
72386
72387 [Q8N8A2-2]
72388 [Q8N8A2-3]
72389 [Q8N8A2-4]
72390 [Q8N8A2-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N8A2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N8A2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000065413 Expressed in 197 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8N8A2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N8A2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA030122
HPA056549

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP6R1.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124841, 26 interactors

Protein interaction database and analysis system

More...
IntActi
Q8N8A2, 14 interactors

Molecular INTeraction database

More...
MINTi
Q8N8A2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000387233

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8N8A2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8N8A2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati7 – 36ANK 1Add BLAST30
Repeati40 – 69ANK 2Add BLAST30
Repeati73 – 102ANK 3Add BLAST30
Repeati106 – 135ANK 4Add BLAST30
Repeati139 – 168ANK 5Add BLAST30
Repeati172 – 201ANK 6Add BLAST30
Repeati205 – 234ANK 7Add BLAST30
Repeati238 – 267ANK 8Add BLAST30
Repeati271 – 301ANK 9Add BLAST31
Repeati305 – 334ANK 10Add BLAST30
Repeati338 – 367ANK 11Add BLAST30
Repeati371 – 400ANK 12Add BLAST30
Repeati404 – 433ANK 13Add BLAST30
Repeati437 – 466ANK 14Add BLAST30
Repeati470 – 498ANK 15Add BLAST29
Repeati531 – 561ANK 16Add BLAST31
Repeati566 – 595ANK 17Add BLAST30
Repeati599 – 628ANK 18Add BLAST30
Repeati633 – 662ANK 19Add BLAST30
Repeati669 – 698ANK 20Add BLAST30
Repeati702 – 731ANK 21Add BLAST30
Repeati735 – 764ANK 22Add BLAST30
Repeati771 – 800ANK 23Add BLAST30
Repeati803 – 832ANK 24Add BLAST30
Repeati838 – 867ANK 25Add BLAST30
Repeati871 – 901ANK 26Add BLAST31
Repeati905 – 934ANK 27Add BLAST30
Repeati941 – 970ANK 28Add BLAST30

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153535

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000033959

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG067697

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N8A2

KEGG Orthology (KO)

More...
KOi
K15503

Identification of Orthologs from Complete Genome Data

More...
OMAi
EDCSFKD

Database of Orthologous Groups

More...
OrthoDBi
1115202at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N8A2

TreeFam database of animal gene trees

More...
TreeFami
TF329520

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00204 ANK, 7 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 9 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 10 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415 ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 28 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 23 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N8A2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVLKLTDQP PLVQAIFSGD PEEIRMLIHK TEDVNTLDSE KRTPLHVAAF
60 70 80 90 100
LGDAEIIELL ILSGARVNAK DNMWLTPLHR AVASRSEEAV QVLIKHSADV
110 120 130 140 150
NARDKNWQTP LHVAAANKAV KCAEVIIPLL SSVNVSDRGG RTALHHAALN
160 170 180 190 200
GHVEMVNLLL AKGANINAFD KKDRRALHWA AYMGHLDVVA LLINHGAEVT
210 220 230 240 250
CKDKKGYTPL HAAASNGQIN VVKHLLNLGV EIDEINVYGN TALHIACYNG
260 270 280 290 300
QDAVVNELID YGANVNQPNN NGFTPLHFAA ASTHGALCLE LLVNNGADVN
310 320 330 340 350
IQSKDGKSPL HMTAVHGRFT RSQTLIQNGG EIDCVDKDGN TPLHVAARYG
360 370 380 390 400
HELLINTLIT SGADTAKCGI HSMFPLHLAA LNAHSDCCRK LLSSGFEIDT
410 420 430 440 450
PDKFGRTCLH AAAAGGNVEC IKLLQSSGAD FHKKDKCGRT PLHYAAANCH
460 470 480 490 500
FHCIETLVTT GANVNETDDW GRTALHYAAA SDMDRNKTIL GNAHDNSEEL
510 520 530 540 550
ERARELKEKE ATLCLEFLLQ NDANPSIRDK EGYNSIHYAA AYGHRQCLEL
560 570 580 590 600
LLERTNSGFE ESDSGATKSP LHLAAYNGHH QALEVLLQSL VDLDIRDEKG
610 620 630 640 650
RTALDLAAFK GHTECVEALI NQGASIFVKD NVTKRTPLHA SVINGHTLCL
660 670 680 690 700
RLLLEIADNP EAVDVKDAKG QTPLMLAVAY GHIDAVSLLL EKEANVDTVD
710 720 730 740 750
ILGCTALHRG IMTGHEECVQ MLLEQEVSIL CKDSRGRTPL HYAAARGHAT
760 770 780 790 800
WLSELLQMAL SEEDCCFKDN QGYTPLHWAC YNGNENCIEV LLEQKCFRKF
810 820 830 840 850
IGNPFTPLHC AIINDHGNCA SLLLGAIDSS IVSCRDDKGR TPLHAAAFAD
860 870 880 890 900
HVECLQLLLR HSAPVNAVDN SGKTALMMAA ENGQAGAVDI LVNSAQADLT
910 920 930 940 950
VKDKDLNTPL HLACSKGHEK CALLILDKIQ DESLINEKNN ALQTPLHVAA
960 970 980 990
RNGLKVVVEE LLAKGACVLA VDENASRSNG PRSTPGTAVQ KEE
Length:993
Mass (Da):107,603
Last modified:December 16, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3502EBBD0D093566
GO
Isoform 2 (identifier: Q8N8A2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     395-395: G → GQKYSIVSLFSNEHVLSAG
     975-993: ASRSNGPRSTPGTAVQKEE → GC

Note: No experimental confirmation available.
Show »
Length:994
Mass (Da):107,770
Checksum:i8096CE732F8643C3
GO
Isoform 3 (identifier: Q8N8A2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     551-579: LLERTNSGFEESDSGATKSPLHLAAYNGH → VSCFVLFSLTHTHTHTPNHRGINCFFPEL
     580-993: Missing.

Note: No experimental confirmation available.
Show »
Length:579
Mass (Da):63,092
Checksum:i84AAE41B54E12A5B
GO
Isoform 4 (identifier: Q8N8A2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: Missing.
     945-993: Missing.

Note: No experimental confirmation available.
Show »
Length:919
Mass (Da):99,788
Checksum:i84329430141AE9B8
GO
Isoform 5 (identifier: Q8N8A2-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     368-993: Missing.

Show »
Length:367
Mass (Da):39,601
Checksum:i1618211DB6AC424D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C4A0H7C4A0_HUMAN
Serine/threonine-protein phosphatas...
ANKRD44
316Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C209H7C209_HUMAN
Serine/threonine-protein phosphatas...
ANKRD44
791Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y7Y4A0A2R8Y7Y4_HUMAN
Serine/threonine-protein phosphatas...
ANKRD44
1,056Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JY51C9JY51_HUMAN
Serine/threonine-protein phosphatas...
ANKRD44
76Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WBW3F8WBW3_HUMAN
Serine/threonine-protein phosphatas...
ANKRD44
40Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti205K → R in CAB61404 (PubMed:17974005).Curated1
Sequence conflicti359I → R in BAC04946 (PubMed:14702039).Curated1
Sequence conflicti622Q → P in BAC04946 (PubMed:14702039).Curated1
Sequence conflicti844H → R in BAC04946 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0196001 – 25Missing in isoform 4. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_035966368 – 993Missing in isoform 5. 1 PublicationAdd BLAST626
Alternative sequenceiVSP_019601395G → GQKYSIVSLFSNEHVLSAG in isoform 2. 1 Publication1
Alternative sequenceiVSP_019602551 – 579LLERT…AYNGH → VSCFVLFSLTHTHTHTPNHR GINCFFPEL in isoform 3. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_019603580 – 993Missing in isoform 3. 1 PublicationAdd BLAST414
Alternative sequenceiVSP_035965945 – 993Missing in isoform 4. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_019604975 – 993ASRSN…VQKEE → GC in isoform 2. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK097086 mRNA Translation: BAC04946.1
AC010746 Genomic DNA No translation available.
AC013264 Genomic DNA No translation available.
AC017035 Genomic DNA Translation: AAY15060.1
AW629326 mRNA No translation available.
BC016985 mRNA Translation: AAH16985.2
BC050586 mRNA Translation: AAH50586.2
BC063622 mRNA Translation: AAH63622.1
AL133087 mRNA Translation: CAB61404.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33355.2 [Q8N8A2-5]
CCDS74619.1 [Q8N8A2-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
T42691

NCBI Reference Sequences

More...
RefSeqi
NP_001182073.1, NM_001195144.1 [Q8N8A2-1]
NP_710181.2, NM_153697.2 [Q8N8A2-5]
XP_005247005.1, XM_005246948.2 [Q8N8A2-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.432706

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000282272; ENSP00000282272; ENSG00000065413 [Q8N8A2-1]
ENST00000328737; ENSP00000331516; ENSG00000065413 [Q8N8A2-4]
ENST00000409153; ENSP00000387141; ENSG00000065413 [Q8N8A2-3]
ENST00000409919; ENSP00000387233; ENSG00000065413 [Q8N8A2-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
91526

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:91526

UCSC genome browser

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UCSCi
uc002uub.5 human [Q8N8A2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097086 mRNA Translation: BAC04946.1
AC010746 Genomic DNA No translation available.
AC013264 Genomic DNA No translation available.
AC017035 Genomic DNA Translation: AAY15060.1
AW629326 mRNA No translation available.
BC016985 mRNA Translation: AAH16985.2
BC050586 mRNA Translation: AAH50586.2
BC063622 mRNA Translation: AAH63622.1
AL133087 mRNA Translation: CAB61404.1
CCDSiCCDS33355.2 [Q8N8A2-5]
CCDS74619.1 [Q8N8A2-1]
PIRiT42691
RefSeqiNP_001182073.1, NM_001195144.1 [Q8N8A2-1]
NP_710181.2, NM_153697.2 [Q8N8A2-5]
XP_005247005.1, XM_005246948.2 [Q8N8A2-2]
UniGeneiHs.432706

3D structure databases

ProteinModelPortaliQ8N8A2
SMRiQ8N8A2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124841, 26 interactors
IntActiQ8N8A2, 14 interactors
MINTiQ8N8A2
STRINGi9606.ENSP00000387233

PTM databases

iPTMnetiQ8N8A2
PhosphoSitePlusiQ8N8A2

Polymorphism and mutation databases

BioMutaiANKRD44
DMDMi218512105

Proteomic databases

EPDiQ8N8A2
jPOSTiQ8N8A2
MaxQBiQ8N8A2
PaxDbiQ8N8A2
PeptideAtlasiQ8N8A2
PRIDEiQ8N8A2
ProteomicsDBi72386
72387 [Q8N8A2-2]
72388 [Q8N8A2-3]
72389 [Q8N8A2-4]
72390 [Q8N8A2-5]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
91526
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000282272; ENSP00000282272; ENSG00000065413 [Q8N8A2-1]
ENST00000328737; ENSP00000331516; ENSG00000065413 [Q8N8A2-4]
ENST00000409153; ENSP00000387141; ENSG00000065413 [Q8N8A2-3]
ENST00000409919; ENSP00000387233; ENSG00000065413 [Q8N8A2-5]
GeneIDi91526
KEGGihsa:91526
UCSCiuc002uub.5 human [Q8N8A2-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
91526
DisGeNETi91526
EuPathDBiHostDB:ENSG00000065413.16

GeneCards: human genes, protein and diseases

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GeneCardsi
ANKRD44
HGNCiHGNC:25259 ANKRD44
HPAiHPA030122
HPA056549
neXtProtiNX_Q8N8A2
OpenTargetsiENSG00000065413
PharmGKBiPA142672611

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

GeneTreeiENSGT00940000153535
HOGENOMiHOG000033959
HOVERGENiHBG067697
InParanoidiQ8N8A2
KOiK15503
OMAiEDCSFKD
OrthoDBi1115202at2759
PhylomeDBiQ8N8A2
TreeFamiTF329520

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ANKRD44 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
91526

Protein Ontology

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PROi
PR:Q8N8A2

Gene expression databases

BgeeiENSG00000065413 Expressed in 197 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ8N8A2 baseline and differential
GenevisibleiQ8N8A2 HS

Family and domain databases

CDDicd00204 ANK, 7 hits
Gene3Di1.25.40.20, 9 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF12796 Ank_2, 10 hits
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 28 hits
SUPFAMiSSF48403 SSF48403, 4 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 23 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiANR44_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N8A2
Secondary accession number(s): Q53SL9
, Q6P480, Q86VL5, Q8IZ72, Q9UFA4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 16, 2008
Last modified: February 13, 2019
This is version 144 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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