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Protein

Cyclic GMP-AMP synthase

Gene

CGAS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP (PubMed:23258413, PubMed:23707061, PubMed:23722159, PubMed:24077100, PubMed:25131990). Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p] (PubMed:28363908, PubMed:28214358). Acts as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses (PubMed:28363908). Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production (PubMed:28363908, PubMed:28314590). Has antiviral activity by sensing the presence of dsDNA from DNA viruses in the cytoplasm (PubMed:28363908). Also acts as an innate immune sensor of infection by retroviruses, such as HIV-1, by detecting the presence of reverse-transcribed DNA in the cytosol (PubMed:23929945). Detection of retroviral reverse-transcribed DNA in the cytosol may be indirect and be mediated via interaction with PQBP1, which directly binds reverse-transcribed retroviral DNA (PubMed:26046437). Also detects the presence of DNA from bacteria, such as M.tuberculosis (PubMed:26048138). cGAMP can be transferred from producing cells to neighboring cells through gap junctions, leading to promote TMEM173/STING activation and convey immune response to connecting cells (PubMed:24077100). cGAMP can also be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but TMEM173/STING-dependent manner (PubMed:26229115). In addition to antiviral activity, also involved in the response to cellular stresses, such as senescence, DNA damage or genome instability (PubMed:28738408, PubMed:28759889). Acts as a regulator of cellular senescence by binding to cytosolic chromatin fragments that are present in senescent cells, leading to trigger type-I interferon production via TMEM173/STING and promote cellular senescence (By similarity). Also involved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability (PubMed:28738408, PubMed:28759889). Micronuclei, which as frequently found in cancer cells, consist of chromatin surrounded by its own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, CGAS binds self-DNA exposed to the cytosol, leading to cGAMP synthesis and subsequent activation of TMEM173/STING and type-I interferon production (PubMed:28738408, PubMed:28759889).By similarity19 Publications

Catalytic activityi

ATP + GTP = 2 diphosphate + cyclic G-P(2'-5')A-P(3'-5').4 Publications

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity

Activity regulationi

The enzyme activity is strongly increased by double-stranded DNA, but not by single-stranded DNA or RNA (PubMed:23258413, PubMed:23707061, PubMed:26300263). The enzyme activity is impaired by the cleavage at Asp-140 and Asp-157 produced by CASP1 (PubMed:28314590).4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei211GTPBy similarity1
Binding sitei213ATPBy similarity1
Metal bindingi225Magnesium; catalytic2 Publications1
Metal bindingi227Magnesium; catalytic2 Publications1
Metal bindingi319Magnesium; catalyticBy similarity1
Binding sitei319GTP1 Publication1
Binding sitei383ATPBy similarity1
Metal bindingi390Zinc; via tele nitrogen3 Publications1
Metal bindingi396Zinc3 Publications1
Metal bindingi397Zinc3 Publications1
Metal bindingi404Zinc3 Publications1
Binding sitei414ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi376 – 383GTP1 Publication8
Nucleotide bindingi435 – 439ATP1 Publication5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Nucleotidyltransferase, Transferase
Biological processAntiviral defense, Immunity, Innate immunity
LigandATP-binding, GTP-binding, Magnesium, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BRENDAi2.7.7.86 2681
ReactomeiR-HSA-1834941 STING mediated induction of host immune responses

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic GMP-AMP synthase1 Publication (EC:2.7.7.864 Publications)
Short name:
cGAMP synthase1 Publication
Short name:
cGAS1 Publication
Short name:
h-cGAS1 Publication
Alternative name(s):
2'3'-cGAMP synthase1 Publication
Mab-21 domain-containing protein 1
Gene namesi
Name:CGASImported
Synonyms:C6orf150Imported, MB21D1Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000164430.15
HGNCiHGNC:21367 CGAS
MIMi613973 gene
neXtProtiNX_Q8N884

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi33D → A: No effect on type I IFN and RSAD2 induction. No effect on cleavage by CASP1. No effect on cleavage by CASP1; when associated with A-67; A-90 and A-95. Highly decreases cleavage by CASP1 and enhances RSAD2 induction upon DNA virus infection; when associated with A-67; A-90; A-95 and A-140. Abolishes cleavage by CASP1 and enhances RSAD2 induction upon DNA virus infection; when associated with A-67; A-90; A-95; A-140 and A-157. 1 Publication1
Mutagenesisi67D → A: No effect on type I IFN and RSAD2 induction. No effect on cleavage by CASP1; when associated with A-33; A-90 and A-95. Highly decreases cleavage by CASP1 and enhances RSAD2 induction upon DNA virus infection; when associated with A-33; A-90; A-95 and A-140. Abolishes cleavage by CASP1 and enhances RSAD2 induction upon DNA virus infection; when associated with A-33; A-90; A-95; A-140 and A-157. 1 Publication1
Mutagenesisi90D → A: No effect on type I IFN and RSAD2 induction. No effect on cleavage by CASP1; when associated with A-33; A-67 and A-95. Highly decreases cleavage by CASP1 and enhances RSAD2 induction upon DNA virus infection; when associated with A-33; A-67; A-95 and A-140. Abolishes cleavage by CASP1 and enhances RSAD2 induction upon DNA virus infection; when associated with A-33; A-67; A-95; A-140 and A-157. 1 Publication1
Mutagenesisi95D → A: No effect on type I IFN and RSAD2 induction. No effect on cleavage by CASP1; when associated with A-33; A-67 and A-90. Highly decreases cleavage by CASP1 and enhances RSAD2 induction upon DNA virus infection; when associated with A-33; A-67; A-90 and A-140. Abolishes cleavage by CASP1 and enhances RSAD2 induction upon DNA virus infection; when associated with A-33; A-67; A-90; A-140 and A-157. 1 Publication1
Mutagenesisi140D → A: Highly decreases cleavage by CASP1 and enhances type I IFN and RSAD2 induction upon DNA virus infection. Abolishes cleavage by CASP1, enhances RSAD2 induction upon DNA virus infection but no effect on cleavage by CASP5; when associated with A-157. Highly decreases cleavage by CASP1 and enhances RSAD2 induction upon DNA virus infection; when associated with A-33; A-67; A-90 and A-95. Abolishes cleavage by CASP1 and enhances RSAD2 induction upon DNA virus infection; when associated with A-33; A-67; A-90; A-95 and A-157. 1 Publication1
Mutagenesisi140D → H: Highly decreases cleavage by CASP1 and enhances type I IFN and RSAD2 induction upon DNA virus infection. 1 Publication1
Mutagenesisi157D → A: No effect on type I IFN and RSAD2 induction. Highly decreases cleavage by CASP1 and enhances type I IFN and enhances RSAD2 induction upon DNA virus infection. Abolishes cleavage by CASP1, enhances RSAD2 induction upon DNA virus infection but no effect on cleavage by CASP5; when associated with A-140. Abolishes cleavage by CASP1; when associated with A-33; A-67; A-90; A-95 and A-140. 1 Publication1
Mutagenesisi157D → H: Highly decreases cleavage by CASP1 and enhances type I IFN and enhances RSAD2 induction upon DNA virus infection. 1 Publication1
Mutagenesisi171K → A: No effect on stimulation of interferon production. 1 Publication1
Mutagenesisi173K → A: Strongly reduces enzyme activity and stimulation of interferon production; when associated with A-176. No effect on stimulation of interferon production. 3 Publications1
Mutagenesisi173K → E: Strongly reduces stimulation of interferon production. 2 Publications1
Mutagenesisi174L → N: Strongly reduces enzyme activity and stimulation of interferon production. 2 Publications1
Mutagenesisi176R → A: Strongly reduces enzyme activity and stimulation of interferon production; when associated with A-173. 1 Publication1
Mutagenesisi210N → D: More than 75% inhibition of interferon beta production. 1 Publication1
Mutagenesisi211T → Q: Abolishes enzyme activity; when associated with I-376 and I-436. 1 Publication1
Mutagenesisi212 – 213GS → AA: Abolishes enzyme activity. Abolishes stimulation of interferon production. 1 Publication2
Mutagenesisi225E → A: Abolishes enzyme activity and stimulation of interferon production; when associated with A-227. 3 Publications1
Mutagenesisi227D → A: Abolishes enzyme activity and stimulation of interferon production; when associated with A-225. 3 Publications1
Mutagenesisi236R → E: Abolishes stimulation of interferon production; when associated with E-254 and E-327. 1 Publication1
Mutagenesisi254K → E: Abolishes stimulation of interferon production; when associated with E-236 and E-327. 1 Publication1
Mutagenesisi327K → E: Abolishes stimulation of interferon production; when associated with E-236 and E-254. 1 Publication1
Mutagenesisi347K → E: Abolishes stimulation of interferon production. 1 Publication1
Mutagenesisi353R → E: Abolishes stimulation of interferon production. 1 Publication1
Mutagenesisi376R → I: Alters enzyme activity, leading to the appearance of 3'-5' linked cGAMP. Abolishes enzyme activity; when associated with Q-211 and I-436. 1 Publication1
Mutagenesisi384K → A or E: Abolishes stimulation of interferon production. 2 Publications1
Mutagenesisi390H → A: Strongly reduces stimulation of interferon production. 1 Publication1
Mutagenesisi394K → A: Abolishes enzyme activity. No effect on stimulation of interferon production. 2 Publications1
Mutagenesisi394K → E: Abolishes enzyme activity. Abolishes stimulation of interferon production. 1 Publication1
Mutagenesisi396 – 397CC → AA: Abolishes DNA binding and enzyme activity. Abolishes stimulation of interferon production. 1 Publication2
Mutagenesisi396C → A: Abolishes DNA binding and enzyme activity. 1 Publication1
Mutagenesisi397C → A: Abolishes stimulation of interferon production. 1 Publication1
Mutagenesisi400K → E: Abolishes stimulation of interferon production; when associated with E-403. 1 Publication1
Mutagenesisi403K → E: Abolishes stimulation of interferon production; when associated with E-400. 1 Publication1
Mutagenesisi404C → A: Abolishes stimulation of interferon production. 1 Publication1
Mutagenesisi407K → A or E: Abolishes enzyme activity and stimulation of interferon production; when associated with A-411. Abolishes enzyme activity. Abolishes stimulation of interferon production. 2 Publications1
Mutagenesisi411K → A: Abolishes enzyme activity and stimulation of interferon production; when associated with A-407. 1 Publication1
Mutagenesisi414K → A or E: Abolishes stimulation of interferon production. 1 Publication1
Mutagenesisi436Y → I: Abolishes enzyme activity; when associated with Q-211 and I-376. 1 Publication1

Organism-specific databases

DisGeNETi115004
OpenTargetsiENSG00000164430
PharmGKBiPA134956015

Polymorphism and mutation databases

BioMutaiMB21D1
DMDMi68565218

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000895431 – 522Cyclic GMP-AMP synthaseAdd BLAST522

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7N6-acetyllysineCombined sources1
Modified residuei143PhosphoserineCombined sources1
Modified residuei210(Microbial infection) Deamidated asparagine; by herpes simplex virus 1/HHV-1 UL371 Publication1
Modified residuei2865-glutamyl polyglutamateBy similarity1
Modified residuei3145-glutamyl glutamateBy similarity1
Modified residuei389(Microbial infection) Deamidated asparagine; by herpes simplex virus 1/HHV-1 UL371 Publication1
Modified residuei414N6-acetyllysineCombined sources1
Modified residuei451(Microbial infection) Deamidated glutamine; by herpes simplex virus 1/HHV-1 UL371 Publication1
Modified residuei454(Microbial infection) Deamidated glutamine; by herpes simplex virus 1/HHV-1 UL371 Publication1

Post-translational modificationi

(Microbial infection) Deamidated on 'Asn-210' by herpes simplex virus 1 protein UL37. This modification significantly reduces CGAS-dependent cGAMP production and innate immune signaling induced by dsDNA.1 Publication
Polyglutamylated by TTLL6 at Glu-286, leading to impair DNA-binding activity. Monoglutamylated at Glu-314 by TTLL4, leading to impair the nucleotidyltransferase activity. Deglutamylated by AGBL5/CCP5 and AGBL6/CCP6.By similarity
Cleaved by CASP1 at Asp-140 and Asp-157 upon DNA virus infection; the cleavage impairs cGAMP production (PubMed:28314590). Also cleaved by the pyroptotic CASP4 and CASP5 during non-canonical inflammasome activation; they don't cut at the same sites than CASP1 (PubMed:28314590).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei140 – 141Cleavage; by CASP11 Publication2
Sitei157 – 158Cleavage; by CASP11 Publication2

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein

Proteomic databases

EPDiQ8N884
MaxQBiQ8N884
PaxDbiQ8N884
PeptideAtlasiQ8N884
PRIDEiQ8N884
ProteomicsDBi72382
72383 [Q8N884-2]

PTM databases

iPTMnetiQ8N884
PhosphoSitePlusiQ8N884

Expressioni

Tissue specificityi

Expressed in the monocytic cell line THP1.1 Publication

Inductioni

By type I interferons.1 Publication

Gene expression databases

BgeeiENSG00000164430 Expressed in 193 organ(s), highest expression level in sperm
CleanExiHS_C6orf150
GenevisibleiQ8N884 HS

Organism-specific databases

HPAiHPA031700
HPA031702

Interactioni

Subunit structurei

Monomer in the absence of DNA and when bound to dsDNA (PubMed:28363908). Interacts with PQBP1 (via WW domain) (PubMed:26046437). Interacts with TRIM14; this interaction stabilizes CGAS and promotes type I interferon production (PubMed:27666593).2 Publications
(Microbial infection) Interacts with herpes virus 8/HHV-8 protein ORF52; this interaction inhibits cGAS enzymatic activity.1 Publication
(Microbial infection) Interacts with herpes simplex virus 1 protein UL37; this interaction daeminates CGAS and inhibits its activation.1 Publication

Protein-protein interaction databases

BioGridi125408, 8 interactors
IntActiQ8N884, 6 interactors
STRINGi9606.ENSP00000359339

Structurei

Secondary structure

1522
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8N884
SMRiQ8N884
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 160DNA-binding1 PublicationAdd BLAST160
Regioni120 – 160Required for activation upon DNA viral infection1 PublicationAdd BLAST41
Regioni173 – 215DNA-binding1 PublicationAdd BLAST43
Regioni384 – 407DNA-binding1 PublicationAdd BLAST24

Domaini

The N-terminal part (1-160) binds unspecifically dsDNA and expand the binding and moving range of CGAS on dsDNA. Enhances the enzyme activity and activation of innate immune signaling upon cytosolic recognition of dsDNA (PubMed:28363908, PubMed:28214358). When the N-terminal part (1-160) is missing the protein bound to dsDNA homodimerizes (By similarity).By similarity2 Publications

Sequence similaritiesi

Belongs to the mab-21 family.Curated

Phylogenomic databases

eggNOGiENOG410IE27 Eukaryota
ENOG410XTKD LUCA
GeneTreeiENSGT00710000106842
HOGENOMiHOG000293423
HOVERGENiHBG068840
InParanoidiQ8N884
KOiK17834
OMAiPQDSQWD
OrthoDBiEOG091G0MHW
PhylomeDBiQ8N884
TreeFamiTF331255

Family and domain databases

InterProiView protein in InterPro
IPR024810 Mab-21_dom
PfamiView protein in Pfam
PF03281 Mab-21, 1 hit
SMARTiView protein in SMART
SM01265 Mab-21, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8N884-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQPWHGKAMQ RASEAGATAP KASARNARGA PMDPTESPAA PEAALPKAGK
60 70 80 90 100
FGPARKSGSR QKKSAPDTQE RPPVRATGAR AKKAPQRAQD TQPSDATSAP
110 120 130 140 150
GAEGLEPPAA REPALSRAGS CRQRGARCST KPRPPPGPWD VPSPGLPVSA
160 170 180 190 200
PILVRRDAAP GASKLRAVLE KLKLSRDDIS TAAGMVKGVV DHLLLRLKCD
210 220 230 240 250
SAFRGVGLLN TGSYYEHVKI SAPNEFDVMF KLEVPRIQLE EYSNTRAYYF
260 270 280 290 300
VKFKRNPKEN PLSQFLEGEI LSASKMLSKF RKIIKEEIND IKDTDVIMKR
310 320 330 340 350
KRGGSPAVTL LISEKISVDI TLALESKSSW PASTQEGLRI QNWLSAKVRK
360 370 380 390 400
QLRLKPFYLV PKHAKEGNGF QEETWRLSFS HIEKEILNNH GKSKTCCENK
410 420 430 440 450
EEKCCRKDCL KLMKYLLEQL KERFKDKKHL DKFSSYHVKT AFFHVCTQNP
460 470 480 490 500
QDSQWDRKDL GLCFDNCVTY FLQCLRTEKL ENYFIPEFNL FSSNLIDKRS
510 520
KEFLTKQIEY ERNNEFPVFD EF
Length:522
Mass (Da):58,814
Last modified:July 5, 2005 - v2
Checksum:i808FF6F9F3BF8C50
GO
Isoform 2 (identifier: Q8N884-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     445-447: VCT → RLY
     448-522: Missing.

Note: No experimental confirmation available.
Show »
Length:447
Mass (Da):49,762
Checksum:i61504BFBBB6FD338
GO

Sequence cautioni

The sequence AAH12928 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05081135T → N2 PublicationsCorresponds to variant dbSNP:rs9352000Ensembl.1
Natural variantiVAR_033677261P → H1 PublicationCorresponds to variant dbSNP:rs610913Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014388445 – 447VCT → RLY in isoform 2. 1 Publication3
Alternative sequenceiVSP_014389448 – 522Missing in isoform 2. 1 PublicationAdd BLAST75

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KC294566 mRNA Translation: AGB51853.1
AK097148 mRNA Translation: BAC04965.1
AC019205 Genomic DNA No translation available.
AL603910 Genomic DNA No translation available.
BC012928 mRNA Translation: AAH12928.1 Different initiation.
BC108714 mRNA Translation: AAI08715.1
BC113606 mRNA Translation: AAI13607.1
BC113608 mRNA Translation: AAI13609.1
BC143694 mRNA Translation: AAI43695.1
CCDSiCCDS4978.1 [Q8N884-1]
RefSeqiNP_612450.2, NM_138441.2 [Q8N884-1]
UniGeneiHs.658405

Genome annotation databases

EnsembliENST00000370315; ENSP00000359339; ENSG00000164430 [Q8N884-1]
ENST00000370318; ENSP00000359342; ENSG00000164430 [Q8N884-2]
GeneIDi115004
KEGGihsa:115004
UCSCiuc003pgx.2 human [Q8N884-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KC294566 mRNA Translation: AGB51853.1
AK097148 mRNA Translation: BAC04965.1
AC019205 Genomic DNA No translation available.
AL603910 Genomic DNA No translation available.
BC012928 mRNA Translation: AAH12928.1 Different initiation.
BC108714 mRNA Translation: AAI08715.1
BC113606 mRNA Translation: AAI13607.1
BC113608 mRNA Translation: AAI13609.1
BC143694 mRNA Translation: AAI43695.1
CCDSiCCDS4978.1 [Q8N884-1]
RefSeqiNP_612450.2, NM_138441.2 [Q8N884-1]
UniGeneiHs.658405

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4KM5X-ray2.50A157-522[»]
4LEVX-ray1.95A/B157-522[»]
4LEWX-ray2.04A/B157-522[»]
4MKPX-ray1.95A161-522[»]
4O67X-ray2.44A/B161-522[»]
4O68X-ray2.44A147-522[»]
4O69X-ray2.25A161-522[»]
5V8HX-ray2.76A/B161-522[»]
5V8JX-ray2.93A/B161-522[»]
5V8NX-ray3.23A/B161-522[»]
5V8OX-ray3.10A/B161-522[»]
5VDOX-ray3.22A/B161-522[»]
5VDPX-ray2.30A/B161-522[»]
5VDQX-ray3.25A/B161-522[»]
5VDRX-ray3.04A/B161-522[»]
5VDSX-ray2.77A/B161-522[»]
5VDTX-ray2.58A/B161-522[»]
5VDUX-ray2.73A/B161-522[»]
5VDVX-ray3.00A/B161-522[»]
5VDWX-ray2.71A/B161-522[»]
6CT9X-ray2.26A157-522[»]
6CTAX-ray2.78A157-522[»]
ProteinModelPortaliQ8N884
SMRiQ8N884
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125408, 8 interactors
IntActiQ8N884, 6 interactors
STRINGi9606.ENSP00000359339

PTM databases

iPTMnetiQ8N884
PhosphoSitePlusiQ8N884

Polymorphism and mutation databases

BioMutaiMB21D1
DMDMi68565218

Proteomic databases

EPDiQ8N884
MaxQBiQ8N884
PaxDbiQ8N884
PeptideAtlasiQ8N884
PRIDEiQ8N884
ProteomicsDBi72382
72383 [Q8N884-2]

Protocols and materials databases

DNASUi115004
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370315; ENSP00000359339; ENSG00000164430 [Q8N884-1]
ENST00000370318; ENSP00000359342; ENSG00000164430 [Q8N884-2]
GeneIDi115004
KEGGihsa:115004
UCSCiuc003pgx.2 human [Q8N884-1]

Organism-specific databases

CTDi115004
DisGeNETi115004
EuPathDBiHostDB:ENSG00000164430.15
GeneCardsiCGAS
H-InvDBiHIX0022366
HGNCiHGNC:21367 CGAS
HPAiHPA031700
HPA031702
MIMi613973 gene
neXtProtiNX_Q8N884
OpenTargetsiENSG00000164430
PharmGKBiPA134956015
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE27 Eukaryota
ENOG410XTKD LUCA
GeneTreeiENSGT00710000106842
HOGENOMiHOG000293423
HOVERGENiHBG068840
InParanoidiQ8N884
KOiK17834
OMAiPQDSQWD
OrthoDBiEOG091G0MHW
PhylomeDBiQ8N884
TreeFamiTF331255

Enzyme and pathway databases

BRENDAi2.7.7.86 2681
ReactomeiR-HSA-1834941 STING mediated induction of host immune responses

Miscellaneous databases

ChiTaRSiMB21D1 human
GenomeRNAii115004
PROiPR:Q8N884
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164430 Expressed in 193 organ(s), highest expression level in sperm
CleanExiHS_C6orf150
GenevisibleiQ8N884 HS

Family and domain databases

InterProiView protein in InterPro
IPR024810 Mab-21_dom
PfamiView protein in Pfam
PF03281 Mab-21, 1 hit
SMARTiView protein in SMART
SM01265 Mab-21, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCGAS_HUMAN
AccessioniPrimary (citable) accession number: Q8N884
Secondary accession number(s): L0L2J9
, Q14CV6, Q32NC9, Q5SWL0, Q5SWL1, Q96E45
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: October 10, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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