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Entry version 150 (17 Jun 2020)
Sequence version 2 (16 May 2006)
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Protein

Zinc finger protein 614

Gene

ZNF614

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri205 – 227C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri257 – 281C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri287 – 309C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri315 – 337C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri343 – 365C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri371 – 393C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri399 – 421C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri427 – 449C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri455 – 477C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri483 – 505C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri511 – 533C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri539 – 561C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436 Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 614
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF614
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000142556.18

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24722 ZNF614

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N883

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
80110

Open Targets

More...
OpenTargetsi
ENSG00000142556

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134914044

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8N883 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF614

Domain mapping of disease mutations (DMDM)

More...
DMDMi
97219309

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002345981 – 585Zinc finger protein 614Add BLAST585

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8N883

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8N883

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8N883

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8N883

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N883

PeptideAtlas

More...
PeptideAtlasi
Q8N883

PRoteomics IDEntifications database

More...
PRIDEi
Q8N883

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
72381 [Q8N883-1]
78918

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q8N883

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q8N883

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N883

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000142556 Expressed in forebrain and 191 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8N883 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N883 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000142556 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
123116, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q8N883, 4 interactors

Molecular INTeraction database

More...
MINTi
Q8N883

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000270649

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8N883 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8N883

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 79KRABPROSITE-ProRule annotationAdd BLAST72

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri205 – 227C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri257 – 281C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri287 – 309C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri315 – 337C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri343 – 365C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri371 – 393C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri399 – 421C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri427 – 449C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri455 – 477C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri483 – 505C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri511 – 533C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri539 – 561C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162748

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002678_69_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8N883

KEGG Orthology (KO)

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KOi
K09228

Identification of Orthologs from Complete Genome Data

More...
OMAi
KKMHIRE

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N883

TreeFam database of animal gene trees

More...
TreeFami
TF350804

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765 KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 9 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 11 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 11 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N883-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIKTQESLTL EDVAVEFSWE EWQLLDTAQK NLYRDVMVEN YNHLVSLGYQ
60 70 80 90 100
TSKPDVLSKL AHGQEPWTTD AKIQNKNCPG IGKVDSHLQE HSPNQRLLKS
110 120 130 140 150
VQQCNGQNTL RNIVHLSKTH FPIVQNHDTF DLYRKNLKSS LSLINQKRRH
160 170 180 190 200
GINNPVEFIG GEKTLLHGKH ERTHTKTRFS ENAKCIHTKF QVFKHQRTQK
210 220 230 240 250
IEKPHACIEC EQTFLRKSQL IYHENICIQE NPGSGQCEKL SRSVLFTKHL
260 270 280 290 300
KTNTTDKICI PNEYRKGSTV KSSLITHQQT HTEEKSYMCS ECGKGFTMKR
310 320 330 340 350
YLIAHQRTHS GEKPYVCKEC GKGFTVKSNL IVHQRTHTGE KPYICSECGK
360 370 380 390 400
GFTMKRYLVV HQRTHTGEKP YMCSECGKGF TVKSNLIVHQ RSHTGEKSYI
410 420 430 440 450
CSECGKGFTV KRTLVIHQRT HTGEKSYICN ECGKGFTTKR TLIIHQRTHT
460 470 480 490 500
GEKPYECNEC GKAFSQKICL IQHERCHTGK TPFVCTECGK SYSHKYGLIT
510 520 530 540 550
HQRIHTGEKP YECNECGKAF TTKSVLNVHQ RTHTGERPYG CSDCEKAFSH
560 570 580
LSNLVKHKKM HTREMGRISQ VENSCNGESQ LLPYK
Length:585
Mass (Da):67,215
Last modified:May 16, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i761FFD8B035CDAA4
GO
Isoform 2 (identifier: Q8N883-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     161-198: GEKTLLHGKH...KFQVFKHQRT → ETGSLERPRQ...LCLLKIHTKN
     199-585: Missing.

Show »
Length:198
Mass (Da):22,783
Checksum:i6FE01C3BEE09643F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QYG4M0QYG4_HUMAN
Zinc finger protein 614
ZNF614
39Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R1H2M0R1H2_HUMAN
Zinc finger protein 614
ZNF614
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti250L → P in BAC04966 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05287868T → I. Corresponds to variant dbSNP:rs9636139Ensembl.1
Natural variantiVAR_061959160G → E. Corresponds to variant dbSNP:rs45596739Ensembl.1
Natural variantiVAR_052879223H → R. Corresponds to variant dbSNP:rs35098634Ensembl.1
Natural variantiVAR_052880415V → I. Corresponds to variant dbSNP:rs8104890Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_056549161 – 198GEKTL…KHQRT → ETGSLERPRQADHLRSEVQD QPGQRGETLCLLKIHTKN in isoform 2. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_056550199 – 585Missing in isoform 2. 1 PublicationAdd BLAST387

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK097156 mRNA Translation: BAC04966.1
AC011468 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW72058.1
BC004930 mRNA Translation: AAH04930.1
BC022246 mRNA Translation: AAH22246.1
BC101392 mRNA Translation: AAI01393.1
BC101393 mRNA Translation: AAI01394.1
BC101394 mRNA Translation: AAI01395.1
BC101395 mRNA Translation: AAI01396.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12847.1 [Q8N883-1]

NCBI Reference Sequences

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RefSeqi
NP_079316.2, NM_025040.3 [Q8N883-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000270649; ENSP00000270649; ENSG00000142556 [Q8N883-1]
ENST00000356322; ENSP00000348674; ENSG00000142556 [Q8N883-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
80110

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:80110

UCSC genome browser

More...
UCSCi
uc002pyi.5 human [Q8N883-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097156 mRNA Translation: BAC04966.1
AC011468 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW72058.1
BC004930 mRNA Translation: AAH04930.1
BC022246 mRNA Translation: AAH22246.1
BC101392 mRNA Translation: AAI01393.1
BC101393 mRNA Translation: AAI01394.1
BC101394 mRNA Translation: AAI01395.1
BC101395 mRNA Translation: AAI01396.1
CCDSiCCDS12847.1 [Q8N883-1]
RefSeqiNP_079316.2, NM_025040.3 [Q8N883-1]

3D structure databases

SMRiQ8N883
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi123116, 4 interactors
IntActiQ8N883, 4 interactors
MINTiQ8N883
STRINGi9606.ENSP00000270649

PTM databases

CarbonylDBiQ8N883
iPTMnetiQ8N883
PhosphoSitePlusiQ8N883

Polymorphism and mutation databases

BioMutaiZNF614
DMDMi97219309

Proteomic databases

EPDiQ8N883
jPOSTiQ8N883
MassIVEiQ8N883
MaxQBiQ8N883
PaxDbiQ8N883
PeptideAtlasiQ8N883
PRIDEiQ8N883
ProteomicsDBi72381 [Q8N883-1]
78918

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
21569 126 antibodies

Genome annotation databases

EnsembliENST00000270649; ENSP00000270649; ENSG00000142556 [Q8N883-1]
ENST00000356322; ENSP00000348674; ENSG00000142556 [Q8N883-2]
GeneIDi80110
KEGGihsa:80110
UCSCiuc002pyi.5 human [Q8N883-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
80110
DisGeNETi80110
EuPathDBiHostDB:ENSG00000142556.18

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF614
HGNCiHGNC:24722 ZNF614
HPAiENSG00000142556 Low tissue specificity
neXtProtiNX_Q8N883
OpenTargetsiENSG00000142556
PharmGKBiPA134914044

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000162748
HOGENOMiCLU_002678_69_0_1
InParanoidiQ8N883
KOiK09228
OMAiKKMHIRE
OrthoDBi1318335at2759
PhylomeDBiQ8N883
TreeFamiTF350804

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
80110 3 hits in 809 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
80110
PharosiQ8N883 Tdark

Protein Ontology

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PROi
PR:Q8N883
RNActiQ8N883 protein

Gene expression databases

BgeeiENSG00000142556 Expressed in forebrain and 191 other tissues
ExpressionAtlasiQ8N883 baseline and differential
GenevisibleiQ8N883 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 9 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 11 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 11 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN614_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N883
Secondary accession number(s): Q494T8, Q8TCF4, Q9BSN8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 16, 2006
Last modified: June 17, 2020
This is version 150 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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