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Protein

Uncharacterized protein C7orf31

Gene

C7orf31

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C7orf31
Gene namesi
Name:C7orf31
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000153790.11
HGNCiHGNC:21722 C7orf31
MIMi616071 gene
neXtProtiNX_Q8N865

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000153790
PharmGKBiPA134924921

Polymorphism and mutation databases

BioMutaiC7orf31
DMDMi269849700

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000895871 – 590Uncharacterized protein C7orf31Add BLAST590

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei219PhosphothreonineBy similarity1
Modified residuei407PhosphoserineBy similarity1
Modified residuei422PhosphoserineBy similarity1
Cross-linki427Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei442PhosphotyrosineBy similarity1
Modified residuei485PhosphoserineBy similarity1
Cross-linki545Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei547PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8N865
PaxDbiQ8N865
PeptideAtlasiQ8N865
PRIDEiQ8N865
ProteomicsDBi72377

PTM databases

iPTMnetiQ8N865
PhosphoSitePlusiQ8N865

Expressioni

Gene expression databases

BgeeiENSG00000153790 Expressed in 146 organ(s), highest expression level in sperm
CleanExiHS_C7orf31
ExpressionAtlasiQ8N865 baseline and differential
GenevisibleiQ8N865 HS

Organism-specific databases

HPAiHPA020346

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
A8K5H93EBI-10174456,EBI-10174421

Protein-protein interaction databases

BioGridi126465, 5 interactors
IntActiQ8N865, 10 interactors
STRINGi9606.ENSP00000283905

Structurei

3D structure databases

ProteinModelPortaliQ8N865
SMRiQ8N865
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IIJZ Eukaryota
ENOG410YGE7 LUCA
GeneTreeiENSGT00390000015236
HOVERGENiHBG081124
InParanoidiQ8N865
OMAiCPDCTPR
OrthoDBiEOG091G066S
PhylomeDBiQ8N865
TreeFamiTF336164

Family and domain databases

InterProiView protein in InterPro
IPR027886 DUF4555
PANTHERiPTHR31393 PTHR31393, 1 hit
PfamiView protein in Pfam
PF15093 DUF4555, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q8N865-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEVIHGRPYC CRELEGADIL SNTFYSNELH NPLQTVTRPT ASEDRYQELR
60 70 80 90 100
ESLQQCRLPW GAEREYGGII PISLPEDHRP KYEPPRVMGK GHQHYGFGGE
110 120 130 140 150
TWPRKLPVEQ FYYLTQNKKS DVYGNDSLIP KPPNSTVGEI CLPYPIEHPY
160 170 180 190 200
HTHICRGAMF PTFTSPEDLY TGIKARTQQP FPPTVPTKAY DSTVLKTRGN
210 220 230 240 250
PYRYELIDIP MDSKKKALTW PGQGVYYDFP RGVEKNKPVF YPKPPKTFAP
260 270 280 290 300
NTSLNSWDPI CSAKEANIQR NLERSHWLTS YTHDFTGLGP MDPLELDDYH
310 320 330 340 350
EKMVAELTRK IGFDPEPQEK FHPVFKPPRP LEGRIARLIQ NRRSLEAIVQ
360 370 380 390 400
QRPRSCPDCT PRVLCNFHTF VPSSKEMVAL SDNIPAGVTH KNQDIEEKII
410 420 430 440 450
EEQSLLSTYE LPSCYPTKDL TSIYDIKPFP KITDTKKTED LYWRQQSLKT
460 470 480 490 500
QPTPYCKPDH WIHYENLKSP LRDQYNMCPD PVSLSKPSVL QNKQDTEAFT
510 520 530 540 550
LEHFLSKPEE ELFLNMENNE ETRPVLGWIP RAGVTKPQTN LLELKNSFSK
560 570 580 590
TGAQKRFHKS ILEDHKDLRD NEHSGMKHQF YGHNSYYFYN
Length:590
Mass (Da):68,464
Last modified:November 24, 2009 - v3
Checksum:iE2FCDAA48BB8ED8E
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JTB1C9JTB1_HUMAN
Uncharacterized protein C7orf31
C7orf31
153Annotation score:
C9J431C9J431_HUMAN
Uncharacterized protein C7orf31
C7orf31
115Annotation score:
C9JF06C9JF06_HUMAN
Uncharacterized protein C7orf31
C7orf31
92Annotation score:

Sequence cautioni

The sequence AAP22338 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAC05255 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05680913E → K. Corresponds to variant dbSNP:rs11980216Ensembl.1
Natural variantiVAR_02278182Y → C1 PublicationCorresponds to variant dbSNP:rs2717858Ensembl.1
Natural variantiVAR_05681086R → C. Corresponds to variant dbSNP:rs3213642Ensembl.1
Natural variantiVAR_060608143P → Q1 PublicationCorresponds to variant dbSNP:rs17855102Ensembl.1
Natural variantiVAR_022782158A → T3 PublicationsCorresponds to variant dbSNP:rs12535348Ensembl.1
Natural variantiVAR_022783187T → S4 PublicationsCorresponds to variant dbSNP:rs2523072Ensembl.1
Natural variantiVAR_056811238P → Q1 PublicationCorresponds to variant dbSNP:rs11984293Ensembl.1
Natural variantiVAR_056812249A → T. Corresponds to variant dbSNP:rs17150982Ensembl.1
Natural variantiVAR_022784300H → R4 PublicationsCorresponds to variant dbSNP:rs2285738Ensembl.1
Natural variantiVAR_060609518N → D1 PublicationCorresponds to variant dbSNP:rs17857512Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097248 mRNA Translation: BAC04985.1
AK098189 mRNA Translation: BAC05255.1 Different initiation.
AC004129 Genomic DNA Translation: AAP22338.1 Sequence problems.
CH236948 Genomic DNA Translation: EAL24238.1
CH471073 Genomic DNA Translation: EAW93827.1
BC015397 mRNA Translation: AAH15397.2
BC043269 mRNA Translation: AAH43269.1
BC060879 mRNA Translation: AAH60879.1
BX640851 mRNA Translation: CAE45919.1
CCDSiCCDS5394.1
RefSeqiNP_620166.3, NM_138811.3
XP_005249676.1, XM_005249619.3
XP_005249677.1, XM_005249620.3
XP_011513427.1, XM_011515125.2
UniGeneiHs.122055

Genome annotation databases

EnsembliENST00000283905; ENSP00000283905; ENSG00000153790
ENST00000409280; ENSP00000386604; ENSG00000153790
GeneIDi136895
KEGGihsa:136895
UCSCiuc003sxn.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097248 mRNA Translation: BAC04985.1
AK098189 mRNA Translation: BAC05255.1 Different initiation.
AC004129 Genomic DNA Translation: AAP22338.1 Sequence problems.
CH236948 Genomic DNA Translation: EAL24238.1
CH471073 Genomic DNA Translation: EAW93827.1
BC015397 mRNA Translation: AAH15397.2
BC043269 mRNA Translation: AAH43269.1
BC060879 mRNA Translation: AAH60879.1
BX640851 mRNA Translation: CAE45919.1
CCDSiCCDS5394.1
RefSeqiNP_620166.3, NM_138811.3
XP_005249676.1, XM_005249619.3
XP_005249677.1, XM_005249620.3
XP_011513427.1, XM_011515125.2
UniGeneiHs.122055

3D structure databases

ProteinModelPortaliQ8N865
SMRiQ8N865
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126465, 5 interactors
IntActiQ8N865, 10 interactors
STRINGi9606.ENSP00000283905

PTM databases

iPTMnetiQ8N865
PhosphoSitePlusiQ8N865

Polymorphism and mutation databases

BioMutaiC7orf31
DMDMi269849700

Proteomic databases

EPDiQ8N865
PaxDbiQ8N865
PeptideAtlasiQ8N865
PRIDEiQ8N865
ProteomicsDBi72377

Protocols and materials databases

DNASUi136895
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000283905; ENSP00000283905; ENSG00000153790
ENST00000409280; ENSP00000386604; ENSG00000153790
GeneIDi136895
KEGGihsa:136895
UCSCiuc003sxn.2 human

Organism-specific databases

CTDi136895
EuPathDBiHostDB:ENSG00000153790.11
GeneCardsiC7orf31
H-InvDBiHIX0201151
HGNCiHGNC:21722 C7orf31
HPAiHPA020346
MIMi616071 gene
neXtProtiNX_Q8N865
OpenTargetsiENSG00000153790
PharmGKBiPA134924921
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIJZ Eukaryota
ENOG410YGE7 LUCA
GeneTreeiENSGT00390000015236
HOVERGENiHBG081124
InParanoidiQ8N865
OMAiCPDCTPR
OrthoDBiEOG091G066S
PhylomeDBiQ8N865
TreeFamiTF336164

Miscellaneous databases

ChiTaRSiC7orf31 human
GenomeRNAii136895
PROiPR:Q8N865
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000153790 Expressed in 146 organ(s), highest expression level in sperm
CleanExiHS_C7orf31
ExpressionAtlasiQ8N865 baseline and differential
GenevisibleiQ8N865 HS

Family and domain databases

InterProiView protein in InterPro
IPR027886 DUF4555
PANTHERiPTHR31393 PTHR31393, 1 hit
PfamiView protein in Pfam
PF15093 DUF4555, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCG031_HUMAN
AccessioniPrimary (citable) accession number: Q8N865
Secondary accession number(s): A4D165
, Q6MZV8, Q6P989, Q7LE28, Q86XK1, Q8N1H5, Q96BN4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: November 24, 2009
Last modified: November 7, 2018
This is version 103 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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