Tubulin polyglutamylase TTLL6

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ATP binding Source: UniProtKB-KW
• protein-glutamic acid ligase activity Source: UniProtKB
• tubulin binding Source: UniProtKB
• tubulin-glutamic acid ligase activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• microtubule bundle formation Source: Ensembl
• microtubule cytoskeleton organization Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• microtubule severing Source: Ensembl
• positive regulation of cilium movement Source: Ensembl
• protein polyglutamylation Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

Organism-specific databases

Miscellaneous databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• tubulin binding Source: UniProtKB

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MPQCPTLESQ EGENSEEKGD SSKEDPKETV ALAFVRENPG AQNGLQNAQQ 
        60         70         80         90        100
QGKKKRKKKR LVINLSSCRY ESVRRAAQQY GFREGGEDDD WTLYWTDYSV 
       110        120        130        140        150
SLERVMEMKS YQKINHFPGM SEICRKDLLA RNMSRMLKMF PKDFRFFPRT 
       160        170        180        190        200
WCLPADWGDL QTYSRSRKNK TYICKPDSGC QGKGIFITRT VKEIKPGEDM 
       210        220        230        240        250
ICQLYISKPF IIDGFKFDLR IYVLVTSCDP LRIFVYNEGL ARFATTSYSR 
       260        270        280        290        300
PCTDNLDDIC MHLTNYSINK HSSNFSRDAH SGSKRKLSTF SAYLEDHSYN 
       310        320        330        340        350
VEQIWRDIED VIIKTLISAH PIIRHNYHTC FPNHTLNSAC FEILGFDILL 
       360        370        380        390        400
DHKLKPWLLE VNHSPSFSTD SRLDKEVKDG LLYDTLVLIN LESCDKKKVL 
       410        420        430        440        450
EEERQRGQFL QQCCSREMRI EEAKGFRAVQ LKKTETYEKE NCGGFRLIYP 
       460        470        480        490        500
SLNSEKYEKF FQDNNSLFQN TVASRAREEY ARQLIQELRL KREKKPFQMK 
       510        520        530        540        550
KKVEMQGESA GEQVRKKGMR GWQQKQQQKD KAATQASKQY IQPLTLVSYT 
       560        570        580        590        600
PDLLLSVRGE RKNETDSSLN QEAPTEEASS VFPKLTSAKP FSSLPDLRNI 
       610        620        630        640        650
NLSSSKLEPS KPNFSIKEAK SASAVNVFTG TVHLTSVETT PESTTQLSIS 
       660        670        680        690        700
PKSPPTLAVT ASSEYSGPET DRVVSFKCKK QQTPPHLTQK KMLKSFLPTK 
       710        720        730        740        750
SKSFWESPNT NWTLLKSDMN KPHLISELLT KLQLSGKLSF FPAHYNPKLG 
       760        770        780        790        800
MNNLSQNPSL PGECHSRSDS SGEKRQLDVS SLLLQSPQSY NVTLRDLLVI 
       810        820        830        840 
ATPAQLDPRP CRSHASAMRD PCMQDQEAYS HCLISGQKGC ERS        

        10         20         30         40         50
MEGCLGVAEL RKLSTFSAYL EDHSYNVEQI WRDIEDVIIK TLISAHPIIR 
        60         70         80         90        100
HNYHTCFPNH TLNSACFEIL GFDILLDHKL KPWLLEVNHS PSFSTDSRLD 
       110        120        130        140        150
KEVKDGLLYD TLVLINLESC DKKKVLEEER QRGQFLQQCC SREMRIEEAK 
       160        170        180        190        200
GFRAVQLKKT ETYEKENCGG FRLIYPSLNS EKYEKFFQDN NSLFQNTVAS 
       210        220        230        240        250
RAREEYARQL IQELRLKREK KPFQMKKKVE MQGESAGEQV RKKGMRGWQQ 
       260        270        280        290        300
KQQQKDKAAT QASKQYIQPL TLVSYTPDLL LSVRGERKNE TDSSLNQEAP 
       310        320        330        340        350
TEEASSVFPK LTSAKPFSSL PDLRNINLSS SKLEPSKPNF SIKEAKSASA 
       360        370        380        390        400
VNVFTGTVHL TSVETTPEST TQLSISPKSP PTLAVTASSE YSGPETDRVV 
       410        420        430        440        450
SFKCKKQQTP PHLTQKKMLK SFLPTKSKSF WESPNTNWTL LKSDMNKPHL 
       460        470        480        490        500
ISELLTKLQL SGKLSFFPAH YNPKLGMNNL SQNPSLPGEC HSRSDSSGEK 
       510        520        530        540        550
RQLDVSSLLL QSPQSYNVTL RDLLVIATPA QLDPRPCRSH ASAMRDPCMQ 
       560 
DQEAYSHCLI SGQKGCERS                                   

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Human polymorphisms and disease mutations
   Index of human polymorphisms and disease mutations
2. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
3. SIMILARITY comments
   Index of protein domains and families
4. Human chromosome 17
   Human chromosome 17: entries, gene names and cross-references to MIM
5. Human entries with polymorphisms or disease mutations
   List of human entries with polymorphisms or disease mutations