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Entry version 133 (02 Dec 2020)
Sequence version 2 (18 Mar 2008)
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Protein

Tubulin polyglutamylase TTLL6

Gene

TTLL6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Polyglutamylase which preferentially modifies alpha-tubulin. Mediates tubulin polyglutamylation in cilia. Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation step. Generates long side-chains. Generates polyglutamylation of CGAS, leading to impair the DNA-binding activity of CGAS.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei216ATPBy similarity1
Binding sitei218ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi203 – 206ATP bindingBy similarity4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8N841

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8955332, Carboxyterminal post-translational modifications of tubulin

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tubulin polyglutamylase TTLL6 (EC:6.-.-.-)
Alternative name(s):
Tubulin--tyrosine ligase-like protein 6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TTLL6Imported
Synonyms:TTL.61 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

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EuPathDBi
HostDB:ENSG00000170703.15

Human Gene Nomenclature Database

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HGNCi
HGNC:26664, TTLL6

Online Mendelian Inheritance in Man (OMIM)

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MIMi
610849, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N841

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi396 – 398KKK → EEE: Decreased binding to microtubules and polyglutamylase activity; when associated with E-416 and E-419. 1 Publication3
Mutagenesisi416R → E: Decreased binding to microtubules and polyglutamylase activity; when associated with 396-E--E-398 and E-419. 1 Publication1
Mutagenesisi419R → E: Decreased binding to microtubules and polyglutamylase activity; when associated with 396-E--E-398 and E-416. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
284076

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA143485662

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8N841, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TTLL6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
172045779

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003261601 – 843Tubulin polyglutamylase TTLL6Add BLAST843

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8N841

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8N841

PeptideAtlas

More...
PeptideAtlasi
Q8N841

PRoteomics IDEntifications database

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PRIDEi
Q8N841

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
72370 [Q8N841-1]
72371 [Q8N841-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N841

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N841

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000170703, Expressed in testis and 117 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8N841, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8N841, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000170703, Tissue enhanced (fallopian tube, intestine, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Found in a complex with CEP41.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
129751, 7 interactors

Protein interaction database and analysis system

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IntActi
Q8N841, 3 interactors

Molecular INTeraction database

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MINTi
Q8N841

STRING: functional protein association networks

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STRINGi
9606.ENSP00000377043

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q8N841, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8N841

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini58 – 401TTLPROSITE-ProRule annotationAdd BLAST344

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni372 – 451c-MTBD region1 PublicationAdd BLAST80

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The flexible c-MTBD (cationic microtubule binding domain) region mediates binding to microtubules. It is positively charged and becomes ordered when bound to microtubules: it interacts with a negatively charged patch on tubulin. The presence of positive charges in the c-MTBD region is essential for proper binding.By similarity1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tubulin--tyrosine ligase family.Sequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2158, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_036158_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8N841

Database of Orthologous Groups

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OrthoDBi
1251554at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8N841

TreeFam database of animal gene trees

More...
TreeFami
TF313087

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1490.20, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR013815, ATP_grasp_subdomain_1
IPR004344, TTL/TTLL_fam
IPR027754, TTLL6

The PANTHER Classification System

More...
PANTHERi
PTHR12241:SF96, PTHR12241:SF96, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03133, TTL, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51221, TTL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q8N841-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPQCPTLESQ EGENSEEKGD SSKEDPKETV ALAFVRENPG AQNGLQNAQQ
60 70 80 90 100
QGKKKRKKKR LVINLSSCRY ESVRRAAQQY GFREGGEDDD WTLYWTDYSV
110 120 130 140 150
SLERVMEMKS YQKINHFPGM SEICRKDLLA RNMSRMLKMF PKDFRFFPRT
160 170 180 190 200
WCLPADWGDL QTYSRSRKNK TYICKPDSGC QGKGIFITRT VKEIKPGEDM
210 220 230 240 250
ICQLYISKPF IIDGFKFDLR IYVLVTSCDP LRIFVYNEGL ARFATTSYSR
260 270 280 290 300
PCTDNLDDIC MHLTNYSINK HSSNFSRDAH SGSKRKLSTF SAYLEDHSYN
310 320 330 340 350
VEQIWRDIED VIIKTLISAH PIIRHNYHTC FPNHTLNSAC FEILGFDILL
360 370 380 390 400
DHKLKPWLLE VNHSPSFSTD SRLDKEVKDG LLYDTLVLIN LESCDKKKVL
410 420 430 440 450
EEERQRGQFL QQCCSREMRI EEAKGFRAVQ LKKTETYEKE NCGGFRLIYP
460 470 480 490 500
SLNSEKYEKF FQDNNSLFQN TVASRAREEY ARQLIQELRL KREKKPFQMK
510 520 530 540 550
KKVEMQGESA GEQVRKKGMR GWQQKQQQKD KAATQASKQY IQPLTLVSYT
560 570 580 590 600
PDLLLSVRGE RKNETDSSLN QEAPTEEASS VFPKLTSAKP FSSLPDLRNI
610 620 630 640 650
NLSSSKLEPS KPNFSIKEAK SASAVNVFTG TVHLTSVETT PESTTQLSIS
660 670 680 690 700
PKSPPTLAVT ASSEYSGPET DRVVSFKCKK QQTPPHLTQK KMLKSFLPTK
710 720 730 740 750
SKSFWESPNT NWTLLKSDMN KPHLISELLT KLQLSGKLSF FPAHYNPKLG
760 770 780 790 800
MNNLSQNPSL PGECHSRSDS SGEKRQLDVS SLLLQSPQSY NVTLRDLLVI
810 820 830 840
ATPAQLDPRP CRSHASAMRD PCMQDQEAYS HCLISGQKGC ERS
Length:843
Mass (Da):96,401
Last modified:March 18, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD1C24002A551D54D
GO
Isoform 22 Publications (identifier: Q8N841-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-274: Missing.
     275-284: FSRDAHSGSK → MEGCLGVAEL

Show »
Length:569
Mass (Da):64,547
Checksum:i0E5AE7873AA3E5E3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WDP8F8WDP8_HUMAN
Tubulin polyglutamylase TTLL6
TTLL6
185Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W9N0F8W9N0_HUMAN
Tubulin polyglutamylase TTLL6
TTLL6
208Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6QD81F6QD81_HUMAN
Tubulin polyglutamylase TTLL6
TTLL6
48Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W896F8W896_HUMAN
Tubulin polyglutamylase TTLL6
TTLL6
27Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC04066 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_039993664E → D2 PublicationsCorresponds to variant dbSNP:rs2032844Ensembl.1
Isoform 22 Publications (identifier: Q8N841-2)
Natural variantiVAR_0829309E → V1 PublicationCorresponds to variant dbSNP:rs17853181Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0527271 – 274Missing in isoform 2. 2 PublicationsAdd BLAST274
Alternative sequenceiVSP_052728275 – 284FSRDAHSGSK → MEGCLGVAEL in isoform 2. 2 Publications10

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY898275 Genomic DNA Translation: AAY28091.1
AY898276 Genomic DNA Translation: AAY28092.1
AY898277 Genomic DNA Translation: AAY28093.1
AY898278 Genomic DNA Translation: AAY28094.1
AY898279 Genomic DNA Translation: AAY28095.1
AY898280 Genomic DNA Translation: AAY28096.1
AY898281 Genomic DNA Translation: AAY28097.1
AY898282 Genomic DNA Translation: AAY28098.1
AY898283 Genomic DNA Translation: AAY28099.1
AY898284 Genomic DNA Translation: AAY28100.1
AY898285 Genomic DNA Translation: AAY28101.1
AY898286 Genomic DNA Translation: AAY28102.1
AY898287 Genomic DNA Translation: AAY28103.1
AY898288 Genomic DNA Translation: AAY28104.1
AY898289 Genomic DNA Translation: AAY28105.1
AY898290 Genomic DNA Translation: AAY28106.1
AY898291 Genomic DNA Translation: AAY28107.1
AY898292 Genomic DNA Translation: AAY28108.1
AY898293 Genomic DNA Translation: AAY28109.1
AY898294 Genomic DNA Translation: AAY28110.1
AY898295 Genomic DNA Translation: AAY28111.1
AY898296 Genomic DNA Translation: AAY28112.1
AY898297 Genomic DNA Translation: AAY28113.1
AY898298 Genomic DNA Translation: AAY28114.1
AY898299 Genomic DNA Translation: AAY28115.1
AY898300 Genomic DNA Translation: AAY28116.1
AY898301 Genomic DNA Translation: AAY28117.1
AY898302 Genomic DNA Translation: AAY28118.1
AY898303 Genomic DNA Translation: AAY28119.1
AY898304 Genomic DNA Translation: AAY28120.1
AY898305 Genomic DNA Translation: AAY28121.1
AY898306 Genomic DNA Translation: AAY28122.1
AY898307 Genomic DNA Translation: AAY28123.1
AY898308 Genomic DNA Translation: AAY28124.1
AY898309 Genomic DNA Translation: AAY28125.1
AY898317 Genomic DNA Translation: AAX86172.1
AY898318 Genomic DNA Translation: AAX86173.1
AY898319 Genomic DNA Translation: AAX86174.1
AY898320 Genomic DNA Translation: AAX86175.1
AY898321 Genomic DNA Translation: AAX86176.1
AY898322 Genomic DNA Translation: AAX86177.1
AY898323 Genomic DNA Translation: AAX86178.1
AY898324 Genomic DNA Translation: AAX86179.1
AY898325 Genomic DNA Translation: AAX86180.1
AY898326 Genomic DNA Translation: AAX86181.1
AY898327 Genomic DNA Translation: AAX86182.1
AY898328 Genomic DNA Translation: AAX86183.1
AY898329 Genomic DNA Translation: AAX86184.1
AY898330 Genomic DNA Translation: AAX86185.1
AY898331 Genomic DNA Translation: AAX86186.1
AY898332 Genomic DNA Translation: AAX86187.1
AY898333 Genomic DNA Translation: AAX86188.1
AY898334 Genomic DNA Translation: AAX86189.1
AY898335 Genomic DNA Translation: AAX86190.1
AY898336 Genomic DNA Translation: AAX86191.1
AY898337 Genomic DNA Translation: AAX86192.1
AY898338 Genomic DNA Translation: AAX86193.1
AY898339 Genomic DNA Translation: AAX86194.1
AY898340 Genomic DNA Translation: AAX86195.1
AY898341 Genomic DNA Translation: AAX86196.1
AY898342 Genomic DNA Translation: AAX86197.1
AY898343 Genomic DNA Translation: AAX86198.1
AY898344 Genomic DNA Translation: AAX86199.1
AY898345 Genomic DNA Translation: AAX86200.1
AY898346 Genomic DNA Translation: AAX86201.1
AY898347 Genomic DNA Translation: AAX86202.1
AY898348 Genomic DNA Translation: AAX86203.1
AY898349 Genomic DNA Translation: AAX86204.1
AY898350 Genomic DNA Translation: AAX86205.1
AY898351 Genomic DNA Translation: AAX86206.1
AY898359 Genomic DNA Translation: AAX86214.1
AY898360 Genomic DNA Translation: AAX86215.1
AY898361 Genomic DNA Translation: AAX86216.1
AY898362 Genomic DNA Translation: AAX86217.1
AY898363 Genomic DNA Translation: AAX86218.1
AY898364 Genomic DNA Translation: AAX86219.1
AY898365 Genomic DNA Translation: AAX86220.1
AY898366 Genomic DNA Translation: AAX86221.1
AY898367 Genomic DNA Translation: AAX86222.1
AY898368 Genomic DNA Translation: AAX86223.1
AY898369 Genomic DNA Translation: AAX86224.1
AY898370 Genomic DNA Translation: AAX86225.1
AY898371 Genomic DNA Translation: AAX86226.1
AY898372 Genomic DNA Translation: AAX86227.1
AY898373 Genomic DNA Translation: AAX86228.1
AY898374 Genomic DNA Translation: AAX86229.1
AY898375 Genomic DNA Translation: AAX86230.1
AY898376 Genomic DNA Translation: AAX86231.1
AY898377 Genomic DNA Translation: AAX86232.1
AY898378 Genomic DNA Translation: AAX86233.1
AY898379 Genomic DNA Translation: AAX86234.1
AY898380 Genomic DNA Translation: AAX86235.1
AY898381 Genomic DNA Translation: AAX86236.1
AY898382 Genomic DNA Translation: AAX86237.1
AY898383 Genomic DNA Translation: AAX86238.1
AY898384 Genomic DNA Translation: AAX86239.1
AY898385 Genomic DNA Translation: AAX86240.1
AY898386 Genomic DNA Translation: AAX86241.1
AY898387 Genomic DNA Translation: AAX86242.1
AY898388 Genomic DNA Translation: AAX86243.1
AY898389 Genomic DNA Translation: AAX86244.1
AY898390 Genomic DNA Translation: AAX86245.1
AY898391 Genomic DNA Translation: AAX86246.1
AY898392 Genomic DNA Translation: AAX86247.1
AY898393 Genomic DNA Translation: AAX86248.1
AY898401 Genomic DNA Translation: AAX86256.1
AY898402 Genomic DNA Translation: AAX86257.1
AY898403 Genomic DNA Translation: AAX86258.1
AY898404 Genomic DNA Translation: AAX86259.1
AY898405 Genomic DNA Translation: AAX86260.1
AY898406 Genomic DNA Translation: AAX86261.1
AY898407 Genomic DNA Translation: AAX86262.1
AY898408 Genomic DNA Translation: AAX86263.1
AY898409 Genomic DNA Translation: AAX86264.1
AY898410 Genomic DNA Translation: AAX86265.1
AY898411 Genomic DNA Translation: AAX86266.1
AY898412 Genomic DNA Translation: AAX86267.1
AY898413 Genomic DNA Translation: AAX86268.1
AY898414 Genomic DNA Translation: AAX86269.1
AY898415 Genomic DNA Translation: AAX86270.1
AY898416 Genomic DNA Translation: AAX86271.1
AY898417 Genomic DNA Translation: AAX86272.1
AY898418 Genomic DNA Translation: AAX86273.1
AY898419 Genomic DNA Translation: AAX86274.1
AY898420 Genomic DNA Translation: AAX86275.1
AY898421 Genomic DNA Translation: AAX86276.1
AY898422 Genomic DNA Translation: AAX86277.1
AY898423 Genomic DNA Translation: AAX86278.1
AY898424 Genomic DNA Translation: AAX86279.1
AY898425 Genomic DNA Translation: AAX86280.1
AY898426 Genomic DNA Translation: AAX86281.1
AY898427 Genomic DNA Translation: AAX86282.1
AY898428 Genomic DNA Translation: AAX86283.1
AY898429 Genomic DNA Translation: AAX86284.1
AY898430 Genomic DNA Translation: AAX86285.1
AY898431 Genomic DNA Translation: AAX86286.1
AY898432 Genomic DNA Translation: AAX86287.1
AY898433 Genomic DNA Translation: AAX86288.1
AY898434 Genomic DNA Translation: AAX86289.1
AY898435 Genomic DNA Translation: AAX86290.1
AY898443 Genomic DNA Translation: AAX86298.1
AY898444 Genomic DNA Translation: AAX86299.1
AY898445 Genomic DNA Translation: AAX86300.1
AY898446 Genomic DNA Translation: AAX86301.1
AY898447 Genomic DNA Translation: AAX86302.1
AY898448 Genomic DNA Translation: AAX86303.1
AY898449 Genomic DNA Translation: AAX86304.1
AY898450 Genomic DNA Translation: AAX86305.1
AY898451 Genomic DNA Translation: AAX86306.1
AY898452 Genomic DNA Translation: AAX86307.1
AY898453 Genomic DNA Translation: AAX86308.1
AY898454 Genomic DNA Translation: AAX86309.1
AY898455 Genomic DNA Translation: AAX86310.1
AY898456 Genomic DNA Translation: AAX86311.1
AY898457 Genomic DNA Translation: AAX86312.1
AY898458 Genomic DNA Translation: AAX86313.1
AY898459 Genomic DNA Translation: AAX86314.1
AY898460 Genomic DNA Translation: AAX86315.1
AY898461 Genomic DNA Translation: AAX86316.1
AY898462 Genomic DNA Translation: AAX86317.1
AY898463 Genomic DNA Translation: AAX86318.1
AY898464 Genomic DNA Translation: AAX86319.1
AY898465 Genomic DNA Translation: AAX86320.1
AY898466 Genomic DNA Translation: AAX86321.1
AY898467 Genomic DNA Translation: AAX86322.1
AY898468 Genomic DNA Translation: AAX86323.1
AY898469 Genomic DNA Translation: AAX86324.1
AY898470 Genomic DNA Translation: AAX86325.1
AY898471 Genomic DNA Translation: AAX86326.1
AY898472 Genomic DNA Translation: AAX86327.1
AY898473 Genomic DNA Translation: AAX86328.1
AY898474 Genomic DNA Translation: AAX86329.1
AY898475 Genomic DNA Translation: AAX86330.1
AY898476 Genomic DNA Translation: AAX86331.1
AY898477 Genomic DNA Translation: AAX86332.1
AY898485 Genomic DNA Translation: AAX86340.1
AY898486 Genomic DNA Translation: AAX86341.1
AY898487 Genomic DNA Translation: AAX86342.1
AY898488 Genomic DNA Translation: AAX86343.1
AY898489 Genomic DNA Translation: AAX86344.1
AY898490 Genomic DNA Translation: AAX86345.1
AY898491 Genomic DNA Translation: AAX86346.1
AY898492 Genomic DNA Translation: AAX86347.1
AY898493 Genomic DNA Translation: AAX86348.1
AY898494 Genomic DNA Translation: AAX86349.1
AY898495 Genomic DNA Translation: AAX86350.1
AY898496 Genomic DNA Translation: AAX86351.1
AY898497 Genomic DNA Translation: AAX86352.1
AY898498 Genomic DNA Translation: AAX86353.1
AY898499 Genomic DNA Translation: AAX86354.1
AY898500 Genomic DNA Translation: AAX86355.1
AY898501 Genomic DNA Translation: AAX86356.1
AY898502 Genomic DNA Translation: AAX86357.1
AY898503 Genomic DNA Translation: AAX86358.1
AY898504 Genomic DNA Translation: AAX86359.1
AY898505 Genomic DNA Translation: AAX86360.1
AY898506 Genomic DNA Translation: AAX86361.1
AY898507 Genomic DNA Translation: AAX86362.1
AY898508 Genomic DNA Translation: AAX86363.1
AY898509 Genomic DNA Translation: AAX86364.1
AY898510 Genomic DNA Translation: AAX86365.1
AY898511 Genomic DNA Translation: AAX86366.1
AY898512 Genomic DNA Translation: AAX86367.1
AY898513 Genomic DNA Translation: AAX86368.1
AY898514 Genomic DNA Translation: AAX86369.1
AY898515 Genomic DNA Translation: AAX86370.1
AY898516 Genomic DNA Translation: AAX86371.1
AY898517 Genomic DNA Translation: AAX86372.1
AY898518 Genomic DNA Translation: AAX86373.1
AY898519 Genomic DNA Translation: AAX86374.1
AY898527 Genomic DNA Translation: AAX86382.1
AY898528 Genomic DNA Translation: AAX86383.1
AY898529 Genomic DNA Translation: AAX86384.1
AY898530 Genomic DNA Translation: AAX86385.1
AY898531 Genomic DNA Translation: AAX86386.1
AY898532 Genomic DNA Translation: AAX86387.1
AY898533 Genomic DNA Translation: AAX86388.1
AY898534 Genomic DNA Translation: AAX86389.1
AY898535 Genomic DNA Translation: AAX86390.1
AY898536 Genomic DNA Translation: AAX86391.1
AY898537 Genomic DNA Translation: AAX86392.1
AY898538 Genomic DNA Translation: AAX86393.1
AY898539 Genomic DNA Translation: AAX86394.1
AY898540 Genomic DNA Translation: AAX86395.1
AY898541 Genomic DNA Translation: AAX86396.1
AY898542 Genomic DNA Translation: AAX86397.1
AY898543 Genomic DNA Translation: AAX86398.1
AY898544 Genomic DNA Translation: AAX86399.1
AY898545 Genomic DNA Translation: AAX86400.1
AY898546 Genomic DNA Translation: AAX86401.1
AY898547 Genomic DNA Translation: AAX86402.1
AY898548 Genomic DNA Translation: AAX86403.1
AY898549 Genomic DNA Translation: AAX86404.1
AY898550 Genomic DNA Translation: AAX86405.1
AY898551 Genomic DNA Translation: AAX86406.1
AY898552 Genomic DNA Translation: AAX86407.1
AY898553 Genomic DNA Translation: AAX86408.1
AY898554 Genomic DNA Translation: AAX86409.1
AY898555 Genomic DNA Translation: AAX86410.1
AY898556 Genomic DNA Translation: AAX86411.1
AY898557 Genomic DNA Translation: AAX86412.1
AY898558 Genomic DNA Translation: AAX86413.1
AY898559 Genomic DNA Translation: AAX86414.1
AY898560 Genomic DNA Translation: AAX86415.1
AY898561 Genomic DNA Translation: AAX86416.1
AY898569 Genomic DNA Translation: AAX86424.1
AY898570 Genomic DNA Translation: AAX86425.1
AY898571 Genomic DNA Translation: AAX86426.1
AY898572 Genomic DNA Translation: AAX86427.1
AY898573 Genomic DNA Translation: AAX86428.1
AY898574 Genomic DNA Translation: AAX86429.1
AY898575 Genomic DNA Translation: AAX86430.1
AY898576 Genomic DNA Translation: AAX86431.1
AY898577 Genomic DNA Translation: AAX86432.1
AY898578 Genomic DNA Translation: AAX86433.1
AY898579 Genomic DNA Translation: AAX86434.1
AY898580 Genomic DNA Translation: AAX86435.1
AY898581 Genomic DNA Translation: AAX86436.1
AY898582 Genomic DNA Translation: AAX86437.1
AY898583 Genomic DNA Translation: AAX86438.1
AY898584 Genomic DNA Translation: AAX86439.1
AY898585 Genomic DNA Translation: AAX86440.1
AY898586 Genomic DNA Translation: AAX86441.1
AY898587 Genomic DNA Translation: AAX86442.1
AY898588 Genomic DNA Translation: AAX86443.1
AY898589 Genomic DNA Translation: AAX86444.1
AY898590 Genomic DNA Translation: AAX86445.1
AY898591 Genomic DNA Translation: AAX86446.1
AY898592 Genomic DNA Translation: AAX86447.1
AY898593 Genomic DNA Translation: AAX86448.1
AY898594 Genomic DNA Translation: AAX86449.1
AY898595 Genomic DNA Translation: AAX86450.1
AY898596 Genomic DNA Translation: AAX86451.1
AY898597 Genomic DNA Translation: AAX86452.1
AY898598 Genomic DNA Translation: AAX86453.1
AY898599 Genomic DNA Translation: AAX86454.1
AY898600 Genomic DNA Translation: AAX86455.1
AY898601 Genomic DNA Translation: AAX86456.1
AY898602 Genomic DNA Translation: AAX86457.1
AY898603 Genomic DNA Translation: AAX86458.1
AK093127 mRNA Translation: BAC04066.1 Different initiation.
AK302952 mRNA Translation: BAG64107.1
AC068531 Genomic DNA No translation available.
BC033563 mRNA Translation: AAH33563.1

NCBI Reference Sequences

More...
RefSeqi
NP_001124390.1, NM_001130918.1
NP_775894.2, NM_173623.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000393382; ENSP00000377043; ENSG00000170703
ENST00000433608; ENSP00000399211; ENSG00000170703

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
284076

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:284076

UCSC genome browser

More...
UCSCi
uc002iob.4, human [Q8N841-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY898275 Genomic DNA Translation: AAY28091.1
AY898276 Genomic DNA Translation: AAY28092.1
AY898277 Genomic DNA Translation: AAY28093.1
AY898278 Genomic DNA Translation: AAY28094.1
AY898279 Genomic DNA Translation: AAY28095.1
AY898280 Genomic DNA Translation: AAY28096.1
AY898281 Genomic DNA Translation: AAY28097.1
AY898282 Genomic DNA Translation: AAY28098.1
AY898283 Genomic DNA Translation: AAY28099.1
AY898284 Genomic DNA Translation: AAY28100.1
AY898285 Genomic DNA Translation: AAY28101.1
AY898286 Genomic DNA Translation: AAY28102.1
AY898287 Genomic DNA Translation: AAY28103.1
AY898288 Genomic DNA Translation: AAY28104.1
AY898289 Genomic DNA Translation: AAY28105.1
AY898290 Genomic DNA Translation: AAY28106.1
AY898291 Genomic DNA Translation: AAY28107.1
AY898292 Genomic DNA Translation: AAY28108.1
AY898293 Genomic DNA Translation: AAY28109.1
AY898294 Genomic DNA Translation: AAY28110.1
AY898295 Genomic DNA Translation: AAY28111.1
AY898296 Genomic DNA Translation: AAY28112.1
AY898297 Genomic DNA Translation: AAY28113.1
AY898298 Genomic DNA Translation: AAY28114.1
AY898299 Genomic DNA Translation: AAY28115.1
AY898300 Genomic DNA Translation: AAY28116.1
AY898301 Genomic DNA Translation: AAY28117.1
AY898302 Genomic DNA Translation: AAY28118.1
AY898303 Genomic DNA Translation: AAY28119.1
AY898304 Genomic DNA Translation: AAY28120.1
AY898305 Genomic DNA Translation: AAY28121.1
AY898306 Genomic DNA Translation: AAY28122.1
AY898307 Genomic DNA Translation: AAY28123.1
AY898308 Genomic DNA Translation: AAY28124.1
AY898309 Genomic DNA Translation: AAY28125.1
AY898317 Genomic DNA Translation: AAX86172.1
AY898318 Genomic DNA Translation: AAX86173.1
AY898319 Genomic DNA Translation: AAX86174.1
AY898320 Genomic DNA Translation: AAX86175.1
AY898321 Genomic DNA Translation: AAX86176.1
AY898322 Genomic DNA Translation: AAX86177.1
AY898323 Genomic DNA Translation: AAX86178.1
AY898324 Genomic DNA Translation: AAX86179.1
AY898325 Genomic DNA Translation: AAX86180.1
AY898326 Genomic DNA Translation: AAX86181.1
AY898327 Genomic DNA Translation: AAX86182.1
AY898328 Genomic DNA Translation: AAX86183.1
AY898329 Genomic DNA Translation: AAX86184.1
AY898330 Genomic DNA Translation: AAX86185.1
AY898331 Genomic DNA Translation: AAX86186.1
AY898332 Genomic DNA Translation: AAX86187.1
AY898333 Genomic DNA Translation: AAX86188.1
AY898334 Genomic DNA Translation: AAX86189.1
AY898335 Genomic DNA Translation: AAX86190.1
AY898336 Genomic DNA Translation: AAX86191.1
AY898337 Genomic DNA Translation: AAX86192.1
AY898338 Genomic DNA Translation: AAX86193.1
AY898339 Genomic DNA Translation: AAX86194.1
AY898340 Genomic DNA Translation: AAX86195.1
AY898341 Genomic DNA Translation: AAX86196.1
AY898342 Genomic DNA Translation: AAX86197.1
AY898343 Genomic DNA Translation: AAX86198.1
AY898344 Genomic DNA Translation: AAX86199.1
AY898345 Genomic DNA Translation: AAX86200.1
AY898346 Genomic DNA Translation: AAX86201.1
AY898347 Genomic DNA Translation: AAX86202.1
AY898348 Genomic DNA Translation: AAX86203.1
AY898349 Genomic DNA Translation: AAX86204.1
AY898350 Genomic DNA Translation: AAX86205.1
AY898351 Genomic DNA Translation: AAX86206.1
AY898359 Genomic DNA Translation: AAX86214.1
AY898360 Genomic DNA Translation: AAX86215.1
AY898361 Genomic DNA Translation: AAX86216.1
AY898362 Genomic DNA Translation: AAX86217.1
AY898363 Genomic DNA Translation: AAX86218.1
AY898364 Genomic DNA Translation: AAX86219.1
AY898365 Genomic DNA Translation: AAX86220.1
AY898366 Genomic DNA Translation: AAX86221.1
AY898367 Genomic DNA Translation: AAX86222.1
AY898368 Genomic DNA Translation: AAX86223.1
AY898369 Genomic DNA Translation: AAX86224.1
AY898370 Genomic DNA Translation: AAX86225.1
AY898371 Genomic DNA Translation: AAX86226.1
AY898372 Genomic DNA Translation: AAX86227.1
AY898373 Genomic DNA Translation: AAX86228.1
AY898374 Genomic DNA Translation: AAX86229.1
AY898375 Genomic DNA Translation: AAX86230.1
AY898376 Genomic DNA Translation: AAX86231.1
AY898377 Genomic DNA Translation: AAX86232.1
AY898378 Genomic DNA Translation: AAX86233.1
AY898379 Genomic DNA Translation: AAX86234.1
AY898380 Genomic DNA Translation: AAX86235.1
AY898381 Genomic DNA Translation: AAX86236.1
AY898382 Genomic DNA Translation: AAX86237.1
AY898383 Genomic DNA Translation: AAX86238.1
AY898384 Genomic DNA Translation: AAX86239.1
AY898385 Genomic DNA Translation: AAX86240.1
AY898386 Genomic DNA Translation: AAX86241.1
AY898387 Genomic DNA Translation: AAX86242.1
AY898388 Genomic DNA Translation: AAX86243.1
AY898389 Genomic DNA Translation: AAX86244.1
AY898390 Genomic DNA Translation: AAX86245.1
AY898391 Genomic DNA Translation: AAX86246.1
AY898392 Genomic DNA Translation: AAX86247.1
AY898393 Genomic DNA Translation: AAX86248.1
AY898401 Genomic DNA Translation: AAX86256.1
AY898402 Genomic DNA Translation: AAX86257.1
AY898403 Genomic DNA Translation: AAX86258.1
AY898404 Genomic DNA Translation: AAX86259.1
AY898405 Genomic DNA Translation: AAX86260.1
AY898406 Genomic DNA Translation: AAX86261.1
AY898407 Genomic DNA Translation: AAX86262.1
AY898408 Genomic DNA Translation: AAX86263.1
AY898409 Genomic DNA Translation: AAX86264.1
AY898410 Genomic DNA Translation: AAX86265.1
AY898411 Genomic DNA Translation: AAX86266.1
AY898412 Genomic DNA Translation: AAX86267.1
AY898413 Genomic DNA Translation: AAX86268.1
AY898414 Genomic DNA Translation: AAX86269.1
AY898415 Genomic DNA Translation: AAX86270.1
AY898416 Genomic DNA Translation: AAX86271.1
AY898417 Genomic DNA Translation: AAX86272.1
AY898418 Genomic DNA Translation: AAX86273.1
AY898419 Genomic DNA Translation: AAX86274.1
AY898420 Genomic DNA Translation: AAX86275.1
AY898421 Genomic DNA Translation: AAX86276.1
AY898422 Genomic DNA Translation: AAX86277.1
AY898423 Genomic DNA Translation: AAX86278.1
AY898424 Genomic DNA Translation: AAX86279.1
AY898425 Genomic DNA Translation: AAX86280.1
AY898426 Genomic DNA Translation: AAX86281.1
AY898427 Genomic DNA Translation: AAX86282.1
AY898428 Genomic DNA Translation: AAX86283.1
AY898429 Genomic DNA Translation: AAX86284.1
AY898430 Genomic DNA Translation: AAX86285.1
AY898431 Genomic DNA Translation: AAX86286.1
AY898432 Genomic DNA Translation: AAX86287.1
AY898433 Genomic DNA Translation: AAX86288.1
AY898434 Genomic DNA Translation: AAX86289.1
AY898435 Genomic DNA Translation: AAX86290.1
AY898443 Genomic DNA Translation: AAX86298.1
AY898444 Genomic DNA Translation: AAX86299.1
AY898445 Genomic DNA Translation: AAX86300.1
AY898446 Genomic DNA Translation: AAX86301.1
AY898447 Genomic DNA Translation: AAX86302.1
AY898448 Genomic DNA Translation: AAX86303.1
AY898449 Genomic DNA Translation: AAX86304.1
AY898450 Genomic DNA Translation: AAX86305.1
AY898451 Genomic DNA Translation: AAX86306.1
AY898452 Genomic DNA Translation: AAX86307.1
AY898453 Genomic DNA Translation: AAX86308.1
AY898454 Genomic DNA Translation: AAX86309.1
AY898455 Genomic DNA Translation: AAX86310.1
AY898456 Genomic DNA Translation: AAX86311.1
AY898457 Genomic DNA Translation: AAX86312.1
AY898458 Genomic DNA Translation: AAX86313.1
AY898459 Genomic DNA Translation: AAX86314.1
AY898460 Genomic DNA Translation: AAX86315.1
AY898461 Genomic DNA Translation: AAX86316.1
AY898462 Genomic DNA Translation: AAX86317.1
AY898463 Genomic DNA Translation: AAX86318.1
AY898464 Genomic DNA Translation: AAX86319.1
AY898465 Genomic DNA Translation: AAX86320.1
AY898466 Genomic DNA Translation: AAX86321.1
AY898467 Genomic DNA Translation: AAX86322.1
AY898468 Genomic DNA Translation: AAX86323.1
AY898469 Genomic DNA Translation: AAX86324.1
AY898470 Genomic DNA Translation: AAX86325.1
AY898471 Genomic DNA Translation: AAX86326.1
AY898472 Genomic DNA Translation: AAX86327.1
AY898473 Genomic DNA Translation: AAX86328.1
AY898474 Genomic DNA Translation: AAX86329.1
AY898475 Genomic DNA Translation: AAX86330.1
AY898476 Genomic DNA Translation: AAX86331.1
AY898477 Genomic DNA Translation: AAX86332.1
AY898485 Genomic DNA Translation: AAX86340.1
AY898486 Genomic DNA Translation: AAX86341.1
AY898487 Genomic DNA Translation: AAX86342.1
AY898488 Genomic DNA Translation: AAX86343.1
AY898489 Genomic DNA Translation: AAX86344.1
AY898490 Genomic DNA Translation: AAX86345.1
AY898491 Genomic DNA Translation: AAX86346.1
AY898492 Genomic DNA Translation: AAX86347.1
AY898493 Genomic DNA Translation: AAX86348.1
AY898494 Genomic DNA Translation: AAX86349.1
AY898495 Genomic DNA Translation: AAX86350.1
AY898496 Genomic DNA Translation: AAX86351.1
AY898497 Genomic DNA Translation: AAX86352.1
AY898498 Genomic DNA Translation: AAX86353.1
AY898499 Genomic DNA Translation: AAX86354.1
AY898500 Genomic DNA Translation: AAX86355.1
AY898501 Genomic DNA Translation: AAX86356.1
AY898502 Genomic DNA Translation: AAX86357.1
AY898503 Genomic DNA Translation: AAX86358.1
AY898504 Genomic DNA Translation: AAX86359.1
AY898505 Genomic DNA Translation: AAX86360.1
AY898506 Genomic DNA Translation: AAX86361.1
AY898507 Genomic DNA Translation: AAX86362.1
AY898508 Genomic DNA Translation: AAX86363.1
AY898509 Genomic DNA Translation: AAX86364.1
AY898510 Genomic DNA Translation: AAX86365.1
AY898511 Genomic DNA Translation: AAX86366.1
AY898512 Genomic DNA Translation: AAX86367.1
AY898513 Genomic DNA Translation: AAX86368.1
AY898514 Genomic DNA Translation: AAX86369.1
AY898515 Genomic DNA Translation: AAX86370.1
AY898516 Genomic DNA Translation: AAX86371.1
AY898517 Genomic DNA Translation: AAX86372.1
AY898518 Genomic DNA Translation: AAX86373.1
AY898519 Genomic DNA Translation: AAX86374.1
AY898527 Genomic DNA Translation: AAX86382.1
AY898528 Genomic DNA Translation: AAX86383.1
AY898529 Genomic DNA Translation: AAX86384.1
AY898530 Genomic DNA Translation: AAX86385.1
AY898531 Genomic DNA Translation: AAX86386.1
AY898532 Genomic DNA Translation: AAX86387.1
AY898533 Genomic DNA Translation: AAX86388.1
AY898534 Genomic DNA Translation: AAX86389.1
AY898535 Genomic DNA Translation: AAX86390.1
AY898536 Genomic DNA Translation: AAX86391.1
AY898537 Genomic DNA Translation: AAX86392.1
AY898538 Genomic DNA Translation: AAX86393.1
AY898539 Genomic DNA Translation: AAX86394.1
AY898540 Genomic DNA Translation: AAX86395.1
AY898541 Genomic DNA Translation: AAX86396.1
AY898542 Genomic DNA Translation: AAX86397.1
AY898543 Genomic DNA Translation: AAX86398.1
AY898544 Genomic DNA Translation: AAX86399.1
AY898545 Genomic DNA Translation: AAX86400.1
AY898546 Genomic DNA Translation: AAX86401.1
AY898547 Genomic DNA Translation: AAX86402.1
AY898548 Genomic DNA Translation: AAX86403.1
AY898549 Genomic DNA Translation: AAX86404.1
AY898550 Genomic DNA Translation: AAX86405.1
AY898551 Genomic DNA Translation: AAX86406.1
AY898552 Genomic DNA Translation: AAX86407.1
AY898553 Genomic DNA Translation: AAX86408.1
AY898554 Genomic DNA Translation: AAX86409.1
AY898555 Genomic DNA Translation: AAX86410.1
AY898556 Genomic DNA Translation: AAX86411.1
AY898557 Genomic DNA Translation: AAX86412.1
AY898558 Genomic DNA Translation: AAX86413.1
AY898559 Genomic DNA Translation: AAX86414.1
AY898560 Genomic DNA Translation: AAX86415.1
AY898561 Genomic DNA Translation: AAX86416.1
AY898569 Genomic DNA Translation: AAX86424.1
AY898570 Genomic DNA Translation: AAX86425.1
AY898571 Genomic DNA Translation: AAX86426.1
AY898572 Genomic DNA Translation: AAX86427.1
AY898573 Genomic DNA Translation: AAX86428.1
AY898574 Genomic DNA Translation: AAX86429.1
AY898575 Genomic DNA Translation: AAX86430.1
AY898576 Genomic DNA Translation: AAX86431.1
AY898577 Genomic DNA Translation: AAX86432.1
AY898578 Genomic DNA Translation: AAX86433.1
AY898579 Genomic DNA Translation: AAX86434.1
AY898580 Genomic DNA Translation: AAX86435.1
AY898581 Genomic DNA Translation: AAX86436.1
AY898582 Genomic DNA Translation: AAX86437.1
AY898583 Genomic DNA Translation: AAX86438.1
AY898584 Genomic DNA Translation: AAX86439.1
AY898585 Genomic DNA Translation: AAX86440.1
AY898586 Genomic DNA Translation: AAX86441.1
AY898587 Genomic DNA Translation: AAX86442.1
AY898588 Genomic DNA Translation: AAX86443.1
AY898589 Genomic DNA Translation: AAX86444.1
AY898590 Genomic DNA Translation: AAX86445.1
AY898591 Genomic DNA Translation: AAX86446.1
AY898592 Genomic DNA Translation: AAX86447.1
AY898593 Genomic DNA Translation: AAX86448.1
AY898594 Genomic DNA Translation: AAX86449.1
AY898595 Genomic DNA Translation: AAX86450.1
AY898596 Genomic DNA Translation: AAX86451.1
AY898597 Genomic DNA Translation: AAX86452.1
AY898598 Genomic DNA Translation: AAX86453.1
AY898599 Genomic DNA Translation: AAX86454.1
AY898600 Genomic DNA Translation: AAX86455.1
AY898601 Genomic DNA Translation: AAX86456.1
AY898602 Genomic DNA Translation: AAX86457.1
AY898603 Genomic DNA Translation: AAX86458.1
AK093127 mRNA Translation: BAC04066.1 Different initiation.
AK302952 mRNA Translation: BAG64107.1
AC068531 Genomic DNA No translation available.
BC033563 mRNA Translation: AAH33563.1
RefSeqiNP_001124390.1, NM_001130918.1
NP_775894.2, NM_173623.3

3D structure databases

SMRiQ8N841
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi129751, 7 interactors
IntActiQ8N841, 3 interactors
MINTiQ8N841
STRINGi9606.ENSP00000377043

PTM databases

iPTMnetiQ8N841
PhosphoSitePlusiQ8N841

Polymorphism and mutation databases

BioMutaiTTLL6
DMDMi172045779

Proteomic databases

EPDiQ8N841
PaxDbiQ8N841
PeptideAtlasiQ8N841
PRIDEiQ8N841
ProteomicsDBi72370 [Q8N841-1]
72371 [Q8N841-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
17865, 38 antibodies

Genome annotation databases

EnsembliENST00000393382; ENSP00000377043; ENSG00000170703
ENST00000433608; ENSP00000399211; ENSG00000170703
GeneIDi284076
KEGGihsa:284076
UCSCiuc002iob.4, human [Q8N841-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
284076
DisGeNETi284076
EuPathDBiHostDB:ENSG00000170703.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TTLL6
HGNCiHGNC:26664, TTLL6
HPAiENSG00000170703, Tissue enhanced (fallopian tube, intestine, testis)
MIMi610849, gene
neXtProtiNX_Q8N841
PharmGKBiPA143485662

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2158, Eukaryota
HOGENOMiCLU_036158_0_0_1
InParanoidiQ8N841
OrthoDBi1251554at2759
PhylomeDBiQ8N841
TreeFamiTF313087

Enzyme and pathway databases

PathwayCommonsiQ8N841
ReactomeiR-HSA-8955332, Carboxyterminal post-translational modifications of tubulin

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
284076, 6 hits in 838 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TTLL6, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
284076
PharosiQ8N841, Tdark

Protein Ontology

More...
PROi
PR:Q8N841
RNActiQ8N841, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000170703, Expressed in testis and 117 other tissues
ExpressionAtlasiQ8N841, baseline and differential
GenevisibleiQ8N841, HS

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
InterProiView protein in InterPro
IPR013815, ATP_grasp_subdomain_1
IPR004344, TTL/TTLL_fam
IPR027754, TTLL6
PANTHERiPTHR12241:SF96, PTHR12241:SF96, 1 hit
PfamiView protein in Pfam
PF03133, TTL, 1 hit
PROSITEiView protein in PROSITE
PS51221, TTL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTTLL6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N841
Secondary accession number(s): B4DZJ5
, C9J233, Q24KB1, Q24KB2, Q24KB6, Q24KF3, Q24KJ5, Q24KN7, Q24KS9, Q24KX1, Q24L13, Q24L55, Q24L76, Q8IYW6, Q8NA62
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: December 2, 2020
This is version 133 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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