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Entry version 140 (02 Jun 2021)
Sequence version 2 (02 Sep 2008)
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Protein

Probable protein phosphatase 1N

Gene

PPM1N

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi103Manganese 1By similarity1
Metal bindingi103Manganese 2By similarity1
Metal bindingi104Manganese 1; via carbonyl oxygenBy similarity1
Metal bindingi274Manganese 2By similarity1
Metal bindingi317Manganese 2By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandMagnesium, Manganese, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8N819

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable protein phosphatase 1N (EC:3.1.3.16)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPM1N
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26845, PPM1N

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N819

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000213889.10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
147699

Open Targets

More...
OpenTargetsi
ENSG00000213889

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165394107

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8N819, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PPM1N

Domain mapping of disease mutations (DMDM)

More...
DMDMi
205829293

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003492311 – 430Probable protein phosphatase 1NAdd BLAST430

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8N819

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N819

PeptideAtlas

More...
PeptideAtlasi
Q8N819

PRoteomics IDEntifications database

More...
PRIDEi
Q8N819

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
72364 [Q8N819-1]
72365 [Q8N819-2]
72366 [Q8N819-3]

PTM databases

DEPOD human dephosphorylation database

More...
DEPODi
PPM1N

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000213889, Expressed in muscle tissue and 115 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8N819, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N819, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000213889, Tissue enhanced (blood, skeletal muscle)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
127077, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q8N819, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000397050

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8N819, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8N819

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini66 – 326PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST261

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni16 – 65DisorderedSequence analysisAdd BLAST50
Regioni407 – 430DisorderedSequence analysisAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi16 – 39Basic and acidic residuesSequence analysisAdd BLAST24

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PP2C family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0697, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162694

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_146811_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N819

Identification of Orthologs from Complete Genome Data

More...
OMAi
LWTACKK

Database of Orthologous Groups

More...
OrthoDBi
957254at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N819

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00143, PP2Cc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.430, 1 hit
3.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012911, PP2C_C
IPR036580, PP2C_C_sf
IPR036457, PPM-type_dom_sf
IPR001932, PPM-type_phosphatase_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00481, PP2C, 1 hit
PF07830, PP2C_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00332, PP2Cc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF81601, SSF81601, 1 hit
SSF81606, SSF81606, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51746, PPM_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N819-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVLARQLQR LLWTACKKKE REKEGREEEE EEEAGRRAPE GPRSLLTAPR
60 70 80 90 100
RAQRPHGGAE ASGGLRFGAS AAQGWRARME DAHCTWLSLP GLPPGWALFA
110 120 130 140 150
VLDGHGGARA ARFGARHLPG HVLQELGPEP SEPEGVREAL RRAFLSADER
160 170 180 190 200
LRSLWPRVET GGCTAVVLLV SPRFLYLAHC GDSRAVLSRA GAVAFSTEDH
210 220 230 240 250
RPLRPRERER IHAAGGTIRR RRVEGSLAVS RALGDFTYKE APGRPPELQL
260 270 280 290 300
VSAEPEVAAL ARQAEDEFML LASDGVWDTV SGAALAGLVA SRLRLGLAPE
310 320 330 340 350
LLCAQLLDTC LCKGSLDNMT CILVCFPGAP RPSEEAIRRE LALDAALGCR
360 370 380 390 400
IAELCASAQK PPSLNTVFRT LASEDIPDLP PGGGLDCKAT VIAEVYSQIC
410 420 430
QVSEECGEKG QDGAGKSNPT HLGSALDMEA
Length:430
Mass (Da):46,170
Last modified:September 2, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i297363BEB0E73F22
GO
Isoform 2 (identifier: Q8N819-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-78: Missing.
     314-430: GSLDNMTCIL...HLGSALDMEA → VLGAWRGTFG...LISAGRWKSR

Show »
Length:340
Mass (Da):37,165
Checksum:i8F1E0C00BBE5128A
GO
Isoform 3 (identifier: Q8N819-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-318: Missing.

Show »
Length:112
Mass (Da):11,674
Checksum:i5B7BD06837D3E628
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MXX7A8MXX7_HUMAN
Protein-serine/threonine phosphatas...
PPM1N
137Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B5MCQ2B5MCQ2_HUMAN
Protein-serine/threonine phosphatas...
PPM1N
140Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ENL9E7ENL9_HUMAN
Protein-serine/threonine phosphatas...
PPM1N
130Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C347H7C347_HUMAN
Probable protein phosphatase 1N
PPM1N
374Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0352331 – 318Missing in isoform 3. 1 PublicationAdd BLAST318
Alternative sequenceiVSP_0352341 – 78Missing in isoform 2. 2 PublicationsAdd BLAST78
Alternative sequenceiVSP_035235314 – 430GSLDN…LDMEA → VLGAWRGTFGAWCSRGREPR GFGEEGFDREARVKLAKEGI GLKRRAWPEVGRAKIQGRSL RDALRHGRVSGRDLRERAWS FGKGRFWVVGAGPEVLISAG RWKSR in isoform 2. 2 PublicationsAdd BLAST117

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC138534 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW57360.1
AK097444 mRNA Translation: BAC05056.1
BC028228 mRNA Translation: AAH28228.1
BC062452 mRNA Translation: AAH62452.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS46115.1 [Q8N819-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001073870.1, NM_001080401.1 [Q8N819-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000396735; ENSP00000379961; ENSG00000213889 [Q8N819-3]
ENST00000396737; ENSP00000379963; ENSG00000213889 [Q8N819-3]
ENST00000401705; ENSP00000384318; ENSG00000213889 [Q8N819-3]
ENST00000451287; ENSP00000397050; ENSG00000213889 [Q8N819-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
147699

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:147699

UCSC genome browser

More...
UCSCi
uc002pce.4, human [Q8N819-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC138534 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW57360.1
AK097444 mRNA Translation: BAC05056.1
BC028228 mRNA Translation: AAH28228.1
BC062452 mRNA Translation: AAH62452.1
CCDSiCCDS46115.1 [Q8N819-1]
RefSeqiNP_001073870.1, NM_001080401.1 [Q8N819-1]

3D structure databases

SMRiQ8N819
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi127077, 1 interactor
IntActiQ8N819, 1 interactor
STRINGi9606.ENSP00000397050

PTM databases

DEPODiPPM1N

Genetic variation databases

BioMutaiPPM1N
DMDMi205829293

Proteomic databases

MassIVEiQ8N819
PaxDbiQ8N819
PeptideAtlasiQ8N819
PRIDEiQ8N819
ProteomicsDBi72364 [Q8N819-1]
72365 [Q8N819-2]
72366 [Q8N819-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
31351, 9 antibodies

The DNASU plasmid repository

More...
DNASUi
147699

Genome annotation databases

EnsembliENST00000396735; ENSP00000379961; ENSG00000213889 [Q8N819-3]
ENST00000396737; ENSP00000379963; ENSG00000213889 [Q8N819-3]
ENST00000401705; ENSP00000384318; ENSG00000213889 [Q8N819-3]
ENST00000451287; ENSP00000397050; ENSG00000213889 [Q8N819-1]
GeneIDi147699
KEGGihsa:147699
UCSCiuc002pce.4, human [Q8N819-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
147699
DisGeNETi147699

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PPM1N
HGNCiHGNC:26845, PPM1N
HPAiENSG00000213889, Tissue enhanced (blood, skeletal muscle)
neXtProtiNX_Q8N819
OpenTargetsiENSG00000213889
PharmGKBiPA165394107
VEuPathDBiHostDB:ENSG00000213889.10

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0697, Eukaryota
GeneTreeiENSGT00940000162694
HOGENOMiCLU_146811_0_0_1
InParanoidiQ8N819
OMAiLWTACKK
OrthoDBi957254at2759
PhylomeDBiQ8N819

Enzyme and pathway databases

PathwayCommonsiQ8N819

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
147699, 5 hits in 992 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PPM1N, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
147699
PharosiQ8N819, Tdark

Protein Ontology

More...
PROi
PR:Q8N819
RNActiQ8N819, protein

Gene expression databases

BgeeiENSG00000213889, Expressed in muscle tissue and 115 other tissues
ExpressionAtlasiQ8N819, baseline and differential
GenevisibleiQ8N819, HS

Family and domain databases

CDDicd00143, PP2Cc, 1 hit
Gene3Di1.10.10.430, 1 hit
3.60.40.10, 1 hit
InterProiView protein in InterPro
IPR012911, PP2C_C
IPR036580, PP2C_C_sf
IPR036457, PPM-type_dom_sf
IPR001932, PPM-type_phosphatase_dom
PfamiView protein in Pfam
PF00481, PP2C, 1 hit
PF07830, PP2C_C, 1 hit
SMARTiView protein in SMART
SM00332, PP2Cc, 1 hit
SUPFAMiSSF81601, SSF81601, 1 hit
SSF81606, SSF81606, 1 hit
PROSITEiView protein in PROSITE
PS51746, PPM_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPPM1N_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N819
Secondary accession number(s): Q6P662
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: June 2, 2021
This is version 140 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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