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Protein

Cyclin N-terminal domain-containing protein 1

Gene

CNTD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Enzyme and pathway databases

SignaLinkiQ8N815

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin N-terminal domain-containing protein 1
Gene namesi
Name:CNTD1
Synonyms:CNTD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000176563.9
HGNCiHGNC:26847 CNTD1
neXtProtiNX_Q8N815

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000176563
PharmGKBiPA142672089

Polymorphism and mutation databases

BioMutaiCNTD1
DMDMi166216083

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003137151 – 330Cyclin N-terminal domain-containing protein 1Add BLAST330

Proteomic databases

PaxDbiQ8N815
PeptideAtlasiQ8N815
PRIDEiQ8N815
ProteomicsDBi72360
72361 [Q8N815-2]

PTM databases

iPTMnetiQ8N815
PhosphoSitePlusiQ8N815

Expressioni

Gene expression databases

BgeeiENSG00000176563
CleanExiHS_CNTD1
ExpressionAtlasiQ8N815 baseline and differential
GenevisibleiQ8N815 HS

Organism-specific databases

HPAiHPA023324

Interactioni

Protein-protein interaction databases

BioGridi125891, 1 interactor
STRINGi9606.ENSP00000465204

Structurei

3D structure databases

ProteinModelPortaliQ8N815
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 178Cyclin N-terminalAdd BLAST152

Phylogenomic databases

eggNOGiENOG410IE73 Eukaryota
ENOG4111VV0 LUCA
GeneTreeiENSGT00440000033966
HOGENOMiHOG000111847
HOVERGENiHBG103696
InParanoidiQ8N815
OMAiMDGPMRP
OrthoDBiEOG091G0SDV
PhylomeDBiQ8N815

Family and domain databases

InterProiView protein in InterPro
IPR036915 Cyclin-like_sf
IPR006671 Cyclin_N
PfamiView protein in Pfam
PF00134 Cyclin_N, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N815-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDGPMRPRSA SLVDFQFGVV ATETIEDALL HLAQQNEQAV REASGRLGRF
60 70 80 90 100
REPQIVEFVF LLSEQWCLEK SVSYQAVEIL ERFMVKQAEN ICRQATIQPR
110 120 130 140 150
DNKRESQNWR ALKQQLVNKF TLRLVSCVQL ASKLSFRNKI ISNITVLNFL
160 170 180 190 200
QALGYLHTKE ELLESELDVL KSLNFRINLP TPLAYVETLL EVLGYNGCLV
210 220 230 240 250
PAMRLHATCL TLLDLVYLLH EPIYESLLRA SIENSTPSQL QGEKFTSVKE
260 270 280 290 300
DFMLLAVGII AASAFIQNHE CWSQVVGHLQ SITGIALASI AEFSYAILTH
310 320 330
GVGANTPGRQ QSIPPHLAAR ALKTVASSNT
Length:330
Mass (Da):36,921
Last modified:January 15, 2008 - v2
Checksum:i6A08ED50392706ED
GO
Isoform 2 (identifier: Q8N815-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-202: Missing.

Note: No experimental confirmation available.
Show »
Length:128
Mass (Da):13,813
Checksum:i41B012C89E267EFD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4P → S in BAC05060 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037708145T → P. Corresponds to variant dbSNP:rs12947820Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0301111 – 202Missing in isoform 2. 1 PublicationAdd BLAST202

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097456 mRNA Translation: BAC05060.1
AL833052 mRNA Translation: CAH56287.1
CH471152 Genomic DNA Translation: EAW60886.1
BC026187 mRNA Translation: AAH26187.1
CCDSiCCDS11440.1 [Q8N815-1]
RefSeqiNP_001317151.1, NM_001330222.1
NP_775749.2, NM_173478.2 [Q8N815-1]
UniGeneiHs.12272

Genome annotation databases

EnsembliENST00000588408; ENSP00000465204; ENSG00000176563 [Q8N815-1]
GeneIDi124817
KEGGihsa:124817
UCSCiuc002ibm.5 human [Q8N815-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCNTD1_HUMAN
AccessioniPrimary (citable) accession number: Q8N815
Secondary accession number(s): Q658Q6, Q8NEP1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: June 20, 2018
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

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