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Entry version 122 (17 Jun 2020)
Sequence version 2 (08 Apr 2008)
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Protein

Ankyrin repeat domain-containing protein 31

Gene

ANKRD31

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for DNA double-strand breaks (DSBs) formation during meiotic recombination. Regulates the spatial and temporal patterns of pre-DSB recombinosome assembly and recombination activity by acting as a scaffold that anchors REC114 and other factors to specific genomic locations, thereby regulating DSB formation. Plays a key role in recombination in the pseudoautosomal regions of sex chromosomes.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDNA recombination, Meiosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 31Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANKRD31Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000145700.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26853 ANKRD31

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
618423 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N7Z5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
256006

Open Targets

More...
OpenTargetsi
ENSG00000145700

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134879237

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8N7Z5 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ANKRD31

Domain mapping of disease mutations (DMDM)

More...
DMDMi
182627587

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003288391 – 1873Ankyrin repeat domain-containing protein 31Add BLAST1873

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N7Z5

PeptideAtlas

More...
PeptideAtlasi
Q8N7Z5

PRoteomics IDEntifications database

More...
PRIDEi
Q8N7Z5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
72350

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q8N7Z5

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N7Z5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N7Z5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000145700 Expressed in testis and 37 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8N7Z5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N7Z5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000145700 Tissue enhanced (pituitary gland, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with REC114; the interaction is direct.

Interacts with IHO1.

By similarity

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q8N7Z5, 3 interactors

Molecular INTeraction database

More...
MINTi
Q8N7Z5

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000274361

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8N7Z5 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8N7Z5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati488 – 517ANK 1Add BLAST30
Repeati521 – 550ANK 2Add BLAST30
Repeati554 – 583ANK 3Add BLAST30
Repeati1154 – 1183ANK 4Add BLAST30
Repeati1187 – 1216ANK 5Add BLAST30
Repeati1220 – 1249ANK 6Add BLAST30
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1683 – 1778RAMASequence analysisAdd BLAST96

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGFS Eukaryota
ENOG410XUCG LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162618

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003348_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N7Z5

Database of Orthologous Groups

More...
OrthoDBi
51193at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N7Z5

TreeFam database of animal gene trees

More...
TreeFami
TF326440

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR042334 ANKRD31
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR040843 RAMA

The PANTHER Classification System

More...
PANTHERi
PTHR24176 PTHR24176, 4 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00023 Ank, 2 hits
PF12796 Ank_2, 1 hit
PF18755 RAMA, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415 ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 2 hits
PS50088 ANK_REPEAT, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8N7Z5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEGVQAPDW DSDETVIEGS VTESDLEEKE LPWRRLLFDQ DASLKSEFSL
60 70 80 90 100
HPDTRGMCKG MPSPEIQLGF KLREDLQEQM NKNKMMPVLS EDTILQSQDE
110 120 130 140 150
TERNQALLQT RKNCSMFIGS FRQSGLSLNH QNIEGPEAES PEVLPHIEKE
160 170 180 190 200
LSEGRDSPEV SLLSGTAITV SDTVAVKETS LVEPEKILAA PNTFFEPRKE
210 220 230 240 250
VTMTMTSEET KDEESSLETF VSALESLLTS PESTQEERLF ELVSDFDRKE
260 270 280 290 300
LMNPLSDSLS SISIPLNSWS ACHRDLLEDA KDDALPAELL EALNTLSEAK
310 320 330 340 350
VETICHRKEG GSSLIARNEC LEVEFNTSQT NEDCTQIAET LQDPNPSGLQ
360 370 380 390 400
TLAHQNITSC EPLSNKRNSN SVTNSSDQET ACVLRRSSRL EKLKVSRDAK
410 420 430 440 450
YSDHMYKMPE KILPKILGCE DLTNNNSSAQ NFRMQDPALM IDGKEKNMHS
460 470 480 490 500
ARFKNGKQIR KNEQFSGKKE KMKVNKISLH SINRRNIFGE NLVYKAALHD
510 520 530 540 550
DADLVHHCIK KGGNVNQPSY AGWTALHEAS VGGFYRTASE LLKGGADVNI
560 570 580 590 600
KGLYQITPLH DAVMNGHYKV AELLLLNGAD PLFRNDDGKC ALDEAKDLCM
610 620 630 640 650
KRLLERYIPK HQKCLTSAQR SSIDPLDIED VYQHKKPKFS SKSHIWHVYN
660 670 680 690 700
ENSNRQKLEH VKVNKGSKAS LFINKEDVYE YYQKDPKNTK FGKSKHKQST
710 720 730 740 750
LDQIYSTGLR KGNLHNVKDP NTNVPKGIGR RKTQHKRTQV DDVDCNPRKI
760 770 780 790 800
LAVSPSRRIN RLVTYQQHIP ETHNDLPEEL CEPSSLTLSS LRNGLDSSTE
810 820 830 840 850
ACSVSKEKHI QNLDLSDSQE VQCLELESVD QTEAVSFPGL LLHKEIKLPV
860 870 880 890 900
VTTDKQPHTL QEQHHVLYKS HENSNLVPKD ERFNKWENSF LSFVKENSDN
910 920 930 940 950
DDDDDCSTSE KAITSKKVLC STGGKKHYNF KENLTNKKEM GFQQFLLSED
960 970 980 990 1000
HLSQENELKA VSLTTLPEQE AVNFSYSDNA VISEHVANYE QCIFGPSFDH
1010 1020 1030 1040 1050
SNGNPEQNSL ACMRTLLTHE ASKLTNHVEL FKKPQDYIPR APTFLMNQTD
1060 1070 1080 1090 1100
THIVEKMAKN CDTERNYIDR DQKIIYSNEP LSIVAHSQVI ETTKVEKRRQ
1110 1120 1130 1140 1150
NHLESETIHN IDSHSTDNMS KELANISKLS QREKKEISHK PGMKAGRINK
1160 1170 1180 1190 1200
RNARGESQLH LAVRRGNLPL VKALIESGAD VNLNDNAGWT PLHEASNEGS
1210 1220 1230 1240 1250
IDIIVELLKA GAKVNCENID GILPLHDAVA NNHLKAAEIL LQNGANPNQK
1260 1270 1280 1290 1300
DQKQKSALDE ADDEKMKELL RSYGAIETVN RDESDAIVNE KIPAVRSKRH
1310 1320 1330 1340 1350
KQCFCDDGKT IDSSSLSHQE RSRESLSVHQ TLSAILQDIE EKQEYLLEFE
1360 1370 1380 1390 1400
IRNPEDAEQY IEKMLKIKKI MDNVLAKQKA ERDDLAKKYR VSIESFKHGA
1410 1420 1430 1440 1450
LREQLANLAA RQKSLLVVAK KQKKISLKIQ NCRNVTSLPC LSLRKLPPRS
1460 1470 1480 1490 1500
EISSEKDSQE LTSLENLEHP QSGSLSPVSG SMQETQLSLE TWNYSQNTNI
1510 1520 1530 1540 1550
CLNSEAVRRG EFSGNDMNSK QNGSDCTLDG FPKSRHSDGT EKNKLPSQPV
1560 1570 1580 1590 1600
AFIGQTEYSQ KENDLTEATD KDHEFYVSSP VIGKLNISET ASVLAENAAH
1610 1620 1630 1640 1650
PSNIICDQDL SNYDPKRGNR KTSSQQSPTG ASESLAHQGI AVLGSDTVHQ
1660 1670 1680 1690 1700
MKPYLKKSVS VVPCADDSQI SSSSGSGQQD TIKKALNYST APKKKCIQIK
1710 1720 1730 1740 1750
DLILLGRINP GNNILEFKTQ ETTHKASILL NGKLKVESGQ IYKNPVTWLK
1760 1770 1780 1790 1800
DLLGGNSYVT WNYAWSKVTY LGKELLRYVS EDAPILPEPN SVPQQYQPCL
1810 1820 1830 1840 1850
PEVACLDDPV QEPNKSMFEK TKFGQGTSRE SMQSSPRYLQ INEILLISDQ
1860 1870
EFLPCHIMDQ HWKFCVECEE LTP
Length:1,873
Mass (Da):210,816
Last modified:April 8, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3491754C9B0923ED
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RJB7D6RJB7_HUMAN
Ankyrin repeat domain-containing pr...
ANKRD31
1,930Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A669KAY2A0A669KAY2_HUMAN
Ankyrin repeat domain-containing pr...
ANKRD31
35Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti444K → R in BAC05081 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_042542702D → N. Corresponds to variant dbSNP:rs1422698Ensembl.1
Natural variantiVAR_042543758R → G. Corresponds to variant dbSNP:rs6893216Ensembl.1
Natural variantiVAR_0425441609D → E. Corresponds to variant dbSNP:rs961098Ensembl.1
Natural variantiVAR_0425451777R → K. Corresponds to variant dbSNP:rs4489037Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC008769 Genomic DNA No translation available.
AC093259 Genomic DNA No translation available.
AK097510 mRNA Translation: BAC05081.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47233.1

NCBI Reference Sequences

More...
RefSeqi
NP_001157915.1, NM_001164443.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000274361; ENSP00000274361; ENSG00000145700

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
256006

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:256006

UCSC genome browser

More...
UCSCi
uc003kdo.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008769 Genomic DNA No translation available.
AC093259 Genomic DNA No translation available.
AK097510 mRNA Translation: BAC05081.1
CCDSiCCDS47233.1
RefSeqiNP_001157915.1, NM_001164443.1

3D structure databases

SMRiQ8N7Z5
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ8N7Z5, 3 interactors
MINTiQ8N7Z5
STRINGi9606.ENSP00000274361

PTM databases

CarbonylDBiQ8N7Z5
iPTMnetiQ8N7Z5
PhosphoSitePlusiQ8N7Z5

Polymorphism and mutation databases

BioMutaiANKRD31
DMDMi182627587

Proteomic databases

PaxDbiQ8N7Z5
PeptideAtlasiQ8N7Z5
PRIDEiQ8N7Z5
ProteomicsDBi72350

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
48719 5 antibodies

Genome annotation databases

EnsembliENST00000274361; ENSP00000274361; ENSG00000145700
GeneIDi256006
KEGGihsa:256006
UCSCiuc003kdo.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
256006
DisGeNETi256006
EuPathDBiHostDB:ENSG00000145700.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ANKRD31
HGNCiHGNC:26853 ANKRD31
HPAiENSG00000145700 Tissue enhanced (pituitary gland, testis)
MIMi618423 gene
neXtProtiNX_Q8N7Z5
OpenTargetsiENSG00000145700
PharmGKBiPA134879237

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IGFS Eukaryota
ENOG410XUCG LUCA
GeneTreeiENSGT00940000162618
HOGENOMiCLU_003348_0_0_1
InParanoidiQ8N7Z5
OrthoDBi51193at2759
PhylomeDBiQ8N7Z5
TreeFamiTF326440

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
256006 7 hits in 718 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ANKRD31 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
256006
PharosiQ8N7Z5 Tdark

Protein Ontology

More...
PROi
PR:Q8N7Z5
RNActiQ8N7Z5 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000145700 Expressed in testis and 37 other tissues
ExpressionAtlasiQ8N7Z5 baseline and differential
GenevisibleiQ8N7Z5 HS

Family and domain databases

Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR042334 ANKRD31
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR040843 RAMA
PANTHERiPTHR24176 PTHR24176, 4 hits
PfamiView protein in Pfam
PF00023 Ank, 2 hits
PF12796 Ank_2, 1 hit
PF18755 RAMA, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SUPFAMiSSF48403 SSF48403, 2 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 2 hits
PS50088 ANK_REPEAT, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiANR31_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N7Z5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: June 17, 2020
This is version 122 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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