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UniProtKB - Q8N7Z5 (ANR31_HUMAN)

Protein

Putative ankyrin repeat domain-containing protein 31

Gene

ANKRD31

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

Caution

Product of a dubious CDS prediction.Curated

Names & Taxonomyi

Protein namesi
Recommended name:
Putative ankyrin repeat domain-containing protein 31
Gene namesi
Name:ANKRD31
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000145700.9
HGNCiHGNC:26853 ANKRD31
neXtProtiNX_Q8N7Z5

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000145700
PharmGKBiPA134879237

Polymorphism and mutation databases

BioMutaiANKRD31
DMDMi182627587

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003288391 – 1873Putative ankyrin repeat domain-containing protein 31Add BLAST1873

Proteomic databases

PaxDbiQ8N7Z5
PeptideAtlasiQ8N7Z5
PRIDEiQ8N7Z5
ProteomicsDBi72350

PTM databases

CarbonylDBiQ8N7Z5
iPTMnetiQ8N7Z5
PhosphoSitePlusiQ8N7Z5

Expressioni

Gene expression databases

BgeeiENSG00000145700 Expressed in 38 organ(s), highest expression level in testis
CleanExiHS_ANKRD31
ExpressionAtlasiQ8N7Z5 baseline and differential
GenevisibleiQ8N7Z5 HS

Organism-specific databases

HPAiHPA057566

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000274361

Structurei

3D structure databases

ProteinModelPortaliQ8N7Z5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati488 – 517ANK 1Add BLAST30
Repeati521 – 550ANK 2Add BLAST30
Repeati554 – 583ANK 3Add BLAST30
Repeati1154 – 1183ANK 4Add BLAST30
Repeati1187 – 1216ANK 5Add BLAST30
Repeati1220 – 1249ANK 6Add BLAST30

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IGFS Eukaryota
ENOG410XUCG LUCA
GeneTreeiENSGT00760000119090
HOGENOMiHOG000033960
InParanoidiQ8N7Z5
PhylomeDBiQ8N7Z5
TreeFamiTF326440

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF00023 Ank, 2 hits
PF12796 Ank_2, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SUPFAMiSSF48403 SSF48403, 2 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 2 hits
PS50088 ANK_REPEAT, 5 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8N7Z5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEGVQAPDW DSDETVIEGS VTESDLEEKE LPWRRLLFDQ DASLKSEFSL 
        60         70         80         90        100
HPDTRGMCKG MPSPEIQLGF KLREDLQEQM NKNKMMPVLS EDTILQSQDE 
       110        120        130        140        150
TERNQALLQT RKNCSMFIGS FRQSGLSLNH QNIEGPEAES PEVLPHIEKE 
       160        170        180        190        200
LSEGRDSPEV SLLSGTAITV SDTVAVKETS LVEPEKILAA PNTFFEPRKE 
       210        220        230        240        250
VTMTMTSEET KDEESSLETF VSALESLLTS PESTQEERLF ELVSDFDRKE 
       260        270        280        290        300
LMNPLSDSLS SISIPLNSWS ACHRDLLEDA KDDALPAELL EALNTLSEAK 
       310        320        330        340        350
VETICHRKEG GSSLIARNEC LEVEFNTSQT NEDCTQIAET LQDPNPSGLQ 
       360        370        380        390        400
TLAHQNITSC EPLSNKRNSN SVTNSSDQET ACVLRRSSRL EKLKVSRDAK 
       410        420        430        440        450
YSDHMYKMPE KILPKILGCE DLTNNNSSAQ NFRMQDPALM IDGKEKNMHS 
       460        470        480        490        500
ARFKNGKQIR KNEQFSGKKE KMKVNKISLH SINRRNIFGE NLVYKAALHD 
       510        520        530        540        550
DADLVHHCIK KGGNVNQPSY AGWTALHEAS VGGFYRTASE LLKGGADVNI 
       560        570        580        590        600
KGLYQITPLH DAVMNGHYKV AELLLLNGAD PLFRNDDGKC ALDEAKDLCM 
       610        620        630        640        650
KRLLERYIPK HQKCLTSAQR SSIDPLDIED VYQHKKPKFS SKSHIWHVYN 
       660        670        680        690        700
ENSNRQKLEH VKVNKGSKAS LFINKEDVYE YYQKDPKNTK FGKSKHKQST 
       710        720        730        740        750
LDQIYSTGLR KGNLHNVKDP NTNVPKGIGR RKTQHKRTQV DDVDCNPRKI 
       760        770        780        790        800
LAVSPSRRIN RLVTYQQHIP ETHNDLPEEL CEPSSLTLSS LRNGLDSSTE 
       810        820        830        840        850
ACSVSKEKHI QNLDLSDSQE VQCLELESVD QTEAVSFPGL LLHKEIKLPV 
       860        870        880        890        900
VTTDKQPHTL QEQHHVLYKS HENSNLVPKD ERFNKWENSF LSFVKENSDN 
       910        920        930        940        950
DDDDDCSTSE KAITSKKVLC STGGKKHYNF KENLTNKKEM GFQQFLLSED 
       960        970        980        990       1000
HLSQENELKA VSLTTLPEQE AVNFSYSDNA VISEHVANYE QCIFGPSFDH 
      1010       1020       1030       1040       1050
SNGNPEQNSL ACMRTLLTHE ASKLTNHVEL FKKPQDYIPR APTFLMNQTD 
      1060       1070       1080       1090       1100
THIVEKMAKN CDTERNYIDR DQKIIYSNEP LSIVAHSQVI ETTKVEKRRQ 
      1110       1120       1130       1140       1150
NHLESETIHN IDSHSTDNMS KELANISKLS QREKKEISHK PGMKAGRINK 
      1160       1170       1180       1190       1200
RNARGESQLH LAVRRGNLPL VKALIESGAD VNLNDNAGWT PLHEASNEGS 
      1210       1220       1230       1240       1250
IDIIVELLKA GAKVNCENID GILPLHDAVA NNHLKAAEIL LQNGANPNQK 
      1260       1270       1280       1290       1300
DQKQKSALDE ADDEKMKELL RSYGAIETVN RDESDAIVNE KIPAVRSKRH 
      1310       1320       1330       1340       1350
KQCFCDDGKT IDSSSLSHQE RSRESLSVHQ TLSAILQDIE EKQEYLLEFE 
      1360       1370       1380       1390       1400
IRNPEDAEQY IEKMLKIKKI MDNVLAKQKA ERDDLAKKYR VSIESFKHGA 
      1410       1420       1430       1440       1450
LREQLANLAA RQKSLLVVAK KQKKISLKIQ NCRNVTSLPC LSLRKLPPRS 
      1460       1470       1480       1490       1500
EISSEKDSQE LTSLENLEHP QSGSLSPVSG SMQETQLSLE TWNYSQNTNI 
      1510       1520       1530       1540       1550
CLNSEAVRRG EFSGNDMNSK QNGSDCTLDG FPKSRHSDGT EKNKLPSQPV 
      1560       1570       1580       1590       1600
AFIGQTEYSQ KENDLTEATD KDHEFYVSSP VIGKLNISET ASVLAENAAH 
      1610       1620       1630       1640       1650
PSNIICDQDL SNYDPKRGNR KTSSQQSPTG ASESLAHQGI AVLGSDTVHQ 
      1660       1670       1680       1690       1700
MKPYLKKSVS VVPCADDSQI SSSSGSGQQD TIKKALNYST APKKKCIQIK 
      1710       1720       1730       1740       1750
DLILLGRINP GNNILEFKTQ ETTHKASILL NGKLKVESGQ IYKNPVTWLK 
      1760       1770       1780       1790       1800
DLLGGNSYVT WNYAWSKVTY LGKELLRYVS EDAPILPEPN SVPQQYQPCL 
      1810       1820       1830       1840       1850
PEVACLDDPV QEPNKSMFEK TKFGQGTSRE SMQSSPRYLQ INEILLISDQ 
      1860       1870 
EFLPCHIMDQ HWKFCVECEE LTP
Length:1,873
Mass (Da):210,816
Last modified:April 8, 2008 - v2
Checksum:i3491754C9B0923ED
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RJB7D6RJB7_HUMAN
Putative ankyrin repeat domain-cont...
ANKRD31
1,930Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti444K → R in BAC05081 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_042542702D → N. Corresponds to variant dbSNP:rs1422698Ensembl.1
Natural variantiVAR_042543758R → G. Corresponds to variant dbSNP:rs6893216Ensembl.1
Natural variantiVAR_0425441609D → E. Corresponds to variant dbSNP:rs961098Ensembl.1
Natural variantiVAR_0425451777R → K. Corresponds to variant dbSNP:rs4489037Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008769 Genomic DNA No translation available.
AC093259 Genomic DNA No translation available.
AK097510 mRNA Translation: BAC05081.1
CCDSiCCDS47233.1
RefSeqiNP_001157915.1, NM_001164443.1
UniGeneiHs.482533

Genome annotation databases

EnsembliENST00000274361; ENSP00000274361; ENSG00000145700
GeneIDi256006
KEGGihsa:256006
UCSCiuc003kdo.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008769 Genomic DNA No translation available.
AC093259 Genomic DNA No translation available.
AK097510 mRNA Translation: BAC05081.1
CCDSiCCDS47233.1
RefSeqiNP_001157915.1, NM_001164443.1
UniGeneiHs.482533

3D structure databases

ProteinModelPortaliQ8N7Z5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000274361

PTM databases

CarbonylDBiQ8N7Z5
iPTMnetiQ8N7Z5
PhosphoSitePlusiQ8N7Z5

Polymorphism and mutation databases

BioMutaiANKRD31
DMDMi182627587

Proteomic databases

PaxDbiQ8N7Z5
PeptideAtlasiQ8N7Z5
PRIDEiQ8N7Z5
ProteomicsDBi72350

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000274361; ENSP00000274361; ENSG00000145700
GeneIDi256006
KEGGihsa:256006
UCSCiuc003kdo.2 human

Organism-specific databases

CTDi256006
EuPathDBiHostDB:ENSG00000145700.9
GeneCardsiANKRD31
HGNCiHGNC:26853 ANKRD31
HPAiHPA057566
neXtProtiNX_Q8N7Z5
OpenTargetsiENSG00000145700
PharmGKBiPA134879237
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGFS Eukaryota
ENOG410XUCG LUCA
GeneTreeiENSGT00760000119090
HOGENOMiHOG000033960
InParanoidiQ8N7Z5
PhylomeDBiQ8N7Z5
TreeFamiTF326440

Miscellaneous databases

ChiTaRSiANKRD31 human
GenomeRNAii256006

Gene expression databases

BgeeiENSG00000145700 Expressed in 38 organ(s), highest expression level in testis
CleanExiHS_ANKRD31
ExpressionAtlasiQ8N7Z5 baseline and differential
GenevisibleiQ8N7Z5 HS

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF00023 Ank, 2 hits
PF12796 Ank_2, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SUPFAMiSSF48403 SSF48403, 2 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 2 hits
PS50088 ANK_REPEAT, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiANR31_HUMAN
AccessioniPrimary (citable) accession number: Q8N7Z5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: November 7, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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