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Protein

Putative ankyrin repeat domain-containing protein 31

Gene

ANKRD31

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

Caution

Product of a dubious CDS prediction.Curated

Names & Taxonomyi

Protein namesi
Recommended name:
Putative ankyrin repeat domain-containing protein 31
Gene namesi
Name:ANKRD31
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000145700.9
HGNCiHGNC:26853 ANKRD31
neXtProtiNX_Q8N7Z5

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000145700
PharmGKBiPA134879237

Polymorphism and mutation databases

BioMutaiANKRD31
DMDMi182627587

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003288391 – 1873Putative ankyrin repeat domain-containing protein 31Add BLAST1873

Proteomic databases

PaxDbiQ8N7Z5
PeptideAtlasiQ8N7Z5
PRIDEiQ8N7Z5
ProteomicsDBi72350

PTM databases

CarbonylDBiQ8N7Z5
iPTMnetiQ8N7Z5
PhosphoSitePlusiQ8N7Z5

Expressioni

Gene expression databases

BgeeiENSG00000145700 Expressed in 38 organ(s), highest expression level in testis
CleanExiHS_ANKRD31
ExpressionAtlasiQ8N7Z5 baseline and differential
GenevisibleiQ8N7Z5 HS

Organism-specific databases

HPAiHPA057566

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000274361

Structurei

3D structure databases

ProteinModelPortaliQ8N7Z5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati488 – 517ANK 1Add BLAST30
Repeati521 – 550ANK 2Add BLAST30
Repeati554 – 583ANK 3Add BLAST30
Repeati1154 – 1183ANK 4Add BLAST30
Repeati1187 – 1216ANK 5Add BLAST30
Repeati1220 – 1249ANK 6Add BLAST30

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IGFS Eukaryota
ENOG410XUCG LUCA
GeneTreeiENSGT00760000119090
HOGENOMiHOG000033960
InParanoidiQ8N7Z5
PhylomeDBiQ8N7Z5
TreeFamiTF326440

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF00023 Ank, 2 hits
PF12796 Ank_2, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SUPFAMiSSF48403 SSF48403, 2 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 2 hits
PS50088 ANK_REPEAT, 5 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8N7Z5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEGVQAPDW DSDETVIEGS VTESDLEEKE LPWRRLLFDQ DASLKSEFSL
60 70 80 90 100
HPDTRGMCKG MPSPEIQLGF KLREDLQEQM NKNKMMPVLS EDTILQSQDE
110 120 130 140 150
TERNQALLQT RKNCSMFIGS FRQSGLSLNH QNIEGPEAES PEVLPHIEKE
160 170 180 190 200
LSEGRDSPEV SLLSGTAITV SDTVAVKETS LVEPEKILAA PNTFFEPRKE
210 220 230 240 250
VTMTMTSEET KDEESSLETF VSALESLLTS PESTQEERLF ELVSDFDRKE
260 270 280 290 300
LMNPLSDSLS SISIPLNSWS ACHRDLLEDA KDDALPAELL EALNTLSEAK
310 320 330 340 350
VETICHRKEG GSSLIARNEC LEVEFNTSQT NEDCTQIAET LQDPNPSGLQ
360 370 380 390 400
TLAHQNITSC EPLSNKRNSN SVTNSSDQET ACVLRRSSRL EKLKVSRDAK
410 420 430 440 450
YSDHMYKMPE KILPKILGCE DLTNNNSSAQ NFRMQDPALM IDGKEKNMHS
460 470 480 490 500
ARFKNGKQIR KNEQFSGKKE KMKVNKISLH SINRRNIFGE NLVYKAALHD
510 520 530 540 550
DADLVHHCIK KGGNVNQPSY AGWTALHEAS VGGFYRTASE LLKGGADVNI
560 570 580 590 600
KGLYQITPLH DAVMNGHYKV AELLLLNGAD PLFRNDDGKC ALDEAKDLCM
610 620 630 640 650
KRLLERYIPK HQKCLTSAQR SSIDPLDIED VYQHKKPKFS SKSHIWHVYN
660 670 680 690 700
ENSNRQKLEH VKVNKGSKAS LFINKEDVYE YYQKDPKNTK FGKSKHKQST
710 720 730 740 750
LDQIYSTGLR KGNLHNVKDP NTNVPKGIGR RKTQHKRTQV DDVDCNPRKI
760 770 780 790 800
LAVSPSRRIN RLVTYQQHIP ETHNDLPEEL CEPSSLTLSS LRNGLDSSTE
810 820 830 840 850
ACSVSKEKHI QNLDLSDSQE VQCLELESVD QTEAVSFPGL LLHKEIKLPV
860 870 880 890 900
VTTDKQPHTL QEQHHVLYKS HENSNLVPKD ERFNKWENSF LSFVKENSDN
910 920 930 940 950
DDDDDCSTSE KAITSKKVLC STGGKKHYNF KENLTNKKEM GFQQFLLSED
960 970 980 990 1000
HLSQENELKA VSLTTLPEQE AVNFSYSDNA VISEHVANYE QCIFGPSFDH
1010 1020 1030 1040 1050
SNGNPEQNSL ACMRTLLTHE ASKLTNHVEL FKKPQDYIPR APTFLMNQTD
1060 1070 1080 1090 1100
THIVEKMAKN CDTERNYIDR DQKIIYSNEP LSIVAHSQVI ETTKVEKRRQ
1110 1120 1130 1140 1150
NHLESETIHN IDSHSTDNMS KELANISKLS QREKKEISHK PGMKAGRINK
1160 1170 1180 1190 1200
RNARGESQLH LAVRRGNLPL VKALIESGAD VNLNDNAGWT PLHEASNEGS
1210 1220 1230 1240 1250
IDIIVELLKA GAKVNCENID GILPLHDAVA NNHLKAAEIL LQNGANPNQK
1260 1270 1280 1290 1300
DQKQKSALDE ADDEKMKELL RSYGAIETVN RDESDAIVNE KIPAVRSKRH
1310 1320 1330 1340 1350
KQCFCDDGKT IDSSSLSHQE RSRESLSVHQ TLSAILQDIE EKQEYLLEFE
1360 1370 1380 1390 1400
IRNPEDAEQY IEKMLKIKKI MDNVLAKQKA ERDDLAKKYR VSIESFKHGA
1410 1420 1430 1440 1450
LREQLANLAA RQKSLLVVAK KQKKISLKIQ NCRNVTSLPC LSLRKLPPRS
1460 1470 1480 1490 1500
EISSEKDSQE LTSLENLEHP QSGSLSPVSG SMQETQLSLE TWNYSQNTNI
1510 1520 1530 1540 1550
CLNSEAVRRG EFSGNDMNSK QNGSDCTLDG FPKSRHSDGT EKNKLPSQPV
1560 1570 1580 1590 1600
AFIGQTEYSQ KENDLTEATD KDHEFYVSSP VIGKLNISET ASVLAENAAH
1610 1620 1630 1640 1650
PSNIICDQDL SNYDPKRGNR KTSSQQSPTG ASESLAHQGI AVLGSDTVHQ
1660 1670 1680 1690 1700
MKPYLKKSVS VVPCADDSQI SSSSGSGQQD TIKKALNYST APKKKCIQIK
1710 1720 1730 1740 1750
DLILLGRINP GNNILEFKTQ ETTHKASILL NGKLKVESGQ IYKNPVTWLK
1760 1770 1780 1790 1800
DLLGGNSYVT WNYAWSKVTY LGKELLRYVS EDAPILPEPN SVPQQYQPCL
1810 1820 1830 1840 1850
PEVACLDDPV QEPNKSMFEK TKFGQGTSRE SMQSSPRYLQ INEILLISDQ
1860 1870
EFLPCHIMDQ HWKFCVECEE LTP
Length:1,873
Mass (Da):210,816
Last modified:April 8, 2008 - v2
Checksum:i3491754C9B0923ED
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RJB7D6RJB7_HUMAN
Putative ankyrin repeat domain-cont...
ANKRD31
1,930Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti444K → R in BAC05081 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_042542702D → N. Corresponds to variant dbSNP:rs1422698Ensembl.1
Natural variantiVAR_042543758R → G. Corresponds to variant dbSNP:rs6893216Ensembl.1
Natural variantiVAR_0425441609D → E. Corresponds to variant dbSNP:rs961098Ensembl.1
Natural variantiVAR_0425451777R → K. Corresponds to variant dbSNP:rs4489037Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008769 Genomic DNA No translation available.
AC093259 Genomic DNA No translation available.
AK097510 mRNA Translation: BAC05081.1
CCDSiCCDS47233.1
RefSeqiNP_001157915.1, NM_001164443.1
UniGeneiHs.482533

Genome annotation databases

EnsembliENST00000274361; ENSP00000274361; ENSG00000145700
GeneIDi256006
KEGGihsa:256006
UCSCiuc003kdo.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008769 Genomic DNA No translation available.
AC093259 Genomic DNA No translation available.
AK097510 mRNA Translation: BAC05081.1
CCDSiCCDS47233.1
RefSeqiNP_001157915.1, NM_001164443.1
UniGeneiHs.482533

3D structure databases

ProteinModelPortaliQ8N7Z5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000274361

PTM databases

CarbonylDBiQ8N7Z5
iPTMnetiQ8N7Z5
PhosphoSitePlusiQ8N7Z5

Polymorphism and mutation databases

BioMutaiANKRD31
DMDMi182627587

Proteomic databases

PaxDbiQ8N7Z5
PeptideAtlasiQ8N7Z5
PRIDEiQ8N7Z5
ProteomicsDBi72350

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000274361; ENSP00000274361; ENSG00000145700
GeneIDi256006
KEGGihsa:256006
UCSCiuc003kdo.2 human

Organism-specific databases

CTDi256006
EuPathDBiHostDB:ENSG00000145700.9
GeneCardsiANKRD31
HGNCiHGNC:26853 ANKRD31
HPAiHPA057566
neXtProtiNX_Q8N7Z5
OpenTargetsiENSG00000145700
PharmGKBiPA134879237
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGFS Eukaryota
ENOG410XUCG LUCA
GeneTreeiENSGT00760000119090
HOGENOMiHOG000033960
InParanoidiQ8N7Z5
PhylomeDBiQ8N7Z5
TreeFamiTF326440

Miscellaneous databases

ChiTaRSiANKRD31 human
GenomeRNAii256006

Gene expression databases

BgeeiENSG00000145700 Expressed in 38 organ(s), highest expression level in testis
CleanExiHS_ANKRD31
ExpressionAtlasiQ8N7Z5 baseline and differential
GenevisibleiQ8N7Z5 HS

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF00023 Ank, 2 hits
PF12796 Ank_2, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SUPFAMiSSF48403 SSF48403, 2 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 2 hits
PS50088 ANK_REPEAT, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiANR31_HUMAN
AccessioniPrimary (citable) accession number: Q8N7Z5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: November 7, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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