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Entry version 101 (11 Dec 2019)
Sequence version 3 (28 Mar 2018)
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Protein

Golgin subfamily A member 6-like protein 1

Gene

GOLGA6L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Golgin subfamily A member 6-like protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000273976.1

Human Gene Nomenclature Database

More...
HGNCi
HGNC:37444 GOLGA6L1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N7Z2

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000273976

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8N7Z2 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GOLGA6L1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
300669642

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003260271 – 668Golgin subfamily A member 6-like protein 1Add BLAST668

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8N7Z2

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q8N7Z2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N7Z2

PeptideAtlas

More...
PeptideAtlasi
Q8N7Z2

PRoteomics IDEntifications database

More...
PRIDEi
Q8N7Z2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
72349

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N7Z2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000273976 Expressed in 19 organ(s), highest expression level in testis

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA047733

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000478478

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8N7Z2 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8N7Z2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili177 – 663Sequence analysisAdd BLAST487

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi8 – 48His-richPROSITE-ProRule annotationAdd BLAST41
Compositional biasi86 – 89Poly-LysSequence analysis4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GOLGA6 family.Curated

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410INYH Eukaryota
ENOG410XZ9A LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163338

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000218631

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N7Z2

Identification of Orthologs from Complete Genome Data

More...
OMAi
QEENLWE

Database of Orthologous Groups

More...
OrthoDBi
358120at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N7Z2

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026737 GOLGA6L

The PANTHER Classification System

More...
PANTHERi
PTHR23143 PTHR23143, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8N7Z2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLMWPQPHLP THPHLPTHPH LPTHPHLPTH PHLPTHPHLP THPHLPTHPM
60 70 80 90 100
MSKETRQSKL AEAKEQLTDH HPQTNPSVGT AASDTKKKKI NNGTNPETTT
110 120 130 140 150
SGGCHSPEDE QKASHQHQEA LRRELEAQVH TIRILTCQKT ELQMALYYSQ
160 170 180 190 200
HAVKQLEGEA RDLISRLHDS WKFAGELEQA LSAVATQKKK ADRYIEELTK
210 220 230 240 250
ERDALSLELY RNTITDEELK EKNAKLQEKL QLVESEKSEI QLNVKELKRK
260 270 280 290 300
LERAKLLLPQ QQLQAEADHL GKELQSVSAK LQAQVEENEL WNRLNQQQEE
310 320 330 340 350
KMWRQEEKIQ EWEEKIQEQE EKIREQEEKI REQEEKMRRQ EEMMWEKEEK
360 370 380 390 400
MRRQEEMMWE KEEKMRRLEE MMWEKEEKIR ELEEKMHEQE KIREQEEKRQ
410 420 430 440 450
EEEKIREQEK RQEQEAKMWR QEEKIREQEE KIREQEKKMW RQEEKIHEQE
460 470 480 490 500
KIREEEKRQE QEEMWRQEEK IREQEEIWRQ KEKMHEQEKI RKQEEKVWRQ
510 520 530 540 550
EEKMHDQEEK IREQEEKMWR QEEKIREQEE KIREQEEKIR EQEEMMQEQE
560 570 580 590 600
EKMGEQEEKM QEQEKMRRQE EKIREQEEKI REQKEKIREQ EEKIWEQEEK
610 620 630 640 650
IREQEEMMQE QEEKMWEQEE KMCEQEEKMQ EQEEKMRRQE EKMWEQEVRL
660
RQQEEKMQEH QEHLEAAI
Length:668
Mass (Da):83,069
Last modified:March 28, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6BEF9F37A46E1A6A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti491R → W in AK097517 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK097517 mRNA No translation available.
AC116165 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS73699.1

NCBI Reference Sequences

More...
RefSeqi
NP_001001413.3, NM_001001413.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000611085; ENSP00000482864; ENSG00000278247
ENST00000614055; ENSP00000478478; ENSG00000273976
ENST00000616813; ENSP00000483916; ENSG00000275009

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
283767

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:283767

UCSC genome browser

More...
UCSCi
uc032bvr.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097517 mRNA No translation available.
AC116165 Genomic DNA No translation available.
CCDSiCCDS73699.1
RefSeqiNP_001001413.3, NM_001001413.3

3D structure databases

SMRiQ8N7Z2
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000478478

PTM databases

PhosphoSitePlusiQ8N7Z2

Polymorphism and mutation databases

BioMutaiGOLGA6L1
DMDMi300669642

Proteomic databases

jPOSTiQ8N7Z2
MassIVEiQ8N7Z2
PaxDbiQ8N7Z2
PeptideAtlasiQ8N7Z2
PRIDEiQ8N7Z2
ProteomicsDBi72349

Genome annotation databases

EnsembliENST00000611085; ENSP00000482864; ENSG00000278247
ENST00000614055; ENSP00000478478; ENSG00000273976
ENST00000616813; ENSP00000483916; ENSG00000275009
GeneIDi283767
KEGGihsa:283767
UCSCiuc032bvr.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
283767
EuPathDBiHostDB:ENSG00000273976.1

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GOLGA6L1
HGNCiHGNC:37444 GOLGA6L1
HPAiHPA047733
neXtProtiNX_Q8N7Z2
OpenTargetsiENSG00000273976

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410INYH Eukaryota
ENOG410XZ9A LUCA
GeneTreeiENSGT00940000163338
HOGENOMiHOG000218631
InParanoidiQ8N7Z2
OMAiQEENLWE
OrthoDBi358120at2759
PhylomeDBiQ8N7Z2

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
GOLGA6L1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
283767
PharosiQ8N7Z2 Tdark

Protein Ontology

More...
PROi
PR:Q8N7Z2
RNActiQ8N7Z2 protein

Gene expression databases

BgeeiENSG00000273976 Expressed in 19 organ(s), highest expression level in testis

Family and domain databases

InterProiView protein in InterPro
IPR026737 GOLGA6L
PANTHERiPTHR23143 PTHR23143, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGG6L1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N7Z2
Secondary accession number(s): A0A087WU96
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 28, 2018
Last modified: December 11, 2019
This is version 101 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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