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Entry version 132 (29 Sep 2021)
Sequence version 2 (13 Sep 2005)
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Protein

Melanoma-associated antigen B6

Gene

MAGEB6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTumor antigen

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8N7X4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Melanoma-associated antigen B6
Alternative name(s):
Cancer/testis antigen 3.4
Short name:
CT3.4
MAGE-B6 antigen
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MAGEB6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23796, MAGEB6

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300467, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N7X4

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000176746

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
158809

Open Targets

More...
OpenTargetsi
ENSG00000176746

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134864191

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8N7X4, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MAGEB6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
84027854

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001567171 – 407Melanoma-associated antigen B6Add BLAST407

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8N7X4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8N7X4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N7X4

PeptideAtlas

More...
PeptideAtlasi
Q8N7X4

PRoteomics IDEntifications database

More...
PRIDEi
Q8N7X4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
72345

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q8N7X4, 2 sites, 2 O-linked glycans (2 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N7X4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N7X4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in testis. Not expressed in other normal tissues, but is expressed in tumors of different histological origins.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000176746, Expressed in testis and 8 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N7X4, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000176746, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
127710, 10 interactors

Protein interaction database and analysis system

More...
IntActi
Q8N7X4, 23 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000368320

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8N7X4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8N7X4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini195 – 394MAGEPROSITE-ProRule annotationAdd BLAST200

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 175DisorderedSequence analysisAdd BLAST175

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 15Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi16 – 50Polar residuesSequence analysisAdd BLAST35
Compositional biasi57 – 117Polar residuesSequence analysisAdd BLAST61
Compositional biasi131 – 159Polar residuesSequence analysisAdd BLAST29

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4562, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159951

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_039582_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N7X4

Identification of Orthologs from Complete Genome Data

More...
OMAi
QKAIIFK

Database of Orthologous Groups

More...
OrthoDBi
1195799at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N7X4

TreeFam database of animal gene trees

More...
TreeFami
TF328505

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.1200, 1 hit
1.10.10.1210, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037445, MAGE
IPR021072, MAGE_N
IPR041898, MAGE_WH1
IPR041899, MAGE_WH2
IPR002190, MHD_dom

The PANTHER Classification System

More...
PANTHERi
PTHR11736, PTHR11736, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01454, MAGE, 1 hit
PF12440, MAGE_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01373, MAGE, 1 hit
SM01392, MAGE_N, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50838, MAGE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8N7X4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRGHKSKLR TCEKRQETNG QPQGLTGPQA TAEKQEESHS SSSSSRACLG
60 70 80 90 100
DCRRSSDASI PQESQGVSPT GSPDAVVSYS KSDVAANGQD EKSPSTSRDA
110 120 130 140 150
SVPQESQGAS PTGSPDAGVS GSKYDVAANG QDEKSPSTSH DVSVPQESQG
160 170 180 190 200
ASPTGSPDAG VSGSKYDVAA EGEDEESVSA SQKAIIFKRL SKDAVKKKAC
210 220 230 240 250
TLAQFLQKKF EKKESILKAD MLKCVRREYK PYFPQILNRT SQHLVVAFGV
260 270 280 290 300
ELKEMDSSGE SYTLVSKLGL PSEGILSGDN ALPKSGLLMS LLVVIFMNGN
310 320 330 340 350
CATEEEVWEF LGLLGIYDGI LHSIYGDARK IITEDLVQDK YVVYRQVCNS
360 370 380 390 400
DPPCYEFLWG PRAYAETTKM RVLRVLADSS NTSPGLYPHL YEDALIDEVE

RALRLRA
Length:407
Mass (Da):43,992
Last modified:September 13, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3674F422020355DA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti172G → R in BAC05102 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK097561 mRNA Translation: BAC05102.1
BC067286 mRNA Translation: AAH67286.1
BC074920 mRNA Translation: AAH74920.1
AF320514 Genomic DNA Translation: AAG48624.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14217.1

NCBI Reference Sequences

More...
RefSeqi
NP_775794.2, NM_173523.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000379034; ENSP00000368320; ENSG00000176746

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
158809

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:158809

UCSC genome browser

More...
UCSCi
uc004dbr.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097561 mRNA Translation: BAC05102.1
BC067286 mRNA Translation: AAH67286.1
BC074920 mRNA Translation: AAH74920.1
AF320514 Genomic DNA Translation: AAG48624.1
CCDSiCCDS14217.1
RefSeqiNP_775794.2, NM_173523.2

3D structure databases

SMRiQ8N7X4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi127710, 10 interactors
IntActiQ8N7X4, 23 interactors
STRINGi9606.ENSP00000368320

PTM databases

GlyGeniQ8N7X4, 2 sites, 2 O-linked glycans (2 sites)
iPTMnetiQ8N7X4
PhosphoSitePlusiQ8N7X4

Genetic variation databases

BioMutaiMAGEB6
DMDMi84027854

Proteomic databases

jPOSTiQ8N7X4
MassIVEiQ8N7X4
PaxDbiQ8N7X4
PeptideAtlasiQ8N7X4
PRIDEiQ8N7X4
ProteomicsDBi72345

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
24623, 91 antibodies

The DNASU plasmid repository

More...
DNASUi
158809

Genome annotation databases

EnsembliENST00000379034; ENSP00000368320; ENSG00000176746
GeneIDi158809
KEGGihsa:158809
UCSCiuc004dbr.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
158809
DisGeNETi158809

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MAGEB6
HGNCiHGNC:23796, MAGEB6
HPAiENSG00000176746, Tissue enriched (testis)
MIMi300467, gene
neXtProtiNX_Q8N7X4
OpenTargetsiENSG00000176746
PharmGKBiPA134864191
VEuPathDBiHostDB:ENSG00000176746

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4562, Eukaryota
GeneTreeiENSGT00940000159951
HOGENOMiCLU_039582_1_0_1
InParanoidiQ8N7X4
OMAiQKAIIFK
OrthoDBi1195799at2759
PhylomeDBiQ8N7X4
TreeFamiTF328505

Enzyme and pathway databases

PathwayCommonsiQ8N7X4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
158809, 13 hits in 635 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
158809
PharosiQ8N7X4, Tdark

Protein Ontology

More...
PROi
PR:Q8N7X4
RNActiQ8N7X4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000176746, Expressed in testis and 8 other tissues
GenevisibleiQ8N7X4, HS

Family and domain databases

Gene3Di1.10.10.1200, 1 hit
1.10.10.1210, 1 hit
InterProiView protein in InterPro
IPR037445, MAGE
IPR021072, MAGE_N
IPR041898, MAGE_WH1
IPR041899, MAGE_WH2
IPR002190, MHD_dom
PANTHERiPTHR11736, PTHR11736, 1 hit
PfamiView protein in Pfam
PF01454, MAGE, 1 hit
PF12440, MAGE_N, 1 hit
SMARTiView protein in SMART
SM01373, MAGE, 1 hit
SM01392, MAGE_N, 2 hits
PROSITEiView protein in PROSITE
PS50838, MAGE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMAGB6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N7X4
Secondary accession number(s): Q6GS19, Q9H219
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: September 13, 2005
Last modified: September 29, 2021
This is version 132 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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