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Protein

Androglobin

Gene

ADGB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks the conserved active site residues. Probably catalytically inactive.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C02.972

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Androglobin
Alternative name(s):
Calpain-7-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ADGB
Synonyms:C6orf103, CAPN7L
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000118492.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21212 ADGB

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614630 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N7X0

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
79747

Open Targets

More...
OpenTargetsi
ENSG00000118492

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134944476

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ADGB

Domain mapping of disease mutations (DMDM)

More...
DMDMi
298286920

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002325251 – 1667AndroglobinAdd BLAST1667

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8N7X0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8N7X0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N7X0

PeptideAtlas

More...
PeptideAtlasi
Q8N7X0

PRoteomics IDEntifications database

More...
PRIDEi
Q8N7X0

ProteomicsDB human proteome resource

More...
ProteomicsDBi
72338
72339 [Q8N7X0-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N7X0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N7X0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000118492 Expressed in 69 organ(s), highest expression level in testis

CleanEx database of gene expression profiles

More...
CleanExi
HS_C6orf103

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8N7X0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N7X0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA036340
HPA036341

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000381036

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8N7X0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini70 – 411Calpain catalyticPROSITE-ProRule annotationAdd BLAST342
Domaini906 – 935IQPROSITE-ProRule annotationAdd BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1588 – 1629Sequence analysisAdd BLAST42

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C2 family.Curated

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0045 Eukaryota
ENOG410XP0B LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000014904

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000169304

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG058494

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N7X0

Identification of Orthologs from Complete Genome Data

More...
OMAi
KAHGEKH

Database of Orthologous Groups

More...
OrthoDBi
EOG091G027Y

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N7X0

TreeFam database of animal gene trees

More...
TreeFami
TF329120

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.490.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012292 Globin/Proto
IPR000048 IQ_motif_EF-hand-BS
IPR038765 Papain_like_cys_pep_sf
IPR001300 Peptidase_C2_calpain_cat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00648 Peptidase_C2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00230 CysPc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54001 SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50203 CALPAIN_CAT, 1 hit
PS50096 IQ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N7X0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASKQTKKKE VHRINSAHGS DKSKDFYPFG SNVQSGSTEQ KKGKFPLWPE
60 70 80 90 100
WSEADINSEK WDAGKGAKEK DKTGKSPVFH FFEDPEGKIE LPPSLKIYSW
110 120 130 140 150
KRPQDILFSQ TPVVVKNEIT FDLFSANEHL LCSELMRWII SEIYAVWKIF
160 170 180 190 200
NGGILSNYFK GTSGEPPLLP WKPWEHIYSL CKAVKGHMPL FNSYGKYVVK
210 220 230 240 250
LYWMGCWRKI TIDDFLPFDE DNNLLLPATT YEFELWPMLL SKAIIKLANI
260 270 280 290 300
DIHVADRREL GEFTVIHALT GWLPEVISLH PGYMDKVWEL LKEILPEFKL
310 320 330 340 350
SDEASSESKI AVLDSKLKEP GKEGKEGKEI KDGKEVKDVK EFKPESSLTT
360 370 380 390 400
LKAPEKSDKV PKEKADARDI GKKRSKDGEK EKFKFSLHGS RPSSEVQYSV
410 420 430 440 450
QSLSDCSSAI QTSHMVVYAT FTPLYLFENK IFSLEKMADS AEKLREYGLS
460 470 480 490 500
HICSHPVLVT RSRSCPLVAP PKPPPLPPWK LIRQKKETVI TDEAQELIVK
510 520 530 540 550
KPERFLEISS PFLNYRMTPF TIPTEMHFVR SLIKKGIPPG SDLPSVSETD
560 570 580 590 600
ETATHSQTDL SQITKATSQG NTASQVILGK GTDEQTDFGL GDAHQSDGLN
610 620 630 640 650
LEREIVSQTT ATQEKSQEEL PTTNNSVSKE IWLDFEDFCV CFQNIYIFHK
660 670 680 690 700
PSSYCLNFQK SEFKFSEERV SYYLFVDSLK PIELLVCFSA LVRWGEYGAL
710 720 730 740 750
TKDSPPIEPG LLTAETFSWK SLKPGSLVLK IHTYATKATV VRLPVGRHML
760 770 780 790 800
LFNAYSPVGH SIHICSMVSF VIGDEHVVLP NFEPESCRFT EQSLLIMKAI
810 820 830 840 850
GNVIANFKDK GKLSAALKDL QTAHYPVPFH DKELTAQHFR VFHLSLWRLM
860 870 880 890 900
KKVQITKPPP NFKFAFRAMV LDLELLNSSL EEVSLVEWLD VKYCMPTSDK
910 920 930 940 950
EYSAEEVAAA IKIQAMWRGT YVRLLMKARI PDTKENISVA DTLQKVWAVL
960 970 980 990 1000
EMNLEQYAVS LLRLMFKSKC KSLESYPCYQ DEETKIAFAD YTVTYQEQPP
1010 1020 1030 1040 1050
NSWFIVFRET FLVHQDMILV PKVYTTLPIC ILHIVNNDTM EQVPKVFQKV
1060 1070 1080 1090 1100
VPYLYTKNKK GYTFVAEAFT GDTYVAASRW KLRLIGSSAP LPCLSRDSPC
1110 1120 1130 1140 1150
NSFAIKEIRD YYIPNDKKIL FRYSVKVLTP QPATIQVRTS KPDAFIKLQV
1160 1170 1180 1190 1200
LENEETMVSS TGKGQAIIPA FHFLKSEKGL SSQSSKHILS FHSASKKEQE
1210 1220 1230 1240 1250
VYVKKKAAQG IQKSPKGRAV SAIQDIGLPL VEEETTSTPT REDSSSTPLQ
1260 1270 1280 1290 1300
NYKYIIQCSV LYNSWPLTES QLTFVQALKD LKKSNTKAYG ERHEELINLG
1310 1320 1330 1340 1350
SPDSHTISEG QKSSVTSKTT RKGKEKSSEK EKTAKEKQAP RFEPQISTVH
1360 1370 1380 1390 1400
PQQEDPNKPY WILRLVTEHN ESELFEVKKD TERADEIRAM KQAWETTEPG
1410 1420 1430 1440 1450
RAIKASQARL HYLSGFIKKT SDAESPPISE SQTKPKEEVE TAARGVKEPN
1460 1470 1480 1490 1500
SKNSAGSESK EMTQTGSGSA VWKKWQLTKG LRDVAKSTSS ESGGVSSPGK
1510 1520 1530 1540 1550
EEREQSTRKE NIQTGPRTRS PTILETSPRL IRKALEFMDL SQYVRKTDTD
1560 1570 1580 1590 1600
PLLQTDELNQ QQAMQKAEEI HQFRQHRTRV LSIRNIDQEE RLKLKDEVLD
1610 1620 1630 1640 1650
MYKEMQDSLD EARQKIFDIR EEYRNKLLEA EHLKLETLAA QEAAMKLETE
1660
KMTPAPDTQK KKKGKKK
Length:1,667
Mass (Da):189,713
Last modified:June 15, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i46732C56A6C63B3F
GO
Isoform 2 (identifier: Q8N7X0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-951: Missing.
     1185-1288: Missing.

Note: Gene prediction based on EST data.
Show »
Length:612
Mass (Da):70,082
Checksum:i884B8EB975F203EC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YC38H0YC38_HUMAN
Androglobin
ADGB
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBE5H0YBE5_HUMAN
Androglobin
ADGB
714Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y333H0Y333_HUMAN
Androglobin
ADGB
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y334H0Y334_HUMAN
Androglobin
ADGB
625Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RFN4E5RFN4_HUMAN
Androglobin
ADGB
178Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RGD1E5RGD1_HUMAN
Androglobin
ADGB
220Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W7W4F8W7W4_HUMAN
Androglobin
ADGB
259Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RG76E5RG76_HUMAN
Androglobin
ADGB
141Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RIM8E5RIM8_HUMAN
Androglobin
ADGB
35Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AL832192 differs from that shown. Intron retention.Curated
The sequence AL832192 differs from that shown. Reason: Frameshift at positions 81, 281 and 581.Curated
The sequence CAI16490 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI20488 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence DN831198 differs from that shown. Reason: Frameshift at positions 944, 946 and 960.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti205 – 280Missing in AL832192 (PubMed:17974005).CuratedAdd BLAST76
Sequence conflicti570 – 580Missing in AL832192 (PubMed:17974005).CuratedAdd BLAST11
Sequence conflicti716T → R in DN831198 (Ref. 4) Curated1
Sequence conflicti747 – 754RHMLLFNA → YEVASFFP in BAC05106 (PubMed:14702039).Curated8
Sequence conflicti810K → M in AL832192 (PubMed:17974005).Curated1
Sequence conflicti931P → R in DN831198 (Ref. 4) Curated1
Sequence conflicti944Q → L in DN831198 (Ref. 4) Curated1
Sequence conflicti1639A → S in CAI14697 (PubMed:14574404).Curated1
Sequence conflicti1639A → S in CAI20489 (PubMed:14574404).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_025948310I → T1 PublicationCorresponds to variant dbSNP:rs9497606Ensembl.1
Natural variantiVAR_0631581637T → A1 PublicationCorresponds to variant dbSNP:rs1052445Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0392431 – 951Missing in isoform 2. CuratedAdd BLAST951
Alternative sequenceiVSP_0392441185 – 1288Missing in isoform 2. CuratedAdd BLAST104

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL832192 mRNA No translation available.
AL138916, AL158199 Genomic DNA Translation: CAI14697.1
AL138916, AL158199 Genomic DNA Translation: CAI14698.1
AL158199, AL359547 Genomic DNA Translation: CAI20488.1 Sequence problems.
AL158199, AL138916 Genomic DNA Translation: CAI20489.1
AL158199, AL138916 Genomic DNA Translation: CAI20490.1
AL359547, AL158199 Genomic DNA Translation: CAI16490.1 Sequence problems.
AK097570 mRNA Translation: BAC05106.1
DN831198 mRNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_078970.3, NM_024694.3 [Q8N7X0-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.720870

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000397944; ENSP00000381036; ENSG00000118492 [Q8N7X0-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
79747

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:79747

UCSC genome browser

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UCSCi
uc010khx.4 human [Q8N7X0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL832192 mRNA No translation available.
AL138916, AL158199 Genomic DNA Translation: CAI14697.1
AL138916, AL158199 Genomic DNA Translation: CAI14698.1
AL158199, AL359547 Genomic DNA Translation: CAI20488.1 Sequence problems.
AL158199, AL138916 Genomic DNA Translation: CAI20489.1
AL158199, AL138916 Genomic DNA Translation: CAI20490.1
AL359547, AL158199 Genomic DNA Translation: CAI16490.1 Sequence problems.
AK097570 mRNA Translation: BAC05106.1
DN831198 mRNA No translation available.
RefSeqiNP_078970.3, NM_024694.3 [Q8N7X0-1]
UniGeneiHs.720870

3D structure databases

ProteinModelPortaliQ8N7X0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000381036

Protein family/group databases

MEROPSiC02.972

PTM databases

iPTMnetiQ8N7X0
PhosphoSitePlusiQ8N7X0

Polymorphism and mutation databases

BioMutaiADGB
DMDMi298286920

Proteomic databases

EPDiQ8N7X0
MaxQBiQ8N7X0
PaxDbiQ8N7X0
PeptideAtlasiQ8N7X0
PRIDEiQ8N7X0
ProteomicsDBi72338
72339 [Q8N7X0-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000397944; ENSP00000381036; ENSG00000118492 [Q8N7X0-1]
GeneIDi79747
KEGGihsa:79747
UCSCiuc010khx.4 human [Q8N7X0-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
79747
DisGeNETi79747
EuPathDBiHostDB:ENSG00000118492.16

GeneCards: human genes, protein and diseases

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GeneCardsi
ADGB

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0006280
HGNCiHGNC:21212 ADGB
HPAiHPA036340
HPA036341
MIMi614630 gene
neXtProtiNX_Q8N7X0
OpenTargetsiENSG00000118492
PharmGKBiPA134944476

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0045 Eukaryota
ENOG410XP0B LUCA
GeneTreeiENSGT00390000014904
HOGENOMiHOG000169304
HOVERGENiHBG058494
InParanoidiQ8N7X0
OMAiKAHGEKH
OrthoDBiEOG091G027Y
PhylomeDBiQ8N7X0
TreeFamiTF329120

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ADGB human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
79747

Protein Ontology

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PROi
PR:Q8N7X0

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000118492 Expressed in 69 organ(s), highest expression level in testis
CleanExiHS_C6orf103
ExpressionAtlasiQ8N7X0 baseline and differential
GenevisibleiQ8N7X0 HS

Family and domain databases

Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR012292 Globin/Proto
IPR000048 IQ_motif_EF-hand-BS
IPR038765 Papain_like_cys_pep_sf
IPR001300 Peptidase_C2_calpain_cat
PfamiView protein in Pfam
PF00648 Peptidase_C2, 1 hit
SMARTiView protein in SMART
SM00230 CysPc, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50203 CALPAIN_CAT, 1 hit
PS50096 IQ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiADGB_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N7X0
Secondary accession number(s): Q5T402, Q5T904, Q5T905
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: June 15, 2010
Last modified: December 5, 2018
This is version 121 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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