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Protein

BEN domain-containing protein 7

Gene

BEND7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
BEN domain-containing protein 7
Gene namesi
Name:BEND7
Synonyms:C10orf30
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000165626.16
HGNCiHGNC:23514 BEND7
neXtProtiNX_Q8N7W2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000165626
PharmGKBiPA164716578

Polymorphism and mutation databases

BioMutaiBEND7
DMDMi109820782

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002440801 – 519BEN domain-containing protein 7Add BLAST519

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki16Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki56Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki85Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki243Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei324PhosphothreonineCombined sources1
Modified residuei328PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8N7W2
PaxDbiQ8N7W2
PeptideAtlasiQ8N7W2
PRIDEiQ8N7W2
ProteomicsDBi72335
72336 [Q8N7W2-2]
72337 [Q8N7W2-3]

PTM databases

iPTMnetiQ8N7W2
PhosphoSitePlusiQ8N7W2

Expressioni

Gene expression databases

BgeeiENSG00000165626 Expressed in 183 organ(s), highest expression level in kidney epithelium
CleanExiHS_BEND7
ExpressionAtlasiQ8N7W2 baseline and differential
GenevisibleiQ8N7W2 HS

Organism-specific databases

HPAiHPA037835

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi128797, 46 interactors
IntActiQ8N7W2, 82 interactors
MINTiQ8N7W2
STRINGi9606.ENSP00000345773

Structurei

3D structure databases

ProteinModelPortaliQ8N7W2
SMRiQ8N7W2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini287 – 392BENPROSITE-ProRule annotationAdd BLAST106

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi217 – 220Poly-Lys4

Phylogenomic databases

eggNOGiENOG410IGCJ Eukaryota
ENOG410XQ7C LUCA
GeneTreeiENSGT00390000004595
HOGENOMiHOG000231662
HOVERGENiHBG080388
InParanoidiQ8N7W2
OMAiCTANHVD
OrthoDBiEOG091G08TA
PhylomeDBiQ8N7W2
TreeFamiTF332993

Family and domain databases

InterProiView protein in InterPro
IPR018379 BEN_domain
PfamiView protein in Pfam
PF10523 BEN, 1 hit
SMARTiView protein in SMART
SM01025 BEN, 1 hit
PROSITEiView protein in PROSITE
PS51457 BEN, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.iShow all

Isoform 1 (identifier: Q8N7W2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEFSERKRSR KSQSFKLVSR DYHHEVYKIP EFSNDVNGEA KETQPIFLGD
60 70 80 90 100
ESMEIKKQIT GMRRLLNDST GRIYQRVGKE GEKLKEEPQD LDLVWPPRLN
110 120 130 140 150
SSAEAPQSLH PSSRGVWNEL PPQSGQFSGQ YGTRSRTFQS QPHPTTSSNG
160 170 180 190 200
ELPVVNSSAG SNCCTCNCQS TLQAILQELK TMRKLMQIQA VGTQNRQQPP
210 220 230 240 250
ISLICSQRTA VSRKRNKKKK VPPKTVEPLT VKQKPSGSEM EKKSVVASEL
260 270 280 290 300
SALQAAEHTS PEESRVLGFG IVLESPSSDP EVQLAEGFDV FMPKSQLDSI
310 320 330 340 350
LSNYTRSGSL LFRKLVCAFF DDKTLANSLP NGKRKRGLND NRKGLDQNIV
360 370 380 390 400
GAIKVFTEKY CTANHVDKLP GPRDWVQILQ DQIKLARRRL KRGSEIADSD
410 420 430 440 450
ERLDGIALPP TGACGGPCTV LPGGSAAVTL VLQSSPQTMS QEKGQMAEPW
460 470 480 490 500
EEQHLVLLNN LTRDRAETGA LSQTSQDFKH HSFLITQVSA TLHHQRGIRN
510
FPTPGSAKSL TLHISCLSL
Length:519
Mass (Da):57,549
Last modified:June 27, 2006 - v2
Checksum:i28DCC0E7A21FADA8
GO
Isoform 2 (identifier: Q8N7W2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-52: Missing.
     149-149: N → NGMVVNKHSEGSHG
     412-413: GA → VV
     414-519: Missing.

Show »
Length:374
Mass (Da):41,365
Checksum:i577A783B89AEA087
GO
Isoform 3 (identifier: Q8N7W2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-52: Missing.
     394-394: S → SA

Show »
Length:468
Mass (Da):51,461
Checksum:i6CB4D4728BA7575C
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MSS7A0A0A0MSS7_HUMAN
BEN domain-containing protein 7
BEND7
117Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti503T → A in BAC05114 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035501313R → T in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_057830341N → S. Corresponds to variant dbSNP:rs12247033Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0398461 – 52Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST52
Alternative sequenceiVSP_019506149N → NGMVVNKHSEGSHG in isoform 2. 1 Publication1
Alternative sequenceiVSP_039847394S → SA in isoform 3. 1 Publication1
Alternative sequenceiVSP_019507412 – 413GA → VV in isoform 2. 1 Publication2
Alternative sequenceiVSP_019508414 – 519Missing in isoform 2. 1 PublicationAdd BLAST106

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097602 mRNA Translation: BAC05114.1
AL359172 Genomic DNA No translation available.
AL590677 Genomic DNA No translation available.
BC031618 mRNA Translation: AAH31618.1
CD300572 mRNA No translation available.
CCDSiCCDS41490.1 [Q8N7W2-2]
CCDS7099.1 [Q8N7W2-3]
RefSeqiNP_001094382.1, NM_001100912.1 [Q8N7W2-2]
NP_689964.2, NM_152751.2 [Q8N7W2-3]
XP_011517694.1, XM_011519392.2 [Q8N7W2-1]
XP_011517713.1, XM_011519411.2 [Q8N7W2-2]
UniGeneiHs.498740

Genome annotation databases

EnsembliENST00000341083; ENSP00000345773; ENSG00000165626 [Q8N7W2-3]
ENST00000378605; ENSP00000367868; ENSG00000165626 [Q8N7W2-2]
GeneIDi222389
KEGGihsa:222389
UCSCiuc001imm.3 human [Q8N7W2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097602 mRNA Translation: BAC05114.1
AL359172 Genomic DNA No translation available.
AL590677 Genomic DNA No translation available.
BC031618 mRNA Translation: AAH31618.1
CD300572 mRNA No translation available.
CCDSiCCDS41490.1 [Q8N7W2-2]
CCDS7099.1 [Q8N7W2-3]
RefSeqiNP_001094382.1, NM_001100912.1 [Q8N7W2-2]
NP_689964.2, NM_152751.2 [Q8N7W2-3]
XP_011517694.1, XM_011519392.2 [Q8N7W2-1]
XP_011517713.1, XM_011519411.2 [Q8N7W2-2]
UniGeneiHs.498740

3D structure databases

ProteinModelPortaliQ8N7W2
SMRiQ8N7W2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128797, 46 interactors
IntActiQ8N7W2, 82 interactors
MINTiQ8N7W2
STRINGi9606.ENSP00000345773

PTM databases

iPTMnetiQ8N7W2
PhosphoSitePlusiQ8N7W2

Polymorphism and mutation databases

BioMutaiBEND7
DMDMi109820782

Proteomic databases

EPDiQ8N7W2
PaxDbiQ8N7W2
PeptideAtlasiQ8N7W2
PRIDEiQ8N7W2
ProteomicsDBi72335
72336 [Q8N7W2-2]
72337 [Q8N7W2-3]

Protocols and materials databases

DNASUi222389
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341083; ENSP00000345773; ENSG00000165626 [Q8N7W2-3]
ENST00000378605; ENSP00000367868; ENSG00000165626 [Q8N7W2-2]
GeneIDi222389
KEGGihsa:222389
UCSCiuc001imm.3 human [Q8N7W2-1]

Organism-specific databases

CTDi222389
EuPathDBiHostDB:ENSG00000165626.16
GeneCardsiBEND7
H-InvDBiHIX0008656
HGNCiHGNC:23514 BEND7
HPAiHPA037835
neXtProtiNX_Q8N7W2
OpenTargetsiENSG00000165626
PharmGKBiPA164716578
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGCJ Eukaryota
ENOG410XQ7C LUCA
GeneTreeiENSGT00390000004595
HOGENOMiHOG000231662
HOVERGENiHBG080388
InParanoidiQ8N7W2
OMAiCTANHVD
OrthoDBiEOG091G08TA
PhylomeDBiQ8N7W2
TreeFamiTF332993

Miscellaneous databases

GenomeRNAii222389
PROiPR:Q8N7W2

Gene expression databases

BgeeiENSG00000165626 Expressed in 183 organ(s), highest expression level in kidney epithelium
CleanExiHS_BEND7
ExpressionAtlasiQ8N7W2 baseline and differential
GenevisibleiQ8N7W2 HS

Family and domain databases

InterProiView protein in InterPro
IPR018379 BEN_domain
PfamiView protein in Pfam
PF10523 BEN, 1 hit
SMARTiView protein in SMART
SM01025 BEN, 1 hit
PROSITEiView protein in PROSITE
PS51457 BEN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBEND7_HUMAN
AccessioniPrimary (citable) accession number: Q8N7W2
Secondary accession number(s): Q5SYY7
, Q5SYY8, Q5SYY9, Q8N5T7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: September 12, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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