UniProtKB - Q8N7W2 (BEND7_HUMAN)
Protein
BEN domain-containing protein 7
Gene
BEND7
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: BEN domain-containing protein 7 |
Gene namesi | Name:BEND7 Synonyms:C10orf30 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23514, BEND7 |
neXtProti | NX_Q8N7W2 |
VEuPathDBi | HostDB:ENSG00000165626.16 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 222389 |
OpenTargetsi | ENSG00000165626 |
PharmGKBi | PA164716578 |
Miscellaneous databases
Pharosi | Q8N7W2, Tdark |
Genetic variation databases
BioMutai | BEND7 |
DMDMi | 109820782 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000244080 | 1 – 519 | BEN domain-containing protein 7Add BLAST | 519 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 16 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 56 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 85 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 243 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 324 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 328 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q8N7W2 |
jPOSTi | Q8N7W2 |
MassIVEi | Q8N7W2 |
PaxDbi | Q8N7W2 |
PeptideAtlasi | Q8N7W2 |
PRIDEi | Q8N7W2 |
ProteomicsDBi | 72335 [Q8N7W2-1] 72336 [Q8N7W2-2] 72337 [Q8N7W2-3] |
PTM databases
iPTMneti | Q8N7W2 |
PhosphoSitePlusi | Q8N7W2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000165626, Expressed in kidney epithelium and 197 other tissues |
ExpressionAtlasi | Q8N7W2, baseline and differential |
Genevisiblei | Q8N7W2, HS |
Organism-specific databases
HPAi | ENSG00000165626, Low tissue specificity |
Interactioni
Binary interactionsi
Q8N7W2
With | #Exp. | IntAct |
---|---|---|
NIF3L1 [Q9GZT8] | 3 | EBI-743382,EBI-740897 |
Isoform 2 [Q8N7W2-2]
Protein-protein interaction databases
BioGRIDi | 128797, 93 interactors |
IntActi | Q8N7W2, 87 interactors |
MINTi | Q8N7W2 |
STRINGi | 9606.ENSP00000345773 |
Miscellaneous databases
RNActi | Q8N7W2, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 287 – 392 | BENPROSITE-ProRule annotationAdd BLAST | 106 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 217 – 220 | Poly-Lys | 4 |
Phylogenomic databases
eggNOGi | ENOG502QQVD, Eukaryota |
GeneTreei | ENSGT00940000162606 |
HOGENOMi | CLU_043816_1_0_1 |
InParanoidi | Q8N7W2 |
OMAi | SVGPNCC |
OrthoDBi | 652532at2759 |
PhylomeDBi | Q8N7W2 |
TreeFami | TF332993 |
Family and domain databases
InterProi | View protein in InterPro IPR018379, BEN_domain |
Pfami | View protein in Pfam PF10523, BEN, 1 hit |
SMARTi | View protein in SMART SM01025, BEN, 1 hit |
PROSITEi | View protein in PROSITE PS51457, BEN, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8N7W2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEFSERKRSR KSQSFKLVSR DYHHEVYKIP EFSNDVNGEA KETQPIFLGD
60 70 80 90 100
ESMEIKKQIT GMRRLLNDST GRIYQRVGKE GEKLKEEPQD LDLVWPPRLN
110 120 130 140 150
SSAEAPQSLH PSSRGVWNEL PPQSGQFSGQ YGTRSRTFQS QPHPTTSSNG
160 170 180 190 200
ELPVVNSSAG SNCCTCNCQS TLQAILQELK TMRKLMQIQA VGTQNRQQPP
210 220 230 240 250
ISLICSQRTA VSRKRNKKKK VPPKTVEPLT VKQKPSGSEM EKKSVVASEL
260 270 280 290 300
SALQAAEHTS PEESRVLGFG IVLESPSSDP EVQLAEGFDV FMPKSQLDSI
310 320 330 340 350
LSNYTRSGSL LFRKLVCAFF DDKTLANSLP NGKRKRGLND NRKGLDQNIV
360 370 380 390 400
GAIKVFTEKY CTANHVDKLP GPRDWVQILQ DQIKLARRRL KRGSEIADSD
410 420 430 440 450
ERLDGIALPP TGACGGPCTV LPGGSAAVTL VLQSSPQTMS QEKGQMAEPW
460 470 480 490 500
EEQHLVLLNN LTRDRAETGA LSQTSQDFKH HSFLITQVSA TLHHQRGIRN
510
FPTPGSAKSL TLHISCLSL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3B3IU36 | A0A3B3IU36_HUMAN | BEN domain-containing protein 7 | BEND7 | 320 | Annotation score: | ||
A0A0A0MSS7 | A0A0A0MSS7_HUMAN | BEN domain-containing protein 7 | BEND7 | 117 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 503 | T → A in BAC05114 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035501 | 313 | R → T in a breast cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_057830 | 341 | N → S. Corresponds to variant dbSNP:rs12247033Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_039846 | 1 – 52 | Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST | 52 | |
Alternative sequenceiVSP_019506 | 149 | N → NGMVVNKHSEGSHG in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_039847 | 394 | S → SA in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_019507 | 412 – 413 | GA → VV in isoform 2. 1 Publication | 2 | |
Alternative sequenceiVSP_019508 | 414 – 519 | Missing in isoform 2. 1 PublicationAdd BLAST | 106 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK097602 mRNA Translation: BAC05114.1 AL359172 Genomic DNA No translation available. AL590677 Genomic DNA No translation available. BC031618 mRNA Translation: AAH31618.1 CD300572 mRNA No translation available. |
CCDSi | CCDS41490.1 [Q8N7W2-2] CCDS7099.1 [Q8N7W2-3] |
RefSeqi | NP_001094382.1, NM_001100912.1 [Q8N7W2-2] NP_689964.2, NM_152751.2 [Q8N7W2-3] XP_011517694.1, XM_011519392.2 [Q8N7W2-1] XP_011517713.1, XM_011519411.2 [Q8N7W2-2] |
Genome annotation databases
Ensembli | ENST00000341083; ENSP00000345773; ENSG00000165626 [Q8N7W2-3] ENST00000378605; ENSP00000367868; ENSG00000165626 [Q8N7W2-2] |
GeneIDi | 222389 |
KEGGi | hsa:222389 |
UCSCi | uc001imm.3, human [Q8N7W2-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK097602 mRNA Translation: BAC05114.1 AL359172 Genomic DNA No translation available. AL590677 Genomic DNA No translation available. BC031618 mRNA Translation: AAH31618.1 CD300572 mRNA No translation available. |
CCDSi | CCDS41490.1 [Q8N7W2-2] CCDS7099.1 [Q8N7W2-3] |
RefSeqi | NP_001094382.1, NM_001100912.1 [Q8N7W2-2] NP_689964.2, NM_152751.2 [Q8N7W2-3] XP_011517694.1, XM_011519392.2 [Q8N7W2-1] XP_011517713.1, XM_011519411.2 [Q8N7W2-2] |
3D structure databases
SMRi | Q8N7W2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 128797, 93 interactors |
IntActi | Q8N7W2, 87 interactors |
MINTi | Q8N7W2 |
STRINGi | 9606.ENSP00000345773 |
PTM databases
iPTMneti | Q8N7W2 |
PhosphoSitePlusi | Q8N7W2 |
Genetic variation databases
BioMutai | BEND7 |
DMDMi | 109820782 |
Proteomic databases
EPDi | Q8N7W2 |
jPOSTi | Q8N7W2 |
MassIVEi | Q8N7W2 |
PaxDbi | Q8N7W2 |
PeptideAtlasi | Q8N7W2 |
PRIDEi | Q8N7W2 |
ProteomicsDBi | 72335 [Q8N7W2-1] 72336 [Q8N7W2-2] 72337 [Q8N7W2-3] |
Protocols and materials databases
Antibodypediai | 44073, 128 antibodies |
DNASUi | 222389 |
Genome annotation databases
Ensembli | ENST00000341083; ENSP00000345773; ENSG00000165626 [Q8N7W2-3] ENST00000378605; ENSP00000367868; ENSG00000165626 [Q8N7W2-2] |
GeneIDi | 222389 |
KEGGi | hsa:222389 |
UCSCi | uc001imm.3, human [Q8N7W2-1] |
Organism-specific databases
CTDi | 222389 |
DisGeNETi | 222389 |
GeneCardsi | BEND7 |
HGNCi | HGNC:23514, BEND7 |
HPAi | ENSG00000165626, Low tissue specificity |
neXtProti | NX_Q8N7W2 |
OpenTargetsi | ENSG00000165626 |
PharmGKBi | PA164716578 |
VEuPathDBi | HostDB:ENSG00000165626.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QQVD, Eukaryota |
GeneTreei | ENSGT00940000162606 |
HOGENOMi | CLU_043816_1_0_1 |
InParanoidi | Q8N7W2 |
OMAi | SVGPNCC |
OrthoDBi | 652532at2759 |
PhylomeDBi | Q8N7W2 |
TreeFami | TF332993 |
Enzyme and pathway databases
PathwayCommonsi | Q8N7W2 |
Miscellaneous databases
BioGRID-ORCSi | 222389, 5 hits in 991 CRISPR screens |
ChiTaRSi | BEND7, human |
GenomeRNAii | 222389 |
Pharosi | Q8N7W2, Tdark |
PROi | PR:Q8N7W2 |
RNActi | Q8N7W2, protein |
Gene expression databases
Bgeei | ENSG00000165626, Expressed in kidney epithelium and 197 other tissues |
ExpressionAtlasi | Q8N7W2, baseline and differential |
Genevisiblei | Q8N7W2, HS |
Family and domain databases
InterProi | View protein in InterPro IPR018379, BEN_domain |
Pfami | View protein in Pfam PF10523, BEN, 1 hit |
SMARTi | View protein in SMART SM01025, BEN, 1 hit |
PROSITEi | View protein in PROSITE PS51457, BEN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BEND7_HUMAN | |
Accessioni | Q8N7W2Primary (citable) accession number: Q8N7W2 Secondary accession number(s): Q5SYY7 Q8N5T7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 27, 2006 |
Last sequence update: | June 27, 2006 | |
Last modified: | April 7, 2021 | |
This is version 140 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports