DNAJC5G

Functionⁱ

Keywordsⁱ

Molecular function	Chaperone

Molecular function

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: DnaJ homolog subfamily C member 5G Alternative name(s): Cysteine string protein-gamma Short name: CSP-gamma
Gene namesⁱ	Name:DNAJC5G
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000163793.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:24844 DNAJC5G
MIMⁱ	613946 gene
neXtProtⁱ	NX_Q8N7S2

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000163793
PharmGKBⁱ	PA134880296

Polymorphism and mutation databases

BioMutaⁱ	DNAJC5G
DMDMⁱ	50400554

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000071057	1 – 189	DnaJ homolog subfamily C member 5GAdd BLAST		189

Post-translational modificationⁱ

Palmitoylated.By similarity

Keywords - PTMⁱ

Lipoprotein, Palmitate

Proteomic databases

PaxDbⁱ	Q8N7S2
PeptideAtlas More...PeptideAtlasⁱ	Q8N7S2
PRIDEⁱ	Q8N7S2
ProteomicsDBⁱ	72324

PTM databases

iPTMnetⁱ	Q8N7S2
PhosphoSitePlusⁱ	Q8N7S2

Expressionⁱ

Tissue specificityⁱ

Testis specific.

Gene expression databases

Bgeeⁱ	ENSG00000163793 Expressed in 68 organ(s), highest expression level in testis
CleanExⁱ	HS_DNAJC5G
ExpressionAtlasⁱ	Q8N7S2 baseline and differential
Genevisibleⁱ	Q8N7S2 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA041445

HPAⁱ

HPA041445

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000296097

STRINGⁱ

9606.ENSP00000296097

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8N7S2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	17 – 98	JPROSITE-ProRule annotationAdd BLAST		82

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	131 – 147	Cys-richAdd BLAST		17

Phylogenomic databases

eggNOGⁱ	KOG0716 Eukaryota COG0484 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000148989
HOGENOMⁱ	HOG000231969
HOVERGENⁱ	HBG005414
InParanoidⁱ	Q8N7S2
KEGG Orthology (KO) More...KOⁱ	K09525
OMAⁱ	CCGTLKP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0QJP
PhylomeDBⁱ	Q8N7S2
TreeFamⁱ	TF105164

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06257 DnaJ, 1 hit
Gene3Dⁱ	1.10.287.110, 1 hit
InterProⁱ	View protein in InterPro IPR001623 DnaJ_domain IPR018253 DnaJ_domain_CS IPR036869 J_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00226 DnaJ, 1 hit
PRINTSⁱ	PR00625 JDOMAIN
SMARTⁱ	View protein in SMART SM00271 DnaJ, 1 hit
SUPFAMⁱ	SSF46565 SSF46565, 2 hits
PROSITEⁱ	View protein in PROSITE PS00636 DNAJ_1, 1 hit PS50076 DNAJ_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.ⁱShow all

Isoform 1 (identifier: Q8N7S2-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSTVKEAAHR LSKSEMSLYA VLDLKKGASP EDFKKSYSHS ALLPHPPFEY 
        60         70         80         90        100
HLGRKLALRY HPDKNPGNAQ AAEIFKEINA AHAILSDSKK RKIYDQHGSL 
       110        120        130        140        150
GIYLYDHFGE EGVRYYFILN SCWFKTLVIL CTLLTCCCFC CCCCFCCGAL 
       160        170        180 
KPPPEQDSGR KYQQNVQSQP PRSGAKCDFR SEENSEDDF

Length:189

Mass (Da):21,433

Last modified:October 1, 2002 - v1

Checksum:ⁱEF8FCAE0F1A841A1

GO

Isoform 2 (identifier: Q8N7S2-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
38-104: SHSALLPHPP...DQHGSLGIYL → RHLSSCVLCS...RKIAKMIFKR
105-189: Missing.

« Hide

        10         20         30         40         50
MSTVKEAAHR LSKSEMSLYA VLDLKKGASP EDFKKSYRHL SSCVLCSLVA 
        60         70         80         90        100
VSVVAAVFAV EHLNHHLSRI VGENISRMSR VSLQGQEPNV ILEARKIAKM 

IFKR

Note: No experimental confirmation available.

Show »

Length:104

Mass (Da):11,579

Checksum:ⁱC1494934DFFABEC8

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation
	B5MCA9	B5MCA9_HUMAN		DnaJ homolog subfamily C member 5G DnaJ homolog subfamily C member 5G	DNAJC5G	173	Annotation score:
	C9J078	C9J078_HUMAN		DnaJ homolog subfamily C member 5G DnaJ homolog subfamily C member 5G	DNAJC5G	62	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_033882	4	V → G. Corresponds to variant dbSNP:rs17005979Ensembl.		1
Natural variantⁱVAR_033883	51	H → R. Corresponds to variant dbSNP:rs13414011Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056967	38 – 104	SHSAL…LGIYL → RHLSSCVLCSLVAVSVVAAV FAVEHLNHHLSRIVGENISR MSRVSLQGQEPNVILEARKI AKMIFKR in isoform 2. 1 PublicationAdd BLAST		67
Alternative sequenceⁱVSP_056968	105 – 189	Missing in isoform 2. 1 PublicationAdd BLAST		85

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK097736 mRNA Translation: BAC05155.1 AK302239 mRNA Translation: BAG63591.1 AC013413 Genomic DNA Translation: AAY24295.1 CH471053 Genomic DNA Translation: EAX00608.1 CH471053 Genomic DNA Translation: EAX00609.1 BC035194 mRNA Translation: AAH35194.2 AF368277 mRNA Translation: AAK60572.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1744.1 [Q8N7S2-1] CCDS77397.1 [Q8N7S2-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001290056.1, NM_001303127.1 [Q8N7S2-1] NP_001290057.1, NM_001303128.1 [Q8N7S2-2] NP_775921.1, NM_173650.2 [Q8N7S2-1] XP_006712058.1, XM_006711995.3 [Q8N7S2-1] XP_016859361.1, XM_017003872.1 [Q8N7S2-1] XP_016859362.1, XM_017003873.1 [Q8N7S2-1] XP_016859363.1, XM_017003874.1 [Q8N7S2-1]
UniGeneⁱ	Hs.116303 Hs.709163

Genome annotation databases

Ensemblⁱ	ENST00000296097; ENSP00000296097; ENSG00000163793 [Q8N7S2-1] ENST00000402462; ENSP00000384305; ENSG00000163793 [Q8N7S2-1] ENST00000406962; ENSP00000385533; ENSG00000163793 [Q8N7S2-2]
GeneIDⁱ	285126
KEGGⁱ	hsa:285126
UCSC genome browser More...UCSCⁱ	uc002rjl.2 human [Q8N7S2-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8N7S2	DNAJC5G isoform 3		PANTR		189	UniRef90_Q8N7S2
DNAJC5G isoform 1		PONAB		189
DnaJ heat shock protein family (Hsp40) member C5 gamma		RHIRO		189
DnaJ heat shock protein family (Hsp40) member C5 gamma		PANPA		189
DnaJ heat shock protein family (Hsp40) member C5 gamma		COLAP		181
+9
Q8N7S2-2	DnaJ homolog subfamily C member 5G (Fragment)		HUMAN		62	UniRef90_Q8N7S2-2
DNAJC5G isoform 1		PANTR		104
UPI0006C9D513		PANPA		104
DNAJC5G isoform 6 (Fragment)		PANTR		62

Protein	Similar proteins		Species	Score	Length	Source
Q8N7S2	DNAJC5G isoform 1		PONAB		189	UniRef50_Q8N7S2
DnaJ heat shock protein family (Hsp40) member C5 gamma		PANPA		189
DNAJC5G isoform 3		PANTR		189
DnaJ heat shock protein family (Hsp40) member C5 gamma		RHIRO		189
DnaJ heat shock protein family (Hsp40) member C5 gamma		COLAP		181
+79
Q8N7S2-2	DnaJ homolog subfamily C member 5G (Fragment)		HUMAN		62	UniRef50_Q8N7S2-2
DNAJC5G isoform 1		PANTR		104
UPI0006C9D513		PANPA		104
DNAJC5G isoform 6 (Fragment)		PANTR		62

Entry informationⁱ

Entry nameⁱ	DNJ5G_HUMAN
Accessionⁱ	Q8N7S2Primary (citable) accession number: Q8N7S2 Secondary accession number(s): B4DY29 , Q53SY5, Q8IYQ4, Q96RJ8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
	Last sequence update:	October 1, 2002
	Last modified:	September 12, 2018
	This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8N7S2 (DNJ5G_HUMAN)

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DnaJ homolog subfamily C member 5G

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Computationally mapped potential isoform sequencesⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ