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UniProtKB - Q8N7S2 (DNJ5G_HUMAN)
Protein
DnaJ homolog subfamily C member 5G
Gene
DNAJC5G
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: DnaJ homolog subfamily C member 5GAlternative name(s): Cysteine string protein-gamma Short name: CSP-gamma |
Gene namesi | Name:DNAJC5G |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24844, DNAJC5G |
MIMi | 613946, gene |
neXtProti | NX_Q8N7S2 |
VEuPathDBi | HostDB:ENSG00000163793 |
Subcellular locationi
Other locations
- Membrane By similarity; Lipid-anchor By similarity
Other locations
- membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000163793 |
PharmGKBi | PA134880296 |
Miscellaneous databases
Pharosi | Q8N7S2, Tdark |
Genetic variation databases
BioMutai | DNAJC5G |
DMDMi | 50400554 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000071057 | 1 – 189 | DnaJ homolog subfamily C member 5GAdd BLAST | 189 |
Post-translational modificationi
Palmitoylated.By similarity
Keywords - PTMi
Lipoprotein, PalmitateProteomic databases
PaxDbi | Q8N7S2 |
PeptideAtlasi | Q8N7S2 |
PRIDEi | Q8N7S2 |
ProteomicsDBi | 5491 |
PTM databases
iPTMneti | Q8N7S2 |
PhosphoSitePlusi | Q8N7S2 |
Expressioni
Tissue specificityi
Testis specific.
Gene expression databases
Bgeei | ENSG00000163793, Expressed in testis and 89 other tissues |
ExpressionAtlasi | Q8N7S2, baseline and differential |
Genevisiblei | Q8N7S2, HS |
Organism-specific databases
HPAi | ENSG00000163793, Group enriched (epididymis, testis) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 130021, 9 interactors |
STRINGi | 9606.ENSP00000296097 |
Miscellaneous databases
RNActi | Q8N7S2, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 17 – 98 | JPROSITE-ProRule annotationAdd BLAST | 82 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 154 – 189 | DisorderedSequence analysisAdd BLAST | 36 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 158 – 174 | Polar residuesSequence analysisAdd BLAST | 17 |
Phylogenomic databases
eggNOGi | KOG0716, Eukaryota |
GeneTreei | ENSGT00940000162434 |
HOGENOMi | CLU_2249162_0_0_1 |
InParanoidi | Q8N7S2 |
OMAi | MNSCWFK |
OrthoDBi | 1401920at2759 |
PhylomeDBi | Q8N7S2 |
TreeFami | TF105164 |
Family and domain databases
CDDi | cd06257, DnaJ, 1 hit |
Gene3Di | 1.10.287.110, 1 hit |
InterProi | View protein in InterPro IPR001623, DnaJ_domain IPR018253, DnaJ_domain_CS IPR036869, J_dom_sf |
Pfami | View protein in Pfam PF00226, DnaJ, 1 hit |
PRINTSi | PR00625, JDOMAIN |
SMARTi | View protein in SMART SM00271, DnaJ, 1 hit |
SUPFAMi | SSF46565, SSF46565, 2 hits |
PROSITEi | View protein in PROSITE PS00636, DNAJ_1, 1 hit PS50076, DNAJ_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8N7S2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSTVKEAAHR LSKSEMSLYA VLDLKKGASP EDFKKSYSHS ALLPHPPFEY
60 70 80 90 100
HLGRKLALRY HPDKNPGNAQ AAEIFKEINA AHAILSDSKK RKIYDQHGSL
110 120 130 140 150
GIYLYDHFGE EGVRYYFILN SCWFKTLVIL CTLLTCCCFC CCCCFCCGAL
160 170 180
KPPPEQDSGR KYQQNVQSQP PRSGAKCDFR SEENSEDDF
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB5MCA9 | B5MCA9_HUMAN | DnaJ homolog subfamily C member 5G | DNAJC5G | 173 | Annotation score: | ||
C9J078 | C9J078_HUMAN | DnaJ homolog subfamily C member 5G | DNAJC5G | 62 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_033882 | 4 | V → G. Corresponds to variant dbSNP:rs17005979Ensembl. | 1 | |
Natural variantiVAR_033883 | 51 | H → R. Corresponds to variant dbSNP:rs13414011Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056967 | 38 – 104 | SHSAL…LGIYL → RHLSSCVLCSLVAVSVVAAV FAVEHLNHHLSRIVGENISR MSRVSLQGQEPNVILEARKI AKMIFKR in isoform 2. 1 PublicationAdd BLAST | 67 | |
Alternative sequenceiVSP_056968 | 105 – 189 | Missing in isoform 2. 1 PublicationAdd BLAST | 85 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK097736 mRNA Translation: BAC05155.1 AK302239 mRNA Translation: BAG63591.1 AC013413 Genomic DNA Translation: AAY24295.1 CH471053 Genomic DNA Translation: EAX00608.1 CH471053 Genomic DNA Translation: EAX00609.1 BC035194 mRNA Translation: AAH35194.2 AF368277 mRNA Translation: AAK60572.1 |
CCDSi | CCDS1744.1 [Q8N7S2-1] CCDS77397.1 [Q8N7S2-2] |
RefSeqi | NP_001290056.1, NM_001303127.1 [Q8N7S2-1] NP_001290057.1, NM_001303128.1 [Q8N7S2-2] NP_775921.1, NM_173650.2 [Q8N7S2-1] XP_006712058.1, XM_006711995.3 [Q8N7S2-1] XP_016859361.1, XM_017003872.1 [Q8N7S2-1] XP_016859362.1, XM_017003873.1 [Q8N7S2-1] XP_016859363.1, XM_017003874.1 [Q8N7S2-1] |
Genome annotation databases
Ensembli | ENST00000296097; ENSP00000296097; ENSG00000163793 ENST00000402462; ENSP00000384305; ENSG00000163793 ENST00000406962; ENSP00000385533; ENSG00000163793 [Q8N7S2-2] |
GeneIDi | 285126 |
KEGGi | hsa:285126 |
MANE-Selecti | ENST00000296097.8; ENSP00000296097.3; NM_173650.3; NP_775921.1 |
UCSCi | uc002rjl.2, human [Q8N7S2-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK097736 mRNA Translation: BAC05155.1 AK302239 mRNA Translation: BAG63591.1 AC013413 Genomic DNA Translation: AAY24295.1 CH471053 Genomic DNA Translation: EAX00608.1 CH471053 Genomic DNA Translation: EAX00609.1 BC035194 mRNA Translation: AAH35194.2 AF368277 mRNA Translation: AAK60572.1 |
CCDSi | CCDS1744.1 [Q8N7S2-1] CCDS77397.1 [Q8N7S2-2] |
RefSeqi | NP_001290056.1, NM_001303127.1 [Q8N7S2-1] NP_001290057.1, NM_001303128.1 [Q8N7S2-2] NP_775921.1, NM_173650.2 [Q8N7S2-1] XP_006712058.1, XM_006711995.3 [Q8N7S2-1] XP_016859361.1, XM_017003872.1 [Q8N7S2-1] XP_016859362.1, XM_017003873.1 [Q8N7S2-1] XP_016859363.1, XM_017003874.1 [Q8N7S2-1] |
3D structure databases
SMRi | Q8N7S2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 130021, 9 interactors |
STRINGi | 9606.ENSP00000296097 |
PTM databases
iPTMneti | Q8N7S2 |
PhosphoSitePlusi | Q8N7S2 |
Genetic variation databases
BioMutai | DNAJC5G |
DMDMi | 50400554 |
Proteomic databases
PaxDbi | Q8N7S2 |
PeptideAtlasi | Q8N7S2 |
PRIDEi | Q8N7S2 |
ProteomicsDBi | 5491 |
Protocols and materials databases
Antibodypediai | 28353, 124 antibodies from 24 providers |
DNASUi | 285126 |
Genome annotation databases
Ensembli | ENST00000296097; ENSP00000296097; ENSG00000163793 ENST00000402462; ENSP00000384305; ENSG00000163793 ENST00000406962; ENSP00000385533; ENSG00000163793 [Q8N7S2-2] |
GeneIDi | 285126 |
KEGGi | hsa:285126 |
MANE-Selecti | ENST00000296097.8; ENSP00000296097.3; NM_173650.3; NP_775921.1 |
UCSCi | uc002rjl.2, human [Q8N7S2-1] |
Organism-specific databases
CTDi | 285126 |
GeneCardsi | DNAJC5G |
HGNCi | HGNC:24844, DNAJC5G |
HPAi | ENSG00000163793, Group enriched (epididymis, testis) |
MIMi | 613946, gene |
neXtProti | NX_Q8N7S2 |
OpenTargetsi | ENSG00000163793 |
PharmGKBi | PA134880296 |
VEuPathDBi | HostDB:ENSG00000163793 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0716, Eukaryota |
GeneTreei | ENSGT00940000162434 |
HOGENOMi | CLU_2249162_0_0_1 |
InParanoidi | Q8N7S2 |
OMAi | MNSCWFK |
OrthoDBi | 1401920at2759 |
PhylomeDBi | Q8N7S2 |
TreeFami | TF105164 |
Enzyme and pathway databases
PathwayCommonsi | Q8N7S2 |
Miscellaneous databases
BioGRID-ORCSi | 285126, 8 hits in 1035 CRISPR screens |
GenomeRNAii | 285126 |
Pharosi | Q8N7S2, Tdark |
PROi | PR:Q8N7S2 |
RNActi | Q8N7S2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000163793, Expressed in testis and 89 other tissues |
ExpressionAtlasi | Q8N7S2, baseline and differential |
Genevisiblei | Q8N7S2, HS |
Family and domain databases
CDDi | cd06257, DnaJ, 1 hit |
Gene3Di | 1.10.287.110, 1 hit |
InterProi | View protein in InterPro IPR001623, DnaJ_domain IPR018253, DnaJ_domain_CS IPR036869, J_dom_sf |
Pfami | View protein in Pfam PF00226, DnaJ, 1 hit |
PRINTSi | PR00625, JDOMAIN |
SMARTi | View protein in SMART SM00271, DnaJ, 1 hit |
SUPFAMi | SSF46565, SSF46565, 2 hits |
PROSITEi | View protein in PROSITE PS00636, DNAJ_1, 1 hit PS50076, DNAJ_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DNJ5G_HUMAN | |
Accessioni | Q8N7S2Primary (citable) accession number: Q8N7S2 Secondary accession number(s): B4DY29 Q96RJ8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2004 |
Last sequence update: | October 1, 2002 | |
Last modified: | February 23, 2022 | |
This is version 138 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot