UniProtKB - Q8N7R7 (CCYL1_HUMAN)
Protein
Cyclin-Y-like protein 1
Gene
CCNYL1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- cyclin-dependent protein serine/threonine kinase regulator activity Source: GO_Central
- protein kinase binding Source: InterPro
GO - Biological processi
- flagellated sperm motility Source: Ensembl
- positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
- spermatogenesis Source: Ensembl
Keywordsi
Molecular function | Cyclin |
Enzyme and pathway databases
PathwayCommonsi | Q8N7R7 |
SignaLinki | Q8N7R7 |
Names & Taxonomyi
Protein namesi | Recommended name: Cyclin-Y-like protein 1 |
Gene namesi | Name:CCNYL1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26868, CCNYL1 |
neXtProti | NX_Q8N7R7 |
VEuPathDBi | HostDB:ENSG00000163249.9 |
Subcellular locationi
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 151195 |
OpenTargetsi | ENSG00000163249 |
PharmGKBi | PA162382009 |
Miscellaneous databases
Pharosi | Q8N7R7, Tdark |
Genetic variation databases
BioMutai | CCNYL1 |
DMDMi | 160380580 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000309321 | 1 – 359 | Cyclin-Y-like protein 1Add BLAST | 359 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 67 | PhosphoserineCombined sources | 1 | |
Modified residuei | 105 | PhosphoserineCombined sources | 1 | |
Modified residuei | 112 | PhosphoserineCombined sources | 1 | |
Modified residuei | 344 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q8N7R7 |
jPOSTi | Q8N7R7 |
MassIVEi | Q8N7R7 |
MaxQBi | Q8N7R7 |
PeptideAtlasi | Q8N7R7 |
PRIDEi | Q8N7R7 |
ProteomicsDBi | 72321 [Q8N7R7-1] 72322 [Q8N7R7-2] 72323 [Q8N7R7-3] |
PTM databases
iPTMneti | Q8N7R7 |
PhosphoSitePlusi | Q8N7R7 |
SwissPalmi | Q8N7R7 |
Expressioni
Gene expression databases
Bgeei | ENSG00000163249, Expressed in secondary oocyte and 210 other tissues |
ExpressionAtlasi | Q8N7R7, baseline and differential |
Genevisiblei | Q8N7R7, HS |
Organism-specific databases
HPAi | ENSG00000163249, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ8N7R7
With | #Exp. | IntAct |
---|---|---|
CDK16 [Q00536] | 3 | EBI-10103094,EBI-726261 |
Isoform 2 [Q8N7R7-2]
With | #Exp. | IntAct |
---|---|---|
MEOX2 [Q6FHY5] | 3 | EBI-12382996,EBI-16439278 |
GO - Molecular functioni
- protein kinase binding Source: InterPro
Protein-protein interaction databases
BioGRIDi | 127353, 44 interactors |
IntActi | Q8N7R7, 35 interactors |
Miscellaneous databases
RNActi | Q8N7R7, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 145 – 267 | Cyclin N-terminalAdd BLAST | 123 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00940000154453 |
HOGENOMi | CLU_055026_0_0_1 |
InParanoidi | Q8N7R7 |
OMAi | LRTTIKX |
OrthoDBi | 916284at2759 |
PhylomeDBi | Q8N7R7 |
TreeFami | TF314464 |
Family and domain databases
CDDi | cd00043, CYCLIN, 1 hit |
InterProi | View protein in InterPro IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR006671, Cyclin_N IPR012399, Cyclin_Y |
Pfami | View protein in Pfam PF00134, Cyclin_N, 1 hit |
PIRSFi | PIRSF028934, Cyclin_CG14939, 1 hit |
SMARTi | View protein in SMART SM00385, CYCLIN, 1 hit |
SUPFAMi | SSF47954, SSF47954, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8N7R7-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGNTLTCCVS PNASPKLGRR AGSAELYCAS DIYEAVSGDA VAVAPAVVEP
60 70 80 90 100
AELDFGEGEG HHLQHISDRE MPEDLALESN PSDHPRASTI FLSKSQTDVR
110 120 130 140 150
EKRKSNHLNH VSPGQLTKKY SSCSTIFLDD STVSQPNLRT TVKCVTLAIY
160 170 180 190 200
YHIKNRDANR SLDIFDERSH PLTREKVPEE YFKHDPEHKF IYRFVRTLFS
210 220 230 240 250
AAQLTAECAI VTLVYLERLL TYAEIDICPT NWKRIVLGAI LLASKVWDDQ
260 270 280 290 300
AVWNVDYCQI LKDITVEDMN EMERHFLELL QFNINVPASV YAKYYFDLRS
310 320 330 340 350
LADDNNLNFL FAPLSKERAQ NLEAISRLCE DKDLCRAAMR RSFSADNFIG
IQRSKAILS
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A494C0K2 | A0A494C0K2_HUMAN | Cyclin-Y-like protein 1 | CCNYL1 | 125 | Annotation score: | ||
H7C0P7 | H7C0P7_HUMAN | Cyclin-Y-like protein 1 | CCNYL1 | 147 | Annotation score: | ||
C9IYB8 | C9IYB8_HUMAN | Cyclin-Y-like protein 1 | CCNYL1 | 101 | Annotation score: | ||
H7BZD2 | H7BZD2_HUMAN | Cyclin-Y-like protein 1 | CCNYL1 | 119 | Annotation score: |
Sequence cautioni
The sequence AAH67253 differs from that shown. Reason: Frameshift.Curated
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_029133 | 1 – 70 | Missing in isoform 3. 1 PublicationAdd BLAST | 70 | |
Alternative sequenceiVSP_029134 | 111 – 173 | VSPGQ…SHPLT → CDLSNILPHKEQ in isoform 2. 1 PublicationAdd BLAST | 63 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK097751 mRNA Translation: BAC05160.1 AC096772 Genomic DNA Translation: AAY24056.1 CH471063 Genomic DNA Translation: EAW70420.1 BC067253 mRNA Translation: AAH67253.1 Frameshift. |
CCDSi | CCDS2377.1 [Q8N7R7-3] CCDS46503.1 [Q8N7R7-2] CCDS82564.1 [Q8N7R7-1] |
RefSeqi | NP_001135772.1, NM_001142300.1 [Q8N7R7-2] NP_001317147.1, NM_001330218.1 [Q8N7R7-1] NP_689736.1, NM_152523.2 [Q8N7R7-3] |
Genome annotation databases
Ensembli | ENST00000295414; ENSP00000295414; ENSG00000163249 [Q8N7R7-1] ENST00000339882; ENSP00000342344; ENSG00000163249 [Q8N7R7-2] ENST00000392209; ENSP00000376045; ENSG00000163249 [Q8N7R7-3] |
GeneIDi | 151195 |
KEGGi | hsa:151195 |
UCSCi | uc002vch.4, human [Q8N7R7-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK097751 mRNA Translation: BAC05160.1 AC096772 Genomic DNA Translation: AAY24056.1 CH471063 Genomic DNA Translation: EAW70420.1 BC067253 mRNA Translation: AAH67253.1 Frameshift. |
CCDSi | CCDS2377.1 [Q8N7R7-3] CCDS46503.1 [Q8N7R7-2] CCDS82564.1 [Q8N7R7-1] |
RefSeqi | NP_001135772.1, NM_001142300.1 [Q8N7R7-2] NP_001317147.1, NM_001330218.1 [Q8N7R7-1] NP_689736.1, NM_152523.2 [Q8N7R7-3] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 127353, 44 interactors |
IntActi | Q8N7R7, 35 interactors |
PTM databases
iPTMneti | Q8N7R7 |
PhosphoSitePlusi | Q8N7R7 |
SwissPalmi | Q8N7R7 |
Genetic variation databases
BioMutai | CCNYL1 |
DMDMi | 160380580 |
Proteomic databases
EPDi | Q8N7R7 |
jPOSTi | Q8N7R7 |
MassIVEi | Q8N7R7 |
MaxQBi | Q8N7R7 |
PeptideAtlasi | Q8N7R7 |
PRIDEi | Q8N7R7 |
ProteomicsDBi | 72321 [Q8N7R7-1] 72322 [Q8N7R7-2] 72323 [Q8N7R7-3] |
Protocols and materials databases
Antibodypediai | 52166, 116 antibodies |
Genome annotation databases
Ensembli | ENST00000295414; ENSP00000295414; ENSG00000163249 [Q8N7R7-1] ENST00000339882; ENSP00000342344; ENSG00000163249 [Q8N7R7-2] ENST00000392209; ENSP00000376045; ENSG00000163249 [Q8N7R7-3] |
GeneIDi | 151195 |
KEGGi | hsa:151195 |
UCSCi | uc002vch.4, human [Q8N7R7-1] |
Organism-specific databases
CTDi | 151195 |
DisGeNETi | 151195 |
GeneCardsi | CCNYL1 |
HGNCi | HGNC:26868, CCNYL1 |
HPAi | ENSG00000163249, Low tissue specificity |
neXtProti | NX_Q8N7R7 |
OpenTargetsi | ENSG00000163249 |
PharmGKBi | PA162382009 |
VEuPathDBi | HostDB:ENSG00000163249.9 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000154453 |
HOGENOMi | CLU_055026_0_0_1 |
InParanoidi | Q8N7R7 |
OMAi | LRTTIKX |
OrthoDBi | 916284at2759 |
PhylomeDBi | Q8N7R7 |
TreeFami | TF314464 |
Enzyme and pathway databases
PathwayCommonsi | Q8N7R7 |
SignaLinki | Q8N7R7 |
Miscellaneous databases
BioGRID-ORCSi | 151195, 64 hits in 875 CRISPR screens |
ChiTaRSi | CCNYL1, human |
GenomeRNAii | 151195 |
Pharosi | Q8N7R7, Tdark |
PROi | PR:Q8N7R7 |
RNActi | Q8N7R7, protein |
Gene expression databases
Bgeei | ENSG00000163249, Expressed in secondary oocyte and 210 other tissues |
ExpressionAtlasi | Q8N7R7, baseline and differential |
Genevisiblei | Q8N7R7, HS |
Family and domain databases
CDDi | cd00043, CYCLIN, 1 hit |
InterProi | View protein in InterPro IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR006671, Cyclin_N IPR012399, Cyclin_Y |
Pfami | View protein in Pfam PF00134, Cyclin_N, 1 hit |
PIRSFi | PIRSF028934, Cyclin_CG14939, 1 hit |
SMARTi | View protein in SMART SM00385, CYCLIN, 1 hit |
SUPFAMi | SSF47954, SSF47954, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CCYL1_HUMAN | |
Accessioni | Q8N7R7Primary (citable) accession number: Q8N7R7 Secondary accession number(s): Q6NX60 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 13, 2007 |
Last sequence update: | November 13, 2007 | |
Last modified: | February 10, 2021 | |
This is version 152 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM