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Protein

Zinc finger protein 676

Gene

ZNF676

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri169 – 191C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri197 – 219C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri225 – 247C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri253 – 275C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri281 – 303C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 331C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 359C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri365 – 387C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri393 – 415C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri421 – 443C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri449 – 471C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri477 – 499C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri505 – 527C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri533 – 555C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri561 – 583C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 676
Gene namesi
Name:ZNF676
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000196109.6
HGNCiHGNC:20429 ZNF676
neXtProtiNX_Q8N7Q3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi163223
OpenTargetsiENSG00000196109
PharmGKBiPA142670477

Polymorphism and mutation databases

BioMutaiZNF676
DMDMi215273918

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002339961 – 588Zinc finger protein 676Add BLAST588

Proteomic databases

EPDiQ8N7Q3
MaxQBiQ8N7Q3
PaxDbiQ8N7Q3
PeptideAtlasiQ8N7Q3
PRIDEiQ8N7Q3
ProteomicsDBi72318

PTM databases

iPTMnetiQ8N7Q3
PhosphoSitePlusiQ8N7Q3

Expressioni

Gene expression databases

BgeeiENSG00000196109 Expressed in 78 organ(s), highest expression level in thyroid gland
CleanExiHS_ZNF676

Interactioni

Protein-protein interaction databases

BioGridi127857, 1 interactor
IntActiQ8N7Q3, 1 interactor
STRINGi9606.ENSP00000380310

Structurei

3D structure databases

ProteinModelPortaliQ8N7Q3
SMRiQ8N7Q3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 43KRABPROSITE-ProRule annotationAdd BLAST43

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri169 – 191C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri197 – 219C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri225 – 247C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri253 – 275C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri281 – 303C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 331C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 359C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri365 – 387C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri393 – 415C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri421 – 443C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri449 – 471C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri477 – 499C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri505 – 527C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri533 – 555C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri561 – 583C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144042
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ8N7Q3
KOiK09228
OMAiFLECGPS
OrthoDBiEOG091G02KC
PhylomeDBiQ8N7Q3
TreeFamiTF342117

Family and domain databases

InterProiView protein in InterPro
IPR001909 KRAB
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 12 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 14 hits
SUPFAMiSSF57667 SSF57667, 9 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 12 hits
PS50157 ZINC_FINGER_C2H2_2, 15 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8N7Q3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLENYRNLVF LGIAAFKPDL IIFLEQGKEP WNMKRHEMVE EPPVICSHFS
60 70 80 90 100
QEFWPEQGIE DSFQKMILRR YDKCGHENLH LKISCTNVDE CNVHKEGYNK
110 120 130 140 150
LNQSLTTTQS KVFQCGKYAN VFHKCSNSNR HKIRHTGEKG LKCKEYVRSF
160 170 180 190 200
CMLSHLSQHE RIYTRENSYK CEENGKAFNW SSTLTYYKSI HTGEKPYKCE
210 220 230 240 250
ECGKAFSKFS ILTKHKVIHT GEKPYKCEEC GKAFNRSSIL TKHKIIHTGE
260 270 280 290 300
KPYKCEECGK GFSSVSTLNT HKAIHAEEKP YKCEECGKAS NSSSKLMEHK
310 320 330 340 350
RIHTGEKPYK CEECGKAFSW SSSLTEHKRI HAGEKPYKCE ECGKAFNRSS
360 370 380 390 400
ILTKHKIIHT GEKPYKCEGC GKAFSKVSTL NTHKAIHAEE KPYKCEECGK
410 420 430 440 450
ASNSSSKLME HKRIHTGEKP YKCEECGKAF SWSSSLTEHK RIHAGEKPYK
460 470 480 490 500
CEECGKAFTW SSSFTKHKRI HAAEKPYKCE ECGKGFSTFS ILTKHKIIHT
510 520 530 540 550
GEKRYKCEEC GKAFSWSSIL TEHKIIHTGE KPYKCEECGK AFSRSSSLTR
560 570 580
HKRIHTGEKP YKCEECGKAF KSSSTVSYHK KIHTGENP
Length:588
Mass (Da):67,624
Last modified:November 25, 2008 - v2
Checksum:i662E28DBE1CBB6D6
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JP77A0A0G2JP77_HUMAN
Zinc finger protein 676
ZNF676
568Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti180W → S in BAC05174 (PubMed:14702039).Curated1
Sequence conflicti183 – 190TLTYYKSI → NLMEHKRV in BAC05174 (PubMed:14702039).Curated8
Sequence conflicti208 – 220KFSIL…KVIHT → WSSSLTEHKRIHA in BAC05174 (PubMed:14702039).CuratedAdd BLAST13

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04743727G → E. Corresponds to variant dbSNP:rs8104929Ensembl.1
Natural variantiVAR_04743896E → K. Corresponds to variant dbSNP:rs12986319Ensembl.1
Natural variantiVAR_047439292S → W. Corresponds to variant dbSNP:rs11671538Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073539 Genomic DNA No translation available.
AK097798 mRNA Translation: BAC05174.1
CCDSiCCDS42539.1
RefSeqiNP_001001411.2, NM_001001411.2
UniGeneiHs.55452

Genome annotation databases

EnsembliENST00000395385; ENSP00000378783; ENSG00000276219
ENST00000397121; ENSP00000380310; ENSG00000196109
GeneIDi163223
KEGGihsa:163223
UCSCiuc002nqs.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073539 Genomic DNA No translation available.
AK097798 mRNA Translation: BAC05174.1
CCDSiCCDS42539.1
RefSeqiNP_001001411.2, NM_001001411.2
UniGeneiHs.55452

3D structure databases

ProteinModelPortaliQ8N7Q3
SMRiQ8N7Q3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127857, 1 interactor
IntActiQ8N7Q3, 1 interactor
STRINGi9606.ENSP00000380310

PTM databases

iPTMnetiQ8N7Q3
PhosphoSitePlusiQ8N7Q3

Polymorphism and mutation databases

BioMutaiZNF676
DMDMi215273918

Proteomic databases

EPDiQ8N7Q3
MaxQBiQ8N7Q3
PaxDbiQ8N7Q3
PeptideAtlasiQ8N7Q3
PRIDEiQ8N7Q3
ProteomicsDBi72318

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000395385; ENSP00000378783; ENSG00000276219
ENST00000397121; ENSP00000380310; ENSG00000196109
GeneIDi163223
KEGGihsa:163223
UCSCiuc002nqs.2 human

Organism-specific databases

CTDi163223
DisGeNETi163223
EuPathDBiHostDB:ENSG00000196109.6
GeneCardsiZNF676
HGNCiHGNC:20429 ZNF676
neXtProtiNX_Q8N7Q3
OpenTargetsiENSG00000196109
PharmGKBiPA142670477
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144042
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ8N7Q3
KOiK09228
OMAiFLECGPS
OrthoDBiEOG091G02KC
PhylomeDBiQ8N7Q3
TreeFamiTF342117

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

GenomeRNAii163223
PROiPR:Q8N7Q3

Gene expression databases

BgeeiENSG00000196109 Expressed in 78 organ(s), highest expression level in thyroid gland
CleanExiHS_ZNF676

Family and domain databases

InterProiView protein in InterPro
IPR001909 KRAB
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 12 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 14 hits
SUPFAMiSSF57667 SSF57667, 9 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 12 hits
PS50157 ZINC_FINGER_C2H2_2, 15 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN676_HUMAN
AccessioniPrimary (citable) accession number: Q8N7Q3
Secondary accession number(s): A8MVX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: November 25, 2008
Last modified: November 7, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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