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UniProtKB - Q8N7Q3 (ZN676_HUMAN)
Protein
Zinc finger protein 676
Gene
ZNF676
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 169 – 191 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 197 – 219 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 225 – 247 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 253 – 275 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 281 – 303 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 309 – 331 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 337 – 359 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 365 – 387 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 393 – 415 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 421 – 443 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 449 – 471 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 477 – 499 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 505 – 527 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 533 – 555 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 561 – 583 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q8N7Q3 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
SignaLinki | Q8N7Q3 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 676 |
Gene namesi | Name:ZNF676 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20429, ZNF676 |
neXtProti | NX_Q8N7Q3 |
VEuPathDBi | HostDB:ENSG00000196109 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 163223 |
OpenTargetsi | ENSG00000196109 |
PharmGKBi | PA142670477 |
Miscellaneous databases
Pharosi | Q8N7Q3, Tdark |
Genetic variation databases
BioMutai | ZNF676 |
DMDMi | 215273918 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000233996 | 1 – 588 | Zinc finger protein 676Add BLAST | 588 |
Proteomic databases
EPDi | Q8N7Q3 |
jPOSTi | Q8N7Q3 |
MaxQBi | Q8N7Q3 |
PaxDbi | Q8N7Q3 |
PeptideAtlasi | Q8N7Q3 |
PRIDEi | Q8N7Q3 |
ProteomicsDBi | 72318 |
PTM databases
iPTMneti | Q8N7Q3 |
PhosphoSitePlusi | Q8N7Q3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000196109, Expressed in frontal cortex and 100 other tissues |
ExpressionAtlasi | Q8N7Q3, baseline and differential |
Organism-specific databases
HPAi | ENSG00000196109, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 127857, 1 interactor |
IntActi | Q8N7Q3, 1 interactor |
STRINGi | 9606.ENSP00000380310 |
Miscellaneous databases
RNActi | Q8N7Q3, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 43 | KRABPROSITE-ProRule annotationAdd BLAST | 43 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 169 – 191 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 197 – 219 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 225 – 247 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 253 – 275 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 281 – 303 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 309 – 331 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 337 – 359 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 365 – 387 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 393 – 415 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 421 – 443 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 449 – 471 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 477 – 499 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 505 – 527 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 533 – 555 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 561 – 583 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000153236 |
HOGENOMi | CLU_002678_44_0_1 |
InParanoidi | Q8N7Q3 |
OMAi | YERCGHE |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8N7Q3 |
TreeFami | TF342117 |
Family and domain databases
InterProi | View protein in InterPro IPR001909, KRAB IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 10 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 14 hits |
SUPFAMi | SSF57667, SSF57667, 9 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 12 hits PS50157, ZINC_FINGER_C2H2_2, 15 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q8N7Q3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLENYRNLVF LGIAAFKPDL IIFLEQGKEP WNMKRHEMVE EPPVICSHFS
60 70 80 90 100
QEFWPEQGIE DSFQKMILRR YDKCGHENLH LKISCTNVDE CNVHKEGYNK
110 120 130 140 150
LNQSLTTTQS KVFQCGKYAN VFHKCSNSNR HKIRHTGEKG LKCKEYVRSF
160 170 180 190 200
CMLSHLSQHE RIYTRENSYK CEENGKAFNW SSTLTYYKSI HTGEKPYKCE
210 220 230 240 250
ECGKAFSKFS ILTKHKVIHT GEKPYKCEEC GKAFNRSSIL TKHKIIHTGE
260 270 280 290 300
KPYKCEECGK GFSSVSTLNT HKAIHAEEKP YKCEECGKAS NSSSKLMEHK
310 320 330 340 350
RIHTGEKPYK CEECGKAFSW SSSLTEHKRI HAGEKPYKCE ECGKAFNRSS
360 370 380 390 400
ILTKHKIIHT GEKPYKCEGC GKAFSKVSTL NTHKAIHAEE KPYKCEECGK
410 420 430 440 450
ASNSSSKLME HKRIHTGEKP YKCEECGKAF SWSSSLTEHK RIHAGEKPYK
460 470 480 490 500
CEECGKAFTW SSSFTKHKRI HAAEKPYKCE ECGKGFSTFS ILTKHKIIHT
510 520 530 540 550
GEKRYKCEEC GKAFSWSSIL TEHKIIHTGE KPYKCEECGK AFSRSSSLTR
560 570 580
HKRIHTGEKP YKCEECGKAF KSSSTVSYHK KIHTGENP
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3B3ITU2 | A0A3B3ITU2_HUMAN | Zinc finger protein 676 | ZNF676 | 620 | Annotation score: | ||
A0A0G2JP77 | A0A0G2JP77_HUMAN | Zinc finger protein 676 | ZNF676 | 568 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 180 | W → S in BAC05174 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 183 – 190 | TLTYYKSI → NLMEHKRV in BAC05174 (PubMed:14702039).Curated | 8 | |
Sequence conflicti | 208 – 220 | KFSIL…KVIHT → WSSSLTEHKRIHA in BAC05174 (PubMed:14702039).CuratedAdd BLAST | 13 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_047437 | 27 | G → E. Corresponds to variant dbSNP:rs8104929Ensembl. | 1 | |
Natural variantiVAR_047438 | 96 | E → K. Corresponds to variant dbSNP:rs12986319Ensembl. | 1 | |
Natural variantiVAR_047439 | 292 | S → W. Corresponds to variant dbSNP:rs11671538Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC073539 Genomic DNA No translation available. AK097798 mRNA Translation: BAC05174.1 |
CCDSi | CCDS42539.1 |
RefSeqi | NP_001001411.2, NM_001001411.2 |
Genome annotation databases
Ensembli | ENST00000395385; ENSP00000378783; ENSG00000276219 ENST00000397121; ENSP00000380310; ENSG00000196109 |
GeneIDi | 163223 |
KEGGi | hsa:163223 |
MANE-Selecti | ENST00000397121.3; ENSP00000380310.1; NM_001001411.3; NP_001001411.2 |
UCSCi | uc002nqs.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC073539 Genomic DNA No translation available. AK097798 mRNA Translation: BAC05174.1 |
CCDSi | CCDS42539.1 |
RefSeqi | NP_001001411.2, NM_001001411.2 |
3D structure databases
SMRi | Q8N7Q3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 127857, 1 interactor |
IntActi | Q8N7Q3, 1 interactor |
STRINGi | 9606.ENSP00000380310 |
PTM databases
iPTMneti | Q8N7Q3 |
PhosphoSitePlusi | Q8N7Q3 |
Genetic variation databases
BioMutai | ZNF676 |
DMDMi | 215273918 |
Proteomic databases
EPDi | Q8N7Q3 |
jPOSTi | Q8N7Q3 |
MaxQBi | Q8N7Q3 |
PaxDbi | Q8N7Q3 |
PeptideAtlasi | Q8N7Q3 |
PRIDEi | Q8N7Q3 |
ProteomicsDBi | 72318 |
Protocols and materials databases
Antibodypediai | 44182, 33 antibodies from 10 providers |
DNASUi | 163223 |
Genome annotation databases
Ensembli | ENST00000395385; ENSP00000378783; ENSG00000276219 ENST00000397121; ENSP00000380310; ENSG00000196109 |
GeneIDi | 163223 |
KEGGi | hsa:163223 |
MANE-Selecti | ENST00000397121.3; ENSP00000380310.1; NM_001001411.3; NP_001001411.2 |
UCSCi | uc002nqs.2, human |
Organism-specific databases
CTDi | 163223 |
DisGeNETi | 163223 |
GeneCardsi | ZNF676 |
HGNCi | HGNC:20429, ZNF676 |
HPAi | ENSG00000196109, Low tissue specificity |
neXtProti | NX_Q8N7Q3 |
OpenTargetsi | ENSG00000196109 |
PharmGKBi | PA142670477 |
VEuPathDBi | HostDB:ENSG00000196109 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000153236 |
HOGENOMi | CLU_002678_44_0_1 |
InParanoidi | Q8N7Q3 |
OMAi | YERCGHE |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8N7Q3 |
TreeFami | TF342117 |
Enzyme and pathway databases
PathwayCommonsi | Q8N7Q3 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
SignaLinki | Q8N7Q3 |
Miscellaneous databases
BioGRID-ORCSi | 163223, 290 hits in 986 CRISPR screens |
GenomeRNAii | 163223 |
Pharosi | Q8N7Q3, Tdark |
PROi | PR:Q8N7Q3 |
RNActi | Q8N7Q3, protein |
Gene expression databases
Bgeei | ENSG00000196109, Expressed in frontal cortex and 100 other tissues |
ExpressionAtlasi | Q8N7Q3, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR001909, KRAB IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 10 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 14 hits |
SUPFAMi | SSF57667, SSF57667, 9 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 12 hits PS50157, ZINC_FINGER_C2H2_2, 15 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN676_HUMAN | |
Accessioni | Q8N7Q3Primary (citable) accession number: Q8N7Q3 Secondary accession number(s): A8MVX5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 2, 2006 |
Last sequence update: | November 25, 2008 | |
Last modified: | February 23, 2022 | |
This is version 149 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families