ZNF676

Functionⁱ

May be involved in transcriptional regulation.

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	169 – 191	C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	197 – 219	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	225 – 247	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	253 – 275	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	281 – 303	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	309 – 331	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	337 – 359	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	365 – 387	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	393 – 415	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	421 – 443	C2H2-type 10PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	449 – 471	C2H2-type 11PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	477 – 499	C2H2-type 12PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	505 – 527	C2H2-type 13PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	533 – 555	C2H2-type 14PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	561 – 583	C2H2-type 15PROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-212436 Generic Transcription Pathway

Reactomeⁱ

R-HSA-212436 Generic Transcription Pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein 676
Gene namesⁱ	Name:ZNF676
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000196109.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:20429 ZNF676
neXtProtⁱ	NX_Q8N7Q3

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	163223
Open Targets More...OpenTargetsⁱ	ENSG00000196109
PharmGKBⁱ	PA142670477

Polymorphism and mutation databases

BioMutaⁱ	ZNF676
DMDMⁱ	215273918

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000233996	1 – 588	Zinc finger protein 676Add BLAST		588

Proteomic databases

EPDⁱ	Q8N7Q3
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8N7Q3
PaxDbⁱ	Q8N7Q3
PeptideAtlas More...PeptideAtlasⁱ	Q8N7Q3
PRIDEⁱ	Q8N7Q3
ProteomicsDBⁱ	72318

PTM databases

iPTMnetⁱ	Q8N7Q3
PhosphoSitePlusⁱ	Q8N7Q3

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000196109 Expressed in 78 organ(s), highest expression level in thyroid gland
CleanExⁱ	HS_ZNF676

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	127857, 1 interactor
IntActⁱ	Q8N7Q3, 1 interactor
STRINGⁱ	9606.ENSP00000380310

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8N7Q3
SMRⁱ	Q8N7Q3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	1 – 43	KRABPROSITE-ProRule annotationAdd BLAST		43

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	169 – 191	C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	197 – 219	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	225 – 247	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	253 – 275	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	281 – 303	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	309 – 331	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	337 – 359	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	365 – 387	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	393 – 415	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	421 – 443	C2H2-type 10PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	449 – 471	C2H2-type 11PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	477 – 499	C2H2-type 12PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	505 – 527	C2H2-type 13PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	533 – 555	C2H2-type 14PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	561 – 583	C2H2-type 15PROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144042
HOGENOMⁱ	HOG000234617
HOVERGENⁱ	HBG018163
InParanoidⁱ	Q8N7Q3
KEGG Orthology (KO) More...KOⁱ	K09228
OMAⁱ	FLECGPS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02KC
PhylomeDBⁱ	Q8N7Q3
TreeFamⁱ	TF342117

Family and domain databases

InterProⁱ	View protein in InterPro IPR001909 KRAB IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 12 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 14 hits
SUPFAMⁱ	SSF57667 SSF57667, 9 hits
PROSITEⁱ	View protein in PROSITE PS50805 KRAB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 12 hits PS50157 ZINC_FINGER_C2H2_2, 15 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q8N7Q3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLENYRNLVF LGIAAFKPDL IIFLEQGKEP WNMKRHEMVE EPPVICSHFS 
        60         70         80         90        100
QEFWPEQGIE DSFQKMILRR YDKCGHENLH LKISCTNVDE CNVHKEGYNK 
       110        120        130        140        150
LNQSLTTTQS KVFQCGKYAN VFHKCSNSNR HKIRHTGEKG LKCKEYVRSF 
       160        170        180        190        200
CMLSHLSQHE RIYTRENSYK CEENGKAFNW SSTLTYYKSI HTGEKPYKCE 
       210        220        230        240        250
ECGKAFSKFS ILTKHKVIHT GEKPYKCEEC GKAFNRSSIL TKHKIIHTGE 
       260        270        280        290        300
KPYKCEECGK GFSSVSTLNT HKAIHAEEKP YKCEECGKAS NSSSKLMEHK 
       310        320        330        340        350
RIHTGEKPYK CEECGKAFSW SSSLTEHKRI HAGEKPYKCE ECGKAFNRSS 
       360        370        380        390        400
ILTKHKIIHT GEKPYKCEGC GKAFSKVSTL NTHKAIHAEE KPYKCEECGK 
       410        420        430        440        450
ASNSSSKLME HKRIHTGEKP YKCEECGKAF SWSSSLTEHK RIHAGEKPYK 
       460        470        480        490        500
CEECGKAFTW SSSFTKHKRI HAAEKPYKCE ECGKGFSTFS ILTKHKIIHT 
       510        520        530        540        550
GEKRYKCEEC GKAFSWSSIL TEHKIIHTGE KPYKCEECGK AFSRSSSLTR 
       560        570        580 
HKRIHTGEKP YKCEECGKAF KSSSTVSYHK KIHTGENP

Length:588

Mass (Da):67,624

Last modified:November 25, 2008 - v2

Checksum:ⁱ662E28DBE1CBB6D6

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A0G2JP77	A0A0G2JP77_HUMAN		Zinc finger protein 676 Zinc finger protein 676	ZNF676	568	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	180	W → S in BAC05174 (PubMed:14702039).Curated	1
Sequence conflictⁱ	183 – 190	TLTYYKSI → NLMEHKRV in BAC05174 (PubMed:14702039).Curated	8
Sequence conflictⁱ	208 – 220	KFSIL…KVIHT → WSSSLTEHKRIHA in BAC05174 (PubMed:14702039).CuratedAdd BLAST	13

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_047437	27	G → E. Corresponds to variant dbSNP:rs8104929Ensembl.	1
Natural variantⁱVAR_047438	96	E → K. Corresponds to variant dbSNP:rs12986319Ensembl.	1
Natural variantⁱVAR_047439	292	S → W. Corresponds to variant dbSNP:rs11671538Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC073539 Genomic DNA No translation available. AK097798 mRNA Translation: BAC05174.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS42539.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001001411.2, NM_001001411.2
UniGeneⁱ	Hs.55452

Genome annotation databases

Ensemblⁱ	ENST00000395385; ENSP00000378783; ENSG00000276219 ENST00000397121; ENSP00000380310; ENSG00000196109
GeneIDⁱ	163223
KEGGⁱ	hsa:163223
UCSC genome browser More...UCSCⁱ	uc002nqs.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8N7Q3	Uncharacterized protein		PONAB		588	UniRef90_Q8N7Q3
Zinc finger protein 676		PANTR		588
Uncharacterized protein		NOMLE		588

Protein	Similar proteins		Species	Score	Length	Source
Q8N7Q3	Isoform 2 of Zinc finger protein 93		HUMAN		592	UniRef50_P35789-2
Uncharacterized protein		NOMLE		484
ZNF626 isoform 2		PANTR		540
Uncharacterized protein		PAPAN		584
Zinc finger protein 66		MACFA		579
+32

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC073539 Genomic DNA No translation available. AK097798 mRNA Translation: BAC05174.1
CCDSⁱ	CCDS42539.1
RefSeqⁱ	NP_001001411.2, NM_001001411.2
UniGeneⁱ	Hs.55452

3D structure databases

ProteinModelPortalⁱ	Q8N7Q3
SMRⁱ	Q8N7Q3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	127857, 1 interactor
IntActⁱ	Q8N7Q3, 1 interactor
STRINGⁱ	9606.ENSP00000380310

PTM databases

iPTMnetⁱ	Q8N7Q3
PhosphoSitePlusⁱ	Q8N7Q3

Polymorphism and mutation databases

BioMutaⁱ	ZNF676
DMDMⁱ	215273918

Proteomic databases

EPDⁱ	Q8N7Q3
MaxQBⁱ	Q8N7Q3
PaxDbⁱ	Q8N7Q3
PeptideAtlasⁱ	Q8N7Q3
PRIDEⁱ	Q8N7Q3
ProteomicsDBⁱ	72318

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000395385; ENSP00000378783; ENSG00000276219 ENST00000397121; ENSP00000380310; ENSG00000196109
GeneIDⁱ	163223
KEGGⁱ	hsa:163223
UCSCⁱ	uc002nqs.2 human

Organism-specific databases

CTDⁱ	163223
DisGeNETⁱ	163223
EuPathDBⁱ	HostDB:ENSG00000196109.6
GeneCardsⁱ	ZNF676
HGNCⁱ	HGNC:20429 ZNF676
neXtProtⁱ	NX_Q8N7Q3
OpenTargetsⁱ	ENSG00000196109
PharmGKBⁱ	PA142670477
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00910000144042
HOGENOMⁱ	HOG000234617
HOVERGENⁱ	HBG018163
InParanoidⁱ	Q8N7Q3
KOⁱ	K09228
OMAⁱ	FLECGPS
OrthoDBⁱ	EOG091G02KC
PhylomeDBⁱ	Q8N7Q3
TreeFamⁱ	TF342117

Enzyme and pathway databases

Reactomeⁱ	R-HSA-212436 Generic Transcription Pathway

Reactomeⁱ

R-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

GenomeRNAiⁱ	163223
Protein Ontology More...PROⁱ	PR:Q8N7Q3

Gene expression databases

Bgeeⁱ	ENSG00000196109 Expressed in 78 organ(s), highest expression level in thyroid gland
CleanExⁱ	HS_ZNF676

Family and domain databases

InterProⁱ	View protein in InterPro IPR001909 KRAB IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 12 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 14 hits
SUPFAMⁱ	SSF57667 SSF57667, 9 hits
PROSITEⁱ	View protein in PROSITE PS50805 KRAB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 12 hits PS50157 ZINC_FINGER_C2H2_2, 15 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZN676_HUMAN
Accessionⁱ	Q8N7Q3Primary (citable) accession number: Q8N7Q3 Secondary accession number(s): A8MVX5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 2, 2006
	Last sequence update:	November 25, 2008
	Last modified:	November 7, 2018
	This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM

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Supporting data

UniProtKB - Q8N7Q3 (ZN676_HUMAN)

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Zinc finger protein 676

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ