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Protein

Claudin-22

Gene

CLDN22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-420029 Tight junction interactions

Protein family/group databases

TCDBi1.H.1.1.3 the claudin tight junction (claudin1) family

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-22
Gene namesi
Name:CLDN22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000177300.6
HGNCiHGNC:2044 CLDN22
neXtProtiNX_Q8N7P3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicSequence analysis10
Transmembranei11 – 30HelicalSequence analysisAdd BLAST20
Topological domaini31 – 81ExtracellularSequence analysisAdd BLAST51
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 117CytoplasmicSequence analysisAdd BLAST15
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21
Topological domaini139 – 164ExtracellularSequence analysisAdd BLAST26
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
Topological domaini186 – 220CytoplasmicSequence analysisAdd BLAST35

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000177300
PharmGKBiPA26570

Polymorphism and mutation databases

BioMutaiCLDN22
DMDMi62298548

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447851 – 220Claudin-22Add BLAST220

Proteomic databases

PaxDbiQ8N7P3
PeptideAtlasiQ8N7P3
PRIDEiQ8N7P3
ProteomicsDBi72315

Expressioni

Gene expression databases

BgeeiENSG00000177300 Expressed in 66 organ(s), highest expression level in right lobe of liver

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8N7P3, 7 interactors
STRINGi9606.ENSP00000318113

Structurei

3D structure databases

ProteinModelPortaliQ8N7P3
SMRiQ8N7P3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410INS5 Eukaryota
ENOG4111QE3 LUCA
GeneTreeiENSGT00760000119222
HOGENOMiHOG000220937
HOVERGENiHBG104065
InParanoidiQ8N7P3
KOiK06087
OMAiNYLPQWK
OrthoDBiEOG091G0QQ0
PhylomeDBiQ8N7P3
TreeFamiTF331936

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q8N7P3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALVFRTVAQ LAGVSLSLLG WVLSCLTNYL PHWKNLNLDL NEMENWTMGL
60 70 80 90 100
WQTCVIQEEV GMQCKDFDSF LALPAELRVS RILMFLSNGL GFLGLLVSGF
110 120 130 140 150
GLDCLRIGES QRDLKRRLLI LGGILSWASG VTALVPVSWV AHKTVQEFWD
160 170 180 190 200
ENVPDFVPRW EFGEALFLGW FAGLSLLLGG CLLHCAACSS HAPLASGHYA
210 220
VAQTQDHHQE LETRNTNLKH
Length:220
Mass (Da):24,509
Last modified:March 29, 2005 - v3
Checksum:i0DBB146E10EBE91D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti111Q → L in AK098064 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093844 Genomic DNA No translation available.
AK098064 mRNA No translation available.
CCDSiCCDS43286.1
RefSeqiNP_001104789.1, NM_001111319.1
UniGeneiHs.333179

Genome annotation databases

EnsembliENST00000323319; ENSP00000318113; ENSG00000177300
GeneIDi53842
KEGGihsa:53842
UCSCiuc010isa.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093844 Genomic DNA No translation available.
AK098064 mRNA No translation available.
CCDSiCCDS43286.1
RefSeqiNP_001104789.1, NM_001111319.1
UniGeneiHs.333179

3D structure databases

ProteinModelPortaliQ8N7P3
SMRiQ8N7P3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8N7P3, 7 interactors
STRINGi9606.ENSP00000318113

Protein family/group databases

TCDBi1.H.1.1.3 the claudin tight junction (claudin1) family

Polymorphism and mutation databases

BioMutaiCLDN22
DMDMi62298548

Proteomic databases

PaxDbiQ8N7P3
PeptideAtlasiQ8N7P3
PRIDEiQ8N7P3
ProteomicsDBi72315

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000323319; ENSP00000318113; ENSG00000177300
GeneIDi53842
KEGGihsa:53842
UCSCiuc010isa.2 human

Organism-specific databases

CTDi53842
EuPathDBiHostDB:ENSG00000177300.6
GeneCardsiCLDN22
HGNCiHGNC:2044 CLDN22
neXtProtiNX_Q8N7P3
OpenTargetsiENSG00000177300
PharmGKBiPA26570
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410INS5 Eukaryota
ENOG4111QE3 LUCA
GeneTreeiENSGT00760000119222
HOGENOMiHOG000220937
HOVERGENiHBG104065
InParanoidiQ8N7P3
KOiK06087
OMAiNYLPQWK
OrthoDBiEOG091G0QQ0
PhylomeDBiQ8N7P3
TreeFamiTF331936

Enzyme and pathway databases

ReactomeiR-HSA-420029 Tight junction interactions

Miscellaneous databases

GeneWikiiCLDN22
GenomeRNAii53842
PROiPR:Q8N7P3

Gene expression databases

BgeeiENSG00000177300 Expressed in 66 organ(s), highest expression level in right lobe of liver

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCLD22_HUMAN
AccessioniPrimary (citable) accession number: Q8N7P3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: March 29, 2005
Last modified: November 7, 2018
This is version 113 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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