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Protein

Inactive phospholipase D5

Gene

PLD5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

In contrast to other members of the family, it lacks the conserved active sites, suggesting that it has no phospholipase activity.Curated

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive phospholipase D5
Short name:
Inactive PLD 5
Alternative name(s):
Inactive choline phosphatase 5
Inactive phosphatidylcholine-hydrolyzing phospholipase D5
PLDc
Gene namesi
Name:PLD5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000180287.16
HGNCiHGNC:26879 PLD5
neXtProtiNX_Q8N7P1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei69 – 89HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi200150
OpenTargetsiENSG00000180287
PharmGKBiPA142671168

Polymorphism and mutation databases

BioMutaiPLD5
DMDMi152112223

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002886061 – 536Inactive phospholipase D5Add BLAST536

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi121N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi302N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8N7P1
PaxDbiQ8N7P1
PeptideAtlasiQ8N7P1
PRIDEiQ8N7P1
ProteomicsDBi72311
72312 [Q8N7P1-2]
72313 [Q8N7P1-3]
72314 [Q8N7P1-4]

PTM databases

iPTMnetiQ8N7P1
PhosphoSitePlusiQ8N7P1

Expressioni

Gene expression databases

BgeeiENSG00000180287 Expressed in 111 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_PLD5
ExpressionAtlasiQ8N7P1 baseline and differential
GenevisibleiQ8N7P1 HS

Organism-specific databases

HPAiHPA028389
HPA050367

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000440896

Structurei

3D structure databases

ProteinModelPortaliQ8N7P1
SMRiQ8N7P1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini215 – 242PLD phosphodiesterase 1Add BLAST28
Domaini434 – 460PLD phosphodiesterase 2Add BLAST27

Sequence similaritiesi

Belongs to the phospholipase D family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3603 Eukaryota
ENOG410XQZ4 LUCA
GeneTreeiENSGT00390000009798
HOGENOMiHOG000293407
HOVERGENiHBG108266
InParanoidiQ8N7P1
KOiK16861
OMAiERDWYSH
OrthoDBiEOG091G07LR
PhylomeDBiQ8N7P1
TreeFamiTF313378

Family and domain databases

InterProiView protein in InterPro
IPR032803 PLDc_3
IPR001736 PLipase_D/transphosphatidylase
PfamiView protein in Pfam
PF13918 PLDc_3, 1 hit
SMARTiView protein in SMART
SM00155 PLDc, 2 hits

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N7P1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEIRQHEWLS ASPHEGFEQM RLKSRPKEPS PSLTRVGANF YSSVKQQDYS
60 70 80 90 100
ASVWLRRKDK LEHSQQKCIV IFALVCCFAI LVALIFSAVD IMGEDEDGLS
110 120 130 140 150
EKNCQNKCRI ALVENIPEGL NYSENAPFHL SLFQGWMNLL NMAKKSVDIV
160 170 180 190 200
SSHWDLNHTH PSACQGQRLF EKLLQLTSQN IEIKLVSDVT ADSKVLEALK
210 220 230 240 250
LKGAEVTYMN MTAYNKGRLQ SSFWIVDKQH VYIGSAGLDW QSLGQMKELG
260 270 280 290 300
VIFYNCSCLV LDLQRIFALY SSLKFKSRVP QTWSKRLYGV YDNEKKLQLQ
310 320 330 340 350
LNETKSQAFV SNSPKLFCPK NRSFDIDAIY SVIDDAKQYV YIAVMDYLPI
360 370 380 390 400
SSTSTKRTYW PDLDAKIREA LVLRSVRVRL LLSFWKETDP LTFNFISSLK
410 420 430 440 450
AICTEIANCS LKVKFFDLER ENACATKEQK NHTFPRLNRN KYMVTDGAAY
460 470 480 490 500
IGNFDWVGND FTQNAGTGLV INQADVRNNR SIIKQLKDVF ERDWYSPYAK
510 520 530
TLQPTKQPNC SSLFKLKPLS NKTATDDTGG KDPRNV
Length:536
Mass (Da):61,312
Last modified:May 29, 2007 - v2
Checksum:i2FC94D6AB4A19934
GO
Isoform 2 (identifier: Q8N7P1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-108: MEIRQHEWLS...LSEKNCQNKC → MRMDSQKKIAKINVGK

Note: No experimental confirmation available.
Show »
Length:444
Mass (Da):50,795
Checksum:i71582866A7BE84DC
GO
Isoform 3 (identifier: Q8N7P1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-208: Missing.

Show »
Length:328
Mass (Da):37,736
Checksum:i38A06E30E98C3D57
GO
Isoform 4 (identifier: Q8N7P1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-62: Missing.
     63-63: H → M

Show »
Length:474
Mass (Da):53,990
Checksum:iD8B8CBD3D9DB4436
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5GXZ8F5GXZ8_HUMAN
Inactive phospholipase D5
PLD5
197Annotation score:
J3KP61J3KP61_HUMAN
Inactive phospholipase D5
PLD5
109Annotation score:
F8W7H1F8W7H1_HUMAN
Inactive phospholipase D5
PLD5
47Annotation score:
F5H329F5H329_HUMAN
Inactive phospholipase D5
PLD5
140Annotation score:

Sequence cautioni

The sequence AAI01374 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI01375 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI01376 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0257241 – 208Missing in isoform 3. 1 PublicationAdd BLAST208
Alternative sequenceiVSP_0257251 – 108MEIRQ…CQNKC → MRMDSQKKIAKINVGK in isoform 2. 1 PublicationAdd BLAST108
Alternative sequenceiVSP_0257261 – 62Missing in isoform 4. 2 PublicationsAdd BLAST62
Alternative sequenceiVSP_02572763H → M in isoform 4. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY461578 mRNA Translation: AAS91020.1
AK091691 mRNA Translation: BAC03722.1
AK098092 mRNA Translation: BAC05230.1
AK295421 mRNA Translation: BAH12060.1
AL360271 Genomic DNA No translation available.
AL583845 Genomic DNA No translation available.
AL591686 Genomic DNA No translation available.
AL445704 Genomic DNA No translation available.
BC101373 mRNA Translation: AAI01374.1 Different initiation.
BC101374 mRNA Translation: AAI01375.1 Different initiation.
BC101375 mRNA Translation: AAI01376.1 Different initiation.
CCDSiCCDS1621.2 [Q8N7P1-1]
CCDS55692.1 [Q8N7P1-4]
RefSeqiNP_001182740.1, NM_001195811.1 [Q8N7P1-4]
NP_001182741.1, NM_001195812.1 [Q8N7P1-3]
NP_001307201.1, NM_001320272.1 [Q8N7P1-2]
NP_689879.2, NM_152666.2 [Q8N7P1-1]
XP_006711815.1, XM_006711752.2 [Q8N7P1-1]
XP_011542417.1, XM_011544115.2
XP_011542418.1, XM_011544116.2
XP_011542422.1, XM_011544120.2 [Q8N7P1-3]
XP_011542423.1, XM_011544121.2 [Q8N7P1-3]
XP_011542424.1, XM_011544122.2 [Q8N7P1-3]
XP_016856056.1, XM_017000567.1 [Q8N7P1-2]
XP_016856057.1, XM_017000568.1 [Q8N7P1-2]
XP_016856058.1, XM_017000569.1 [Q8N7P1-3]
XP_016856059.1, XM_017000570.1 [Q8N7P1-3]
UniGeneiHs.672452

Genome annotation databases

EnsembliENST00000427495; ENSP00000401285; ENSG00000180287 [Q8N7P1-4]
ENST00000442594; ENSP00000414188; ENSG00000180287 [Q8N7P1-1]
ENST00000536534; ENSP00000440896; ENSG00000180287 [Q8N7P1-1]
GeneIDi200150
KEGGihsa:200150
UCSCiuc001hzl.4 human [Q8N7P1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY461578 mRNA Translation: AAS91020.1
AK091691 mRNA Translation: BAC03722.1
AK098092 mRNA Translation: BAC05230.1
AK295421 mRNA Translation: BAH12060.1
AL360271 Genomic DNA No translation available.
AL583845 Genomic DNA No translation available.
AL591686 Genomic DNA No translation available.
AL445704 Genomic DNA No translation available.
BC101373 mRNA Translation: AAI01374.1 Different initiation.
BC101374 mRNA Translation: AAI01375.1 Different initiation.
BC101375 mRNA Translation: AAI01376.1 Different initiation.
CCDSiCCDS1621.2 [Q8N7P1-1]
CCDS55692.1 [Q8N7P1-4]
RefSeqiNP_001182740.1, NM_001195811.1 [Q8N7P1-4]
NP_001182741.1, NM_001195812.1 [Q8N7P1-3]
NP_001307201.1, NM_001320272.1 [Q8N7P1-2]
NP_689879.2, NM_152666.2 [Q8N7P1-1]
XP_006711815.1, XM_006711752.2 [Q8N7P1-1]
XP_011542417.1, XM_011544115.2
XP_011542418.1, XM_011544116.2
XP_011542422.1, XM_011544120.2 [Q8N7P1-3]
XP_011542423.1, XM_011544121.2 [Q8N7P1-3]
XP_011542424.1, XM_011544122.2 [Q8N7P1-3]
XP_016856056.1, XM_017000567.1 [Q8N7P1-2]
XP_016856057.1, XM_017000568.1 [Q8N7P1-2]
XP_016856058.1, XM_017000569.1 [Q8N7P1-3]
XP_016856059.1, XM_017000570.1 [Q8N7P1-3]
UniGeneiHs.672452

3D structure databases

ProteinModelPortaliQ8N7P1
SMRiQ8N7P1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000440896

PTM databases

iPTMnetiQ8N7P1
PhosphoSitePlusiQ8N7P1

Polymorphism and mutation databases

BioMutaiPLD5
DMDMi152112223

Proteomic databases

EPDiQ8N7P1
PaxDbiQ8N7P1
PeptideAtlasiQ8N7P1
PRIDEiQ8N7P1
ProteomicsDBi72311
72312 [Q8N7P1-2]
72313 [Q8N7P1-3]
72314 [Q8N7P1-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000427495; ENSP00000401285; ENSG00000180287 [Q8N7P1-4]
ENST00000442594; ENSP00000414188; ENSG00000180287 [Q8N7P1-1]
ENST00000536534; ENSP00000440896; ENSG00000180287 [Q8N7P1-1]
GeneIDi200150
KEGGihsa:200150
UCSCiuc001hzl.4 human [Q8N7P1-1]

Organism-specific databases

CTDi200150
DisGeNETi200150
EuPathDBiHostDB:ENSG00000180287.16
GeneCardsiPLD5
HGNCiHGNC:26879 PLD5
HPAiHPA028389
HPA050367
neXtProtiNX_Q8N7P1
OpenTargetsiENSG00000180287
PharmGKBiPA142671168
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3603 Eukaryota
ENOG410XQZ4 LUCA
GeneTreeiENSGT00390000009798
HOGENOMiHOG000293407
HOVERGENiHBG108266
InParanoidiQ8N7P1
KOiK16861
OMAiERDWYSH
OrthoDBiEOG091G07LR
PhylomeDBiQ8N7P1
TreeFamiTF313378

Miscellaneous databases

ChiTaRSiPLD5 human
GeneWikiiPLD5
GenomeRNAii200150
PROiPR:Q8N7P1

Gene expression databases

BgeeiENSG00000180287 Expressed in 111 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_PLD5
ExpressionAtlasiQ8N7P1 baseline and differential
GenevisibleiQ8N7P1 HS

Family and domain databases

InterProiView protein in InterPro
IPR032803 PLDc_3
IPR001736 PLipase_D/transphosphatidylase
PfamiView protein in Pfam
PF13918 PLDc_3, 1 hit
SMARTiView protein in SMART
SM00155 PLDc, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPLD5_HUMAN
AccessioniPrimary (citable) accession number: Q8N7P1
Secondary accession number(s): A1KXV0
, B7Z324, Q494U9, Q8NB22
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: November 7, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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