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UniProtKB - Q8N7L0 (F216B_HUMAN)

Entry version 112 (02 Jun 2021)
Sequence version 1 (01 Oct 2002)
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Protein

Protein FAM216B

Gene

FAM216B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8N7L0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FAM216B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAM216B
Synonyms:C13orf30
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:26883, FAM216B

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8N7L0

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000179813.6

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000179813

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA147358510

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8N7L0, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		FAM216B

Domain mapping of disease mutations (DMDM)

More...DMDMi		74729231

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002637281 – 139Protein FAM216BAdd BLAST139

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8N7L0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8N7L0

PeptideAtlas

More...PeptideAtlasi		Q8N7L0

PRoteomics IDEntifications database

More...PRIDEi		Q8N7L0

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		72305

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000179813, Expressed in bronchial epithelial cell and 67 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8N7L0, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000179813, Tissue enhanced (brain, epididymis, fallopian tube, lung, ovary)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		126878, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000445786

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8N7L0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM216 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502SAWN, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154512

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_125533_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8N7L0

Identification of Orthologs from Complete Genome Data

More...OMAi		RVPHSIY

Database of Orthologous Groups

More...OrthoDBi		1521353at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8N7L0

TreeFam database of animal gene trees

More...TreeFami		TF337013

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029373, FAM216

The PANTHER Classification System

More...PANTHERi		PTHR16476, PTHR16476, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15107, FAM216B, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8N7L0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGQNWKRQQK LWNVPQLPFI RVPPSIYDTS LLKALNQGQQ RYFYSIMRIY 
        60         70         80         90        100
NSRPQWEALQ TRYIHSLQHQ QLLGYITQRE ALSYALVLRD STKRASAKVA 
       110        120        130 
PQRTIPRKTS AMTRRCPSVL PVSVVLPRAQ SKRRQVLRN
Length:139
Mass (Da):16,362
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1D4FBB5144446FAD
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_033743134R → C. Corresponds to variant dbSNP:rs35889214Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK098238 mRNA Translation: BAC05268.1
AL138819 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08682.1
BC093659 mRNA Translation: AAH93659.1
BC112237 mRNA Translation: AAI12238.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS9386.1

NCBI Reference Sequences

More...RefSeqi		NP_001305861.1, NM_001318932.1
NP_872314.1, NM_182508.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000313851; ENSP00000319336; ENSG00000179813
ENST00000537894; ENSP00000445786; ENSG00000179813

Database of genes from NCBI RefSeq genomes

More...GeneIDi		144809

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:144809

UCSC genome browser

More...UCSCi		uc010tfk.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098238 mRNA Translation: BAC05268.1
AL138819 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08682.1
BC093659 mRNA Translation: AAH93659.1
BC112237 mRNA Translation: AAI12238.1
CCDSiCCDS9386.1
RefSeqiNP_001305861.1, NM_001318932.1
NP_872314.1, NM_182508.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi126878, 1 interactor
STRINGi9606.ENSP00000445786

Genetic variation databases

BioMutaiFAM216B
DMDMi74729231

Proteomic databases

MassIVEiQ8N7L0
PaxDbiQ8N7L0
PeptideAtlasiQ8N7L0
PRIDEiQ8N7L0
ProteomicsDBi72305

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		42211, 47 antibodies

The DNASU plasmid repository

More...DNASUi		144809

Genome annotation databases

EnsembliENST00000313851; ENSP00000319336; ENSG00000179813
ENST00000537894; ENSP00000445786; ENSG00000179813
GeneIDi144809
KEGGihsa:144809
UCSCiuc010tfk.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		144809

GeneCards: human genes, protein and diseases

More...GeneCardsi		FAM216B
HGNCiHGNC:26883, FAM216B
HPAiENSG00000179813, Tissue enhanced (brain, epididymis, fallopian tube, lung, ovary)
neXtProtiNX_Q8N7L0
OpenTargetsiENSG00000179813
PharmGKBiPA147358510
VEuPathDBiHostDB:ENSG00000179813.6

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502SAWN, Eukaryota
GeneTreeiENSGT00940000154512
HOGENOMiCLU_125533_0_0_1
InParanoidiQ8N7L0
OMAiRVPHSIY
OrthoDBi1521353at2759
PhylomeDBiQ8N7L0
TreeFamiTF337013

Enzyme and pathway databases

PathwayCommonsiQ8N7L0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		144809, 11 hits in 979 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		144809
PharosiQ8N7L0, Tdark

Protein Ontology

More...PROi		PR:Q8N7L0
RNActiQ8N7L0, protein

Gene expression databases

BgeeiENSG00000179813, Expressed in bronchial epithelial cell and 67 other tissues
GenevisibleiQ8N7L0, HS

Family and domain databases

InterProiView protein in InterPro
IPR029373, FAM216
PANTHERiPTHR16476, PTHR16476, 1 hit
PfamiView protein in Pfam
PF15107, FAM216B, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF216B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N7L0
Secondary accession number(s): B1ALI3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 1, 2002
Last modified: June 2, 2021
This is version 112 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. SIMILARITY comments
    Index of protein domains and families
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