UniProtKB - Q8N7K0 (ZN433_HUMAN)
Protein
Zinc finger protein 433
Gene
ZNF433
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 142 – 164 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 170 – 192 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 198 – 220 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 226 – 248 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 254 – 276 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 282 – 304 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 310 – 332 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 338 – 360 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 366 – 388 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 394 – 416 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 422 – 444 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 450 – 472 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 478 – 500 | C2H2-type 13; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 506 – 528 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 534 – 556 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 562 – 584 | C2H2-type 16PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 590 – 612 | C2H2-type 17PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 618 – 640 | C2H2-type 18PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 646 – 668 | C2H2-type 19PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q8N7K0 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 433 |
Gene namesi | Name:ZNF433 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20811, ZNF433 |
neXtProti | NX_Q8N7K0 |
VEuPathDBi | HostDB:ENSG00000197647.11 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 163059 |
OpenTargetsi | ENSG00000197647 |
PharmGKBi | PA134943717 |
Miscellaneous databases
Pharosi | Q8N7K0, Tdark |
Genetic variation databases
BioMutai | ZNF433 |
DMDMi | 30173446 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047581 | 1 – 673 | Zinc finger protein 433Add BLAST | 673 |
Proteomic databases
jPOSTi | Q8N7K0 |
MassIVEi | Q8N7K0 |
MaxQBi | Q8N7K0 |
PaxDbi | Q8N7K0 |
PeptideAtlasi | Q8N7K0 |
PRIDEi | Q8N7K0 |
ProteomicsDBi | 72301 [Q8N7K0-1] 72302 [Q8N7K0-2] |
PTM databases
iPTMneti | Q8N7K0 |
PhosphoSitePlusi | Q8N7K0 |
Expressioni
Gene expression databases
Bgeei | ENSG00000197647, Expressed in testis and 114 other tissues |
ExpressionAtlasi | Q8N7K0, baseline and differential |
Organism-specific databases
HPAi | ENSG00000197647, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ8N7K0
Protein-protein interaction databases
BioGRIDi | 127846, 9 interactors |
IntActi | Q8N7K0, 7 interactors |
STRINGi | 9606.ENSP00000339767 |
Miscellaneous databases
RNActi | Q8N7K0, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 7 – 85 | KRABPROSITE-ProRule annotationAdd BLAST | 79 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 142 – 164 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 170 – 192 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 198 – 220 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 226 – 248 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 254 – 276 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 282 – 304 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 310 – 332 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 338 – 360 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 366 – 388 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 394 – 416 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 422 – 444 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 450 – 472 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 478 – 500 | C2H2-type 13; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 506 – 528 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 534 – 556 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 562 – 584 | C2H2-type 16PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 590 – 612 | C2H2-type 17PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 618 – 640 | C2H2-type 18PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 646 – 668 | C2H2-type 19PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00950000182755 |
HOGENOMi | CLU_002678_17_1_1 |
InParanoidi | Q8N7K0 |
OMAi | CQIHEKS |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8N7K0 |
TreeFami | TF343410 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 11 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 19 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 10 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 18 hits PS50157, ZINC_FINGER_C2H2_2, 19 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8N7K0-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MMFQDSVAFE DVAVTFTQEE WALLDPSQKN LCRDVMQETF RNLASIGKKW
60 70 80 90 100
KPQNIYVEYE NLRRNLRIVG ERLFESKEGH QHGEILTQVP DDMLKKTTTG
110 120 130 140 150
VKSCESSVYG EVGSAHSSLN RHIRDDTGHK AYEYQEYGQK PYKCKYCKKP
160 170 180 190 200
FNCLSSVQTH ERAHSGRKLY VCEECGKTFI SHSNLQRHRI MHRGDGPYKC
210 220 230 240 250
KFCGKALMFL SLYLIHKRTH TGEKPYQCKQ CGKAFSHSSS LRIHERTHTG
260 270 280 290 300
EKPYKCNECG KAFHSSTCLH AHKRTHTGEK PYECKQCGKA FSSSHSFQIH
310 320 330 340 350
ERTHTGEKPY ECKECGKAFK CPSSVRRHER THSRKKPYEC KHCGKVLSYL
360 370 380 390 400
TSFQNHLGMH TGEISHKCKI CGKAFYSPSS LQTHEKTHTG EKPYKCNQCG
410 420 430 440 450
KAFNSSSSFR YHERTHTGEK PYECKQCGKA FRSASLLQTH GRTHTGEKPY
460 470 480 490 500
ACKECGKPFS NFSFFQIHER MHREEKPYEC KGYGKTFSLP SLFHRHERTH
510 520 530 540 550
TGGKTYECKQ CGRSFNCSSS FRYHGRTHTG EKPYECKQCG KAFRSASQLQ
560 570 580 590 600
IHGRTHTGEK PYECKQCGKA FGSASHLQMH GRTHTGEKPY ECKQCGKSFG
610 620 630 640 650
CASRLQMHGR THTGEKPYKC KQCGKAFGCP SNLRRHGRTH TGEKPYKCNQ
660 670
CGKVFRCSSQ LQVHGRAHCI DTP
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JQA6 | C9JQA6_HUMAN | Zinc finger protein 433 | ZNF433 | 166 | Annotation score: | ||
F8VU36 | F8VU36_HUMAN | Zinc finger protein 433 | ZNF433 | 117 | Annotation score: | ||
F8VTV7 | F8VTV7_HUMAN | Zinc finger protein 433 | ZNF433 | 207 | Annotation score: | ||
C9JUV2 | C9JUV2_HUMAN | Zinc finger protein 433 | ZNF433 | 77 | Annotation score: | ||
F8W0C9 | F8W0C9_HUMAN | Zinc finger protein 433 | ZNF433 | 77 | Annotation score: | ||
F8VXJ9 | F8VXJ9_HUMAN | Zinc finger protein 433 | ZNF433 | 52 | Annotation score: | ||
F8VP42 | F8VP42_HUMAN | Zinc finger protein 433 | ZNF433 | 41 | Annotation score: | ||
F8W652 | F8W652_HUMAN | Zinc finger protein 433 | ZNF433 | 119 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_035523 | 1 – 35 | Missing in isoform 2. 1 PublicationAdd BLAST | 35 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK098300 mRNA Translation: BAC05279.1 CH471106 Genomic DNA Translation: EAW84254.1 BC047412 mRNA Translation: AAH47412.1 |
CCDSi | CCDS45983.1 [Q8N7K0-1] CCDS77240.1 [Q8N7K0-2] |
RefSeqi | NP_001073880.1, NM_001080411.2 [Q8N7K0-1] NP_001295275.1, NM_001308346.1 NP_001295277.1, NM_001308348.1 NP_001295280.1, NM_001308351.1 [Q8N7K0-2] NP_001295284.1, NM_001308355.1 [Q8N7K0-2] NP_001295286.1, NM_001308357.1 [Q8N7K0-2] XP_006722724.1, XM_006722661.3 [Q8N7K0-2] |
Genome annotation databases
Ensembli | ENST00000344980; ENSP00000339767; ENSG00000197647 [Q8N7K0-1] ENST00000419886; ENSP00000393416; ENSG00000197647 [Q8N7K0-2] |
GeneIDi | 163059 |
KEGGi | hsa:163059 |
UCSCi | uc002msy.2, human [Q8N7K0-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK098300 mRNA Translation: BAC05279.1 CH471106 Genomic DNA Translation: EAW84254.1 BC047412 mRNA Translation: AAH47412.1 |
CCDSi | CCDS45983.1 [Q8N7K0-1] CCDS77240.1 [Q8N7K0-2] |
RefSeqi | NP_001073880.1, NM_001080411.2 [Q8N7K0-1] NP_001295275.1, NM_001308346.1 NP_001295277.1, NM_001308348.1 NP_001295280.1, NM_001308351.1 [Q8N7K0-2] NP_001295284.1, NM_001308355.1 [Q8N7K0-2] NP_001295286.1, NM_001308357.1 [Q8N7K0-2] XP_006722724.1, XM_006722661.3 [Q8N7K0-2] |
3D structure databases
SMRi | Q8N7K0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 127846, 9 interactors |
IntActi | Q8N7K0, 7 interactors |
STRINGi | 9606.ENSP00000339767 |
PTM databases
iPTMneti | Q8N7K0 |
PhosphoSitePlusi | Q8N7K0 |
Genetic variation databases
BioMutai | ZNF433 |
DMDMi | 30173446 |
Proteomic databases
jPOSTi | Q8N7K0 |
MassIVEi | Q8N7K0 |
MaxQBi | Q8N7K0 |
PaxDbi | Q8N7K0 |
PeptideAtlasi | Q8N7K0 |
PRIDEi | Q8N7K0 |
ProteomicsDBi | 72301 [Q8N7K0-1] 72302 [Q8N7K0-2] |
Protocols and materials databases
Antibodypediai | 25988, 133 antibodies |
DNASUi | 163059 |
Genome annotation databases
Ensembli | ENST00000344980; ENSP00000339767; ENSG00000197647 [Q8N7K0-1] ENST00000419886; ENSP00000393416; ENSG00000197647 [Q8N7K0-2] |
GeneIDi | 163059 |
KEGGi | hsa:163059 |
UCSCi | uc002msy.2, human [Q8N7K0-1] |
Organism-specific databases
CTDi | 163059 |
DisGeNETi | 163059 |
GeneCardsi | ZNF433 |
HGNCi | HGNC:20811, ZNF433 |
HPAi | ENSG00000197647, Low tissue specificity |
neXtProti | NX_Q8N7K0 |
OpenTargetsi | ENSG00000197647 |
PharmGKBi | PA134943717 |
VEuPathDBi | HostDB:ENSG00000197647.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00950000182755 |
HOGENOMi | CLU_002678_17_1_1 |
InParanoidi | Q8N7K0 |
OMAi | CQIHEKS |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8N7K0 |
TreeFami | TF343410 |
Enzyme and pathway databases
PathwayCommonsi | Q8N7K0 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 163059, 5 hits in 878 CRISPR screens |
ChiTaRSi | ZNF433, human |
GenomeRNAii | 163059 |
Pharosi | Q8N7K0, Tdark |
PROi | PR:Q8N7K0 |
RNActi | Q8N7K0, protein |
Gene expression databases
Bgeei | ENSG00000197647, Expressed in testis and 114 other tissues |
ExpressionAtlasi | Q8N7K0, baseline and differential |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 11 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 19 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 10 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 18 hits PS50157, ZINC_FINGER_C2H2_2, 19 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN433_HUMAN | |
Accessioni | Q8N7K0Primary (citable) accession number: Q8N7K0 Secondary accession number(s): Q86VX3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 23, 2003 |
Last sequence update: | October 1, 2002 | |
Last modified: | February 10, 2021 | |
This is version 154 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM