UniProtKB - Q8N7K0 (ZN433_HUMAN)

BLAST

>sp|Q8N7K0|ZN433_HUMAN Zinc finger protein 433 OS=Homo sapiens OX=9606 GN=ZNF433 PE=1 SV=1
MMFQDSVAFEDVAVTFTQEEWALLDPSQKNLCRDVMQETFRNLASIGKKWKPQNIYVEYE
NLRRNLRIVGERLFESKEGHQHGEILTQVPDDMLKKTTTGVKSCESSVYGEVGSAHSSLN
RHIRDDTGHKAYEYQEYGQKPYKCKYCKKPFNCLSSVQTHERAHSGRKLYVCEECGKTFI
SHSNLQRHRIMHRGDGPYKCKFCGKALMFLSLYLIHKRTHTGEKPYQCKQCGKAFSHSSS
LRIHERTHTGEKPYKCNECGKAFHSSTCLHAHKRTHTGEKPYECKQCGKAFSSSHSFQIH
ERTHTGEKPYECKECGKAFKCPSSVRRHERTHSRKKPYECKHCGKVLSYLTSFQNHLGMH
TGEISHKCKICGKAFYSPSSLQTHEKTHTGEKPYKCNQCGKAFNSSSSFRYHERTHTGEK
PYECKQCGKAFRSASLLQTHGRTHTGEKPYACKECGKPFSNFSFFQIHERMHREEKPYEC
KGYGKTFSLPSLFHRHERTHTGGKTYECKQCGRSFNCSSSFRYHGRTHTGEKPYECKQCG
KAFRSASQLQIHGRTHTGEKPYECKQCGKAFGSASHLQMHGRTHTGEKPYECKQCGKSFG
CASRLQMHGRTHTGEKPYKCKQCGKAFGCPSNLRRHGRTHTGEKPYKCNQCGKVFRCSSQ
LQVHGRAHCIDTP

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History
Entry version 137 (10 Oct 2018)
Sequence version 1 (01 Oct 2002)
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Protein

Zinc finger protein 433

Gene

ZNF433

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

May be involved in transcriptional regulation.

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	142 – 164	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	170 – 192	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	198 – 220	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	226 – 248	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	254 – 276	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	282 – 304	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	310 – 332	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	338 – 360	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	366 – 388	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	394 – 416	C2H2-type 10PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	422 – 444	C2H2-type 11PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	450 – 472	C2H2-type 12PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	478 – 500	C2H2-type 13; degeneratePROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	506 – 528	C2H2-type 14PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	534 – 556	C2H2-type 15PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	562 – 584	C2H2-type 16PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	590 – 612	C2H2-type 17PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	618 – 640	C2H2-type 18PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	646 – 668	C2H2-type 19PROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-212436 Generic Transcription Pathway

Reactomeⁱ

R-HSA-212436 Generic Transcription Pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein 433
Gene namesⁱ	Name:ZNF433
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000197647.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:20811 ZNF433
neXtProtⁱ	NX_Q8N7K0

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	163059
Open Targets More...OpenTargetsⁱ	ENSG00000197647
PharmGKBⁱ	PA134943717

Polymorphism and mutation databases

BioMutaⁱ	ZNF433
DMDMⁱ	30173446

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047581	1 – 673	Zinc finger protein 433Add BLAST		673

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8N7K0
PaxDbⁱ	Q8N7K0
PeptideAtlas More...PeptideAtlasⁱ	Q8N7K0
PRIDEⁱ	Q8N7K0
ProteomicsDBⁱ	72301 72302 [Q8N7K0-2]

PTM databases

iPTMnetⁱ	Q8N7K0
PhosphoSitePlusⁱ	Q8N7K0

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000197647 Expressed in 91 organ(s), highest expression level in testis
CleanExⁱ	HS_ZNF433
ExpressionAtlasⁱ	Q8N7K0 baseline and differential

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA073724

HPAⁱ

HPA073724

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
KRTAP10-5	P60370	3	EBI-10267553,EBI-10172150
KRTAP10-7	P60409	3	EBI-10267553,EBI-10172290
MDFI	Q99750	3	EBI-10267553,EBI-724076

Protein-protein interaction databases

BioGridⁱ	127846, 7 interactors
IntActⁱ	Q8N7K0, 5 interactors
STRINGⁱ	9606.ENSP00000339767

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8N7K0
SMRⁱ	Q8N7K0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	7 – 85	KRABPROSITE-ProRule annotationAdd BLAST		79

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	142 – 164	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	170 – 192	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	198 – 220	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	226 – 248	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	254 – 276	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	282 – 304	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	310 – 332	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	338 – 360	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	366 – 388	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	394 – 416	C2H2-type 10PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	422 – 444	C2H2-type 11PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	450 – 472	C2H2-type 12PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	478 – 500	C2H2-type 13; degeneratePROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	506 – 528	C2H2-type 14PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	534 – 556	C2H2-type 15PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	562 – 584	C2H2-type 16PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	590 – 612	C2H2-type 17PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	618 – 640	C2H2-type 18PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	646 – 668	C2H2-type 19PROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119089
HOGENOMⁱ	HOG000234617
HOVERGENⁱ	HBG018163
InParanoidⁱ	Q8N7K0
KEGG Orthology (KO) More...KOⁱ	K09228
OMAⁱ	RYHGRTH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02KC
PhylomeDBⁱ	Q8N7K0
TreeFamⁱ	TF343410

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd07765 KRAB_A-box, 1 hit
InterProⁱ	View protein in InterPro IPR001909 KRAB IPR036051 KRAB_dom_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01352 KRAB, 1 hit PF00096 zf-C2H2, 11 hits
SMARTⁱ	View protein in SMART SM00349 KRAB, 1 hit SM00355 ZnF_C2H2, 19 hits
SUPFAMⁱ	SSF109640 SSF109640, 1 hit SSF57667 SSF57667, 10 hits
PROSITEⁱ	View protein in PROSITE PS50805 KRAB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 18 hits PS50157 ZINC_FINGER_C2H2_2, 19 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q8N7K0-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMFQDSVAFE DVAVTFTQEE WALLDPSQKN LCRDVMQETF RNLASIGKKW 
        60         70         80         90        100
KPQNIYVEYE NLRRNLRIVG ERLFESKEGH QHGEILTQVP DDMLKKTTTG 
       110        120        130        140        150
VKSCESSVYG EVGSAHSSLN RHIRDDTGHK AYEYQEYGQK PYKCKYCKKP 
       160        170        180        190        200
FNCLSSVQTH ERAHSGRKLY VCEECGKTFI SHSNLQRHRI MHRGDGPYKC 
       210        220        230        240        250
KFCGKALMFL SLYLIHKRTH TGEKPYQCKQ CGKAFSHSSS LRIHERTHTG 
       260        270        280        290        300
EKPYKCNECG KAFHSSTCLH AHKRTHTGEK PYECKQCGKA FSSSHSFQIH 
       310        320        330        340        350
ERTHTGEKPY ECKECGKAFK CPSSVRRHER THSRKKPYEC KHCGKVLSYL 
       360        370        380        390        400
TSFQNHLGMH TGEISHKCKI CGKAFYSPSS LQTHEKTHTG EKPYKCNQCG 
       410        420        430        440        450
KAFNSSSSFR YHERTHTGEK PYECKQCGKA FRSASLLQTH GRTHTGEKPY 
       460        470        480        490        500
ACKECGKPFS NFSFFQIHER MHREEKPYEC KGYGKTFSLP SLFHRHERTH 
       510        520        530        540        550
TGGKTYECKQ CGRSFNCSSS FRYHGRTHTG EKPYECKQCG KAFRSASQLQ 
       560        570        580        590        600
IHGRTHTGEK PYECKQCGKA FGSASHLQMH GRTHTGEKPY ECKQCGKSFG 
       610        620        630        640        650
CASRLQMHGR THTGEKPYKC KQCGKAFGCP SNLRRHGRTH TGEKPYKCNQ 
       660        670 
CGKVFRCSSQ LQVHGRAHCI DTP

Length:673

Mass (Da):77,243

Last modified:October 1, 2002 - v1

Checksum:ⁱ8C8B1B6D272D08FC

Isoform 2 (identifier: Q8N7K0-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-35: Missing.

« Hide

        10         20         30         40         50
MQETFRNLAS IGKKWKPQNI YVEYENLRRN LRIVGERLFE SKEGHQHGEI 
        60         70         80         90        100
LTQVPDDMLK KTTTGVKSCE SSVYGEVGSA HSSLNRHIRD DTGHKAYEYQ 
       110        120        130        140        150
EYGQKPYKCK YCKKPFNCLS SVQTHERAHS GRKLYVCEEC GKTFISHSNL 
       160        170        180        190        200
QRHRIMHRGD GPYKCKFCGK ALMFLSLYLI HKRTHTGEKP YQCKQCGKAF 
       210        220        230        240        250
SHSSSLRIHE RTHTGEKPYK CNECGKAFHS STCLHAHKRT HTGEKPYECK 
       260        270        280        290        300
QCGKAFSSSH SFQIHERTHT GEKPYECKEC GKAFKCPSSV RRHERTHSRK 
       310        320        330        340        350
KPYECKHCGK VLSYLTSFQN HLGMHTGEIS HKCKICGKAF YSPSSLQTHE 
       360        370        380        390        400
KTHTGEKPYK CNQCGKAFNS SSSFRYHERT HTGEKPYECK QCGKAFRSAS 
       410        420        430        440        450
LLQTHGRTHT GEKPYACKEC GKPFSNFSFF QIHERMHREE KPYECKGYGK 
       460        470        480        490        500
TFSLPSLFHR HERTHTGGKT YECKQCGRSF NCSSSFRYHG RTHTGEKPYE 
       510        520        530        540        550
CKQCGKAFRS ASQLQIHGRT HTGEKPYECK QCGKAFGSAS HLQMHGRTHT 
       560        570        580        590        600
GEKPYECKQC GKSFGCASRL QMHGRTHTGE KPYKCKQCGK AFGCPSNLRR 
       610        620        630 
HGRTHTGEKP YKCNQCGKVF RCSSQLQVHG RAHCIDTP

Show »

Length:638

Mass (Da):73,196

Checksum:ⁱ4E05BFC8FB53F1FD

Computationally mapped potential isoform sequencesⁱ

There are 8 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9JQA6	C9JQA6_HUMAN	Zinc finger protein 433 Zinc finger protein 433	ZNF433	166	Annotation score:
F8VU36	F8VU36_HUMAN	Zinc finger protein 433 Zinc finger protein 433	ZNF433	117	Annotation score:
F8VTV7	F8VTV7_HUMAN	Zinc finger protein 433 Zinc finger protein 433	ZNF433	207	Annotation score:
F8W0C9	F8W0C9_HUMAN	Zinc finger protein 433 Zinc finger protein 433	ZNF433	77	Annotation score:
C9JUV2	C9JUV2_HUMAN	Zinc finger protein 433 Zinc finger protein 433	ZNF433	77	Annotation score:
F8VXJ9	F8VXJ9_HUMAN	Zinc finger protein 433 Zinc finger protein 433	ZNF433	52	Annotation score:
F8W652	F8W652_HUMAN	Zinc finger protein 433 Zinc finger protein 433	ZNF433	119	Annotation score:
F8VP42	F8VP42_HUMAN	Zinc finger protein 433 Zinc finger protein 433	ZNF433	41	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_035523	1 – 35	Missing in isoform 2. 1 PublicationAdd BLAST		35

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK098300 mRNA Translation: BAC05279.1 CH471106 Genomic DNA Translation: EAW84254.1 BC047412 mRNA Translation: AAH47412.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS45983.1 [Q8N7K0-1] CCDS77240.1 [Q8N7K0-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001073880.1, NM_001080411.2 [Q8N7K0-1] NP_001295275.1, NM_001308346.1 NP_001295277.1, NM_001308348.1 NP_001295280.1, NM_001308351.1 [Q8N7K0-2] NP_001295284.1, NM_001308355.1 [Q8N7K0-2] NP_001295286.1, NM_001308357.1 [Q8N7K0-2] XP_006722724.1, XM_006722661.3 [Q8N7K0-2]
UniGeneⁱ	Hs.667776

Genome annotation databases

Ensemblⁱ	ENST00000344980; ENSP00000339767; ENSG00000197647 [Q8N7K0-1] ENST00000419886; ENSP00000393416; ENSG00000197647 [Q8N7K0-2]
GeneIDⁱ	163059
KEGGⁱ	hsa:163059
UCSC genome browser More...UCSCⁱ	uc002msy.2 human [Q8N7K0-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8N7K0	ZNF433 isoform 1		PANTR		724	UniRef90_Q8N7K0
Zinc finger protein 433 (Fragment)		MACMU		110
Zinc finger protein 433 (Fragment)		HUMAN		52
Uncharacterized protein		MACNE		676
Uncharacterized protein		PANPA		674
+86

Protein	Similar proteins		Species	Score	Length	Source
Q8N7K0	ZNF433 isoform 1		PANTR		724	UniRef50_Q8N7K0
Zinc finger protein 433 (Fragment)		MACMU		110
Zinc finger protein 433 (Fragment)		HUMAN		52
Uncharacterized protein		MACNE		676
Uncharacterized protein		MACFA		674
+98

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK098300 mRNA Translation: BAC05279.1 CH471106 Genomic DNA Translation: EAW84254.1 BC047412 mRNA Translation: AAH47412.1
CCDSⁱ	CCDS45983.1 [Q8N7K0-1] CCDS77240.1 [Q8N7K0-2]
RefSeqⁱ	NP_001073880.1, NM_001080411.2 [Q8N7K0-1] NP_001295275.1, NM_001308346.1 NP_001295277.1, NM_001308348.1 NP_001295280.1, NM_001308351.1 [Q8N7K0-2] NP_001295284.1, NM_001308355.1 [Q8N7K0-2] NP_001295286.1, NM_001308357.1 [Q8N7K0-2] XP_006722724.1, XM_006722661.3 [Q8N7K0-2]
UniGeneⁱ	Hs.667776

3D structure databases

ProteinModelPortalⁱ	Q8N7K0
SMRⁱ	Q8N7K0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	127846, 7 interactors
IntActⁱ	Q8N7K0, 5 interactors
STRINGⁱ	9606.ENSP00000339767

PTM databases

iPTMnetⁱ	Q8N7K0
PhosphoSitePlusⁱ	Q8N7K0

Polymorphism and mutation databases

BioMutaⁱ	ZNF433
DMDMⁱ	30173446

Proteomic databases

MaxQBⁱ	Q8N7K0
PaxDbⁱ	Q8N7K0
PeptideAtlasⁱ	Q8N7K0
PRIDEⁱ	Q8N7K0
ProteomicsDBⁱ	72301 72302 [Q8N7K0-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	163059
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000344980; ENSP00000339767; ENSG00000197647 [Q8N7K0-1] ENST00000419886; ENSP00000393416; ENSG00000197647 [Q8N7K0-2]
GeneIDⁱ	163059
KEGGⁱ	hsa:163059
UCSCⁱ	uc002msy.2 human [Q8N7K0-1]

Organism-specific databases

CTDⁱ	163059
DisGeNETⁱ	163059
EuPathDBⁱ	HostDB:ENSG00000197647.11
GeneCardsⁱ	ZNF433
HGNCⁱ	HGNC:20811 ZNF433
HPAⁱ	HPA073724
neXtProtⁱ	NX_Q8N7K0
OpenTargetsⁱ	ENSG00000197647
PharmGKBⁱ	PA134943717
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00760000119089
HOGENOMⁱ	HOG000234617
HOVERGENⁱ	HBG018163
InParanoidⁱ	Q8N7K0
KOⁱ	K09228
OMAⁱ	RYHGRTH
OrthoDBⁱ	EOG091G02KC
PhylomeDBⁱ	Q8N7K0
TreeFamⁱ	TF343410

Enzyme and pathway databases

Reactomeⁱ	R-HSA-212436 Generic Transcription Pathway

Reactomeⁱ

R-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

GenomeRNAiⁱ	163059
Protein Ontology More...PROⁱ	PR:Q8N7K0

Gene expression databases

Bgeeⁱ	ENSG00000197647 Expressed in 91 organ(s), highest expression level in testis
CleanExⁱ	HS_ZNF433
ExpressionAtlasⁱ	Q8N7K0 baseline and differential

Family and domain databases

CDDⁱ	cd07765 KRAB_A-box, 1 hit
InterProⁱ	View protein in InterPro IPR001909 KRAB IPR036051 KRAB_dom_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF01352 KRAB, 1 hit PF00096 zf-C2H2, 11 hits
SMARTⁱ	View protein in SMART SM00349 KRAB, 1 hit SM00355 ZnF_C2H2, 19 hits
SUPFAMⁱ	SSF109640 SSF109640, 1 hit SSF57667 SSF57667, 10 hits
PROSITEⁱ	View protein in PROSITE PS50805 KRAB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 18 hits PS50157 ZINC_FINGER_C2H2_2, 19 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZN433_HUMAN
Accessionⁱ	Q8N7K0Primary (citable) accession number: Q8N7K0 Secondary accession number(s): Q86VX3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 23, 2003
	Last sequence update:	October 1, 2002
	Last modified:	October 10, 2018
	This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8N7K0 (ZN433_HUMAN)

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Zinc finger protein 433

ZNF433

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ