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UniProtKB - Q8N7K0 (ZN433_HUMAN)

Entry version 155 (07 Apr 2021)
Sequence version 1 (01 Oct 2002)
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Protein

Zinc finger protein 433

Gene

ZNF433

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri142 – 164C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri170 – 192C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri198 – 220C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri226 – 248C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri254 – 276C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri282 – 304C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri310 – 332C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri338 – 360C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri366 – 388C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri394 – 416C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri422 – 444C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri450 – 472C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri478 – 500C2H2-type 13; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri506 – 528C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri534 – 556C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri562 – 584C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri590 – 612C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri618 – 640C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri646 – 668C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8N7K0

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-212436, Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 433
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF433
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:20811, ZNF433

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8N7K0

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000197647.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		163059

Open Targets

More...OpenTargetsi		ENSG00000197647

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134943717

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8N7K0, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZNF433

Domain mapping of disease mutations (DMDM)

More...DMDMi		30173446

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000475811 – 673Zinc finger protein 433Add BLAST673

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8N7K0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8N7K0

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8N7K0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8N7K0

PeptideAtlas

More...PeptideAtlasi		Q8N7K0

PRoteomics IDEntifications database

More...PRIDEi		Q8N7K0

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		72301 [Q8N7K0-1]
72302 [Q8N7K0-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8N7K0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8N7K0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000197647, Expressed in testis and 114 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8N7K0, baseline and differential

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000197647, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		127846, 9 interactors

Protein interaction database and analysis system

More...IntActi		Q8N7K0, 7 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000339767

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8N7K0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8N7K0

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini7 – 85KRABPROSITE-ProRule annotationAdd BLAST79

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri142 – 164C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri170 – 192C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri198 – 220C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri226 – 248C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri254 – 276C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri282 – 304C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri310 – 332C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri338 – 360C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri366 – 388C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri394 – 416C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri422 – 444C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri450 – 472C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri478 – 500C2H2-type 13; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri506 – 528C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri534 – 556C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri562 – 584C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri590 – 612C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri618 – 640C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri646 – 668C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182755

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002678_17_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8N7K0

Identification of Orthologs from Complete Genome Data

More...OMAi		CQIHEKS

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8N7K0

TreeFam database of animal gene trees

More...TreeFami		TF343410

Family and domain databases

Conserved Domains Database

More...CDDi		cd07765, KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 11 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 19 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 10 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 18 hits
PS50157, ZINC_FINGER_C2H2_2, 19 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N7K0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMFQDSVAFE DVAVTFTQEE WALLDPSQKN LCRDVMQETF RNLASIGKKW 
        60         70         80         90        100
KPQNIYVEYE NLRRNLRIVG ERLFESKEGH QHGEILTQVP DDMLKKTTTG 
       110        120        130        140        150
VKSCESSVYG EVGSAHSSLN RHIRDDTGHK AYEYQEYGQK PYKCKYCKKP 
       160        170        180        190        200
FNCLSSVQTH ERAHSGRKLY VCEECGKTFI SHSNLQRHRI MHRGDGPYKC 
       210        220        230        240        250
KFCGKALMFL SLYLIHKRTH TGEKPYQCKQ CGKAFSHSSS LRIHERTHTG 
       260        270        280        290        300
EKPYKCNECG KAFHSSTCLH AHKRTHTGEK PYECKQCGKA FSSSHSFQIH 
       310        320        330        340        350
ERTHTGEKPY ECKECGKAFK CPSSVRRHER THSRKKPYEC KHCGKVLSYL 
       360        370        380        390        400
TSFQNHLGMH TGEISHKCKI CGKAFYSPSS LQTHEKTHTG EKPYKCNQCG 
       410        420        430        440        450
KAFNSSSSFR YHERTHTGEK PYECKQCGKA FRSASLLQTH GRTHTGEKPY 
       460        470        480        490        500
ACKECGKPFS NFSFFQIHER MHREEKPYEC KGYGKTFSLP SLFHRHERTH 
       510        520        530        540        550
TGGKTYECKQ CGRSFNCSSS FRYHGRTHTG EKPYECKQCG KAFRSASQLQ 
       560        570        580        590        600
IHGRTHTGEK PYECKQCGKA FGSASHLQMH GRTHTGEKPY ECKQCGKSFG 
       610        620        630        640        650
CASRLQMHGR THTGEKPYKC KQCGKAFGCP SNLRRHGRTH TGEKPYKCNQ 
       660        670 
CGKVFRCSSQ LQVHGRAHCI DTP
Length:673
Mass (Da):77,243
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8C8B1B6D272D08FC
GO
Isoform 2 (identifier: Q8N7K0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: Missing.

Show »
Length:638
Mass (Da):73,196
Checksum:i4E05BFC8FB53F1FD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JQA6C9JQA6_HUMAN
Zinc finger protein 433
ZNF433
166Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VU36F8VU36_HUMAN
Zinc finger protein 433
ZNF433
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VTV7F8VTV7_HUMAN
Zinc finger protein 433
ZNF433
207Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JUV2C9JUV2_HUMAN
Zinc finger protein 433
ZNF433
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W0C9F8W0C9_HUMAN
Zinc finger protein 433
ZNF433
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VXJ9F8VXJ9_HUMAN
Zinc finger protein 433
ZNF433
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VP42F8VP42_HUMAN
Zinc finger protein 433
ZNF433
41Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W652F8W652_HUMAN
Zinc finger protein 433
ZNF433
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0355231 – 35Missing in isoform 2. 1 PublicationAdd BLAST35

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK098300 mRNA Translation: BAC05279.1
CH471106 Genomic DNA Translation: EAW84254.1
BC047412 mRNA Translation: AAH47412.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS45983.1 [Q8N7K0-1]
CCDS77240.1 [Q8N7K0-2]

NCBI Reference Sequences

More...RefSeqi		NP_001073880.1, NM_001080411.2 [Q8N7K0-1]
NP_001295275.1, NM_001308346.1
NP_001295277.1, NM_001308348.1
NP_001295280.1, NM_001308351.1 [Q8N7K0-2]
NP_001295284.1, NM_001308355.1 [Q8N7K0-2]
NP_001295286.1, NM_001308357.1 [Q8N7K0-2]
XP_006722724.1, XM_006722661.3 [Q8N7K0-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000344980; ENSP00000339767; ENSG00000197647 [Q8N7K0-1]
ENST00000419886; ENSP00000393416; ENSG00000197647 [Q8N7K0-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		163059

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:163059

UCSC genome browser

More...UCSCi		uc002msy.2, human [Q8N7K0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098300 mRNA Translation: BAC05279.1
CH471106 Genomic DNA Translation: EAW84254.1
BC047412 mRNA Translation: AAH47412.1
CCDSiCCDS45983.1 [Q8N7K0-1]
CCDS77240.1 [Q8N7K0-2]
RefSeqiNP_001073880.1, NM_001080411.2 [Q8N7K0-1]
NP_001295275.1, NM_001308346.1
NP_001295277.1, NM_001308348.1
NP_001295280.1, NM_001308351.1 [Q8N7K0-2]
NP_001295284.1, NM_001308355.1 [Q8N7K0-2]
NP_001295286.1, NM_001308357.1 [Q8N7K0-2]
XP_006722724.1, XM_006722661.3 [Q8N7K0-2]

3D structure databases

SMRiQ8N7K0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi127846, 9 interactors
IntActiQ8N7K0, 7 interactors
STRINGi9606.ENSP00000339767

PTM databases

iPTMnetiQ8N7K0
PhosphoSitePlusiQ8N7K0

Genetic variation databases

BioMutaiZNF433
DMDMi30173446

Proteomic databases

jPOSTiQ8N7K0
MassIVEiQ8N7K0
MaxQBiQ8N7K0
PaxDbiQ8N7K0
PeptideAtlasiQ8N7K0
PRIDEiQ8N7K0
ProteomicsDBi72301 [Q8N7K0-1]
72302 [Q8N7K0-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		25988, 135 antibodies

The DNASU plasmid repository

More...DNASUi		163059

Genome annotation databases

EnsembliENST00000344980; ENSP00000339767; ENSG00000197647 [Q8N7K0-1]
ENST00000419886; ENSP00000393416; ENSG00000197647 [Q8N7K0-2]
GeneIDi163059
KEGGihsa:163059
UCSCiuc002msy.2, human [Q8N7K0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		163059
DisGeNETi163059

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZNF433
HGNCiHGNC:20811, ZNF433
HPAiENSG00000197647, Low tissue specificity
neXtProtiNX_Q8N7K0
OpenTargetsiENSG00000197647
PharmGKBiPA134943717
VEuPathDBiHostDB:ENSG00000197647.11

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00950000182755
HOGENOMiCLU_002678_17_1_1
InParanoidiQ8N7K0
OMAiCQIHEKS
OrthoDBi1318335at2759
PhylomeDBiQ8N7K0
TreeFamiTF343410

Enzyme and pathway databases

PathwayCommonsiQ8N7K0
ReactomeiR-HSA-212436, Generic Transcription Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		163059, 5 hits in 987 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZNF433, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		163059
PharosiQ8N7K0, Tdark

Protein Ontology

More...PROi		PR:Q8N7K0
RNActiQ8N7K0, protein

Gene expression databases

BgeeiENSG00000197647, Expressed in testis and 114 other tissues
ExpressionAtlasiQ8N7K0, baseline and differential

Family and domain databases

CDDicd07765, KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 11 hits
SMARTiView protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 19 hits
SUPFAMiSSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 10 hits
PROSITEiView protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 18 hits
PS50157, ZINC_FINGER_C2H2_2, 19 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN433_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N7K0
Secondary accession number(s): Q86VX3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: October 1, 2002
Last modified: April 7, 2021
This is version 155 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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