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Protein

Transmembrane protein 217

Gene

TMEM217

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 217
Gene namesi
Name:TMEM217
Synonyms:C6orf128
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000172738.11
HGNCiHGNC:21238 TMEM217
neXtProtiNX_Q8N7C4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Transmembranei67 – 87HelicalSequence analysisAdd BLAST21
Transmembranei94 – 114HelicalSequence analysisAdd BLAST21
Transmembranei129 – 149HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi221468
OpenTargetsiENSG00000172738
PharmGKBiPA162406568

Polymorphism and mutation databases

BioMutaiTMEM217
DMDMi68565216

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000895281 – 229Transmembrane protein 217Add BLAST229

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi39N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi156N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8N7C4
PeptideAtlasiQ8N7C4
PRIDEiQ8N7C4
ProteomicsDBi72287
72288 [Q8N7C4-2]

Expressioni

Gene expression databases

BgeeiENSG00000172738
CleanExiHS_TMEM217
GenevisibleiQ8N7C4 HS

Organism-specific databases

HPAiHPA045432
HPA071187
HPA074578

Structurei

3D structure databases

ProteinModelPortaliQ8N7C4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IX9G Eukaryota
ENOG410YZ2V LUCA
GeneTreeiENSGT00730000111479
HOGENOMiHOG000121780
HOVERGENiHBG081110
InParanoidiQ8N7C4
OMAiWFGLVSR
OrthoDBiEOG091G0NBQ
PhylomeDBiQ8N7C4
TreeFamiTF338544

Family and domain databases

InterProiView protein in InterPro
IPR027862 DUF4534
PANTHERiPTHR34928 PTHR34928, 1 hit
PfamiView protein in Pfam
PF15049 DUF4534, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N7C4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKQQQWCGMT AKMGTVLSGV FTIMAVDMYL IFEQKHLGNG SCTEITPKYR
60 70 80 90 100
GASNIINNFI ICWSFKIVLF LSFITILISC FLLYSVYAQI FRGLVIYIVW
110 120 130 140 150
IFFYETANVV IQILTNNDFD IKEVRIMRWF GLVSRTVMHC FWMFFVINYA
160 170 180 190 200
HITYKNRSQG NIISYKRRIS TAEILHSRNK RLSISSGFSG SHLESQYFER
210 220
QSFHTSIFTC LSPVPSSAPS TCRYTIDVC
Note: No experimental confirmation available.
Length:229
Mass (Da):26,582
Last modified:October 1, 2002 - v1
Checksum:iB469BABA66AA99D7
GO
Isoform 2 (identifier: Q8N7C4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     202-211: SFHTSIFTCL → RRCSGKTSIK
     212-229: Missing.

Note: No experimental confirmation available.
Show »
Length:211
Mass (Da):24,697
Checksum:iC9014F4455AF0423
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014386202 – 211SFHTSIFTCL → RRCSGKTSIK in isoform 2. 1 Publication10
Alternative sequenceiVSP_014387212 – 229Missing in isoform 2. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098666 mRNA Translation: BAC05371.1
AL353579 Genomic DNA No translation available.
BC026012 mRNA Translation: AAH26012.1
CCDSiCCDS4831.1 [Q8N7C4-1]
CCDS69102.1 [Q8N7C4-2]
RefSeqiNP_001273330.1, NM_001286401.1 [Q8N7C4-2]
NP_660359.2, NM_145316.3 [Q8N7C4-1]
XP_011512668.1, XM_011514366.2 [Q8N7C4-1]
UniGeneiHs.520101

Genome annotation databases

EnsembliENST00000336655; ENSP00000338164; ENSG00000172738 [Q8N7C4-1]
ENST00000356757; ENSP00000349198; ENSG00000172738 [Q8N7C4-2]
GeneIDi221468
KEGGihsa:221468
UCSCiuc003onl.5 human [Q8N7C4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTM217_HUMAN
AccessioniPrimary (citable) accession number: Q8N7C4
Secondary accession number(s): Q8TC54
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM

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