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Protein

Casein kinase I isoform alpha-like

Gene

CSNK1A1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei46ATPPROSITE-ProRule annotation1
Active sitei136Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi23 – 31ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processWnt signaling pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ8N752
SIGNORiQ8N752

Names & Taxonomyi

Protein namesi
Recommended name:
Casein kinase I isoform alpha-like (EC:2.7.11.1)
Short name:
CKI-alpha-like
Alternative name(s):
CK1
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000180138.7
HGNCiHGNC:20289 CSNK1A1L
neXtProtiNX_Q8N752

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000180138
PharmGKBiPA134917108

Chemistry databases

ChEMBLiCHEMBL5520

Polymorphism and mutation databases

BioMutaiCSNK1A1L
DMDMi212286065

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001928301 – 337Casein kinase I isoform alpha-likeAdd BLAST337

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8N752
MaxQBiQ8N752
PaxDbiQ8N752
PeptideAtlasiQ8N752
PRIDEiQ8N752
ProteomicsDBi72263

PTM databases

iPTMnetiQ8N752
PhosphoSitePlusiQ8N752

Expressioni

Gene expression databases

BgeeiENSG00000180138 Expressed in 7 organ(s), highest expression level in blood
CleanExiHS_CSNK1A1L

Organism-specific databases

HPAiHPA051334

Interactioni

Protein-protein interaction databases

BioGridi125755, 13 interactors
IntActiQ8N752, 7 interactors
MINTiQ8N752
STRINGi9606.ENSP00000369126

Chemistry databases

BindingDBiQ8N752

Structurei

3D structure databases

ProteinModelPortaliQ8N752
SMRiQ8N752
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 285Protein kinasePROSITE-ProRule annotationAdd BLAST269

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1164 Eukaryota
ENOG410XPGP LUCA
GeneTreeiENSGT00930000150814
HOGENOMiHOG000182055
HOVERGENiHBG000176
InParanoidiQ8N752
KOiK08957
OMAiGIPRIRY
OrthoDBiEOG091G0AFG
PhylomeDBiQ8N752
TreeFamiTF354246

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q8N752-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTNNSGSKAE LVVGGKYKLV RKIGSGSFGD VYLGITTTNG EDVAVKLESQ
60 70 80 90 100
KVKHPQLLYE SKLYTILQGG VGIPHMHWYG QEKDNNVLVM DLLGPSLEDL
110 120 130 140 150
FNFCSRRFTM KTVLMLADQM ISRIEYVHTK NFLHRDIKPD NFLMGTGRHC
160 170 180 190 200
NKLFLIDFGL AKKYRDNRTR QHIPYREDKH LIGTVRYASI NAHLGIEQSR
210 220 230 240 250
RDDMESLGYV FMYFNRTSLP WQGLRAMTKK QKYEKISEKK MSTPVEVLCK
260 270 280 290 300
GFPAEFAMYL NYCRGLRFEE VPDYMYLRQL FRILFRTLNH QYDYTFDWTM
310 320 330
LKQKAAQQAA SSSGQGQQAQ TQTGKQTEKN KNNVKDN
Length:337
Mass (Da):39,086
Last modified:July 22, 2008 - v2
Checksum:i6110F854D739B142
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti225R → K in AAH28723 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0420745S → G1 PublicationCorresponds to variant dbSNP:rs56224973Ensembl.1
Natural variantiVAR_03645021R → Q in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs373362769Ensembl.1
Natural variantiVAR_04207521R → W1 PublicationCorresponds to variant dbSNP:rs56158728Ensembl.1
Natural variantiVAR_04207642D → E1 PublicationCorresponds to variant dbSNP:rs9576175Ensembl.1
Natural variantiVAR_034047170R → S1 PublicationCorresponds to variant dbSNP:rs17773251Ensembl.1
Natural variantiVAR_042077177E → K1 PublicationCorresponds to variant dbSNP:rs17054882Ensembl.1
Natural variantiVAR_042078220P → L1 PublicationCorresponds to variant dbSNP:rs56252856Ensembl.1
Natural variantiVAR_042079230K → N1 PublicationCorresponds to variant dbSNP:rs56252523Ensembl.1
Natural variantiVAR_042080257A → T1 PublicationCorresponds to variant dbSNP:rs55895045Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL391383 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08587.1
BC028723 mRNA Translation: AAH28723.1
CCDSiCCDS9363.1
RefSeqiNP_660204.2, NM_145203.5
UniGeneiHs.512897

Genome annotation databases

EnsembliENST00000379800; ENSP00000369126; ENSG00000180138
GeneIDi122011
KEGGihsa:122011
UCSCiuc001uwm.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL391383 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08587.1
BC028723 mRNA Translation: AAH28723.1
CCDSiCCDS9363.1
RefSeqiNP_660204.2, NM_145203.5
UniGeneiHs.512897

3D structure databases

ProteinModelPortaliQ8N752
SMRiQ8N752
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125755, 13 interactors
IntActiQ8N752, 7 interactors
MINTiQ8N752
STRINGi9606.ENSP00000369126

Chemistry databases

BindingDBiQ8N752
ChEMBLiCHEMBL5520

PTM databases

iPTMnetiQ8N752
PhosphoSitePlusiQ8N752

Polymorphism and mutation databases

BioMutaiCSNK1A1L
DMDMi212286065

Proteomic databases

EPDiQ8N752
MaxQBiQ8N752
PaxDbiQ8N752
PeptideAtlasiQ8N752
PRIDEiQ8N752
ProteomicsDBi72263

Protocols and materials databases

DNASUi122011
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379800; ENSP00000369126; ENSG00000180138
GeneIDi122011
KEGGihsa:122011
UCSCiuc001uwm.2 human

Organism-specific databases

CTDi122011
EuPathDBiHostDB:ENSG00000180138.7
GeneCardsiCSNK1A1L
H-InvDBiHIX0011244
HGNCiHGNC:20289 CSNK1A1L
HPAiHPA051334
neXtProtiNX_Q8N752
OpenTargetsiENSG00000180138
PharmGKBiPA134917108
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1164 Eukaryota
ENOG410XPGP LUCA
GeneTreeiENSGT00930000150814
HOGENOMiHOG000182055
HOVERGENiHBG000176
InParanoidiQ8N752
KOiK08957
OMAiGIPRIRY
OrthoDBiEOG091G0AFG
PhylomeDBiQ8N752
TreeFamiTF354246

Enzyme and pathway databases

SignaLinkiQ8N752
SIGNORiQ8N752

Miscellaneous databases

GenomeRNAii122011
PROiPR:Q8N752

Gene expression databases

BgeeiENSG00000180138 Expressed in 7 organ(s), highest expression level in blood
CleanExiHS_CSNK1A1L

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKC1AL_HUMAN
AccessioniPrimary (citable) accession number: Q8N752
Secondary accession number(s): Q5T2N2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: July 22, 2008
Last modified: November 7, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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Main funding by: National Institutes of Health

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