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Entry version 156 (22 Apr 2020)
Sequence version 2 (24 Nov 2009)
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Protein

Killer cell immunoglobulin-like receptor 3DL3

Gene

KIR3DL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor on natural killer cells. May inhibit the activity of NK cells thus preventing cell lysis.1 Publication

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Killer cell immunoglobulin-like receptor 3DL3
Alternative name(s):
CD158 antigen-like family member Z
Killer cell inhibitory receptor 1
CD_antigen: CD158z
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KIR3DL3
Synonyms:CD158Z, KIR3DL7, KIRC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:16312 KIR3DL3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610095 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N743

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini26 – 322ExtracellularSequence analysisAdd BLAST297
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei323 – 343HelicalSequence analysisAdd BLAST21
Topological domaini344 – 410CytoplasmicSequence analysisAdd BLAST67

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
115653

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134887375

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8N743 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KIR3DL3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
269849611

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001509126 – 410Killer cell immunoglobulin-like receptor 3DL3Sequence analysisAdd BLAST385

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi49 ↔ 95Curated
Disulfide bondi144 ↔ 195By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi179N-linked (GlcNAc...) asparagineCurated1
Glycosylationi239N-linked (GlcNAc...) asparagineCurated1
Disulfide bondi244 ↔ 293By similarity
Glycosylationi273N-linked (GlcNAc...) asparagineCurated1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8N743

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8N743

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N743

PeptideAtlas

More...
PeptideAtlasi
Q8N743

PRoteomics IDEntifications database

More...
PRIDEi
Q8N743

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
72261

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N743

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q8N743, 22 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000291860

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8N743 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8N743

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini42 – 97Ig-like C2-type 1CuratedAdd BLAST56
Domaini137 – 197Ig-like C2-type 2CuratedAdd BLAST61
Domaini237 – 295Ig-like C2-type 3CuratedAdd BLAST59

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410JAMM Eukaryota
ENOG410ZT7K LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N743

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N743

TreeFam database of animal gene trees

More...
TreeFami
TF352669

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00047 ig, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 19 potential isoforms that are computationally mapped.Show allAlign All

Q8N743-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLMVVSMAC VGFFLLEGPW PHVGGQDKPF LSAWPGTVVS EGQHVTLQCR
60 70 80 90 100
SRLGFNEFSL SKEDGMPVPE LYNRIFRNSF LMGPVTPAHA GTYRCCSSHP
110 120 130 140 150
HSPTGWSAPS NPVVIMVTGV HRKPSLLAHP GPLVKSGETV ILQCWSDVRF
160 170 180 190 200
ERFLLHREGI TEDPLRLVGQ LHDAGSQVNY SMGPMTPALA GTYRCFGSVT
210 220 230 240 250
HLPYELSAPS DPLDIVVVGL YGKPSLSAQP GPTVQAGENV TLSCSSRSLF
260 270 280 290 300
DIYHLSREAE AGELRLTAVL RVNGTFQANF PLGPVTHGGN YRCFGSFRAL
310 320 330 340 350
PHAWSDPSDP LPVSVTGNSR HLHVLIGTSV VIIPFAILLF FLLHRWCANK
360 370 380 390 400
KNAVVMDQEP AGNRTVNRED SDEQDPQEVT YAQLNHCVFT QRKITRPSQR
410
PKTPPTDTSV
Length:410
Mass (Da):44,928
Last modified:November 24, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD1C4D06DE8FEF35E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 19 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JLS9A0A0G2JLS9_HUMAN
Killer cell immunoglobulin-like rec...
KIR3DL3
454Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4J1R5A0A0B4J1R5_HUMAN
Killer cell immunoglobulin-like rec...
KIR3DL3
410Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4ZNX4A0A0C4ZNX4_HUMAN
Killer cell immunoglobulin-like rec...
KIR3DL3
410Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4ZQX3A0A0C4ZQX3_HUMAN
Killer cell immunoglobulin-like rec...
KIR3DL3
410Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4ZR07A0A0C4ZR07_HUMAN
Killer cell immunoglobulin-like rec...
KIR3DL3
410Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JLZ2A0A0G2JLZ2_HUMAN
Killer cell immunoglobulin-like rec...
KIR3DL3
410Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JN57A0A0G2JN57_HUMAN
Killer cell immunoglobulin-like rec...
KIR3DL3
410Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JNJ1A0A0G2JNJ1_HUMAN
Killer cell immunoglobulin-like rec...
KIR3DL3
410Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JNR7A0A0G2JNR7_HUMAN
Killer cell immunoglobulin-like rec...
KIR3DL3
425Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JPB3A0A0G2JPB3_HUMAN
Killer cell immunoglobulin-like rec...
KIR3DL3
410Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Various different KIR3DL3 alleles are known: KIR3DL3*00101, KIR3DL3*00102, KIR3DL3*00103, KIR3DL3*00201, KIR3DL3*00202, KIR3DL3*00203, KIR3DL3*00204, KIR3DL3*00205, KIR3DL3*00206, KIR3DL3*00207, KIR3DL3*0030101 KIR3DL3*0030102, KIR3DL3*00401, KIR3DL3*00402, KIR3DL3*005, KIR3DL3*00601, KIR3DL3*00602, KIR3DL3*007, KIR3DL3*00801, KIR3DL3*00802, KIR3DL3*00901, KIR3DL3*00902, KIR3DL3*010, KIR3DL3*01101, KIR3DL3*01102, KIR3DL3*012, KIR3DL3*01301, KIR3DL3*01302, KIR3DL3*01303, KIR3DL3*01304, KIR3DL3*01305, KIR3DL3*01306, KIR3DL3*01307, KIR3DL3*01401, KIR3DL3*01402, KIR3DL3*01403, KIR3DL3*01404, KIR3DL3*01405, KIR3DL3*015 KIR3DL3*016, KIR3DL3*017, KIR3DL3*018, KIR3DL3*019, KIR3DL3*020, KIR3DL3*021, KIR3DL3*022, KIR3DL3*023, KIR3DL3*024, KIR3DL3*025, KIR3DL3*026, KIR3DL3*027, KIR3DL3*028, KIR3DL3*029, KIR3DL3*030 and KIR3DL3*031. The sequence shown corresponds to the alleles KIR3DL3*002.4 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06061052R → H in allele KIR3DL3*00401, allele KIR3DL3*00402, allele KIR3DL3*00801, allele KIR3DL3*00802 and allele KIR3DL3*026. 1 PublicationCorresponds to variant dbSNP:rs113988102Ensembl.1
Natural variantiVAR_06061156N → K in allele KIR3DL3*00601, allele KIR3DL3*00602, allele KIR3DL3*01501 and allele KIR3DL3*01601. Corresponds to variant dbSNP:rs2075731Ensembl.1
Natural variantiVAR_06061277R → W in allele KIR3DL3*010 and allele KIR3DL3*028. Corresponds to variant dbSNP:rs202170060Ensembl.1
Natural variantiVAR_060613149R → S in allele KIR3DL3*00601, allele KIR3DL3*00602, allele KIR3DL3*01501 and allele KIR3DL3*01601. Corresponds to variant dbSNP:rs62132665Ensembl.1
Natural variantiVAR_060614152R → H in allele KIR3DL3*007, allele KIR3DL3*030 and allele KIR3DL3*031. Corresponds to variant dbSNP:rs199609975Ensembl.1
Natural variantiVAR_019426168V → I in allele KIR3DL3*00101, allele KIR3DL3*00102, allele KIR3DL3*00103, allele KIR3DL3*0030101, allele KIR3DL3*00901, allele KIR3DL3*00902, allele KIR3DL3*010 and allele KIR3DL3*028. 1 PublicationCorresponds to variant dbSNP:rs270790Ensembl.1
Natural variantiVAR_060615231G → D in allele KIR3DL3*005. Corresponds to variant dbSNP:rs112412050Ensembl.1
Natural variantiVAR_060616290N → T in allele KIR3DL3*00601, allele KIR3DL3*00602, allele KIR3DL3*01101, allele KIR3DL3*01102, allele KIR3DL3*01501, allele KIR3DL3*01601 and allele KIR3DL3*017. 1 PublicationCorresponds to variant dbSNP:rs2302422Ensembl.1
Natural variantiVAR_060617321H → N in allele KIR3DL3*00101, allele KIR3DL3*00102, allele KIR3DL3*00103, allele KIR3DL3*00601, allele KIR3DL3*00602, allele KIR3DL3*01302, allele KIR3DL3*01305, allele KIR3DL3*01306, allele KIR3DL3*01307, allele KIR3DL3*017 and allele KIR3DL3*026. 1 PublicationCorresponds to variant dbSNP:rs602444Ensembl.1
Natural variantiVAR_060618321H → Y in allele KIR3DL3*00101, allele KIR3DL3*0030101, allele KIR3DL3*00401, allele KIR3DL3*00402, allele KIR3DL3*007, allele KIR3DL3*01404, allele KIR3DL3*01405, allele KIR3DL3*01601 and allele KIR3DL3*028. 1 PublicationCorresponds to variant dbSNP:rs602444Ensembl.1
Natural variantiVAR_060366324V → A in allele KIR3DL3*0030101, allele KIR3DL3*00401, allele KIR3DL3*00402, allele KIR3DL3*007, allele KIR3DL3*01404, allele KIR3DL3*01405, allele KIR3DL3*01601 and allele KIR3DL3*028. Corresponds to variant dbSNP:rs662386Ensembl.1
Natural variantiVAR_060619324V → D in allele KIR3DL3*029. Corresponds to variant dbSNP:rs662386Ensembl.1
Natural variantiVAR_056092348A → P in allele KIR3DL3*027, allele KIR3DL3*029 and allele KIR3DL3*031. Corresponds to variant dbSNP:rs16985907Ensembl.1
Natural variantiVAR_060620373E → D in allele KIR3DL3*027, allele KIR3DL3*029 and allele KIR3DL3*031. Corresponds to variant dbSNP:rs28504993Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF072410 AF072409 Genomic DNA Translation: AAC99763.1
AF352324 mRNA Translation: AAK30258.1
AC006293 Genomic DNA Translation: AAD03159.1
AL133414 Genomic DNA Translation: CAC40702.1
AY987937 Genomic DNA Translation: ABC03227.1
AY987938 Genomic DNA Translation: ABC03228.1
AY987939 Genomic DNA Translation: ABC03229.1
AY987940 Genomic DNA Translation: ABC03230.1
AY987941 Genomic DNA Translation: ABC03231.1
AY987942 Genomic DNA Translation: ABC03232.1
AY987943 Genomic DNA Translation: ABC03233.1
AH015397 Genomic DNA Translation: ABC03234.1
AH015396 Genomic DNA Translation: ABC03226.1
EF153459 Genomic DNA Translation: ABM98078.1
EF153460 Genomic DNA Translation: ABM98079.1
EF153461 Genomic DNA Translation: ABM98080.1
EF153462 Genomic DNA Translation: ABM98081.1
EF153463 Genomic DNA Translation: ABM98082.1
EF153464 Genomic DNA Translation: ABM98083.1
EF153465 Genomic DNA Translation: ABM98084.1
EF153466 Genomic DNA Translation: ABM98085.1
EF153467 Genomic DNA Translation: ABM98086.1
EF165005 Genomic DNA Translation: ABM98087.1
EF165006 Genomic DNA Translation: ABM98088.1
EF165007 Genomic DNA Translation: ABM98089.1
EF165008 Genomic DNA Translation: ABM98090.1
EF165009 Genomic DNA Translation: ABM98091.1
EF175456 Genomic DNA Translation: ABM98092.1
EF175457 Genomic DNA Translation: ABM98093.1
EF175458 Genomic DNA Translation: ABM98094.1
EF175459 Genomic DNA Translation: ABM98095.1
EF175460 Genomic DNA Translation: ABM98096.1
EF379094 Genomic DNA Translation: ABM92653.1
EF379095 Genomic DNA Translation: ABM92654.1
EF492034 Genomic DNA Translation: ABS30929.1
EF492035 Genomic DNA Translation: ABS30930.1
EF492036 Genomic DNA Translation: ABS30931.1
EF492037 Genomic DNA Translation: ABS30932.1
EF492038 Genomic DNA Translation: ABS30933.1
EF492039 Genomic DNA Translation: ABS30934.1
EF492040 Genomic DNA Translation: ABS30935.1
EF492041 Genomic DNA Translation: ABS30936.1
EF492042 Genomic DNA Translation: ABS30937.1
EF492043 Genomic DNA Translation: ABS30938.1
EF492044 Genomic DNA Translation: ABS30939.1
AH011562 Genomic DNA Translation: AAM00023.1
AY083462 Genomic DNA Translation: AAM00024.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS12903.1

Genome annotation databases

UCSC genome browser

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UCSCi
uc032msg.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

IPD-KIR Database

KIR Allele Nomenclature

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF072410 AF072409 Genomic DNA Translation: AAC99763.1
AF352324 mRNA Translation: AAK30258.1
AC006293 Genomic DNA Translation: AAD03159.1
AL133414 Genomic DNA Translation: CAC40702.1
AY987937 Genomic DNA Translation: ABC03227.1
AY987938 Genomic DNA Translation: ABC03228.1
AY987939 Genomic DNA Translation: ABC03229.1
AY987940 Genomic DNA Translation: ABC03230.1
AY987941 Genomic DNA Translation: ABC03231.1
AY987942 Genomic DNA Translation: ABC03232.1
AY987943 Genomic DNA Translation: ABC03233.1
AH015397 Genomic DNA Translation: ABC03234.1
AH015396 Genomic DNA Translation: ABC03226.1
EF153459 Genomic DNA Translation: ABM98078.1
EF153460 Genomic DNA Translation: ABM98079.1
EF153461 Genomic DNA Translation: ABM98080.1
EF153462 Genomic DNA Translation: ABM98081.1
EF153463 Genomic DNA Translation: ABM98082.1
EF153464 Genomic DNA Translation: ABM98083.1
EF153465 Genomic DNA Translation: ABM98084.1
EF153466 Genomic DNA Translation: ABM98085.1
EF153467 Genomic DNA Translation: ABM98086.1
EF165005 Genomic DNA Translation: ABM98087.1
EF165006 Genomic DNA Translation: ABM98088.1
EF165007 Genomic DNA Translation: ABM98089.1
EF165008 Genomic DNA Translation: ABM98090.1
EF165009 Genomic DNA Translation: ABM98091.1
EF175456 Genomic DNA Translation: ABM98092.1
EF175457 Genomic DNA Translation: ABM98093.1
EF175458 Genomic DNA Translation: ABM98094.1
EF175459 Genomic DNA Translation: ABM98095.1
EF175460 Genomic DNA Translation: ABM98096.1
EF379094 Genomic DNA Translation: ABM92653.1
EF379095 Genomic DNA Translation: ABM92654.1
EF492034 Genomic DNA Translation: ABS30929.1
EF492035 Genomic DNA Translation: ABS30930.1
EF492036 Genomic DNA Translation: ABS30931.1
EF492037 Genomic DNA Translation: ABS30932.1
EF492038 Genomic DNA Translation: ABS30933.1
EF492039 Genomic DNA Translation: ABS30934.1
EF492040 Genomic DNA Translation: ABS30935.1
EF492041 Genomic DNA Translation: ABS30936.1
EF492042 Genomic DNA Translation: ABS30937.1
EF492043 Genomic DNA Translation: ABS30938.1
EF492044 Genomic DNA Translation: ABS30939.1
AH011562 Genomic DNA Translation: AAM00023.1
AY083462 Genomic DNA Translation: AAM00024.1
CCDSiCCDS12903.1

3D structure databases

SMRiQ8N743
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ8N743, 22 interactors
STRINGi9606.ENSP00000291860

PTM databases

PhosphoSitePlusiQ8N743

Polymorphism and mutation databases

BioMutaiKIR3DL3
DMDMi269849611

Proteomic databases

jPOSTiQ8N743
MassIVEiQ8N743
PaxDbiQ8N743
PeptideAtlasiQ8N743
PRIDEiQ8N743
ProteomicsDBi72261

Genome annotation databases

UCSCiuc032msg.2 human

Organism-specific databases

DisGeNETi115653

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KIR3DL3
HGNCiHGNC:16312 KIR3DL3
MIMi610095 gene
neXtProtiNX_Q8N743
PharmGKBiPA134887375

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410JAMM Eukaryota
ENOG410ZT7K LUCA
InParanoidiQ8N743
PhylomeDBiQ8N743
TreeFamiTF352669

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
KIR3DL3
PharosiQ8N743 Tbio

Protein Ontology

More...
PROi
PR:Q8N743
RNActiQ8N743 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin
PfamiView protein in Pfam
PF00047 ig, 2 hits
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKI3L3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N743
Secondary accession number(s): A9PL62
, A9PL64, A9PL65, A9PL66, A9PL67, A9PL68, A9PZV4, A9PZV7, A9PZV8, A9Q066, A9Q0R5, A9Q242, A9Q250, A9Q251, O95056, Q1X775, Q1X777, Q1X778, Q1X779, Q1X780, Q1X781, Q1X782, Q1X783, Q7Z7N4, Q8NHI2, Q8NHI3, Q9UEI4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: November 24, 2009
Last modified: April 22, 2020
This is version 156 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  6. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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