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Protein

Neuropeptide W

Gene

NPW

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress (By similarity). NPW23 activates GPR7 and GPR8 more efficiently than NPW30.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNeuropeptide

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptide W
Alternative name(s):
Preproprotein L8
Short name:
hPPL8
Cleaved into the following 2 chains:
Neuropeptide W-23
Short name:
NPW23
Short name:
hL8
Neuropeptide W-30
Short name:
NPW30
Short name:
hL8C
Gene namesi
Name:NPW
Synonyms:PPL8, PPNPW
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000183971.5
HGNCiHGNC:30509 NPW
MIMi607997 gene
neXtProtiNX_Q8N729

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi283869
OpenTargetsiENSG00000183971
PharmGKBiPA142671248

Polymorphism and mutation databases

BioMutaiNPW

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
PeptideiPRO_000001984333 – 62Neuropeptide W-30Add BLAST30
PeptideiPRO_000001984433 – 55Neuropeptide W-23Add BLAST23
PropeptideiPRO_000001984565 – 165Sequence analysisAdd BLAST101

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ8N729
PeptideAtlasiQ8N729
PRIDEiQ8N729
ProteomicsDBi72259

PTM databases

PhosphoSitePlusiQ8N729

Expressioni

Tissue specificityi

Detected at high levels in the substantia nigra, fetal kidney and trachea; at lower levels in testis, uterus, ovary and placenta. Not detectable in many regions of the central nervous system. Also detected at high levels in lymphoblastic leukemia and colorectal adenocarcinoma.

Gene expression databases

BgeeiENSG00000183971 Expressed in 77 organ(s), highest expression level in liver
CleanExiHS_NPW
ExpressionAtlasiQ8N729 baseline and differential
GenevisibleiQ8N729 HS

Organism-specific databases

HPAiHPA064874

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi129692, 1 interactor
STRINGi9606.ENSP00000330070

Structurei

3D structure databases

ProteinModelPortaliQ8N729
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the neuropeptide B/W family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J7Z8 Eukaryota
ENOG41115MZ LUCA
GeneTreeiENSGT00510000049904
HOGENOMiHOG000113846
InParanoidiQ8N729
OrthoDBiEOG091G0QS9
PhylomeDBiQ8N729
TreeFamiTF333179

Family and domain databases

InterProiView protein in InterPro
IPR013297 Neuropept_BW_pre
IPR013299 Neuropept_W_pre
PANTHERiPTHR28553 PTHR28553, 1 hit
PfamiView protein in Pfam
PF15180 NPBW, 1 hit
PRINTSiPR01888 NROPEPTIDEBW
PR01890 PPNRPEPTIDEW
ProDomiView protein in ProDom or Entries sharing at least one domain
PD601995 Neuropept_W_pre, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8N729-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAWRPGERGA PASRPRLALL LLLLLLPLPS GAWYKHVASP RYHTVGRAAG
60 70 80 90 100
LLMGLRRSPY LWRRALRAAA GPLARDTLSP EPAAREAPLL LPSWVQELWE
110 120 130 140 150
TRRRSSQAGI PVRAPRSPRA PEPALEPESL DFSGAGQRLR RDVSRPAVDP
160
AANRLGLPCL APGPF
Length:165
Mass (Da):18,048
Last modified:July 25, 2003 - v2
Checksum:iF426AF4B7FB6E604
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BT17H3BT17_HUMAN
Neuropeptide W
NPW
113Annotation score:
H3BT42H3BT42_HUMAN
Neuropeptide W
NPW
128Annotation score:

Sequence cautioni

The sequence BAC07172 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050292149D → A. Corresponds to variant dbSNP:rs2286472Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB084276 mRNA Translation: BAC07172.1 Different initiation.
CCDSiCCDS42102.1
RefSeqiNP_001092926.2, NM_001099456.2
UniGeneiHs.233533

Genome annotation databases

EnsembliENST00000329610; ENSP00000330070; ENSG00000183971
GeneIDi283869
KEGGihsa:283869
UCSCiuc059pez.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB084276 mRNA Translation: BAC07172.1 Different initiation.
CCDSiCCDS42102.1
RefSeqiNP_001092926.2, NM_001099456.2
UniGeneiHs.233533

3D structure databases

ProteinModelPortaliQ8N729
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129692, 1 interactor
STRINGi9606.ENSP00000330070

PTM databases

PhosphoSitePlusiQ8N729

Polymorphism and mutation databases

BioMutaiNPW

Proteomic databases

PaxDbiQ8N729
PeptideAtlasiQ8N729
PRIDEiQ8N729
ProteomicsDBi72259

Protocols and materials databases

DNASUi283869
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329610; ENSP00000330070; ENSG00000183971
GeneIDi283869
KEGGihsa:283869
UCSCiuc059pez.1 human

Organism-specific databases

CTDi283869
DisGeNETi283869
EuPathDBiHostDB:ENSG00000183971.5
GeneCardsiNPW
H-InvDBiHIX0038533
HGNCiHGNC:30509 NPW
HPAiHPA064874
MIMi607997 gene
neXtProtiNX_Q8N729
OpenTargetsiENSG00000183971
PharmGKBiPA142671248
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J7Z8 Eukaryota
ENOG41115MZ LUCA
GeneTreeiENSGT00510000049904
HOGENOMiHOG000113846
InParanoidiQ8N729
OrthoDBiEOG091G0QS9
PhylomeDBiQ8N729
TreeFamiTF333179

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events

Miscellaneous databases

GeneWikiiNPW
GenomeRNAii283869
PROiPR:Q8N729
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183971 Expressed in 77 organ(s), highest expression level in liver
CleanExiHS_NPW
ExpressionAtlasiQ8N729 baseline and differential
GenevisibleiQ8N729 HS

Family and domain databases

InterProiView protein in InterPro
IPR013297 Neuropept_BW_pre
IPR013299 Neuropept_W_pre
PANTHERiPTHR28553 PTHR28553, 1 hit
PfamiView protein in Pfam
PF15180 NPBW, 1 hit
PRINTSiPR01888 NROPEPTIDEBW
PR01890 PPNRPEPTIDEW
ProDomiView protein in ProDom or Entries sharing at least one domain
PD601995 Neuropept_W_pre, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNPW_HUMAN
AccessioniPrimary (citable) accession number: Q8N729
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: July 25, 2003
Last modified: November 7, 2018
This is version 103 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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