Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 161 (13 Feb 2019)
Sequence version 2 (18 Apr 2012)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Tumor suppressor ARF

Gene

CDKN2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Interacts with COMMD1 and promotes its 'Lys63'-linked polyubiquitination. Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1. Binds to HUWE1 and represses its ubiquitin ligase activity. May play a role in controlling cell proliferation and apoptosis during mammary gland development. Isoform smARF may be involved in regulation of autophagy and caspase-independent cell death; the short-lived mitochondrial isoform is stabilized by C1QBP.12 Publications

Caution

The proteins described here are encoded by the gene CDKN2A, but are completely unrelated in terms of sequence and function to cyclin-dependent kinase inhibitor 2A (AC P42771) which is encoded by the same gene.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processApoptosis, Cell cycle, rRNA processing, Transcription, Transcription regulation, Ubl conjugation pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2559580 Oxidative Stress Induced Senescence
R-HSA-2559585 Oncogene Induced Senescence
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-3232118 SUMOylation of transcription factors
R-HSA-6804757 Regulation of TP53 Degradation
R-HSA-69541 Stabilization of p53
R-HSA-8941858 Regulation of RUNX3 expression and activity

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q8N726

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tumor suppressor ARFCurated
Alternative name(s):
Alternative reading frame1 Publication
Short name:
ARF1 Publication
Cyclin-dependent kinase inhibitor 2AImported
p14ARF1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CDKN2AImported
Synonyms:CDKN2Imported, MLM
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000147889.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1787 CDKN2A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600160 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N726

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNET

More...
DisGeNETi
1029

MalaCards human disease database

More...
MalaCardsi
CDKN2A

Open Targets

More...
OpenTargetsi
ENSG00000147889

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA106

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CDKN2A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
384872321

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001441801 – 132Tumor suppressor ARFAdd BLAST132

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated in normal cells by TRIP12 via the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination at the N-terminus, regardless of the absence of lysine residues. Ubiquitination leads to its proteasomal degradation. In cancer cells, however, TRIP12 is located in a different cell compartment, preventing ubiquitination and degradation.2 Publications

Keywords - PTMi

Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8N726

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8N726

PeptideAtlas

More...
PeptideAtlasi
Q8N726

PRoteomics IDEntifications database

More...
PRIDEi
Q8N726

ProteomicsDB human proteome resource

More...
ProteomicsDBi
72258

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N726

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000147889 Expressed in 195 organ(s), highest expression level in adenohypophysis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8N726 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N726 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB000093
CAB000445
CAB018232
HPA047838

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Does not interact with cyclins, CDK1, CDK2, CDK4, CDK5 or CDK6. Binds to BCL6, E2F1, HUWE1, MDM2, MYC, NPM1/B23, TOP1/TOPOI and UBE2I/UBC9. Interacts with TBRG1 and COMMD1. Interacts with CDKN2AIP and E4F1. Interacts with CDK5RAP3 and MDM2; form a ternary complex involved in regulation of p53/TP53 (PubMed:16173922). Isoform smARF interacts with C1QBP. Interacts with NOP53; the interaction is direct and promotes ARF nucleoplasmic relocalization and ubiquitin-mediated proteasomal degradation (PubMed:27323397).16 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107463, 210 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q8N726

Database of interacting proteins

More...
DIPi
DIP-24171N

Protein interaction database and analysis system

More...
IntActi
Q8N726, 59 interactors

Molecular INTeraction database

More...
MINTi
Q8N726

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8N726

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8N726

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 64Interaction with CDK5RAP3 and MDM21 PublicationAdd BLAST64

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163078

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000111485

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG071056

Database of Orthologous Groups

More...
OrthoDBi
1435166at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010868 Tumor_suppres_ARF

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07392 P19Arf_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Isoform 1 and isoform tumor suppressor ARF arise due to the use of two alternative first exons joined to a common exon 2 at the same acceptor site but in different reading frames, resulting in two completely different isoforms.By similarity

This entry has 6 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform tumor suppressor ARF1 Publication (identifier: Q8N726-1) [UniParc]FASTAAdd to basket
Also known as: p14ARF1 Publication, p19ARF

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVRRFLVTLR IRRACGPPRV RVFVVHIPRL TGEWAAPGAP AAVALVLMLL
60 70 80 90 100
RSQRLGQQPL PRRPGHDDGQ RPSGGAAAAP RRGAQLRRPR HSHPTRARRC
110 120 130
PGGLPGHAGG AAPGRGAAGR ARCLGPSARG PG
Length:132
Mass (Da):13,903
Last modified:April 18, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7739A9050C21BC96
GO
Isoform 1Curated (identifier: P42771-1) [UniParc]FASTAAdd to basket
Also known as: p16INK4aCurated
The sequence of this isoform can be found in the external entry P42771.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:156
Mass (Da):16,533
GO
Isoform 2Curated (identifier: P42771-2) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P42771.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:105
Mass (Da):11,215
GO
Isoform 3Curated (identifier: P42771-3) [UniParc]FASTAAdd to basket
Also known as: p12Curated
The sequence of this isoform can be found in the external entry P42771.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:116
Mass (Da):12,083
GO
Isoform 5 (identifier: P42771-4) [UniParc]FASTAAdd to basket
Also known as: p16gamma
The sequence of this isoform can be found in the external entry P42771.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Barely detectable in non-tumor cells.
Length:167
Mass (Da):17,883
GO
Isoform smARF (identifier: Q8N726-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-47: Missing.

Show »
Length:85
Mass (Da):8,731
Checksum:i4C9E739D74BEC556
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P42771CDN2A_HUMAN
Cyclin-dependent kinase inhibitor 2...
CDKN2A CDKN2, MTS1
156Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QRG6J3QRG6_HUMAN
Cyclin-dependent kinase inhibitor 2...
CDKN2A
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ES20K7ES20_HUMAN
Cyclin-dependent kinase inhibitor 2...
CDKN2A
104Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ENC6K7ENC6_HUMAN
Cyclin-dependent kinase inhibitor 2...
CDKN2A
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB01737 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAC60649 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAH15960 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAH21998 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAM77919 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAH70601 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence EAW58600 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence EAW58601 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti28 – 30PRL → SWF in AAH15960 (PubMed:15489334).Curated3
Sequence conflicti28 – 30PRL → SWF in AAH21998 (PubMed:15489334).Curated3
Sequence conflicti28 – 30PRL → SWF in AAP35666 (PubMed:7624129).Curated3
Sequence conflicti94P → L in AAB01737 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02928717P → S1 PublicationCorresponds to variant dbSNP:rs3731190Ensembl.1
Natural variantiVAR_053033106G → R. Corresponds to variant dbSNP:rs4987127Ensembl.1
Natural variantiVAR_053034113P → L. Corresponds to variant dbSNP:rs34886500EnsemblClinVar.1
Natural variantiVAR_053035116G → D. Corresponds to variant dbSNP:rs35741010EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0449621 – 47Missing in isoform smARF. CuratedAdd BLAST47

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
S78535 mRNA Translation: AAC60649.1 Different initiation.
U38945 mRNA Translation: AAB01737.1 Different initiation.
AF527803 Genomic DNA Translation: AAM77919.1 Different initiation.
AL449423 Genomic DNA Translation: CAH70601.1 Different initiation.
CH471071 Genomic DNA Translation: EAW58600.1 Different initiation.
CH471071 Genomic DNA Translation: EAW58601.1 Different initiation.
BC015960 mRNA Translation: AAH15960.3 Different initiation.
BC021998 mRNA Translation: AAH21998.3 Different initiation.
U26727 mRNA Translation: AAA82236.1
BT007020 mRNA Translation: AAP35666.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6511.2 [Q8N726-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
I39004

NCBI Reference Sequences

More...
RefSeqi
NP_478102.2, NM_058195.3 [Q8N726-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.512599

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000530628; ENSP00000432664; ENSG00000147889 [Q8N726-1]
ENST00000579755; ENSP00000462950; ENSG00000147889 [Q8N726-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1029

UCSC genome browser

More...
UCSCi
uc003zpl.4 human [Q8N726-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S78535 mRNA Translation: AAC60649.1 Different initiation.
U38945 mRNA Translation: AAB01737.1 Different initiation.
AF527803 Genomic DNA Translation: AAM77919.1 Different initiation.
AL449423 Genomic DNA Translation: CAH70601.1 Different initiation.
CH471071 Genomic DNA Translation: EAW58600.1 Different initiation.
CH471071 Genomic DNA Translation: EAW58601.1 Different initiation.
BC015960 mRNA Translation: AAH15960.3 Different initiation.
BC021998 mRNA Translation: AAH21998.3 Different initiation.
U26727 mRNA Translation: AAA82236.1
BT007020 mRNA Translation: AAP35666.1
CCDSiCCDS6511.2 [Q8N726-1]
PIRiI39004
RefSeqiNP_478102.2, NM_058195.3 [Q8N726-1]
UniGeneiHs.512599

3D structure databases

ProteinModelPortaliQ8N726
SMRiQ8N726
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107463, 210 interactors
CORUMiQ8N726
DIPiDIP-24171N
IntActiQ8N726, 59 interactors
MINTiQ8N726

PTM databases

iPTMnetiQ8N726

Polymorphism and mutation databases

BioMutaiCDKN2A
DMDMi384872321

Proteomic databases

jPOSTiQ8N726
MaxQBiQ8N726
PeptideAtlasiQ8N726
PRIDEiQ8N726
ProteomicsDBi72258

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1029
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000530628; ENSP00000432664; ENSG00000147889 [Q8N726-1]
ENST00000579755; ENSP00000462950; ENSG00000147889 [Q8N726-1]
GeneIDi1029
UCSCiuc003zpl.4 human [Q8N726-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1029
DisGeNETi1029
EuPathDBiHostDB:ENSG00000147889.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CDKN2A
HGNCiHGNC:1787 CDKN2A
HPAiCAB000093
CAB000445
CAB018232
HPA047838
MalaCardsiCDKN2A
MIMi600160 gene
neXtProtiNX_Q8N726
OpenTargetsiENSG00000147889
PharmGKBiPA106

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000163078
HOGENOMiHOG000111485
HOVERGENiHBG071056
OrthoDBi1435166at2759

Enzyme and pathway databases

ReactomeiR-HSA-2559580 Oxidative Stress Induced Senescence
R-HSA-2559585 Oncogene Induced Senescence
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-3232118 SUMOylation of transcription factors
R-HSA-6804757 Regulation of TP53 Degradation
R-HSA-69541 Stabilization of p53
R-HSA-8941858 Regulation of RUNX3 expression and activity
SIGNORiQ8N726

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CDKN2A human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1029

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000147889 Expressed in 195 organ(s), highest expression level in adenohypophysis
ExpressionAtlasiQ8N726 baseline and differential
GenevisibleiQ8N726 HS

Family and domain databases

InterProiView protein in InterPro
IPR010868 Tumor_suppres_ARF
PfamiView protein in Pfam
PF07392 P19Arf_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARF_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N726
Secondary accession number(s): D3DRK2
, Q13195, Q13399, Q16360, Q7KZR9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: April 18, 2012
Last modified: February 13, 2019
This is version 161 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again