CDKN2A

Functionⁱ

Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Interacts with COMMD1 and promotes its 'Lys63'-linked polyubiquitination. Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1. Binds to HUWE1 and represses its ubiquitin ligase activity. May play a role in controlling cell proliferation and apoptosis during mammary gland development. Isoform smARF may be involved in regulation of autophagy and caspase-independent cell death; the short-lived mitochondrial isoform is stabilized by C1QBP.12 Publications

Caution

The proteins described here are encoded by the gene CDKN2A, but are completely unrelated in terms of sequence and function to cyclin-dependent kinase inhibitor 2A (AC P42771) which is encoded by the same gene.Curated

GO - Molecular functionⁱ

disordered domain specific binding
Source: CAFA
Inferred from physical interactionⁱ
- 12630860
DNA binding Source: UniProtKB-KW
MDM2/MDM4 family protein binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16173922
p53 binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 9529249
SUMO transferase activity
Source: Reactome
Inferred from experimentⁱ
- 15355988
transcription factor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 19057511
ubiquitin ligase inhibitor activity
Source: CAFA
Inferred from direct assayⁱ
- 18560357
ubiquitin-protein transferase inhibitor activity Source: BHF-UCL

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of cysteine-type endopeptidase activity involved in apoptotic process
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 12082630
amyloid fibril formation
Source: CAFA
Inferred from mutant phenotypeⁱ
- 12630860
apoptotic mitochondrial changes
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 12082630
autophagy of mitochondrion
Source: ParkinsonsUK-UCL
Inferred from mutant phenotypeⁱ
- 25217637
cell cycle arrest
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 15582998
cellular senescence
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 14966292
mitochondrial depolarization
Source: ParkinsonsUK-UCL
Inferred from mutant phenotypeⁱ
- 25217637
negative regulation of B cell proliferation Source: BHF-UCL
negative regulation of cell proliferation
Source: UniProtKB
Inferred from direct assayⁱ
- 17569660
negative regulation of immature T cell proliferation in thymus Source: BHF-UCL
negative regulation of protein kinase activity
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 15582998
negative regulation of protein neddylation
Source: CAFA
Inferred from direct assayⁱ
- 18560357
negative regulation of proteolysis involved in cellular protein catabolic process
Source: ParkinsonsUK-UCL
Inferred from mutant phenotypeⁱ
- 25217637
negative regulation of ubiquitin-dependent protein catabolic process
Source: CAFA
Inferred from direct assayⁱ
- 18560357
negative regulation of ubiquitin protein ligase activity
Source: CAFA
Inferred from direct assayⁱ
- 18560357
negative regulation of ubiquitin-protein transferase activity Source: BHF-UCL
positive regulation of apoptotic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22094112
positive regulation of cell cycle arrest
Source: BHF-UCL
Inferred from direct assayⁱ
- 9529249
positive regulation of DNA damage response, signal transduction by p53 class mediator
Source: BHF-UCL
Inferred from direct assayⁱ
- 9529249
positive regulation of gene expression
Source: CAFA
Inferred from direct assayⁱ
- 17310983
positive regulation of protein localization to nucleus
Source: UniProtKB
Inferred from direct assayⁱ
- 16173922
positive regulation of protein sumoylation
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 19057511
positive regulation of signal transduction by p53 class mediator
Source: UniProtKB
Inferred from direct assayⁱ
- 16173922
positive regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 17569660
positive regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 17569660
protein destabilization
Source: BHF-UCL
Inferred from direct assayⁱ
- 9529249
protein K63-linked ubiquitination
Source: UniProtKB
Inferred from direct assayⁱ
- 18305112
protein polyubiquitination
Source: UniProtKB
Inferred from direct assayⁱ
- 18305112
protein stabilization
Source: BHF-UCL
Inferred from direct assayⁱ
- 10360174
- 9529249
regulation of apoptotic DNA fragmentation
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 12082630
regulation of G2/M transition of mitotic cell cycle
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 15582998
regulation of protein export from nucleus
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 10360174
regulation of protein stability Source: BHF-UCL
regulation of protein targeting to mitochondrion
Source: ParkinsonsUK-UCL
Inferred from mutant phenotypeⁱ
- 25217637
rRNA processing Source: UniProtKB-KW
somatic stem cell division Source: BHF-UCL

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Apoptosis, Cell cycle, rRNA processing, Transcription, Transcription regulation, Ubl conjugation pathway

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2559580 Oxidative Stress Induced Senescence R-HSA-2559585 Oncogene Induced Senescence R-HSA-3108214 SUMOylation of DNA damage response and repair proteins R-HSA-3232118 SUMOylation of transcription factors R-HSA-6804757 Regulation of TP53 Degradation R-HSA-69541 Stabilization of p53 R-HSA-8941858 Regulation of RUNX3 expression and activity
SIGNORⁱ	Q8N726

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Tumor suppressor ARFCurated Alternative name(s): Alternative reading frame1 Publication Short name: ARF1 Publication Cyclin-dependent kinase inhibitor 2AImported p14ARF1 Publication
Gene namesⁱ	Name:CDKN2AImported Synonyms:CDKN2Imported, MLM
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000147889.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1787 CDKN2A
MIMⁱ	600160 gene
neXtProtⁱ	NX_Q8N726

Keywords - Cellular componentⁱ

Mitochondrion, Nucleus

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

Tumor suppressor

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1029
MalaCards human disease database More...MalaCardsⁱ	CDKN2A
Open Targets More...OpenTargetsⁱ	ENSG00000147889
PharmGKBⁱ	PA106

Polymorphism and mutation databases

BioMutaⁱ	UBR5
DMDMⁱ	384872321

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000144180	1 – 132	Tumor suppressor ARFAdd BLAST		132

Post-translational modificationⁱ

Ubiquitinated in normal cells by TRIP12 via the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination at the N-terminus, regardless of the absence of lysine residues. Ubiquitination leads to its proteasomal degradation. In cancer cells, however, TRIP12 is located in a different cell compartment, preventing ubiquitination and degradation.2 Publications

Keywords - PTMⁱ

Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8N726
PeptideAtlas More...PeptideAtlasⁱ	Q8N726
PRIDEⁱ	Q8N726
ProteomicsDBⁱ	72258

PTM databases

iPTMnetⁱ	Q8N726

iPTMnetⁱ

Q8N726

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000147889 Expressed in 195 organ(s), highest expression level in adenohypophysis
CleanExⁱ	HS_CDKN2A
ExpressionAtlasⁱ	Q8N726 baseline and differential
Genevisibleⁱ	Q8N726 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB000093 CAB000445 CAB018232 HPA047838

HPAⁱ

CAB000093
CAB000445
CAB018232
HPA047838

Interactionⁱ

Subunit structureⁱ

Does not interact with cyclins, CDK1, CDK2, CDK4, CDK5 or CDK6. Binds to BCL6, E2F1, HUWE1, MDM2, MYC, NPM1/B23, TOP1/TOPOI and UBE2I/UBC9. Interacts with TBRG1 and COMMD1. Interacts with CDKN2AIP and E4F1. Interacts with CDK5RAP3 and MDM2; form a ternary complex involved in regulation of p53/TP53 (PubMed:16173922). Isoform smARF interacts with C1QBP. Interacts with NOP53; the interaction is direct and promotes ARF nucleoplasmic relocalization and ubiquitin-mediated proteasomal degradation (PubMed:27323397).16 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
C1QBP	Q07021	3	EBI-625922,EBI-347528
DAXX	Q9UER7	8	EBI-625922,EBI-77321
EBNA-LP	Q8AZK7	5	EBI-625922,EBI-1185167	From Epstein-Barr virus (strain B95-8).
EGR1	P18146	4	EBI-625922,EBI-2834611
HUWE1	Q7Z6Z7	5	EBI-625922,EBI-625934
MDM2	Q00987	5	EBI-625922,EBI-389668
MTA1	Q13330	2	EBI-625922,EBI-714236
MYCN	P04198	3	EBI-625922,EBI-878369
NPM1	P06748	2	EBI-625922,EBI-78579
SP1	P08047	4	EBI-625922,EBI-298336
TRIP12	Q14669	4	EBI-625922,EBI-308443
ZNF420	Q8TAQ5	8	EBI-625922,EBI-3923307

GO - Molecular functionⁱ

disordered domain specific binding
Source: CAFA
Inferred from physical interactionⁱ
- 12630860
MDM2/MDM4 family protein binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16173922
p53 binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 9529249
transcription factor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 19057511

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	107463, 183 interactors
CORUMⁱ	Q8N726
Database of interacting proteins More...DIPⁱ	DIP-24171N
IntActⁱ	Q8N726, 57 interactors
Molecular INTeraction database More...MINTⁱ	Q8N726

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8N726
SMRⁱ	Q8N726
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 64	Interaction with CDK5RAP3 and MDM21 PublicationAdd BLAST		64

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000004527
HOGENOMⁱ	HOG000111485
HOVERGENⁱ	HBG071056

Family and domain databases

InterProⁱ	View protein in InterPro IPR010868 Tumor_suppres_ARF
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07392 P19Arf_N, 1 hit

Sequences (6)ⁱ

Sequence statusⁱ: Complete.

This entry describes 6 isoformsⁱ produced by alternative splicing. Align Add to basket

Note: Isoform 1 and isoform tumor suppressor ARF arise due to the use of two alternative first exons joined to a common exon 2 at the same acceptor site but in different reading frames, resulting in two completely different isoforms.By similarity

Isoform tumor suppressor ARF1 Publication (identifier: Q8N726-1) [UniParc]FASTA Add to basket

Also known as: p14ARF1 Publication, p19ARF

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVRRFLVTLR IRRACGPPRV RVFVVHIPRL TGEWAAPGAP AAVALVLMLL 
        60         70         80         90        100
RSQRLGQQPL PRRPGHDDGQ RPSGGAAAAP RRGAQLRRPR HSHPTRARRC 
       110        120        130 
PGGLPGHAGG AAPGRGAAGR ARCLGPSARG PG

Length:132

Mass (Da):13,903

Last modified:April 18, 2012 - v2

Checksum:ⁱ7739A9050C21BC96

GO

Isoform 1Curated (identifier: P42771-1) [UniParc]FASTA Add to basket

Also known as: p16INK4aCurated

The sequence of this isoform can be found in the external entry P42771.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Length:156

Mass (Da):16,533

GO

Isoform 2Curated (identifier: P42771-2) [UniParc]FASTA Add to basket

The sequence of this isoform can be found in the external entry P42771.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Length:105

Mass (Da):11,215

GO

Isoform 3Curated (identifier: P42771-3) [UniParc]FASTA Add to basket

Also known as: p12Curated

The sequence of this isoform can be found in the external entry P42771.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Length:116

Mass (Da):12,083

GO

Isoform 5 (identifier: P42771-4) [UniParc]FASTA Add to basket

Also known as: p16gamma

The sequence of this isoform can be found in the external entry P42771.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: Barely detectable in non-tumor cells.

Length:167

Mass (Da):17,883

GO

Isoform smARF (identifier: Q8N726-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-47: Missing.

« Hide

        10         20         30         40         50
MLLRSQRLGQ QPLPRRPGHD DGQRPSGGAA AAPRRGAQLR RPRHSHPTRA 
        60         70         80 
RRCPGGLPGH AGGAAPGRGA AGRARCLGPS ARGPG

Show »

Length:85

Mass (Da):8,731

Checksum:ⁱ4C9E739D74BEC556

GO

Sequence cautionⁱ

The sequence AAB01737 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence AAC60649 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence AAH15960 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence AAH21998 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence AAM77919 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence CAH70601 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence EAW58600 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence EAW58601 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	28 – 30	PRL → SWF in AAH15960 (PubMed:15489334).Curated	3
Sequence conflictⁱ	28 – 30	PRL → SWF in AAH21998 (PubMed:15489334).Curated	3
Sequence conflictⁱ	28 – 30	PRL → SWF in AAP35666 (PubMed:7624129).Curated	3
Sequence conflictⁱ	94	P → L in AAB01737 (Ref. 2) Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_029287	17	P → S1 PublicationCorresponds to variant dbSNP:rs3731190Ensembl.	1
Natural variantⁱVAR_053033	106	G → R. Corresponds to variant dbSNP:rs4987127Ensembl.	1
Natural variantⁱVAR_053034	113	P → L. Corresponds to variant dbSNP:rs34886500EnsemblClinVar.	1
Natural variantⁱVAR_053035	116	G → D. Corresponds to variant dbSNP:rs35741010EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_044962	1 – 47	Missing in isoform smARF. CuratedAdd BLAST		47

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	S78535 mRNA Translation: AAC60649.1 Different initiation. U38945 mRNA Translation: AAB01737.1 Different initiation. AF527803 Genomic DNA Translation: AAM77919.1 Different initiation. AL449423 Genomic DNA Translation: CAH70601.1 Different initiation. CH471071 Genomic DNA Translation: EAW58600.1 Different initiation. CH471071 Genomic DNA Translation: EAW58601.1 Different initiation. BC015960 mRNA Translation: AAH15960.3 Different initiation. BC021998 mRNA Translation: AAH21998.3 Different initiation. U26727 mRNA Translation: AAA82236.1 BT007020 mRNA Translation: AAP35666.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6511.2 [Q8N726-1]
PIRⁱ	I39004
NCBI Reference Sequences More...RefSeqⁱ	NP_478102.2, NM_058195.3 [Q8N726-1]
UniGeneⁱ	Hs.512599

Genome annotation databases

Ensemblⁱ	ENST00000530628; ENSP00000432664; ENSG00000147889 [Q8N726-1] ENST00000579755; ENSP00000462950; ENSG00000147889 [Q8N726-1]
GeneIDⁱ	1029
UCSC genome browser More...UCSCⁱ	uc003zpl.4 human [Q8N726-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P42771-2	Cyclin-dependent kinase inhibitor 2A	)	HUMAN		156	UniRef100_P42771
Cyclin-dependent kinase inhibitor 2A		HUMAN		156
P42771-3	CDKN2A isoform 8		PANTR		116	UniRef100_A0A2J8QSK3
p16 (Fragment)		HUMAN		67

Protein	Similar proteins		Species	Score	Length	Source
Q8N726	Isoform smARF of Tumor suppressor ARF		HUMAN		85	UniRef90_Q8N726
Cyclin dependent kinase inhibitor 2A		SAIBB		132
Uncharacterized protein		CALJA		132
Uncharacterized protein		Cebus capucinus imitator		132
Uncharacterized protein		COLAP		132
+3
P42771-2	Cyclin-dependent kinase inhibitor 2A	)	HUMAN		156	UniRef90_P42771
CDKN2A isoform 6		PANTR		167
Uncharacterized protein		PANPA		167
Cyclin dependent kinase inhibitor 2A		GORGO		167
Uncharacterized protein		MACFA		160
+36
P42771-3	CDKN2A isoform 8		PANTR		116	UniRef90_A0A2J8QSK3
p16 (Fragment)		HUMAN		67
P42771-4	Cyclin-dependent kinase inhibitor 2A	)	HUMAN		156	UniRef90_P42771
CDKN2A isoform 6		PANTR		167
Uncharacterized protein		PANPA		167
Cyclin dependent kinase inhibitor 2A		GORGO		167
Uncharacterized protein		MACFA		160
+36

Protein	Similar proteins		Species	Score	Length	Source
Q8N726	Isoform smARF of Tumor suppressor ARF		HUMAN		85	UniRef50_Q8N726
Cyclin dependent kinase inhibitor 2A		SAIBB		132
Uncharacterized protein		MACNE		132
Uncharacterized protein		CERAT		132
Uncharacterized protein		CALJA		132
+29
P42771-2	Cyclin-dependent kinase inhibitor 2A	)	HUMAN		156	UniRef50_P42771
CDKN2A isoform 6		PANTR		167
Uncharacterized protein		PANPA		167
Cyclin dependent kinase inhibitor 2A		GORGO		167
Uncharacterized protein		MACFA		160
+39
P42771-3	CDKN2A isoform 8		PANTR		116	UniRef50_A0A2J8QSK3
p16 (Fragment)		HUMAN		67
P42771-4	Cyclin-dependent kinase inhibitor 2A	)	HUMAN		156	UniRef50_P42771
CDKN2A isoform 6		PANTR		167
Uncharacterized protein		PANPA		167
Cyclin dependent kinase inhibitor 2A		GORGO		167
Uncharacterized protein		MACFA		160
+39

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	S78535 mRNA Translation: AAC60649.1 Different initiation. U38945 mRNA Translation: AAB01737.1 Different initiation. AF527803 Genomic DNA Translation: AAM77919.1 Different initiation. AL449423 Genomic DNA Translation: CAH70601.1 Different initiation. CH471071 Genomic DNA Translation: EAW58600.1 Different initiation. CH471071 Genomic DNA Translation: EAW58601.1 Different initiation. BC015960 mRNA Translation: AAH15960.3 Different initiation. BC021998 mRNA Translation: AAH21998.3 Different initiation. U26727 mRNA Translation: AAA82236.1 BT007020 mRNA Translation: AAP35666.1
CCDSⁱ	CCDS6511.2 [Q8N726-1]
PIRⁱ	I39004
RefSeqⁱ	NP_478102.2, NM_058195.3 [Q8N726-1]
UniGeneⁱ	Hs.512599

3D structure databases

ProteinModelPortalⁱ	Q8N726
SMRⁱ	Q8N726
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107463, 183 interactors
CORUMⁱ	Q8N726
DIPⁱ	DIP-24171N
IntActⁱ	Q8N726, 57 interactors
MINTⁱ	Q8N726

PTM databases

iPTMnetⁱ	Q8N726

iPTMnetⁱ

Q8N726

Polymorphism and mutation databases

BioMutaⁱ	UBR5
DMDMⁱ	384872321

Proteomic databases

MaxQBⁱ	Q8N726
PeptideAtlasⁱ	Q8N726
PRIDEⁱ	Q8N726
ProteomicsDBⁱ	72258

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1029
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000530628; ENSP00000432664; ENSG00000147889 [Q8N726-1] ENST00000579755; ENSP00000462950; ENSG00000147889 [Q8N726-1]
GeneIDⁱ	1029
UCSCⁱ	uc003zpl.4 human [Q8N726-1]

Organism-specific databases

CTDⁱ	1029
DisGeNETⁱ	1029
EuPathDBⁱ	HostDB:ENSG00000147889.16
GeneCardsⁱ	CDKN2A
HGNCⁱ	HGNC:1787 CDKN2A
HPAⁱ	CAB000093 CAB000445 CAB018232 HPA047838
MalaCardsⁱ	CDKN2A
MIMⁱ	600160 gene
neXtProtⁱ	NX_Q8N726
OpenTargetsⁱ	ENSG00000147889
PharmGKBⁱ	PA106
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

GeneTreeⁱ	ENSGT00390000004527
HOGENOMⁱ	HOG000111485
HOVERGENⁱ	HBG071056

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2559580 Oxidative Stress Induced Senescence R-HSA-2559585 Oncogene Induced Senescence R-HSA-3108214 SUMOylation of DNA damage response and repair proteins R-HSA-3232118 SUMOylation of transcription factors R-HSA-6804757 Regulation of TP53 Degradation R-HSA-69541 Stabilization of p53 R-HSA-8941858 Regulation of RUNX3 expression and activity
SIGNORⁱ	Q8N726

Miscellaneous databases

ChiTaRSⁱ	CDKN2A human
GenomeRNAiⁱ	1029
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000147889 Expressed in 195 organ(s), highest expression level in adenohypophysis
CleanExⁱ	HS_CDKN2A
ExpressionAtlasⁱ	Q8N726 baseline and differential
Genevisibleⁱ	Q8N726 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR010868 Tumor_suppres_ARF
Pfamⁱ	View protein in Pfam PF07392 P19Arf_N, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ARF_HUMAN
Accessionⁱ	Q8N726Primary (citable) accession number: Q8N726 Secondary accession number(s): D3DRK2 , Q13195, Q13399, Q16360, Q7KZR9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 11, 2005
	Last sequence update:	April 18, 2012
	Last modified:	November 7, 2018
	This is version 158 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8N726 (ARF_HUMAN)

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Tumor suppressor ARF

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Mitochondrion

Mitochondrion

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ