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Entry version 105 (22 Apr 2020)
Sequence version 2 (18 May 2010)
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Protein

Coiled-coil domain-containing protein 185

Gene

CCDC185

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coiled-coil domain-containing protein 185
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCDC185
Synonyms:C1orf65
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26654 CCDC185

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N715

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000178395

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142672515

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8N715 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CCDC185

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296434417

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002471141 – 623Coiled-coil domain-containing protein 185Add BLAST623

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki528Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8N715

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8N715

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8N715

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N715

PeptideAtlas

More...
PeptideAtlasi
Q8N715

PRoteomics IDEntifications database

More...
PRIDEi
Q8N715

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
72254

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N715

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N715

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000178395 Expressed in right testis and 89 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N715 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000178395 Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
127889, 12 interactors

Protein interaction database and analysis system

More...
IntActi
Q8N715, 49 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000355840

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8N715 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8N715

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili266 – 295Sequence analysisAdd BLAST30
Coiled coili359 – 392Sequence analysisAdd BLAST34
Coiled coili431 – 501Sequence analysisAdd BLAST71
Coiled coili534 – 573Sequence analysisAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi69 – 105Arg-richAdd BLAST37
Compositional biasi117 – 150Pro-richAdd BLAST34

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGGR Eukaryota
ENOG410XUIU LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00740000115684

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_029998_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N715

Identification of Orthologs from Complete Genome Data

More...
OMAi
ARSHVHK

Database of Orthologous Groups

More...
OrthoDBi
474796at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N715

TreeFam database of animal gene trees

More...
TreeFami
TF337827

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029090 DUF4659

The PANTHER Classification System

More...
PANTHERi
PTHR33663 PTHR33663, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15558 DUF4659, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8N715-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGFSHFSQP PYRDLWEPPR PGGERESTQR LGGQRSGADS TACSRAGTPG
60 70 80 90 100
AESEAGACWL HPHCSFTPRP RRRGCSDSLR GSRSLSDVAR RPLERSRKHR
110 120 130 140 150
PRSRRLEDAW GETGTKPRPA WQPQTQLPPQ RPQPCPHYPL AQGDSPPPCP
160 170 180 190 200
GGAGTPLSGT FRVEKAQGGD QWAVPLGRHL GRWSPSSVPS ERSSVPSQKF
210 220 230 240 250
KRHSACVCAQ KRDSSDQVES LASRDSQPLA SSKEMRSPHT QVLKSKLEEV
260 270 280 290 300
VVSSQDQQIV ALVLTRLKKA QRIRELQQQA AKAWEELKRS DQKVQMTLER
310 320 330 340 350
ERRLLLRQSQ EQWQEKEQRK TLQSPEQRGL RRDSQRKNVP PGESRWKEQP
360 370 380 390 400
EDQESPRQEK LEKARAQAEH RKQCQVRRLR EQEKMLRNLR EQHSLQLQRR
410 420 430 440 450
LVEACRKRHL HAVEGQKKVQ DTNLSSLINY QARKVLMDCQ AKAEELLRQL
460 470 480 490 500
SLEQSFQRSQ EIHQGLRKER QRELREKAQK EEEQLQQARW RAGESEEQRK
510 520 530 540 550
MRKRILVELA DEKIRQARSH VHKTTRDKVQ HLRELNHLRE KNHHILKLKA
560 570 580 590 600
EKEEKCHIEG IKEAIKKKEQ RVQHISQGKD PNFQEFQKLP QASRREERAP
610 620
PNSSLDQMVL EAQLRACQQN RGY
Length:623
Mass (Da):72,349
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i19103B45552CE57C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_027066195V → A. Corresponds to variant dbSNP:rs6689850Ensembl.1
Natural variantiVAR_027067329G → D1 PublicationCorresponds to variant dbSNP:rs10907376Ensembl.1
Natural variantiVAR_027068331R → W. Corresponds to variant dbSNP:rs6682552Ensembl.1
Natural variantiVAR_027069380R → L1 PublicationCorresponds to variant dbSNP:rs17852896Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK093047 mRNA Translation: BAC04033.1
AL590669 Genomic DNA No translation available.
BC030026 mRNA Translation: AAH30026.1
BC031066 mRNA Translation: AAH31066.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1537.1

NCBI Reference Sequences

More...
RefSeqi
NP_689823.2, NM_152610.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000366875; ENSP00000355840; ENSG00000178395

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
164127

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:164127

UCSC genome browser

More...
UCSCi
uc001hoa.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093047 mRNA Translation: BAC04033.1
AL590669 Genomic DNA No translation available.
BC030026 mRNA Translation: AAH30026.1
BC031066 mRNA Translation: AAH31066.1
CCDSiCCDS1537.1
RefSeqiNP_689823.2, NM_152610.2

3D structure databases

SMRiQ8N715
ModBaseiSearch...

Protein-protein interaction databases

BioGridi127889, 12 interactors
IntActiQ8N715, 49 interactors
STRINGi9606.ENSP00000355840

PTM databases

iPTMnetiQ8N715
PhosphoSitePlusiQ8N715

Polymorphism and mutation databases

BioMutaiCCDC185
DMDMi296434417

Proteomic databases

EPDiQ8N715
jPOSTiQ8N715
MassIVEiQ8N715
PaxDbiQ8N715
PeptideAtlasiQ8N715
PRIDEiQ8N715
ProteomicsDBi72254

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
20747 55 antibodies

The DNASU plasmid repository

More...
DNASUi
164127

Genome annotation databases

EnsembliENST00000366875; ENSP00000355840; ENSG00000178395
GeneIDi164127
KEGGihsa:164127
UCSCiuc001hoa.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
164127

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CCDC185
HGNCiHGNC:26654 CCDC185
HPAiENSG00000178395 Tissue enriched (testis)
neXtProtiNX_Q8N715
OpenTargetsiENSG00000178395
PharmGKBiPA142672515

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IGGR Eukaryota
ENOG410XUIU LUCA
GeneTreeiENSGT00740000115684
HOGENOMiCLU_029998_0_0_1
InParanoidiQ8N715
OMAiARSHVHK
OrthoDBi474796at2759
PhylomeDBiQ8N715
TreeFamiTF337827

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
164127
PharosiQ8N715 Tdark

Protein Ontology

More...
PROi
PR:Q8N715
RNActiQ8N715 protein

Gene expression databases

BgeeiENSG00000178395 Expressed in right testis and 89 other tissues
GenevisibleiQ8N715 HS

Family and domain databases

InterProiView protein in InterPro
IPR029090 DUF4659
PANTHERiPTHR33663 PTHR33663, 1 hit
PfamiView protein in Pfam
PF15558 DUF4659, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCC185_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N715
Secondary accession number(s): Q8N746, Q8NA93
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: May 18, 2010
Last modified: April 22, 2020
This is version 105 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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