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Protein

Protocadherin-20

Gene

PCDH20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein.

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: GO_Central
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro

Keywordsi

Biological processCell adhesion
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin-20
Alternative name(s):
Protocadherin-13
Gene namesi
Name:PCDH20
Synonyms:PCDH13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000197991.11
HostDB:ENSG00000280165.1
HGNCiHGNC:14257 PCDH20
MIMi614449 gene
neXtProtiNX_Q8N6Y1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini61 – 890ExtracellularSequence analysisAdd BLAST830
Transmembranei891 – 911HelicalSequence analysisAdd BLAST21
Topological domaini912 – 951CytoplasmicSequence analysisAdd BLAST40

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi64881
OpenTargetsiENSG00000197991
ENSG00000280165
PharmGKBiPA33004

Polymorphism and mutation databases

BioMutaiPCDH20
DMDMi544584765

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 60Sequence analysisAdd BLAST60
ChainiPRO_000000400561 – 951Protocadherin-20Add BLAST891

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi135N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi326N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi332N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi680N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi748N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi803N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi844N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi849N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8N6Y1
PeptideAtlasiQ8N6Y1
PRIDEiQ8N6Y1
ProteomicsDBi72248

PTM databases

iPTMnetiQ8N6Y1
PhosphoSitePlusiQ8N6Y1

Expressioni

Gene expression databases

BgeeiENSG00000197991 Expressed in 4 organ(s), highest expression level in uterus
CleanExiHS_PCDH20
GenevisibleiQ8N6Y1 HS

Organism-specific databases

HPAiHPA062669

Interactioni

Protein-protein interaction databases

BioGridi122337, 64 interactors
STRINGi9606.ENSP00000386653

Structurei

3D structure databases

ProteinModelPortaliQ8N6Y1
SMRiQ8N6Y1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini64 – 209Cadherin 1PROSITE-ProRule annotationAdd BLAST146
Domaini210 – 320Cadherin 2PROSITE-ProRule annotationAdd BLAST111
Domaini321 – 535Cadherin 3PROSITE-ProRule annotationAdd BLAST215
Domaini536 – 639Cadherin 4PROSITE-ProRule annotationAdd BLAST104
Domaini640 – 742Cadherin 5PROSITE-ProRule annotationAdd BLAST103
Domaini746 – 863Cadherin 6PROSITE-ProRule annotationAdd BLAST118

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFFV Eukaryota
ENOG4110RHM LUCA
GeneTreeiENSGT00920000148958
HOGENOMiHOG000234535
HOVERGENiHBG053523
InParanoidiQ8N6Y1
KOiK16498
OMAiEIVPRYI
OrthoDBiEOG091G011P
PhylomeDBiQ8N6Y1
TreeFamiTF320624

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 6 hits
SUPFAMiSSF49313 SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 5 hits
PS50268 CADHERIN_2, 6 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8N6Y1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRGRGNARSS QALGVSWCPA TWHPRLDMGR LHRPRSSTSY RNLPHLFLFF
60 70 80 90 100
LFVGPFSCLG SYSRATELLY SLNEGLPAGV LIGSLAEDLR LLPRSAGRPD
110 120 130 140 150
PQSQLPERTG AEWNPPLSFS LASRGLSGQY VTLDNRSGEL HTSAQEIDRE
160 170 180 190 200
ALCVEGGGGT AWSGSVSISS SPSDSCLLLL DVLVLPQEYF RFVKVKIAIR
210 220 230 240 250
DINDNAPQFP VSQISVWVPE NAPVNTRLAI EHPAVDPDVG INGVQTYRLL
260 270 280 290 300
DYHGMFTLDV EENENGERTP YLIVMGALDR ETQDQYVSII IAEDGGSPPL
310 320 330 340 350
LGSATLTIGI SDINDNCPLF TDSQINVTVY GNATVGTPIA AVQAVDKDLG
360 370 380 390 400
TNAQITYSYS QKVPQASKDL FHLDENTGVI KLFSKIGGSV LESHKLTILA
410 420 430 440 450
NGPGCIPAVI TALVSIIKVI FRPPEIVPRY IANEIDGVVY LKELEPVNTP
460 470 480 490 500
IAFFTIRDPE GKYKVNCYLD GEGPFRLSPY KPYNNEYLLE TTKPMDYELQ
510 520 530 540 550
QFYEVAVVAW NSEGFHVKRV IKVQLLDDND NAPIFLQPLI ELTIEENNSP
560 570 580 590 600
NAFLTKLYAT DADSEERGQV SYFLGPDAPS YFSLDSVTGI LTVSTQLDRE
610 620 630 640 650
EKEKYRYTVR AVDCGKPPRE SVATVALTVL DKNDNSPRFI NKDFSFFVPE
660 670 680 690 700
NFPGYGEIGV ISVTDADAGR NGWVALSVVN QSDIFVIDTG KGMLRAKVSL
710 720 730 740 750
DREQQSSYTL WVEAVDGGEP ALSSTAKITI LLLDINDNPP LVLFPQSNMS
760 770 780 790 800
YLLVLPSTLP GSPVTEVYAV DKDTGMNAVI AYSIIGRRGP RPESFRIDPK
810 820 830 840 850
TGNITLEEAL LQTDYGLHRL LVKVSDHGYP EPLHSTVMVN LFVNDTVSNE
860 870 880 890 900
SYIESLLRKE PEINIEEKEP QISIEPTHRK VESVSCMPTL VALSVISLGS
910 920 930 940 950
ITLVTGMGIY ICLRKGEKHP REDENLEVQI PLKGKIDLHM RERKPMDISN

I
Length:951
Mass (Da):104,919
Last modified:September 18, 2013 - v2
Checksum:iE8506B94A686A591
GO

Sequence cautioni

The sequence AAH27907 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti291I → T in AAF89690 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036111523V → M in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF169693 mRNA Translation: AAF89690.1
AK289924 mRNA Translation: BAF82613.1
AL833830 mRNA Translation: CAD38690.1
AL592490 Genomic DNA No translation available.
CH471124 Genomic DNA Translation: EAW52085.1
BC027907 mRNA Translation: AAH27907.1 Different initiation.
CCDSiCCDS9442.2
RefSeqiNP_073754.2, NM_022843.3
XP_016876197.1, XM_017020708.1
UniGeneiHs.391781

Genome annotation databases

EnsembliENST00000409204; ENSP00000387250; ENSG00000280165
GeneIDi64881
KEGGihsa:64881
UCSCiuc001vid.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF169693 mRNA Translation: AAF89690.1
AK289924 mRNA Translation: BAF82613.1
AL833830 mRNA Translation: CAD38690.1
AL592490 Genomic DNA No translation available.
CH471124 Genomic DNA Translation: EAW52085.1
BC027907 mRNA Translation: AAH27907.1 Different initiation.
CCDSiCCDS9442.2
RefSeqiNP_073754.2, NM_022843.3
XP_016876197.1, XM_017020708.1
UniGeneiHs.391781

3D structure databases

ProteinModelPortaliQ8N6Y1
SMRiQ8N6Y1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122337, 64 interactors
STRINGi9606.ENSP00000386653

PTM databases

iPTMnetiQ8N6Y1
PhosphoSitePlusiQ8N6Y1

Polymorphism and mutation databases

BioMutaiPCDH20
DMDMi544584765

Proteomic databases

PaxDbiQ8N6Y1
PeptideAtlasiQ8N6Y1
PRIDEiQ8N6Y1
ProteomicsDBi72248

Protocols and materials databases

DNASUi64881
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000409204; ENSP00000387250; ENSG00000280165
GeneIDi64881
KEGGihsa:64881
UCSCiuc001vid.5 human

Organism-specific databases

CTDi64881
DisGeNETi64881
EuPathDBiHostDB:ENSG00000197991.11
HostDB:ENSG00000280165.1
GeneCardsiPCDH20
HGNCiHGNC:14257 PCDH20
HPAiHPA062669
MIMi614449 gene
neXtProtiNX_Q8N6Y1
OpenTargetsiENSG00000197991
ENSG00000280165
PharmGKBiPA33004
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFFV Eukaryota
ENOG4110RHM LUCA
GeneTreeiENSGT00920000148958
HOGENOMiHOG000234535
HOVERGENiHBG053523
InParanoidiQ8N6Y1
KOiK16498
OMAiEIVPRYI
OrthoDBiEOG091G011P
PhylomeDBiQ8N6Y1
TreeFamiTF320624

Miscellaneous databases

GeneWikiiPCDH20
GenomeRNAii64881
PROiPR:Q8N6Y1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197991 Expressed in 4 organ(s), highest expression level in uterus
CleanExiHS_PCDH20
GenevisibleiQ8N6Y1 HS

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 6 hits
SUPFAMiSSF49313 SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 5 hits
PS50268 CADHERIN_2, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPCD20_HUMAN
AccessioniPrimary (citable) accession number: Q8N6Y1
Secondary accession number(s): A8K1K9
, B1AQU2, Q8NDN4, Q9NRT9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: September 18, 2013
Last modified: November 7, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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