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Protein

CUGBP Elav-like family member 5

Gene

CELF5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA.1 Publication

GO - Molecular functioni

  • pre-mRNA binding Source: UniProtKB

GO - Biological processi

  • mRNA processing Source: UniProtKB-KW
  • regulation of alternative mRNA splicing, via spliceosome Source: UniProtKB

Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
CUGBP Elav-like family member 5
Short name:
CELF-5
Alternative name(s):
Bruno-like protein 5
CUG-BP- and ETR-3-like factor 5
RNA-binding protein BRUNOL-5
Gene namesi
Name:CELF5
Synonyms:BRUNOL5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000161082.12
HGNCiHGNC:14058 CELF5
MIMi612680 gene
neXtProtiNX_Q8N6W0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000161082
PharmGKBiPA25429

Polymorphism and mutation databases

BioMutaiCELF5
DMDMi74762534

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002952271 – 485CUGBP Elav-like family member 5Add BLAST485

Proteomic databases

PaxDbiQ8N6W0
PeptideAtlasiQ8N6W0
PRIDEiQ8N6W0
ProteomicsDBi72243
72244 [Q8N6W0-2]

PTM databases

iPTMnetiQ8N6W0
PhosphoSitePlusiQ8N6W0

Expressioni

Tissue specificityi

Expressed in brain.1 Publication

Gene expression databases

BgeeiENSG00000161082 Expressed in 110 organ(s), highest expression level in endothelial cell
CleanExiHS_BRUNOL5
ExpressionAtlasiQ8N6W0 baseline and differential
GenevisibleiQ8N6W0 HS

Organism-specific databases

HPAiHPA042012
HPA060336

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
RHOXF2Q9BQY44EBI-12139335,EBI-372094

Protein-protein interaction databases

BioGridi121954, 13 interactors
IntActiQ8N6W0, 22 interactors
STRINGi9606.ENSP00000292672

Structurei

Secondary structure

1485
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8N6W0
SMRiQ8N6W0
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8N6W0

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini45 – 126RRM 1PROSITE-ProRule annotationAdd BLAST82
Domaini134 – 214RRM 2PROSITE-ProRule annotationAdd BLAST81
Domaini400 – 478RRM 3PROSITE-ProRule annotationAdd BLAST79

Sequence similaritiesi

Belongs to the CELF/BRUNOL family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0146 Eukaryota
ENOG410XNTW LUCA
GeneTreeiENSGT00560000076837
HOVERGENiHBG107646
InParanoidiQ8N6W0
KOiK13207
OMAiQPDGMKD
OrthoDBiEOG091G19O1
PhylomeDBiQ8N6W0
TreeFamiTF314924

Family and domain databases

CDDicd12632 RRM1_CELF3_4_5_6, 1 hit
Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR034648 CELF3/4/5/6_RRM1
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 3 hits
SMARTiView protein in SMART
SM00360 RRM, 3 hits
SUPFAMiSSF54928 SSF54928, 3 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 3 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N6W0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARLTESEAR RQQQQLLQPR PSPVGSSGPE PPGGQPDGMK DLDAIKLFVG
60 70 80 90 100
QIPRHLDEKD LKPLFEQFGR IYELTVLKDP YTGMHKGCAF LTYCARDSAI
110 120 130 140 150
KAQTALHEQK TLPGMARPIQ VKPADSESRG GRDRKLFVGM LNKQQSEEDV
160 170 180 190 200
LRLFQPFGVI DECTVLRGPD GSSKGCAFVK FSSHTEAQAA IHALHGSQTM
210 220 230 240 250
PGASSSLVVK FADTDKERTL RRMQQMVGQL GILTPSLTLP FSPYSAYAQA
260 270 280 290 300
LMQQQTTVLS TSGSYLSPGV AFSPCHIQQI GAVSLNGLPA TPIAPASGLH
310 320 330 340 350
SPPLLGTTAV PGLVAPITNG FAGVVPFPGG HPALETVYAN GLVPYPAQSP
360 370 380 390 400
TVAETLHPAF SGVQQYTAMY PTAAITPIAH SVPQPPPLLQ QQQREGPEGC
410 420 430 440 450
NLFIYHLPQE FGDTELTQMF LPFGNIISSK VFMDRATNQS KCFGFVSFDN
460 470 480
PASAQAAIQA MNGFQIGMKR LKVQLKRPKD PGHPY
Length:485
Mass (Da):52,355
Last modified:October 1, 2002 - v1
Checksum:iAB805B4971619E05
GO
Isoform 2 (identifier: Q8N6W0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     298-322: Missing.
     397-434: PEGCNLFIYH...NIISSKVFMD → VWRHGADADV...PEQVFRLREL
     435-485: Missing.

Show »
Length:409
Mass (Da):44,479
Checksum:i6065BB4FE2DFAE78
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DFI3B4DFI3_HUMAN
CUGBP Elav-like family member 5
CELF5
320Annotation score:
K7ES14K7ES14_HUMAN
CUGBP Elav-like family member 5
CELF5
295Annotation score:

Sequence cautioni

The sequence AAC27666 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAK07476 differs from that shown. Reason: Erroneous termination at position 482. Translated as Gly.Curated
The sequence BAD92304 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti293I → V in AAK07476 (PubMed:11158314).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03326465F → L1 PublicationCorresponds to variant dbSNP:rs17854481Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_026844298 – 322Missing in isoform 2. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_026845397 – 434PEGCN…KVFMD → VWRHGADADVPTLRQYHFLQ GVYGSSYQPEQVFRLREL in isoform 2. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_026846435 – 485Missing in isoform 2. 1 PublicationAdd BLAST51

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209067 mRNA Translation: BAD92304.1 Different initiation.
AC005331 Genomic DNA Translation: AAC27666.1 Different initiation.
AC006505 Genomic DNA No translation available.
AC010649 Genomic DNA No translation available.
AC123911 Genomic DNA No translation available.
CH471139 Genomic DNA Translation: EAW69327.1
CH471139 Genomic DNA Translation: EAW69328.1
BC028101 mRNA Translation: AAH28101.1
AF329266 mRNA Translation: AAK07476.1 Sequence problems.
AF248649 mRNA Translation: AAF86231.1
CCDSiCCDS12106.1 [Q8N6W0-1]
CCDS54197.1 [Q8N6W0-2]
RefSeqiNP_001166144.1, NM_001172673.1 [Q8N6W0-2]
NP_068757.2, NM_021938.3 [Q8N6W0-1]
XP_006722895.1, XM_006722832.1 [Q8N6W0-1]
UniGeneiHs.655747

Genome annotation databases

EnsembliENST00000292672; ENSP00000292672; ENSG00000161082 [Q8N6W0-1]
ENST00000541430; ENSP00000443498; ENSG00000161082 [Q8N6W0-2]
GeneIDi60680
KEGGihsa:60680
UCSCiuc002lxm.4 human [Q8N6W0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209067 mRNA Translation: BAD92304.1 Different initiation.
AC005331 Genomic DNA Translation: AAC27666.1 Different initiation.
AC006505 Genomic DNA No translation available.
AC010649 Genomic DNA No translation available.
AC123911 Genomic DNA No translation available.
CH471139 Genomic DNA Translation: EAW69327.1
CH471139 Genomic DNA Translation: EAW69328.1
BC028101 mRNA Translation: AAH28101.1
AF329266 mRNA Translation: AAK07476.1 Sequence problems.
AF248649 mRNA Translation: AAF86231.1
CCDSiCCDS12106.1 [Q8N6W0-1]
CCDS54197.1 [Q8N6W0-2]
RefSeqiNP_001166144.1, NM_001172673.1 [Q8N6W0-2]
NP_068757.2, NM_021938.3 [Q8N6W0-1]
XP_006722895.1, XM_006722832.1 [Q8N6W0-1]
UniGeneiHs.655747

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DNHNMR-A126-217[»]
ProteinModelPortaliQ8N6W0
SMRiQ8N6W0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121954, 13 interactors
IntActiQ8N6W0, 22 interactors
STRINGi9606.ENSP00000292672

PTM databases

iPTMnetiQ8N6W0
PhosphoSitePlusiQ8N6W0

Polymorphism and mutation databases

BioMutaiCELF5
DMDMi74762534

Proteomic databases

PaxDbiQ8N6W0
PeptideAtlasiQ8N6W0
PRIDEiQ8N6W0
ProteomicsDBi72243
72244 [Q8N6W0-2]

Protocols and materials databases

DNASUi60680
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000292672; ENSP00000292672; ENSG00000161082 [Q8N6W0-1]
ENST00000541430; ENSP00000443498; ENSG00000161082 [Q8N6W0-2]
GeneIDi60680
KEGGihsa:60680
UCSCiuc002lxm.4 human [Q8N6W0-1]

Organism-specific databases

CTDi60680
EuPathDBiHostDB:ENSG00000161082.12
GeneCardsiCELF5
HGNCiHGNC:14058 CELF5
HPAiHPA042012
HPA060336
MIMi612680 gene
neXtProtiNX_Q8N6W0
OpenTargetsiENSG00000161082
PharmGKBiPA25429
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0146 Eukaryota
ENOG410XNTW LUCA
GeneTreeiENSGT00560000076837
HOVERGENiHBG107646
InParanoidiQ8N6W0
KOiK13207
OMAiQPDGMKD
OrthoDBiEOG091G19O1
PhylomeDBiQ8N6W0
TreeFamiTF314924

Miscellaneous databases

EvolutionaryTraceiQ8N6W0
GenomeRNAii60680
PROiPR:Q8N6W0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000161082 Expressed in 110 organ(s), highest expression level in endothelial cell
CleanExiHS_BRUNOL5
ExpressionAtlasiQ8N6W0 baseline and differential
GenevisibleiQ8N6W0 HS

Family and domain databases

CDDicd12632 RRM1_CELF3_4_5_6, 1 hit
Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR034648 CELF3/4/5/6_RRM1
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 3 hits
SMARTiView protein in SMART
SM00360 RRM, 3 hits
SUPFAMiSSF54928 SSF54928, 3 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCELF5_HUMAN
AccessioniPrimary (citable) accession number: Q8N6W0
Secondary accession number(s): D6W614
, O75253, Q59GP2, Q86VW6, Q9BZC0, Q9NR86
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: October 1, 2002
Last modified: September 12, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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